Phosphorylation of the Stat1 Transactivation Domain Is Required for Full-Fledged IFN-γ-Dependent Innate Immunity

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STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas

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Functional Crosstalk between Type I and II Interferon through the Regulated Expression of STAT1

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Stats: Multifaceted Regulators of Transcription

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PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma

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Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains

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Nonconventional Initiation Complex Assembly by STAT and NF-κB Transcription Factors Regulates Nitric Oxide Synthase Expression

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Inducible antibacterial responses in macrophages

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Interferons limit inflammatory responses by induction of tristetraprolin

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STAT proteins: a kaleidoscope of canonical and non-canonical functions in immunity and cancer

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Toxoplasma gondii Dysregulates IFN-γ-Inducible Gene Expression in Human Fibroblasts: Insights from a Genome-Wide Transcriptional Profiling

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Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo

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CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance

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Kinome Profiling for Studying Lipopolysaccharide Signal Transduction in Human Peripheral Blood Mononuclear Cells

Diks, S. H., Kok, K. B., O’Toole, T. G., Hommes, D. W., van Dijken, P., Joore, J., & Peppelenbosch, M. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405028200 · Cited by 132 · see citing works

Macrophages and cytokines in the early defence against herpes simplex virus

Ellermann‐Eriksen, S. (2005) · Virology Journal · doi:10.1186/1743-422x-2-59 · Cited by 133 · see citing works

Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-γ-inducible gbp2 gene

Ramsauer, K., Farlik, M., Zupkovitz, G., Seiser, C., Kröger, A., Häuser, H., & Decker, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610944104 · Cited by 121 · see citing works

Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events

Singh, N., Lawana, V., Luo, J. D., Phong, P., Abdalla, A., Palanisamy, B. N., Rokad, D., Sarkar, S., Jin, H., Anantharam, V., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.05.019 · Cited by 119 · see citing works

Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?

Philip, S., Kumarasiri, M., Teo, T., Yu, M., & Wang, S. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00901 · Cited by 111 · see citing works

Human Cathelicidin Peptide LL-37 Modulates the Effects of IFN-γ on APCs

Nijnik, A., Pistolic, J., Wyatt, A. W., Tam, S., & Hancock, R. E. W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901491 · Cited by 108 · see citing works

Phytosomal curcumin causes natural killer cell-dependent repolarization of glioblastoma (GBM) tumor-associated microglia/macrophages and elimination of GBM and GBM stem cells

Mukherjee, S., Fried, A., Hussaini, R., White, R., Baidoo, J., Yalamanchi, S., & Banerjee, P. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0792-5 · Cited by 100 · see citing works

Phosphorylation–acetylation switch in the regulation of STAT1 signaling

Krämer, O. H., & Heinzel, T. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.10.007 · Cited by 99 · see citing works

The Induction of Lipocalin-2 Protein Expression in Vivo and in Vitro

Zhao, P., Elks, C. M., & Stephens, J. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.532234 · Cited by 98 · see citing works

Hepatitis E virus persists in the presence of a type III interferon response

Yin, X., Li, X., Ambardekar, C., Hu, Z., Lhomme, S., & Feng, Z. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006417 · Cited by 97 · see citing works

TGF-β1 Inhibits T-bet Induction by IFN-γ in Murine CD4+ T Cells through the Protein Tyrosine Phosphatase Src Homology Region 2 Domain-Containing Phosphatase-1

Park, I.-K., Shultz, L. D., Letterio, J. J., & Gorham, J. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.5666 · Cited by 96 · see citing works

Dynamic Regulation of IFN-γ Signaling in Antigen-Specific CD8+ T Cells Responding to Infection

Haring, J. S., Corbin, G. A., & Harty, J. T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.6791 · Cited by 97 · see citing works

Inhibition of Mammalian Target of Rapamycin Augments Lipopolysaccharide-Induced Lung Injury and Apoptosis

Fielhaber, J. A., Carroll, S. F., Dydensborg, A. B., Shourian, M., Triantafillopoulos, A., Harel, S., Hussain, S. N. A., Bouchard, M., Qureshi, S. T., & Kristof, A. S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1003655 · Cited by 95 · see citing works

The role of Janus kinases in haemopoiesis and haematological malignancy

Khwaja, A. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06206.x · Cited by 95 · see citing works

Activation of the JAK/STAT-1 Signaling Pathway by IFN-γ Can Down-Regulate Functional Expression of the MHC Class I-Related Neonatal Fc Receptor for IgG

Liu, X., Ye, L., Bai, Y., Mojidi, H., Simister, N. E., & Zhu, X. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.449 · Cited by 93 · see citing works

ERK Is Integral to the IFN-γ–Mediated Activation of STAT1, the Expression of Key Genes Implicated in Atherosclerosis, and the Uptake of Modified Lipoproteins by Human Macrophages

Li, N., McLaren, J. E., Michael, D. R., Clement, M., Fielding, C. A., & Ramji, D. P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000993 · Cited by 91 · see citing works

A Comprehensive Profile of ChIP-Seq-Based STAT1 Target Genes Suggests the Complexity of STAT1-Mediated Gene Regulatory Mechanisms

Satoh, J., & Tabunoki, H. (2013) · Gene Regulation and Systems Biology · doi:10.4137/grsb.s11433 · Cited by 87 · see citing works

Detecting post-translational modification signatures as potential biomarkers in clinical mass spectrometry

Mnatsakanyan, R., Shema, G., Basik, M., Batist, G., Borchers, C. H., Sickmann, A., & Zahedi, R. P. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1483340 · Cited by 89 · see citing works

Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-κB- and STAT1-dependent chemokine production in astrocytes

Wang, X., Deckert, M., Xuân, N. T., Nishanth, G., Just, S., Waisman, A., Naumann, M., & Schlüter, D. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1183-9 · Cited by 87 · see citing works

Serine-phosphorylated STAT1 is a prosurvival factor in Wilms' tumor pathogenesis

Timofeeva, O. A., Plisov, S. Y., Evseev, A. A., Peng, S., Jose-Kampfner, M., Lovvorn, H. N., Dome, J. S., & Perantoni, A. O. (2006) · Oncogene · doi:10.1038/sj.onc.1209742 · Cited by 84 · see citing works

Interferon-gamma (IFN-γ): Reviewing its mechanisms and signaling pathways on the regulation of endothelial barrier function

Ng, C. T., Fong, L. Y., & Abdullah, M. N. H. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156208 · Cited by 82 · see citing works

The PI3' Kinase Pathway in Interferon Signaling

Kaur, S., Shahab Uddin, M. S., & Platanias, L. C. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.780 · Cited by 82 · see citing works

Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families

Shenoy, A. R., Kim, B.-H., Choi, H.-P., Matsuzawa, T., Tiwari, S., & MacMicking, J. D. (2007) · Immunobiology · doi:10.1016/j.imbio.2007.09.018 · Cited by 82 · see citing works

Immune control of phagosomal bacteria by p47 GTPases

MacMicking, J. D. (2005) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.12.012 · Cited by 80 · see citing works

Resveratrol down-regulates interferon-γ-inducible inflammatory genes in macrophages: molecular mechanism via decreased STAT-1 activation

Chung, E. Y., Kim, B. H., Hong, J. T., Lee, C., Ahn, B., Nam, S.-Y., Han, S., & Kim, Y. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.07.012 · Cited by 79 · see citing works

Signal Regulatory Protein α Ligation Induces Macrophage Nitric Oxide Production through JAK/STAT- and Phosphatidylinositol 3-Kinase/Rac1/NAPDH Oxidase/H2O2-Dependent Pathways

Alblas, J., Honing, H., de Lavalette, C. R., Brown, M. H., Dijkstra, C. D., & van den Berg, T. K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7181-7192.2005 · Cited by 79 · see citing works

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ

Begitt, A., Droescher, M., Knobeloch, K., & Vinkemeier, U. (2011) · Blood · doi:10.1182/blood-2011-04-347930 · Cited by 76 · see citing works

Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3

Aziz, M. H., Manoharan, H. T., & Verma, A. K. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3350 · Cited by 76 · see citing works

Toxoplasma gondii Inhibits Gamma Interferon (IFN-γ)- and IFN-β-Induced Host Cell STAT1 Transcriptional Activity by Increasing the Association of STAT1 with DNA

Rosowski, E. E., Nguyen, Q., Camejo, A., Spooner, E., & Saeij, J. P. J. (2013) · Infection and Immunity · doi:10.1128/iai.01291-13 · Cited by 70 · see citing works

Inhibitor of κB Kinase ϵ (IKKϵ), STAT1, and IFIT2 Proteins Define Novel Innate Immune Effector Pathway against West Nile Virus Infection

Perwitasari, O., Cho, H., Diamond, M., & Gale, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.285205 · Cited by 70 · see citing works

Tuning of macrophage responses by Stat3-inducing cytokines: molecular mechanisms and consequences in infection.

Lang, R. (2005) · Immunobiology · doi:10.1016/j.imbio.2005.05.001 · Cited by 78 · see citing works

Turning off signal transducer and activator of transcription (STAT): The negative regulation of STAT signaling

Chen, W., Daines, M., & Hershey, G. K. K. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.06.042 · Cited by 64 · see citing works

Human Cytomegalovirus IE1 Protein Elicits a Type II Interferon-Like Host Cell Response That Depends on Activated STAT1 but Not Interferon-γ

Knoblach, T., Grandel, B., Seiler, J., Nevels, M. M., & Paulus, C. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002016 · Cited by 62 · see citing works

A Novel c-Jun-dependent Signal Transduction Pathway Necessary for the Transcriptional Activation of Interferon γ Response Genes

Gough, D. J., Sabapathy, K., Ko, E. Y.-N., Arthur, H. A., Schreiber, R. D., Trapani, J. A., Clarke, C. J. P., & Johnstone, R. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607674200 · Cited by 62 · see citing works

Nuclear Export Determines the Cytokine Sensitivity of STAT Transcription Factors

Loedige, I., Marg, A., Wiesner, B., Malecová, B., Oelgeschläger, T., & Vinkemeier, U. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509180200 · Cited by 61 · see citing works

The Heat Shock Protein 90-CDC37 Chaperone Complex Is Required for Signaling by Types I and II Interferons

Shang, L., & Tomasi, T. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509901200 · Cited by 61 · see citing works

Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation

Friedbichler, K., Kerenyi, M. A., Kovačic, B., Li, G., Hoelbl‐Kovacic, A., Yahiaoui, S., Sexl, V., Müllner, E. W., Fajmann, S., Cerny‐Reiterer, S., et al. (2010) · Blood · doi:10.1182/blood-2009-12-258913 · Cited by 60 · see citing works

Analysis of the MCMV resistome by ENU mutagenesis

Crozat, K., Georgel, P., Rutschmann, S., Mann, N., Du, X., Hoebe, K. H. N., & Beutler, B. (2006) · Mammalian Genome · doi:10.1007/s00335-005-0164-2 · Cited by 60 · see citing works

PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis

Berger, A., Hoelbl‐Kovacic, A., Bourgeais, J., Hoefling, L., Warsch, W., Grundschober, E., Uras, I. Z., Menzl, I., Putz, E. M., Hoermann, G., et al. (2013) · Leukemia · doi:10.1038/leu.2013.351 · Cited by 60 · see citing works

Leishmania donovaniAmastigotes Impair Gamma Interferon-Induced STAT1α Nuclear Translocation by Blocking the Interaction between STAT1α and Importin-α5

Matte, C., & Descoteaux, A. (2010) · Infection and Immunity · doi:10.1128/iai.00046-10 · Cited by 58 · see citing works

IRF1 supports DNA binding of STAT1 by promoting its phosphorylation

Zenke, K., Muroi, M., & Tanamoto, K. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12185 · Cited by 58 · see citing works

Signal transducers and activators of transcription—from cytokine signalling to cancer biology

Santos, C. I., & Costa‐Pereira, A. P. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.03.003 · Cited by 56 · see citing works

Protein kinase Cε interacts with Stat3 and regulates its activation that is essential for the development of skin cancer

Aziz, M. H., Manoharan, H. T., Sand, J. M., & Verma, A. K. (2007) · Molecular Carcinogenesis · doi:10.1002/mc.20356 · Cited by 56 · see citing works

Resveratrol Modulates Cytokine-Induced JAK/STAT Activation More Efficiently than 5-Aminosalicylic Acid: An In Vitro Approach

Serra, D., Rufino, A. T., Mendes, A. F., Almeida, L. M., & Dinis, T. C. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109048 · Cited by 55 · see citing works

Response to interferons and antibacterial innate immunity in the absence of tyrosine‐phosphorylated STAT1

Majoros, A., Platanitis, E., Szappanos, D., Cheon, H., Vogl, C., Shukla, P., Stark, G. R., Sexl, V., Schreiber, R. D., Schindler, C., et al. (2016) · EMBO Reports · doi:10.15252/embr.201540726 · Cited by 55 · see citing works

Control of T Helper Cell Differentiation through Cytokine Receptor Inclusion in the Immunological Synapse

Soriano, M. A., Perdomo, L., Irvine, D. J., Decker, T., Maldonado, R., Sigrist, K. S., & Glimcher, L. H. (2009) · Digital Access to Scholarship at Harvard (DASH) (Harvard University) · Cited by 54 · see citing works

Cutting Edge: STAT1 and T-bet Play Distinct Roles in Determining Outcome of Visceral Leishmaniasis Caused by Leishmania donovani

Rosas, L. E., Snider, H. M., Barbi, J. J., Satoskar, A. A., Lugo‐Villarino, G., Keiser, T. L., Papenfuss, T. L., Durbin, J. E., Radzioch, D., Glimcher, L. H., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.22 · Cited by 53 · see citing works

Stat1 and SUMO modification

Song, L., Bhattacharya, S., Yunus, A. A., Lima, C. D., & Schindler, C. (2006) · Blood · doi:10.1182/blood-2006-04-020271 · Cited by 52 · see citing works

MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1

Vanhatupa, S., Ungureanu, D., Paakkunainen, M., & Silvennoinen, O. (2007) · Biochemical Journal · doi:10.1042/bj20070620 · Cited by 51 · see citing works

SENP1 regulates IFN-γ−STAT1 signaling through STAT3−SOCS3 negative feedback loop

Yu, T., Zuo, Y., Cai, R., Huang, X., Wu, S., Zhang, C., Chin, Y. E., Li, D., Zhang, Z., Xia, N., et al. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw042 · Cited by 51 · see citing works

Interferon-γ-activated STAT-1α suppresses MMP-9 gene transcription by sequestration of the coactivators CBP/p300

Ma, Z., Chang, M. J., Shah, R. C., & Benveniste, E. N. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0205112 · Cited by 51 · see citing works

IFNγ-induced PD-L1 expression in ovarian cancer cells is regulated by JAK1, STAT1 and IRF1 signaling

Padmanabhan, S., Gaire, B., Zou, Y., Uddin, M. M., & Vancurova, I. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110400 · Cited by 52 · see citing works

Interferon-β Is a Potent Inducer of Interferon Regulatory Factor-1/2-Dependent IP-10/CXCL10 Expression in Primary Human Endothelial Cells

Buttmann, M., Berberich‐Siebelt, F., Serfling, E., & Rieckmann, P. (2006) · Journal of Vascular Research · doi:10.1159/000097977 · Cited by 50 · see citing works

Critical Role for Casein Kinase 2 and Phosphoinositide-3-Kinase in the Interferon-γ–Induced Expression of Monocyte Chemoattractant Protein-1 and Other Key Genes Implicated in Atherosclerosis

Harvey, E. J., Li, N., & Ramji, D. P. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000258867.79411.96 · Cited by 50 · see citing works

SUMOylation of KLF4 promotes IL-4 induced macrophage M2 polarization

Wang, K., Zhou, W., Cai, Q., Cheng, J., Cai, R., & Xing, R. (2017) · Cell Cycle · doi:10.1080/15384101.2016.1269045 · Cited by 49 · see citing works

Stat1 combines signals derived from IFN‐γ and LPS receptors during macrophage activation

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Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-γ uses a different signaling pathway

Kovarik, P., Stoiber, D., Eyers, P. A., Menghini, R., Neininger, A., Gaestel, M., Cohen, P., & Decker, T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13956 · Cited by 271 · see citing works

The Conserved Leu-724 Residue Is Required for Both Serine Phosphorylation and Co-activator Recruitment for Stat1-mediated Transcription Activation in Response to Interferon-γ

Sun, W. Y., Xu, W., Snyder, M., He, W., Ho, H. H., Ivashkiv, L. B., & Zhang, J. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505797200 · Cited by 12 · see citing works

Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses

Metwally, H., Elbrashy, M. M., Ozawa, T., Okuyama, K., White, J. T., Tulyeu, J., Søndergaard, J. N., Wing, J. B., Muratsu, A., Matsumoto, H., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2402226121 · Cited by 26 · see citing works