Decision to abort after a prenatal diagnosis of sex chromosome abnormality: a systematic review of the literature
Open accessAbstract
We performed a systematic review of factors affecting parental decisions to continue or terminate a pregnancy after prenatal diagnosis of a sex chromosome abnormality, as reported in published studies from 1987 to May 2011. Based on the Matrix Method for systematic reviews, 19 studies were found in five electronic databases, meeting specific inclusion/exclusion criteria. Abstracted data were organized in a matrix. Alongside the search for factors influencing parental decisions, each study was judged on its methodological quality and assigned a methodological quality score. Decisions either to terminate or to continue a sex chromosome abnormality-affected pregnancy shared five similar factors: specific type of sex chromosome abnormality, gestational week at diagnosis, parents' age, providers' genetic expertise, and number of children/desire for (more) children. Factors unique to termination decisions included parents' fear/anxiety and directive counseling. Factors uniquely associated with continuation decisions were parents' socioeconomic status and ethnicity. The studies' average methodological quality score was 10.6 (SD = 1.67; range, 8-14). Findings from this review can be useful in adapting and modifying guidelines for genetic counseling after prenatal diagnosis of a sex chromosome abnormality. Moreover, improving the quality of future studies on this topic may allow clearer understanding of the most influential factors affecting parental decisions.
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Several factors influence prospective parents' decision to continue or terminate a pregnancy with a TS fetus, including fetal ultrasound abnormalities, incidental findings, presence or absence of mosaicism, gestational age at diagnosis, parental age, number of previous children, possibility of infertility, parents' fear/anxiety, parents' socioeconomic status and religious background, ethnicity,遗传学
“Several factors have been found to influence the prospective parents’ decision to continue or terminate a pregnancy with a TS fetus.”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [81]
In countries where termination of pregnancy is allowed, rates of termination of pregnancy following prenatal diagnosis of TS vary between 15.4% and 100%.
“In countries where termination of pregnancy is allowed, rates of termination of pregnancy following prenatal diagnosis of TS vary between 15.4% and 100%.59,81,82”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [81]
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- Authors
- Jeon, K. C., Chen, L.-S., & Goodson, P.
- Affiliations
- Texas A&M University (US)
- Corresponding author
- Jeon, Kwon Chan
- Venue
- Genetics in Medicine
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 14
- Issue
- 1
- Pages
- 27-38
- ISSN
- 1098-3600 (ISSN-L)
- OpenAlex
- W2091333572
- Cited by
- 139
- References
- 39
- Citations by year
- 2026: 3 · 2025: 21 · 2024: 10 · 2023: 4 · 2022: 13 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 37 · 2017: 2 · 2016: 4 · 2015: 8 · 2014: 4 · 2013: 6 · 2012: 7
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Genetics in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Ethics and Legal Issues in Pediatric Healthcare
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- sex chromosome abnormalities, prenatal diagnosis, abortion, continuation of pregnancy, parental decision-making, genetic counseling, gestational age at diagnosis, parental age, socioeconomic status, ethnicity, fear and anxiety, desire for more children
- MeSH terms
- Abortion, Induced, Decision Making, Female, Humans, Parents, Pregnancy, Pregnancy Outcome, Prenatal Diagnosis, Sex Chromosome Aberrations
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