STAT1 plays a role in TLR signal transduction and inflammatory responses

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Toll-like Receptors 2 and 4 Activate STAT1 Serine Phosphorylation by Distinct Mechanisms in Macrophages

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Differential Effects of CpG DNA on IFN-β Induction and STAT1 Activation in Murine Macrophages versus Dendritic Cells: Alternatively Activated STAT1 Negatively Regulates TLR Signaling in Macrophages

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TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K/AKT pathway after spinal cord injury

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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

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MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization

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TRAF Molecules in Inflammation and Inflammatory Diseases

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TET2 Regulates the Neuroinflammatory Response in Microglia

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Abnormal regulation of fibronectin production by fibroblasts in psoriasis

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Current and Emerging Evidence for Toll-Like Receptor Activation in Sjögren’s Syndrome

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Signaling pathways and targeted therapy for rosacea

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Selective inhibition of EZH2 by a small molecule inhibitor regulates microglial gene expression essential for inflammation

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The Role of miRNA in Renal Fibrosis Leading to Chronic Kidney Disease

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Biflorin, Isolated from the Flower Buds ofSyzygium aromaticumL., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock

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Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer’s Disease

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β-Hydroxybutyrate suppresses M1 macrophage polarization through β-hydroxybutyrylation of the STAT1 protein

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Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury

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Genomic instability and innate immune responses to self-DNA in progeria

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Hepatitis B Virus–Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes

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Two Faces of Macrophages: Training and Tolerance

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Activation of the nuclear factor-κB pathway during postnatal lung inflammation preserves alveolarization by suppressing macrophage inflammatory protein-2

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Targeting STAT3 and NF-κB Signaling Pathways in Cancer Prevention and Treatment: The Role of Chalcones

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MiR-27b-3p inhibits the progression of renal fibrosis via suppressing STAT1

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Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia

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Proteomic Analysis of HDAC3 Selective Inhibitor in the Regulation of Inflammatory Response of Primary Microglia

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Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and Tolerance

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Cardioprotective Effect of circ_SMG6 Knockdown against Myocardial Ischemia/Reperfusion Injury Correlates with miR‐138‐5p‐Mediated EGR1/TLR4/TRIF Inactivation

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Cirsimarin, a flavone glucoside from the aerial part of Cirsium japonicum var. ussuriense (Regel) Kitam. ex Ohwi, suppresses the JAK/STAT and IRF-3 signaling pathway in LPS-stimulated RAW 264.7 macrophages

Han, H.-S., Shin, J., Lee, S.-B., Park, J. C., & Lee, K. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.07.024 · Cited by 37 · see citing works

STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria

Chen, T., Tsai, M.-H., Kung, J. T., Lin, K., Decker, T., & Lee, C. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151620 · Cited by 36 · see citing works

PHLPP1 counter-regulates STAT1-mediated inflammatory signaling

Cohen‐Katsenelson, K., Stender, J. D., Kawashima, A. T., Lordén, G., Uchiyama, S., Nizet, V., Glass, C. K., & Newton, A. C. (2019) · eLife · doi:10.7554/elife.48609 · Cited by 33 · see citing works

Metformin and 4SC‐202 synergistically promote intrinsic cell apoptosis by accelerating ΔNp63 ubiquitination and degradation in oral squamous cell carcinoma

He, Y., Tai, S., Deng, M., Fan, Z., Ping, F., He, L., Zhang, C., Huang, Y., Cheng, B., & Xia, J. (2019) · Cancer Medicine · doi:10.1002/cam4.2206 · Cited by 32 · see citing works

Molecular profiling of regulatory T cells in pulmonary sarcoidosis

Kachamakova‐Trojanowska, N., Jaźwa, A., Szade, K., Kasper, Ł., Soja, J., Andrychiewicz, A., Jakieła, B., Plutecka, H., Sanak, M., Józkowicz, A., et al. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.07.012 · Cited by 32 · see citing works

Inhibition of human macrophage activation via pregnane neurosteroid interactions with toll-like receptors: Sex differences and structural requirements

Balan, I., Aurelian, L., Williams, K., Campbell, B., Meeker, R., & Morrow, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940095 · Cited by 29 · see citing works

Tumor-associated macrophages promote invasion via Toll-like receptors signaling in patients with ovarian cancer

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The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response

Salgado, R. C., Fonseca, D. L. M., Marques, A. H. C., Napoleão, S. M. D. S., França, T. T., Akashi, K. T., Prado, C. A. D. S., Baiocchi, G. C., Plaça, D. R., Jansen-Marques, G., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-99838-0 · Cited by 31 · see citing works

Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana

Fernández-Figueroa, E. A., Imaz-Rosshandler, I., Fernandez, J. C., Miranda-Ortíz, H., Fernández-López, J. C., Becker, I., & Rangel‐Escareño, C. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004570 · Cited by 31 · see citing works

Patriscabrin F from the roots of Patrinia scabra attenuates LPS-induced inflammation by downregulating NF-κB, AP-1, IRF3, and STAT1/3 activation in RAW 264.7 macrophages

Shin, J., Kang, S., Lee, H., Kim, S.-Y., Lee, D. H., Jang, D. S., & Lee, K. (2020) · Phytomedicine · doi:10.1016/j.phymed.2019.153167 · Cited by 30 · see citing works

Emerging Evidence for Endogenous Neurosteroid Modulation of Pro-Inflammatory and Anti-Inflammatory Pathways that Impact Neuropsychiatric Disease.

Morrow, A., Boero, G., & Balan, I. (2024) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105558 · Cited by 25 · see citing works

STAT1a and STAT1b of black carp play important roles in the innate immune defense against GCRV

Wu, H., Zhang, Y., Lu, X., Xiao, J., Feng, P., & Feng, H. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.01.037 · Cited by 29 · see citing works

Oxidative Stress Inhibits Endotoxin Tolerance and May Affect Periodontitis

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Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses

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Targeting downstream transcription factors and epigenetic modifications following Toll-like receptor 7/8 ligation to forestall tissue injury in anti-Ro60 associated heart block

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Suppression of Neutrophil Antimicrobial Functions by Total Particulate Matter From Cigarette Smoke

Zhang, Y., Geng, S., Prasad, G. L., & Li, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02274 · Cited by 26 · see citing works

Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production

Song, H., Park, S. H., Kim, H. J., Jang, S., & Kim, T. S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112322 · Cited by 26 · see citing works

Anti-Inflammatory Effect of 3-Bromo-4,5-Dihydroxybenzaldehyde, a Component ofPolysiphonia morrowii,In VivoandIn Vitro

Kang, N.-J., Han, S.-C., Kang, H.-J., Ko, G., Yoon, W., Kang, H., & Yoo, E.-S. (2017) · Toxicological Research · doi:10.5487/tr.2017.33.4.325 · Cited by 26 · see citing works

Zinc Modulates Several Transcription-Factor Regulated Pathways in Mouse Skeletal Muscle Cells

Ferdowsi, P. V., Ng, R., Adulcikas, J., Sohal, S. S., & Myers, S. (2020) · Molecules · doi:10.3390/molecules25215098 · Cited by 25 · see citing works

Quercetin Efficiently Alleviates TNF-α-Stimulated Injury by Signal Transducer and Activator of Transcription 1 and Mitogen-Activated Protein Kinase Pathway in H9c2 Cells: A Protective Role of Quercetin in Myocarditis

Yang, B., Zheng, C., Zhang, R., Zhao, C., Li, S., & An, Y. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001000 · Cited by 25 · see citing works

Serine Phosphorylation of the STAT1 Transactivation Domain Promotes Autoreactive B Cell and Systemic Autoimmunity Development

Chodisetti, S. B., Fike, A. J., Domeier, P. P., Schell, S. L., Mockus, T. E., Choi, N. M., Corradetti, C., Hou, B., Atkins, H., Caricchio, R., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000170 · Cited by 23 · see citing works

4-Phenylbutyrate Benefits Traumatic Hemorrhagic Shock in Rats by Attenuating Oxidative Stress, Not by Attenuating Endoplasmic Reticulum Stress

Yang, G., Peng, X., Hu, Y., Lan, D., Wu, Y., Li, T., & Liu, L. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001469 · Cited by 23 · see citing works

Regulation of PHLDA1 Expression by JAK2-ERK1/2-STAT3 Signaling Pathway

Lyu, J. H., Huang, B., Park, D., & Baek, S. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25296 · Cited by 23 · see citing works

Modulation of experimental acute lung injury by exosomal miR-7704 from mesenchymal stromal cells acts through M2 macrophage polarization

Lin, W.-T., Wu, H.-H., Lee, C., Chen, Y.-F., Huang, L., Ho, J. H., & Lee, O. K. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.102102 · Cited by 22 · see citing works

Grouper STAT1a is involved in antiviral immune response against iridovirus and nodavirus infection

Zhang, J., Huang, X., Ni, S., Liu, J., Hu, Y., Ying, Y., Yu, Y., Zhou, L., Qin, Q., & Huang, Y. (2017) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2017.09.030 · Cited by 22 · see citing works

Harmine Inhibits Multiple TLR-Induced Inflammatory Expression through Modulation of NF-κB p65, JNK, and STAT1

Jin, S.-J., Song, Y., Park, H. S., Park, K. W., Lee, S., & Kang, H. G. (2022) · Life · doi:10.3390/life12122022 · Cited by 21 · see citing works

Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive

Eberhardt, M., Lai, X., Tomar, N., Gupta, S. K., Schmeck, B., Steinkasserer, A., Schuler, G., & Vera, J. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3283-2_9 · Cited by 21 · see citing works

Time course study of the response to LPS targeting the pig immune gene networks

Terenina, E. E., Sautron, V., Ydier, C., Базовкина, Д. В., Sevin-Pujol, A., Gress, L., Lippi, Y., Naylies, C., Billon, Y., Liaubet, L., et al. (2017) · BMC Genomics · doi:10.1186/s12864-017-4363-5 · Cited by 21 · see citing works

Anti-inflammatory effect of trans-4-methoxycinnamaldehyde from Etlingera pavieana in LPS-stimulated macrophages mediated through inactivation of NF-κB and JNK/c-Jun signaling pathways and in rat models of acute inflammation

Srisook, K., Mankhong, S., Chiranthanut, N., Kongsamak, K., Kitwiwat, N.-T., Tongjurai, P., & Aramsangtienchai, P. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.03.026 · Cited by 21 · see citing works

Synergistic inflammatory signaling by cGAS may be involved in the development of atherosclerosis

Lu, G., Chen, S.-C., Xia, Y., Ye, Z.-M., Cao, F., & Hu, B. (2021) · Aging · doi:10.18632/aging.202491 · Cited by 20 · see citing works

Mosloflavone-Resveratrol Hybrid TMS-HDMF-5z Exhibits Potent In Vitro and In Vivo Anti-Inflammatory Effects Through NF-κB, AP-1, and JAK/STAT Inactivation

Kim, S.-Y., Hassan, A. H. E., Chung, K., Kim, S., Han, H.-S., Lee, H., Jung, S.-H., Lee, K.-Y., Shin, J., Jang, E., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.857789 · Cited by 19 · see citing works

Tofacitinib for the Treatment of Steroid-Induced Rosacea

Li, T., Wang, H., Wang, C., & Hao, P. (2022) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s392280 · Cited by 18 · see citing works

Self-propelled smart nanomotors for enhanced mild photothermal therapy of tumors through autophagy modulation

Mei, L., Liu, H., Ding, Q., Xie, Y., Xue, S., Chen, H., Wang, K., Li, M., & He, Q. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.05.063 · Cited by 17 · see citing works

Transcriptomic Profiling of Primary Microglia: Effects of miR-19a-3p and miR-19b-3p on Microglia Activation

Sahebdel, F., Zia, A., Quintá, H. R., Morse, L. R., Olson, J. K., & Battaglino, R. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910601 · Cited by 17 · see citing works

JAK1 inhibitor abrocitinib for the treatment of steroid-induced rosacea: case series

Xu, B., Xu, Z., Ye, S., Sun, H. B., Zhao, B., Wu, N., & Wu, J. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1239869 · Cited by 16 · see citing works

Molecular insights of two STAT1 variants from rock bream (Oplegnathus fasciatus) and their transcriptional regulation in response to pathogenic stress, interleukin-10, and tissue injury

Bathige, S. D. N. K., Umasuthan, N., Godahewa, G. I., Thulasitha, W. S., Jayasinghe, J. D. H. E., Wan, Q., & Lee, J. (2017) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2017.08.015 · Cited by 15 · see citing works

Src Family Kinases Regulate Interferon Regulatory Factor 1 K63 Ubiquitination following Activation by TLR7/8 Vaccine Adjuvant in Human Monocytes and B Cells

Tulli, L., Cattaneo, F., Vinot, J., Baldari, C. T., & D’Oro, U. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00330 · Cited by 15 · see citing works

Molecular characterization and expression analysis of signal transducer and activator of transcription 1 (STAT1) in Japanese eel Anguilla japonica

Wang, T., Lin, P., Guo, S., Wang, Y., Zhang, Z., & Feng, J. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.12.046 · Cited by 13 · see citing works

Disease Risk–Associated Genetic Variants in STAT1 and STAT4 Function in a Complementary Manner to Increase Pattern-Recognition Receptor–Induced Outcomes in Human Macrophages

Hedl, M., Sun, R., & Abraham, C. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901112 · Cited by 13 · see citing works

Pioglitazone Ameliorates Gentamicin Ototoxicity by Affecting the TLR and STAT Pathways in the Early Postnatal Organ of Corti

Sekulic‐Jablanovic, M., Wright, M. B., Petkovic, V., & Bodmer, D. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.566148 · Cited by 12 · see citing works

Tofacitinib Suppresses IL-10/IL-10R Signaling and Modulates Host Defense Responses in Human Macrophages

Knoke, K., Rongisch, R., Grzes, K. M., Schwarz, R., Lorenz, B., Yogev, N., Pearce, E. L., Pearce, E. J., Kofler, D. M., & Fabri, M. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.07.180 · Cited by 12 · see citing works

Transcriptome Profiling of Human Monocyte-Derived Macrophages Upon CCL2 Neutralization Reveals an Association Between Activation of Innate Immune Pathways and Restriction of HIV-1 Gene Expression

Covino, D. A., Kaczor‐Urbanowicz, K. E., Lu, J. N., Chiantore, M. V., Fiorucci, G., Vescio, M. F., Catapano, L., Purificato, C., Galluzzo, C. M., Amici, R., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02129 · Cited by 12 · see citing works

Methyl butyrate attenuates concanavalin A-induced autoimmune hepatitis by inhibiting Th1-cell activation and homing to the liver

Yang, J., Xie, W., Yu, K., Cheng, Q., Shi, G., & Li, N. (2022) · Cellular Immunology · doi:10.1016/j.cellimm.2022.104575 · Cited by 11 · see citing works

Dual requirement for STAT signaling in dendritic cell immunobiology

Donninelli, G., Sanseverino, I., Purificato, C., Gessani, S., & Gauzzi, M. C. (2017) · Immunobiology · doi:10.1016/j.imbio.2017.10.049 · Cited by 11 · see citing works

Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer’s disease

Weerakkody, T. N., Sabelström, H., Andrews, S. V., Chadarevian, J. P., Chin, M. Y., Tatarakis, D., Propson, N. E., Kim, D. J., Theolis, R., Parico, G. C. G., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adw7428 · Cited by 11 · see citing works

Targeted delivery of miR125a-5p and human Factor VIII attenuates molecular mediators of hemophilic arthropathy

Senthilkumar, M. B., Sarangi, P., Amit, S., Senguttuvan, S., Kumar, N., & Jayandharan, G. R. (2023) · Thrombosis Research · doi:10.1016/j.thromres.2023.09.008 · Cited by 10 · see citing works

PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils

Yue, L., Yan, M., Tremblay, M. L., Lin, T., Li, H., Yang, T., Song, X., Xie, T., & Xie, Z. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222753 · Cited by 10 · see citing works

Mechanistic insights into the role of USP14 in adipose tissue macrophage recruitment and insulin resistance in obesity

Wei, D., Tian, X., Ren, Z., Liu, Z., & Sun, C. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131645 · Cited by 9 · see citing works

Repression of JAK2-STAT1 and PD-L1 by CEP-33779 ameliorates the LPS-induced decline in phagocytic activity of alveolar macrophages and mitigates lung injury in mice

Wang, Y.-H., Li, A.-G., Wang, H., & Tu, Y.-S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1472425 · Cited by 8 · see citing works

TRAF6 is a nexus for TLR‐STAT1 crosstalk

Bezbradica, J. S., & Schroder, K. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.71 · Cited by 9 · see citing works

Toll-like Receptors 2 and 4 Activate STAT1 Serine Phosphorylation by Distinct Mechanisms in Macrophages

Rhee, S. H., Jones, B. W., Toshchakov, V. Y., Vogel, S. N., & Fenton, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208633200 · Cited by 115 · see citing works

The role of STATs in TLR signalling

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TLR2- and TLR4-dependent activation of STAT1 serine phosphorylation in murine macrophages is protein kinase C-δ-independent

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TRAF6 is a nexus for TLR‐STAT1 crosstalk

Bezbradica, J. S., & Schroder, K. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.71 · Cited by 9 · see citing works

P93 NFκB activation by TLR agonists is deficient in macrophages lacking STAT2

Alazawi, W., Gamero, A. M., Heath, H., Smith, P., Jacobs, M., Waters, J., & Foster, G. R. (2011) · Gut · doi:10.1136/gutjnl-2011-300857a.93