The effect of glutamine on murine splenic leukocyte responses to T and B cell mitogens
Abstract
Summary: Murine splenic leukocytes cannot be stimulated to synthesize [3 H]‐DNA by various concentrations of either the T cell mitogens, Concanavalin‐A (Con‐A) or phytohaemagglutinin (PHA) or the B cell mitogen, lipopolysaccharide (LPS), unless glutamine is present in the culture medium. The optimum concentration of the T cell mitogens (Con‐A, PHA) remained constant for all levels of glutamine while that of the B cell mitogen (LPS) increased as the concentration of glutamine in the medium increased.
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Glutamine is a key metabolite for supporting T cell function.
“Glutamine has long been known as a key metabolite for supporting T cell function (52).”
From Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013) · cites this paper as [52]
Cites
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Glutamine metabolism in lymphocytes of the rat
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Metabolism of glutamine in lymphocytes
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Cell-cycle control in lymphocyte stimulation
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Fueling Immunity: Insights into Metabolism and Lymphocyte Function
Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363 · see citing works
Tumor suppressors and cell metabolism: a recipe for cancer growth
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Revving the Engine: Signal Transduction Fuels T Cell Activation
Jones, R. G., & Thompson, C. B. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.008 · Cited by 349 · see citing works
The metabolic life and times of a T‐cell
Michalek, R. D., & Rathmell, J. C. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00911.x · Cited by 186 · see citing works
“The amino acid glutamine is also critical for T-cell metabolism and function, although as a mitochondrial fuel in addition to its role as an essential protein building block (98, 99).”
Background
- Authors
- Griffiths, M., & Keast, D.
- Affiliations
- Queen Elizabeth II Medical Centre (AU)
- Corresponding author
- Griffiths, M.
- Venue
- Immunology & Cell Biology
- Publisher
- Wiley
- Published
- 1990-12
- Volume
- 68
- Issue
- 6
- Pages
- 405-408
- ISSN
- 0004-945X (ISSN-L)
- 0818-9641
- 1440-1711
- OpenAlex
- W2318807168
- Cited by
- 41
- References
- 6
- Citations by year
- 2024: 2 · 2020: 1 · 2019: 4 · 2018: 2 · 2013: 1
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunology and Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- glutamine, splenocytes, T cell mitogens, B-cell mitogen, concanavalin A, phytohemagglutinin, lipopolysaccharide, DNA synthesis, murine spleen
- MeSH terms
- Animals, B-Lymphocytes, Concanavalin A, DNA Replication, Female, Glutamine, Lipopolysaccharides, Lymphocyte Activation, Mice, Inbred BALB C, Mitogens, Phytohemagglutinins, Spleen, T-Lymphocytes, Mice
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