Telomerase efficiently elongates highly transcribing telomeres in human cancer cells
Open accessAbstract
RNA polymerase II transcribes the physical ends of linear eukaryotic chromosomes into a variety of long non-coding RNA molecules including telomeric repeat-containing RNA (TERRA). Since TERRA discovery, advances have been made in the characterization of TERRA biogenesis and regulation; on the contrary its associated functions remain elusive. Most of the biological roles so far proposed for TERRA are indeed based on in vitro experiments carried out using short TERRA-like RNA oligonucleotides. In particular, it has been suggested that TERRA inhibits telomerase activity. We have exploited two alternative cellular systems to test whether TERRA and/or telomere transcription influence telomerase-mediated telomere elongation in human cancer cells. In cells lacking the two DNA methyltransferases DNMT1 and DNMT3b, TERRA transcription and steady-state levels are greatly increased while telomerase is able to elongate telomeres normally. Similarly, telomerase can efficiently elongate transgenic inducible telomeres whose transcription has been experimentally augmented. Our data challenge the current hypothesis that TERRA functions as a general inhibitor of telomerase and suggest that telomere length homeostasis is maintained independently of TERRA and telomere transcription.
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Despite a lack of universal consensus regarding the main function of TERRAs, this seems to be the formation of telomeric heterochromatin, the protection of telomeres, and the negative regulation of telomerase.
“Despite a lack of universal consensus regarding the main function of TERRAs, this seems to be the formation of telomeric heterochromatin, the protection of telomeres, and the negative regulation of telomerase [192].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [192]
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Expression of Subtelomeric lncRNAs Links Telomeres Dynamics to RNA Decay in S. cerevisiae
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Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and FunctionsPreprint
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Nature and Functions of Telomeric Transcripts
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Variable TERRA abundance and stability in cervical cancer cells
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Telomeres as dynamic structures of human genome: the effect of endogenous and exogenous factors
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Self-citation
- Authors
- Farnung, B. O., Brun, C. M., Arora, R., Lorenzi, L. E., & Azzalin, C. M.
- Affiliations
- ETH Zurich (CH)
- Corresponding author
- Azzalin, Claus M.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-04-27
- Volume
- 7
- Issue
- 4
- Pages
- e35714
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3338753
- OpenAlex
- W2075029265
- Semantic Scholar
- a7beff34e319d0dcec06c695e7b2a389c7fa2405
- Cited by
- 91
- References
- 32
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 10 · 2023: 8 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 7 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 8 · 2014: 16 · 2013: 11 · 2012: 2
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
- ETH Zürich Research Collection (cc-by)
- Funders
- National Science Foundation
- Boehringer Ingelheim Fonds
- Branco Weiss Fellowship – Society in Science
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (120090, PP00P3, 123356, 3100A0)
- Fondazione Cariplo (2008-2507)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- telomerase, telomere transcription, Terra, telomeric repeat-containing RNA, telomere elongation, telomere length homeostasis, DNMT1, DNMT3B, DNA methylation, long non-coding RNA, human cancer cells, telomere length regulation
- MeSH terms
- DNA (Cytosine-5-)-Methyltransferase 1, DNA Methyltransferase 3B, DNA (Cytosine-5-)-Methyltransferases, Fibroblasts, Humans, Plasmids, Transcription, Genetic, Transfection, Telomere, Telomerase, RNA, Untranslated, Cell Line, Tumor, Telomere Homeostasis, Primary Cell Culture
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