The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Crystal‐induced neutrophil activation
Open accessAbstract
Monosodium urate (MSU) crystals are among the most potent pro‐inflammatory stimuli and an innate immune inflammatory response to the crystal surface is intimately involved in the pathology of gouty arthritis. The responses of human neutrophils to MSU crystals represent an integral part of this innate response and a key component of the acute inflammatory response associated with gout. A significant, though incomplete, body of information concerning the implication of human neutrophils in MSU crystal‐induced inflammation and the signal transduction pathways activated in response to these agonists in neutrophils has accumulated over the last few years. This review focuses on the current state of knowledge concerning the activation of human neutrophils by MSU crystals specifically in the context of acute gout, as recent data begin to draw a comprehensive picture of the events leading to the often excessive functional responses of neutrophils to these particulate agonists. A non‐exhaustive list of the most important questions that remain to be assessed to further describe the physio‐pathological mechanisms of gouty arthritis is presented here.
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Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Roles of PPARs in health and disease
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A pilot study of IL-1 inhibition by anakinra in acute gout
So, A., De Smedt, T., Revaz, S., & Tschopp, J. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2143 · Cited by 727
Cited by
Inflammation in gout: mechanisms and therapeutic targets
So, A. K., & Martinon, F. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.155 · Cited by 608
GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals
Shenoy, A. R., Wellington, D. A., Kumar, P., Kassa, H., Booth, C. J., Cresswell, P., & MacMicking, J. D. (2012) · Science · doi:10.1126/science.1217141 · Cited by 522
Uric acid as a danger signal in gout and its comorbidities
Rock, K. L., Kataoka, H., & Lai, J.-J. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.143 · Cited by 444
Uric acid, hyperuricemia and vascular diseases
Jin, M. (2012) · Frontiers in Bioscience · doi:10.2741/3950 · Cited by 406
The immune response to secondary necrotic cells
Sachet, M., Liang, Y. Y., & Oehler, R. (2017) · Apoptosis · doi:10.1007/s10495-017-1413-z · Cited by 282
Metadata
- Authors
- Popa‐Nita, O., & Naccache, P. H.
- Venue
- Immunology & Cell Biology
- Publisher
- Wiley
- Published
- 2009-12
- Volume
- 88
- Issue
- 1
- Pages
- 32-40
- ISSN
- 0004-945X (ISSN-L)
- 0818-9641
- 1440-1711
- OpenAlex
- W2067270638
- Cited by
- 169
- References
- 5
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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