Functional expression of glucose-dependent insulinotropic polypeptide receptors is coupled to differentiation in a human adipocyte model

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works

Biology of Incretins: GLP-1 and GIP

Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639 · see citing works

Inhibition of gastric inhibitory polypeptide signaling prevents obesity

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Handbook of obesity

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Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation

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Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain.

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Insulin Resistance and Type 2 Diabetes Are Not Related to Resistin Expression in Human Fat Cells or Skeletal Muscle

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Distinct Transcriptional Profiles of Adipogenesisin Vivo and in Vitro

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Adipogenic Differentiation of Human Adult Stem Cells From Bone Marrow Stroma (MSCs)

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Resistin Gene Expression in Human Adipocytes Is Not Related to Insulin Resistance

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Human Mesenchymal Stem Cells as an in Vitro Model for Human Adipogenesis

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Subcutaneous fat in normal and diseased states

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GIF biology and fat metabolism

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Functional GIP Receptors Are Present on Adipocytes

Yip, R. G.-C., Boylan, M. O., Kieffer, T. J., & Wolfe, M. M. (1998) · Endocrinology · doi:10.1210/endo.139.9.6288 · Cited by 237 · see citing works

Activation of Lipoprotein Lipase by Glucose-dependent Insulinotropic Polypeptide in Adipocytes

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Thiazolidinediones and glucocorticoids synergistically induce differentiation of human adipose tissue stromal cells: Biochemical, cellular, and molecular analysis

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Zinc‐α2‐glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytes

Bao, Y., Bing, C., Hunter, L., Jenkins, J. R., Wabitsch, M., & Trayhurn, P. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.11.042 · Cited by 180 · see citing works

Cloning, Functional Expression, and Chromosomal Localization of the Human Pancreatic Islet Glucose-Dependent Insulinotropic Polypeptide Receptor

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Effects of the novel (Pro3)GIP antagonist and exendin(9–39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin

Gault, V. A., O'Harte, F. P. M., Harriott, P., Mooney, M., Green, B., & Flatt, P. R. (2003) · Diabetologia · doi:10.1007/s00125-002-1028-x · Cited by 134 · see citing works

Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets

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Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes

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Resistin Is a Key Mediator of Glucose-dependent Insulinotropic Polypeptide (GIP) Stimulation of Lipoprotein Lipase (LPL) Activity in Adipocytes

Kim, S.-J., Nian, C., & McIntosh, C. H. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704896200 · Cited by 118 · see citing works

Adiponectin expression in humans is dependent on differentiation of adipocytes and down-regulated by humoral serum components of high molecular weight

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Effects of Ingestion of Triglyceride or Galactose on Secretion of Gastric Inhibitory Polypeptide and on Responses to Intravenous Glucose in Normal and Diabetic Subjects

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Investigations into the Actions of Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1(7–36)amide on Lipoprotein Lipase Activity in Explants of Rat Adipose Tissue

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Adipocyte fatty acid-binding protein: regulation of gene expression in vivo and in vitro by an insulin-sensitizing agent.

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Characterization of the Cellular and Metabolic Effects of a Novel Enzyme-Resistant Antagonist of Glucose-Dependent Insulinotropic Polypeptide

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Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice

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Interaction of the Adipocyte Fatty Acid-binding Protein with the Hormone-sensitive Lipase

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Klotho Protein Promotes Adipocyte Differentiation

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Development of White Adipose Tissue

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Gastric inhibitory polypeptide enhancement of the insulin effect on fatty acid incorporation into adipose tissue in the rat

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Glucose-Dependent Insulinotropic Polypeptide Stimulation of Lipolysis in Differentiated 3T3-L1 Cells: Wortmannin-Sensitive Inhibition by Insulin**This work was supported by grants from Zymogenetics Inc. (Seattle, WA), the Medical Research Council of Canada (5–90007-RAP/CHSM) and the Canadian Diabetes Association (CHSM/RAP).

McIntosh, C. H. S., Bremsak, I., Lynn, F. C., Gill, R., Hinke, S. A., Gelling, R., Nian, C., McKnight, G., Jaspers, S., & Pederson, R. A. (1999) · Endocrinology · doi:10.1210/endo.140.1.6464 · Cited by 73 · see citing works

GIP receptor mRNA expression in different fat tissue depots in postmenopausal non-diabetic women

Rudovich, N. N., Kaiser, S., Engeli, S., Osterhoff, M. A., Gögebakan, Ö., Blüher, M., & Pfeiffer, A. F. H. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2007.02.006 · Cited by 68 · see citing works

Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells

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Characterization of Dopamine and β‐Adrenergic Receptors Linked to Cyclic AMP Formation in Intact Cells of the Clone D384 Derived from a Human Astrocytoma

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Characterisation and biological activity of Glu3 amino acid substituted GIP receptor antagonists

Gault, V. A., Hunter, K., Irwin, N., Green, B. D., Greer, B., Harriott, P., O'Harte, F. P. M., & Flatt, P. R. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.03.001 · Cited by 15 · see citing works

How May GIP Enhance the Therapeutic Efficacy of GLP-1?

Samms, R. J., Coghlan, M. P., & Sloop, K. W. (2020) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2020.02.006 · Cited by 419 · see citing works

Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis

Zaragosi, L., Wdziekonski, B., Lebrigand, K., Villageois, P., Mari, B. P., Waldmann, R., Dani, C., & Barbry, P. (2011) · Genome biology · doi:10.1186/gb-2011-12-7-r64 · Cited by 224 · see citing works

Neprilysin, obesity and the metabolic syndrome

Standeven, K. F., Hess, K., Carter, A. M., Rice, G., Cordell, P. A., Balmforth, A. J., Lü, B., Scott, D. J. A., Turner, A. J., Hooper, N. M., et al. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.227 · Cited by 174 · see citing works

Recent Advances in Incretin-Based Pharmacotherapies for the Treatment of Obesity and Diabetes

Tan, Q., Akindehin, S. E., Orsso, C. E., Waldner, R. C., DiMarchi, R. D., Müller, T. D., & Haqq, A. M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.838410 · Cited by 146 · see citing works

Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor

Regmi, A., Aihara, E., Christe, M. E., Varga, G., Beyer, T. P., Ruan, X., Beebe, E., O’Farrell, L. S., Bellinger, M. A., Austin, A. K., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.05.010 · Cited by 135 · see citing works

Nutrient detection by incretin hormone secreting cells

Diakogiannaki, E., Gribble, F. M., & Reimann, F. M. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.12.001 · Cited by 123 · see citing works

Human aquaporin‐11 is a water and glycerol channel and localizes in the vicinity of lipid droplets in human adipocytes

Madeira, A., Fernández‐Veledo, S., Camps, M., Zorzano, A., Moura, T. F., Ceperuelo‐Mallafré, V., Vendrell, J. J., & Soveral, G. (2014) · Obesity · doi:10.1002/oby.20792 · Cited by 122 · see citing works

Glucagon-Like Peptide-1 Receptor Agonists and Dual Glucose-Dependent Insulinotropic Polypeptide/Glucagon-Like Peptide-1 Receptor Agonists in the Treatment of Obesity/Metabolic Syndrome, Prediabetes/Diabetes and Non-Alcoholic Fatty Liver Disease—Current Evidence

Muzurović, E. M., Volčanšek, Š., Zibar, K., Janež, A., Mikhailidis, D. P., Rizzo, M., & Mantzoros, C. S. (2022) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/10742484221146371 · Cited by 99 · see citing works

Glucose-dependent insulinotropic polypeptide (GIP)

Müller, T. D., Adriaenssens, A. E., Ahrén, B., Blüher, M., Birkenfeld, A. L., Campbell, J. E., Coghlan, M. P., D’Alessio, D. D., Deacon, C. F., DelPrato, S., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102118 · Cited by 99 · see citing works

Glucose-dependent insulinotropic polypeptide receptor therapies for the treatment of obesity, do agonists=antagonists?

Killion, E. A., Lu, S.-C., Fort, M., Yamada, Y., Véniant, M. M., & Lloyd, D. J. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnz002 · Cited by 94 · see citing works

Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes

Timper, K., Grisouard, J., Sauter, N. S., Herzog-Radimerski, T., Dembinski, K., Peterli, R., Frey, D. M., Zulewski, H., Keller, U., Müller, B., et al. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00100.2012 · Cited by 88 · see citing works

The influence of Glucose-dependent Insulinotropic Polypeptide (GIP) on human adipose tissue and fat metabolism: Implications for obesity, type 2 diabetes and Non-Alcoholic Fatty Liver Disease (NAFLD)

Thondam, S. K., Cuthbertson, D. J., & Wilding, J. P. H. (2020) · Peptides · doi:10.1016/j.peptides.2019.170208 · Cited by 77 · see citing works

GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue

Campbell, J. E., Beaudry, J. L., Svendsen, B., Baggio, L. L., Gordon, A. N., Ussher, J. R., Wong, C. K., Gribble, F. M., D’Alessio, D. A., Reimann, F. M., et al. (2022) · Diabetes · doi:10.2337/db21-1166 · Cited by 70 · see citing works

The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice

Yu, X., Chen, S., Funcke, J., Straub, L. G., Pirro, V., Emont, M. P., Droz, B. A., Collins, K. A. L., Joung, C., Pearson, M. J., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.11.003 · Cited by 72 · see citing works

The Emerging Role of Dual GLP-1 and GIP Receptor Agonists in Glycemic Management and Cardiovascular Risk Reduction

Rizvi, A. A., & Rizzo, M. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s351982 · Cited by 68 · see citing works

GIP as a Potential Therapeutic Target for Atherosclerotic Cardiovascular Disease–A Systematic Review

Mori, Y., Matsui, T., Hirano, T., & Yamagishi, S.-I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041509 · Cited by 60 · see citing works

Adipocyte expression of the glucose-dependent insulinotropic polypeptide receptor involves gene regulation by PPARγ and histone acetylation

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Glucose‐dependent insulinotropic polypeptide signaling in pancreatic β‐cells and adipocytes

McIntosh, C. H. S., Widenmaier, S. B., & Kim, S. (2012) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2012.00196.x · Cited by 58 · see citing works

Glucose‐dependent insulinotropic peptide impairs insulin signaling <i>via</i> inducing adipocyte inflammation in glucose‐dependent insulinotropic peptide receptor‐overexpressing adipocytes

Nie, Y., Ma, R. C., Chan, J. C. N., Xu, H., & Xu, G. (2012) · The FASEB Journal · doi:10.1096/fj.11-196782 · Cited by 53 · see citing works

A compendium of G-protein–coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure

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Tirzepatide as monotherapy improved markers of beta-cell function and insulin sensitivity in type 2 diabetes (SURPASS-1).

Lee, C. J., Mao, H., Thieu, V. T., Landó, L. F., & Thomas, M. K. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad056 · Cited by 48 · see citing works

Pleiotropic Actions of the Incretin Hormones

McIntosh, C. H. S., Widenmaier, S. B., & Kim, S. (2010) · Vitamins and hormones · doi:10.1016/b978-0-12-381517-0.00002-3 · Cited by 40 · see citing works

GIP receptor deletion in mice confers resistance to high-fat diet-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism

Boer, G. A., Keenan, S. N., Miotto, P. M., Holst, J. J., & Watt, M. J. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00646.2020 · Cited by 38 · see citing works

Gut Hormone Regulation and Secretion via FFA1 and FFA4

Gribble, F. M., Diakogiannaki, E., & Reimann, F. M. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_46 · Cited by 36 · see citing works

GIP’s involvement in the pathophysiology of type 2 diabetes

Christensen, M. B., Gasbjerg, L. S., Heimbürger, S. M., Stensen, S., Vilsbøll, T., & Knop, F. K. (2020) · Peptides · doi:10.1016/j.peptides.2019.170178 · Cited by 35 · see citing works

Exercise prior to fat ingestion lowers fasting and postprandial VLDL and decreases adipose tissue IL-6 and GIP receptor mRNA in hypertriacylglycerolemic men.

Dekker, M. J., Graham, T. E., Ooi, T. C., & Robinson, L. E. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.08.004 · Cited by 32 · see citing works

Glucose‐dependent insulinotropic polypeptide: from pathophysiology to therapeutic opportunities in obesity‐associated disorders

Paschetta, E., Hvalryg, M., & Musso, G. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00897.x · Cited by 32 · see citing works

Effect of caloric restriction with or without n-3 polyunsaturated fatty acids on insulin sensitivity in obese subjects: a randomized placebo controlled trial

Razny, U., Kiec-Wilk, B., Polus, A., Goralska, J., Malczewska-Malec, M., Wnek, D., Zdzienicka, A., Gruca, A., Childs, C. E., Kapusta, M., et al. (2015) · BBA Clinical · doi:10.1016/j.bbacli.2015.05.001 · Cited by 27 · see citing works

Microarray gene expression profiles from mature gonad tissues of Atlantic bluefin tuna, Thunnus thynnus in the Gulf of Mexico

Gardner, L., Jayasundara, N., Castilho, P. C., & Block, B. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-530 · Cited by 24 · see citing works

Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Calcitonin Gene-Related Peptide (CGRP)-I and Procalcitonin (Pro-CT) Production in Human Adipocytes

Timper, K., Grisouard, J., Radimerski, T., Dembinski, K., Peterli, R., Häring, A., Frey, D. M., Zulewski, H., Keller, U. B., Müller-Stich, B. P., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1324 · Cited by 23 · see citing works

LipiD-QuanT: a novel method to quantify lipid accumulation in live cells

Varinli, H., Osmond-McLeod, M. J., Molloy, P. L., & Vallotton, P. (2015) · Journal of Lipid Research · doi:10.1194/jlr.d059758 · Cited by 21 · see citing works

Glucose‐dependent insulinotropic polypeptide modifies adipose plasticity and promotes beige adipogenesis of human omental adipose‐derived stem cells

Chen, X., He, X., Guo, Y., Liu, L., Li, H., Tan, J., Feng, W., Guan, H., Cao, X., Xiao, H., et al. (2021) · The FASEB Journal · doi:10.1096/fj.201903253r · Cited by 21 · see citing works

Free fatty acid receptors in the endocrine regulation of glucose metabolism: Insight from gastrointestinal-pancreatic-adipose interactions

Zhao, Y.-F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.956277 · Cited by 21 · see citing works

211At-Labeled Polymer Nanoparticles for Targeted Radionuclide Therapy of Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR)-Overexpressed Cancer

Shi, X., Li, Q., Zhang, L., Hanyu, M., Xie, L., Hu, K., Nagatsu, K., Zhang, C., Wu, Z., Wang, F., et al. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00263 · Cited by 21 · see citing works

Combined glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonism attenuates atherosclerosis severity in APOE*3-Leiden.CETP mice

van Eenige, R., Ying, Z., Tramper, N., Wiebing, V., Siraj, Z., de Boer, J. F., Lambooij, J. M., Guigas, B., Qu, H., Coşkun, T., et al. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.03.016 · Cited by 19 · see citing works

Pharmacological modulation of adaptive thermogenesis: new clues for obesity management?

Genchi, V. A., Palma, G., Sorice, G. P., D’Oria, R., Caccioppoli, C., Marrano, N., Biondi, G., Caruso, I., Cignarelli, A., Natalicchio, A., et al. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02125-0 · Cited by 19 · see citing works

Epistatic Effects on Abdominal Fat Content in Chickens: Results from a Genome-Wide SNP-SNP Interaction Analysis

Li, F., Hu, G., Zhang, H., Wang, S., Wang, Z., & Li, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081520 · Cited by 18 · see citing works

Gastrointestinal regulatory peptides and their effects on fat tissue

Majumdar, I. D., & Weber, H. C. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32833327dd · Cited by 17 · see citing works

Wnt and Incretin Connections

García‐Jiménez, C. (2010) · Vitamins and hormones · doi:10.1016/b978-0-12-381517-0.00014-x · Cited by 14 · see citing works

Adipose Tissue, at the Core of the Action of Incretin and Glucagon-Based Anti-Obesity Drugs

Villarroya, F., Peyrou, M., & Giralt, M. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00660-w · Cited by 14 · see citing works

A Mechanistic Rationale for Incretin-Based Therapeutics in the Management of Obesity

Samms, R. J., & Kusminski, C. M. (2024) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022724-105443 · Cited by 11 · see citing works

Active Immunization with Glucose‐Dependent Insulinotropic Polypeptide Vaccine Influences Brain Function and Behaviour in Rats

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Lpin1 in human visceral and subcutaneous adipose tissue: similar levels but different associations with lipogenic and lipolytic genes

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The GIPR is Predominantly Localized to Non-Adipocyte Cell Types Within White Adipose Tissue

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Beyond weight loss: How metabolism in human adipocytes is shaped by GLP-1R agonists and dual GIPR/GLP-1R agonists

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The Role of the Equine Enteroinsular Axis in Insulin Dysregulation: In Vitro Mechanistic Insights for Disease Prevention

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The pro-survival effects of glucose-dependent insulinotropic polypeptide receptor signalling on beta cells

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Adipocytes as a Mechanistic Link Between Incretin-Based Therapies and Hair Loss

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Functional GIP Receptors Are Present on Adipocytes

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Glucose-Dependent Insulinotropic Polypeptide Enhances Adipocyte Development and Glucose Uptake in Part Through Akt Activation

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