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Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo
Open accessAbstract
Vaccination with in vitro transcribed RNA coding for tumor antigens is considered a promising approach for cancer immunotherapy and has already entered human clinical testing. One of the basic objectives for development of RNA as a drug is the optimization of immunobioavailability of the encoded antigen in vivo. By analyzing the effect of different synthetic 5' mRNA cap analogs on the kinetics of the encoded protein, we found that m(2)(7,2'-O)Gpp(S)pG (beta-S-ARCA) phosphorothioate caps, in particular the D1 diastereoisomer, profoundly enhance RNA stability and translational efficiency in immature but not mature dendritic cells. Moreover, in vivo delivery of the antigen as beta-S-ARCA(D1)-capped RNA species is superior for protein expression and for efficient priming and expansion of naïve antigen-specific T cells in mice. Our findings establish 5' mRNA cap analogs as yet another module for tuning immunopharmacological properties of recombinant antigen-encoding RNA for vaccination purposes.
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“These strategies have yielded modest improvements in RNA stability10, 13–16, and thus alternative approaches to RNA stabilization, such as circularization, are desirable.”
From Engineering circular RNA for potent and stable translation in eukaryotic cells (2018) · cites this paper as [14]
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Cites
Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,486
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
Sonenberg, N., & Hinnebusch, A. G. (2009) · Cell · doi:10.1016/j.cell.2009.01.042 · Cited by 3,304
Holtkamp, S., Kreiter, S., Selmi, A., Simon, P., Koslowski, M., Huber, C., Türeci, O., & Sahin, U. (2006) · Blood · doi:10.1182/blood-2006-04-015024 · Cited by 625
Self-citationGilboa, E. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31205 · Cited by 589
Quantitating Protein Synthesis, Degradation, and Endogenous Antigen Processing
Princiotta, M. F., Finzi, D., Qian, S.-B., Gibbs, J., Schuchmann, S., Buttgereit, F., Bennink, J. R., & Yewdell, J. W. (2003) · Immunity · doi:10.1016/s1074-7613(03)00051-7 · Cited by 521
Yewdell, J. W., Antón, L. C., & Bennink, J. R. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.5.1823 · Cited by 450
Weide, B., Pascolo, S., Scheel, B., Derhovanessian, E., Pflugfelder, A., Eigentler, T. K., Pawelec, G., Hoerr, I., Rammensee, H.-G., & Garbe, C. (2009) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3181a00068 · Cited by 378 · cited 1×
“9 In summary, our data reveal 5 0 mRNA cap analogs as a further structural feature to modify the stability and translational efficiency of in vitro transcribed RNA for pharmaceutical applications.”
BackgroundSu, Z., Dannull, J., Yang, B. K., Dahm, P., Coleman, D., Yancey, D., Sichi, S., Niedzwiecki, D., Boczkowski, D., Gilboa, E., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3798 · Cited by 359
(2001) · PubMed Central · Cited by 342
Novel “anti-reverse” cap analogs with superior translational properties
Jemielity, J., Fowler, T. E., Zuberek, J., Stȩpiński, J., Lewdorowicz, M., Niedźwiecka-Kornaś, A., Stolarski, R., Darżynkiewicz, E., & Rhoads, R. E. (2003) · RNA · doi:10.1261/rna.5430403 · Cited by 263
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Items 101–200 of 228
mRNA vaccination as a safe approach for specific protection from type I allergy
Weiss, R., Scheiblhofer, S., Roesler, E., Weinberger, E., & Thalhamer, J. (2012) · Expert Review of Vaccines · doi:10.1586/erv.11.168 · Cited by 42
Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination
Vormehr, M., Schrörs, B., Boegel, S., Löwer, M., Türeci, Ö., & Şahin, U. (2015) · Journal of Immunology Research · doi:10.1155/2015/595363 · Cited by 44
Self-citationMannosylated and Histidylated LPR Technology for Vaccination with Tumor Antigen mRNA
Pichon, C., & Midoux, P. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-260-5_16 · Cited by 42
Walczak, S., Nowicka, A. M., Kubacka, D., Fac-Dabrowska, K., Wanat, P., Mroczek, S., Kowalska, J., & Jemielity, J. (2016) · Chemical Science · doi:10.1039/c6sc02437h · Cited by 42
Self-citationPerković, M., Gawletta, S., Hempel, T., Brill, S., Nett, E., Şahin, U., & Beißert, T. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.01.019 · Cited by 46
Translational control of gene function through optically regulated nucleic acids
Darrah, K. E., & Deiters, A. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00257k · Cited by 40
Mamot, A., Sikorski, P. J., Warmiński, M., Kowalska, J., & Jemielity, J. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201709052 · Cited by 38
Self-citationSu, W., Slepenkov, S. V., Grudzien‐Nogalska, E., Kowalska, J., Kulis, M., Zuberek, J., Łukaszewicz, M., Darżynkiewicz, E., Jemielity, J., & Rhoads, R. E. (2011) · RNA · doi:10.1261/rna.2430711 · Cited by 36
Self-citationStereocontrolled access to thioisosteres of nucleoside di- and triphosphates
Zhang, H., Ociepa, M., Nassir, M., Zheng, B., Lewicki, S. A., Salmaso, V., Baburi, H., Nagel, J., Mirza, S., Bueschbell, B., et al. (2023) · Nature Chemistry · doi:10.1038/s41557-023-01347-2 · Cited by 36
Self-citationPhua, K. K. L. (2015) · Journal of Immunology Research · doi:10.1155/2015/680620 · Cited by 35
Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA
Aldon, Y., McKay, P. F., Herrero, J. M., Vogel, A. B., Lévai, R. F., Maisonnasse, P., Dereuddre‐Bosquet, N., Haas, H., Fábián, K., Grand, R. L., et al. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.06.008 · Cited by 34
Prophylactic mRNA vaccination against allergy
Weiss, R., Scheiblhofer, S., Roesler, E., Ferreira, F., & Thalhamer, J. (2010) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32833fd5b6 · Cited by 33
Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles
McCullough, K. C., Milona, P., Thomann, L., Démoulins, T., Englezou, P. C., Suter, R., & Ruggli, N. (2014) · Vaccines · doi:10.3390/vaccines2040735 · Cited by 35
Incorporation of mRNA in Lamellar Lipid Matrices for Parenteral Administration
Ziller, A., Nogueira, S. S., Huehn, E., Funari, S. S., Brezesinski, G., Hartmann, H., Şahin, U., Haas, H., & Langguth, P. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b01022 · Cited by 34
Phosphate analogues in the dissection of mechanism
Korhonen, H. J., Conway, L. P., & Hodgson, D. R. W. (2014) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2014.05.001 · Cited by 32
Rydzik, A. M., Warmiński, M., Sikorski, P. J., Baranowski, M. R., Walczak, S., Kowalska, J., Zuberek, J., Łukaszewicz, M., Nowak, E., Claridge, T. D. W., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx569 · Cited by 32
Self-citationWarmiński, M., Kowalska, J., Nowak, E., Kubacka, D., Tibble, R. W., Kasprzyk, R., Sikorski, P. J., Gross, J. D., Nowotny, M., & Jemielity, J. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.0c00864 · Cited by 31
Self-citationmRNA-Based Vaccines and Mode of Action
Gergen, J., & Petsch, B. (2020) · Current topics in microbiology and immunology · doi:10.1007/82_2020_230 · Cited by 36
Robust genome and cell engineering via in vitro and in situ circularized RNAs
Tong, M., Palmer, N. D., Dailamy, A., Kumar, A., Khaliq, H., Han, S., Finburgh, E. N., Wing, M. K., Hong, C., Xiang, Y., et al. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01245-z · Cited by 32
Holstein, J. M., Anhäuser, L., & Rentmeister, A. (2016) · Angewandte Chemie · doi:10.1002/ange.201604107 · Cited by 29
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer
Vormehr, M., Lehar, S. M., Kranz, L. M., Tähtinen, S., Oei, Y. A., Javinal, V., Delamarre, L., Walzer, K. C., Diken, M., Kreiter, S., et al. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1758004 · Cited by 28
Self-citationKropiwnicka, A., Kuchta, K., Łukaszewicz, M., Kowalska, J., Jemielity, J., Ginalski, K., Darżynkiewicz, E., & Zuberek, J. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.11.032 · Cited by 28
Self-citationReducing cell intrinsic immunity to mRNA vaccine alters adaptive immune responses in mice
Wang, Z., Jacobus, E. J., Stirling, D. C., Krumm, S. A., Flight, K. E., Cunliffe, R. F., Mottl, J., Singh, C., Mosscrop, L. G., Santiago, L. A., et al. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.102045 · Cited by 30
Advances in Nonviral mRNA Delivery Materials and Their Application as Vaccines for Melanoma Therapy
Neill, B., Romero, A. R., & Fenton, O. S. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00721 · Cited by 31
The European Regulatory Environment of RNA-Based Vaccines
Hinz, T., Kallen, K., Britten, C. M., Flamion, B., Granzer, U., Hoos, A., Huber, C., Khleif, S. N., Kreiter, S., Rammensee, H., et al. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6481-9_13 · Cited by 30
Self-citationZiegenhals, T., Frieling, R., Wolf, P., Göbel, K., Koch, S., Lohmann, M., Baiersdörfer, M., Fesser, S., Şahin, U., & Kuhn, A. N. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1291045 · Cited by 29
Self-citationIge, M. A., Ren, X., Yang, Y., Zhang, H., Shen, C., Jiang, Y., Li, J., & Wan, X. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102721 · Cited by 30
Cancer vaccine triggers antiviral-type defences
de Vries, I. J. M., & Figdor, C. G. (2016) · Nature · doi:10.1038/nature18443 · Cited by 28
Li, M., Wang, Z., Xie, C., & Xia, X. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.04.011 · Cited by 30
Synthesis and evaluation of fluorescent cap analogues for mRNA labelling
Ziemniak, M., Szabelski, M., Łukaszewicz, M., Nowicka, A. M., Darżynkiewicz, E., Rhoads, R. E., Wieczorek, Z. J., & Jemielity, J. (2013) · RSC Advances · doi:10.1039/c3ra42769b · Cited by 26
Self-citationSalomon, N., Selmi, A., Grunwitz, C. R., Kong, A. H., Stanganello, E., Neumaier, J., Petschenka, J., Diken, M., Kreiter, S., Türeci, Ö., et al. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-021-03134-9 · Cited by 26
Self-citationWarmiński, M., Kowalska, J., Buck, J., Zuberek, J., Łukaszewicz, M., Nicola, C., Kuhn, A. N., Şahin, U., Darżynkiewicz, E., & Jemielity, J. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.05.001 · Cited by 25
Self-citationSelf-amplifying RNA vaccine protects mice against lethal Ebola virus infection
Krähling, V., Erbar, S., Kupke, A., Nogueira, S. S., Walzer, K. C., Berger, H., Dietzel, E., Halwe, S., Rohde, C., Sauerhering, L., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.10.011 · Cited by 24
Shanmugasundaram, M., Charles, I., & Kore, A. R. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.01.048 · Cited by 24
mRNA delivery technologies: Toward clinical translation
Gómez-Aguado, I., Rodríguez-Castejón, J., Beraza-Millor, M., Rodríguez‐Gascón, A., del Pozo‐Rodríguez, A., & Solinís, M. Á. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.04.010 · Cited by 23
Miedziak, B., Dobieżyńska, A., Darżynkiewicz, Z. M., Bartkowska, J., Miszkiewicz, J., Kowalska, J., Warmiński, M., Tyras, M., Trylska, J., Jemielity, J., et al. (2019) · RNA · doi:10.1261/rna.073304.119 · Cited by 21
Self-citationUnlocking the Potential of Chemically Modified Nucleic Acid Therapeutics
Gao, J., Nutan, B., Gargouri, D., Pisal, N. D., Do, V., Zubair, M., Alanzi, H., Wang, H., Lee, D., Joshi, N., et al. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400231 · Cited by 20
Antitumor Vaccination with Synthetic mRNA: Strategies for In Vitro and In Vivo Preclinical Studies
Diken, M., Kreiter, S., Selmi, A., Türeci, Ö., & Şahin, U. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-260-5_15 · Cited by 19
Self-citationNowakowska, M., Kowalska, J., Martin, F., d'Orchymont, A., Zuberek, J., Łukaszewicz, M., Darżynkiewicz, E., & Jemielity, J. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00059e · Cited by 20
Self-citationModified mRNA as a new therapeutic option for pediatric respiratory diseases and hemoglobinopathies
Antony, J. S., Dewerth, A., Haque, A., Handgretinger, R., & Kormann, M. (2015) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-015-0022-6 · Cited by 18
Neoantigen-specific mRNA/DC vaccines for effective anticancer immunotherapy
Zhang, W., Guan, J., Wang, W., Chen, G., Li, F., & Lu, Z. (2024) · Genes and Immunity · doi:10.1038/s41435-024-00305-3 · Cited by 18
Sutton, W. J. H., Branham, P. J., Williamson, Y. M., Cooper, H. C., Najjar, F. N., Pierce, C. L., Barr, J. R., & Williams, T. L. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.04.044 · Cited by 18
Issur, M., Bougie, I., Despins, S., & Bisaillon, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075310 · Cited by 17
Phosphate-modified analogues of m7GTP and m7Gppppm7G—Synthesis and biochemical properties
Ziemniak, M., Kowalska, J., Łukaszewicz, M., Zuberek, J., Wnek, K., Darżynkiewicz, E., & Jemielity, J. (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.07.052 · Cited by 17
Self-citationmRNA vaccine development and applications: A special focus on tumors (Review)
Chen, B., Yang, Y., Wang, X., Yang, W., Lu, Y., Wang, D., Zhuo, E., Tang, Y., Su, J., Tang, G., et al. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5669 · Cited by 17
Exploring the potential of phosphotriazole 5′ mRNA cap analogues as efficient translation initiators
Walczak, S., Sikorski, P. J., Kasprzyk, R., Kowalska, J., & Jemielity, J. (2018) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob01720d · Cited by 16
Self-citationMaking the Next Generation of Therapeutics: mRNA Meets Synthetic Biology
Hınçer, A., Ahan, R. E., Aras, E., & Şeker, U. Ö. Ş. (2023) · ACS Synthetic Biology · doi:10.1021/acssynbio.3c00253 · Cited by 15
del Nogal, A. W., Surleac, M. D., Kowalska, J., Łukaszewicz, M., Jemielity, J., Bisaillon, M., Darżynkiewicz, E., Milac, A. L., & Bojarska, E. (2013) · FEBS Journal · doi:10.1111/febs.12553 · Cited by 15
Self-citationŻytek, M., Kowalska, J., Łukaszewicz, M., Wojtczak, B. A., Zuberek, J., Ferenc-Mrozek, A., Darżynkiewicz, E., Niedźwiecka-Kornaś, A., & Jemielity, J. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob01579g · Cited by 15
Self-citationCompact polyethylenimine-complexed mRNA vaccines
Herrero, J. M., Stahl, T. B., Erbar, S., Maxeiner, K., Schlegel, A., Bacic, T., Schumacher, J., Cavalcanti, L. P., Schroer, M. A., Svergun, D. I., et al. (2025) · Nature Nanotechnology · doi:10.1038/s41565-025-01961-w · Cited by 16
Emerging trends in the characterization of oligonucleotide diastereomers
Goyon, A., Nguyen, D. N., & Zhang, K. (2025) · Journal of Chromatography A · doi:10.1016/j.chroma.2025.466308 · Cited by 14
Non-viral vectors for chimeric antigen receptor immunotherapy
Tretbar, S., Rurik, J. G., Rustad, E. H., Sürün, D., Koehl, U., Olweus, J., Buchholz, F., Ivics, Z., Fricke, S., & Blache, U. (2024) · Nature Reviews Methods Primers · doi:10.1038/s43586-024-00348-w · Cited by 15
Kasprzyk, R., Starek, B. J., Ciechanowicz, S., Kubacka, D., Kowalska, J., & Jemielity, J. (2019) · Chemistry - A European Journal · doi:10.1002/chem.201900051 · Cited by 14
Self-citationWarmiński, M., Depaix, A., Ziemkiewicz, K., Śpiewla, T., Zuberek, J., Drążkowska, K., Kędzierska, H., Popielec, A., Baranowski, M. R., Sklucka, M., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae763 · Cited by 12
Self-citationTwo-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex
Ziemniak, M., Mugridge, J. S., Kowalska, J., Rhoads, R. E., Gross, J. D., & Jemielity, J. (2016) · RNA · doi:10.1261/rna.055152.115 · Cited by 12
Self-citationThe legacy of mRNA engineering: A lineup of pioneers for the Nobel Prize
Janowski, M., & Andrzejewska, A. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.07.003 · Cited by 12
Synthetic mRNA: Production, Introduction into Cells, and Physiological Consequences
Rhoads, R. E. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3625-0_1 · Cited by 11
T-cell receptor transfer into human T cells with ecotropic retroviral vectors
Koste, L., Beißert, T., Hoff, H., Pretsch, L., Türeci, Ö., & Şahin, U. (2014) · Gene Therapy · doi:10.1038/gt.2014.25 · Cited by 12
Self-citationMeasurement of patellar and ankle tendon reflexes in normal subjects.
Struys, M. A., Jonkman, E. J., & STRIJERS, R. L. M. (1997) · PubMed · Cited by 12
The mRNA-Based Innovative Strategy: Progress and Challenges
Zhou, H., Wei, D., Chen, Z., Chen, H., Dong, C., Cai, W., Wang, J., Liu, X., Li, Y., Yang, Y., et al. (2026) · Nano-Micro Letters · doi:10.1007/s40820-025-01906-x · Cited by 17
Pati, S. S., Dhal, S., Pattnaik, R., Tripathy, S., & Kumar, S. (2025) · Current Medical Science · doi:10.1007/s11596-025-00112-5 · Cited by 11
The forerunners and successful partnerships behind the BioNTech mRNA vaccine
Aygün, I., & Barciszewski, J. (2023) · Journal of Applied Genetics · doi:10.1007/s13353-023-00793-5 · Cited by 10
Generation of TCR-Engineered T Cells and Their Use To Control the Performance of T Cell Assays
Bidmon, N., Attig, S., Rae, R., Schröder, H., Omokoko, T., Simon, P., Kuhn, A. N., Kreiter, S., Şahin, U., Gouttefangeas, C., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1400958 · Cited by 10
Self-citationPeters, D., Kranz, L. M., Eisel, D., Diken, M., Kreiter, S., Türeci, Ö., Şahin, U., & Vormehr, M. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0701 · Cited by 9
Self-citationRazzak, A., Ahmed, F., & Mahmud, M. T. (2025) · Scientific Reports · doi:10.1038/s41598-025-99512-9 · Cited by 9
Ikrar, T., Muchsin, W., & Sophian, A. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115019 · Cited by 10
Diken, M., Vormehr, M., Grunwitz, C. R., Kreiter, S., Türeci, Ö., & Şahin, U. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6481-9_14 · Cited by 9
Self-citationNurturing Deep Tech to Solve Social Problems: Learning from COVID-19 mRNA Vaccine Development
Okuyama, R. (2022) · Pathogens · doi:10.3390/pathogens11121469 · Cited by 11
Engineering circular RNA for molecular and metabolic reprogramming
Sharma, N. K., Dwivedi, P., Bhushan, R., Maurya, P. K., Kumar, A., & Dakal, T. C. (2024) · Functional & Integrative Genomics · doi:10.1007/s10142-024-01394-z · Cited by 8
mRNA—From COVID-19 Treatment to Cancer Immunotherapy
Kŕause, W. (2023) · Biomedicines · doi:10.3390/biomedicines11020308 · Cited by 8
Mamot, A., Sikorski, P. J., Warmiński, M., Kowalska, J., & Jemielity, J. (2017) · Angewandte Chemie · doi:10.1002/ange.201709052 · Cited by 8
Self-citationSalomon, N., Helm, A., Selmi, A., Fournier, C., Diken, M., Schrörs, B., Scholz, M., Kreiter, S., Durante, M., & Vascotto, F. (2023) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2023.12.042 · Cited by 7
Self-citationRibosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes
Schwarz, A., Mueller, M. P., Will, H., Dietrich, L., Giandomenico, S. L., Tushev, G., Bartnik, I., Khusainov, I. S., Fusco, C. M., & Schuman, E. M. (2026) · Science · doi:10.1126/science.adr4287 · Cited by 8
Schlattmann, D., Weber, B., Wyszynski, L., Schönhoff, M., & Haas, H. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114380 · Cited by 8
Probst, J., Fotin‐Mleczek, M., Schlake, T., Theß, A., Kramps, T., & Kallen, K. (2011) · Springer eBooks · doi:10.1007/978-3-7091-0439-2_11 · Cited by 7
Mesenchymal stem cell engineering by ARCA analog-capped mRNA
Andrzejewska, A., Grzela, R., Stankiewicz-Drogoń, A., Rogujski, P., Nagaraj, S., Darżynkiewicz, E., Łukomska, B., & Janowski, M. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.07.006 · Cited by 7
mRNA vaccines for prostate cancer: A novel promising immunotherapy
Tang, Y., Yi, X., & Ai, J. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189333 · Cited by 6
Beyond the Sequence: Chemical and Topological Design and Innovations in mRNA Therapeutics
Liu, D., Chen, H., Pan, A., & Wang, X. (2026) · Chemical Reviews · doi:10.1021/acs.chemrev.5c00347 · Cited by 7
Alom, K. M., Asa, T. A., & Seo, Y. J. (2024) · ACS Chemical Biology · doi:10.1021/acschembio.4c00420 · Cited by 6
Norimatsu, J., Hashim, R., Tockary, T. A., Nazir, M. S., Mochida, Y., & Uchida, S. (2025) · ACS Applied Nano Materials · doi:10.1021/acsanm.5c00633 · Cited by 7
Pascolo, S. (2023) · European Journal of Immunology · doi:10.1002/eji.202249941 · Cited by 6
Diken, M., Kreiter, S., Kloke, B., & Şahin, U. (2015) · Progress in tumor research · doi:10.1159/000437184 · Cited by 6
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Nair, S. K., Boczkowski, D., Pruitt, S. K., & Urban, J. H. (2011) · Informa Healthcare eBooks · doi:10.3109/9781841848303.016 · Cited by 5
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Metadata
- Authors
- Kuhn, A. N., Diken, M., Kreiter, S., Selmi, A., Kowalska, J., Jemielity, J., Darzynkiewicz, E., Huber, C., Türeci, Ö., & Sahin, U.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- University of Warsaw (PL)
- Venue
- Gene Therapy
- Published
- 2010-04-22
- Volume
- 17
- Issue
- 8
- Pages
- 961-971
- ISSN
- 0969-7128 (ISSN-L)
- 1476-5462
- OpenAlex
- W2085865810
- Cited by
- 226
- References
- 32
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 19 · 2023: 21 · 2022: 13 · 2021: 20 · 2020: 15 · 2019: 9 · 2018: 16 · 2017: 11 · 2016: 17 · 2015: 12 · 2014: 14 · 2013: 10 · 2012: 7
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gene Therapy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute (55005604)
- Bundesministerium für Bildung und Forschung
- Ministerstwo Edukacji i Nauki
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- mRNA vaccines, RNA stability, translation efficiency, immature dendritic cells, cancer immunotherapy, in vitro transcribed mRNA, immunopharmacology
- MeSH terms
- Dendritic Cells, Half-Life, Humans, Luciferases, RNA, RNA Cap Analogs, Protein Biosynthesis, Vaccines, Synthetic, Genes, Reporter, Antigen Presentation, Cancer Vaccines, RNA Stability, Phosphorothioate Oligonucleotides
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