Cited by 125Cancer-related Molecular PathwaysUbiquitin and proteasome pathwaysGenomics and Chromatin Dynamics

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Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding

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Wu, Shwu‐Yuan, Chiang, Cheng‐Ming·2009·The EMBO Journal

DOI 10.1038/emboj.2009.83PMC PMC2683057

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Abstract

Covalent modification by small ubiquitin-related modifiers (SUMO) regulates p53 transcription activity through an undefined mechanism. Using reconstituted sumoylation components, we purified SUMO-1-conjugated p53 (Su-p53) to near homogeneity. Su-p53 exists in solution as a tetramer and interacts with p300 histone acetyltransferase as efficiently as the unmodified protein. Nevertheless, it fails to activate p53-dependent chromatin transcription because of its inability to bind DNA. With sequential modification assays, we found that sumoylation of p53 at K386 blocks subsequent acetylation by p300, whereas p300-acetylated p53 remains permissive for ensuing sumoylation at K386 and alleviates sumoylation-inhibited DNA binding. While preventing the free form of p53 from accessing its cognate sites, sumoylation fails to disengage prebound p53 from DNA. The sumoylation-deficient K386R protein, when expressed in p53-null cells, exhibits higher transcription activity and binds better to the endogenous p21 gene compared with the wild-type protein. These studies unravel a molecular mechanism underlying sumoylation-regulated p53 function and further uncover a new role of acetylation in antagonizing the inhibitory effect of sumoylation on p53 binding to DNA.

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Authors: Wu, S., & Chiang, C.
Affiliations: Harold C. Simmons Comprehensive Cancer Center (US)
Corresponding author: Chiang, Cheng‐Ming
ORCID: Wu, Shwu‐Yuan
Chiang, Cheng‐Ming
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 2009-04-02
Volume: 28
Issue: 9
Pages: 1246-1259
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1038/emboj.2009.83
PMC: PMC2683057
OpenAlex: W2073590048
Cited by: 125
References: 68
Citations by year: 2026: 6 · 2025: 7 · 2024: 5 · 2023: 1 · 2022: 8 · 2021: 12 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 6 · 2015: 3 · 2014: 7 · 2013: 12 · 2012: 12
FWCI: 5.83
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: The EMBO Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Cancer Institute (CA103867, R01CA103867, R01CA124760, CA124760)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: p53, SUMOylation, acetylation, SUMO1, P300, histone acetyltransferase, p53 DNA binding, chromatin transcription, post-translational modification, p21 gene, p53 tetramer, transcriptional activation
MeSH terms: p300-CBP-Associated Factor, Acetylation, Chromatin, Chromatography, Gel, DNA, Humans, Protein Binding, Transcription, Genetic, Tumor Suppressor Protein p53, Reverse Transcriptase Polymerase Chain Reaction, Electrophoretic Mobility Shift Assay, Small Ubiquitin-Related Modifier Proteins, Cell Line, Tumor, Chromatin Immunoprecipitation, p300-CBP Transcription Factors

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Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding

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