Exercise type and muscle fiber specific induction of caveolin-1 expression for insulin sensitivity of skeletal muscle
Open accessAbstract
It is well known that exercise can have beneficial effects on insulin resistance by activation of glucose transporter. Following up our previous report that caveolin-1 plays an important role in glucose uptake in L6 skeletal muscle cells, we examined whether exercise alters the expression of caveolin-1, and whether exercise-caused changes are muscle fiber and exercise type specific. Fifty week-old Sprague Dawley (SD) rats were trained to climb a ladder and treadmill for 8 weeks and their soleus muscles (SOL) and extensor digitorum longus muscles (EDL) were removed after the last bout of exercise and compared with those from non-exercised animals. We found that the expression of insulin related proteins and caveolins did not change in SOL muscles after exercise. However, in EDL muscles, the expression of insulin receptor beta (IR beta) and glucose transporter-4 (GLUT-4) as well as phosphorylation of AKT and AMPK increased with resistance exercise but not with aerobic exercise. Also, caveolin-1 and caveolin-3 increased along with insulin related proteins only in EDL muscles by resistance exercise. These results suggest that upregulation of caveolin-1 in the skeletal muscle is fiber specific and exercise type specific, implicating the requirement of the specific mode of exercise to improve insulin sensitivity.
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Resistance exercise increases expression of GLUT-4 in type II fibers and enhances intracellular insulin sensitivity.
“Additionally, resistance exercise has been shown to increase the expression of GLUT-4 in type II fibers and enhance intracellular insulin sensitivity (84–87).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [87]
Resistance exercise specifically promotes hypertrophy in type II muscle fibers, while not significantly affecting type I fibers.
“Resistance exercise has been found to specifically promote hypertrophy in type II muscle fibers, while not significantly affecting type I fibers.”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [87]
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- Authors
- Oh, Y. S., Kim, H. J., Ryu, S. J., Cho, K. A., Park, Y. S., Park, H., Kim, M., Kim, C. K., & Park, S. C.
- Affiliations
- Seoul National University (KR)
- Chonnam National University (KR)
- Corresponding author
- Park, Sang Chul
- Venue
- Experimental & Molecular Medicine
- Published
- 2007-06-01
- Volume
- 39
- Issue
- 3
- Pages
- 395-401
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- OpenAlex
- W2091690650
- Cited by
- 24
- References
- 42
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 2 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2012: 2
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Experimental & Molecular Medicine (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Korea Science and Engineering Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- caveolin-1, caveolin-3, insulin sensitivity, skeletal muscle, exercise type, resistance training, aerobic exercise, muscle fiber type, soleus muscle, extensor digitorum longus, insulin receptor beta, glucose transporter 4, Akt phosphorylation, AMPK phosphorylation, glucose uptake
- MeSH terms
- Animals, Female, Insulin, Multienzyme Complexes, Phosphorylation, Physical Conditioning, Animal, Receptor, Insulin, Up-Regulation, Rats, Sprague-Dawley, Protein Serine-Threonine Kinases, Muscle, Skeletal, Muscle Fibers, Skeletal, Proto-Oncogene Proteins c-akt, Caveolin 1, Caveolin 3, Glucose Transporter Type 4, Rats, AMP-Activated Protein Kinases
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