The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Human colonic microbiota associated with diet, obesity and weight loss
Abstract
Background It has been proposed that the development of obesity in humans is influenced by the relative proportions of the two major phyla of bacteria (Bacteroidetes and Firmicutes) present in the large intestine.Objective To examine the relationships between body mass index, weight loss and the major bacterial groups detected in fecal samples.Design Major groups of fecal bacteria were monitored using fluorescent in situ hybridization (FISH) in obese and non-obese subjects under conditions of weight maintenance, and in obese male volunteers undergoing weight loss on two different reduced carbohydrate weight-loss diets given successively for 4 weeks each.Results We detected no difference between obese and non-obese individuals in the proportion of Bacteroidetes measured in fecal samples, and no significant change in the percentage of Bacteroidetes in feces from obese subjects on weight loss diets. Significant diet-dependent reductions in a group of butyrate-producing Firmicutes were, however, detected in fecal samples from obese subjects on weight loss diets.Conclusions Diets designed to achieve weight loss in obese subjects can significantly alter the species composition of the gut microbiota, but we find no evidence that the proportions of Bacteroidetes and Firmicutes among fecal bacteria have a function in human obesity.
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“Some dietary intervention studies, paradoxically, associated weight loss with reduced abundance of SCFA-producing bacteria.84, 90–93”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [84]
In the citing paper
“Some83 but not all81, 84 cross-sectional studies found an enrichment of the phylum Firmicutes and depletion of the phylum Bacteroidetes in obese individuals compared with lean individuals.”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [84]
In the citing paper
“As reported in mice, several studies in humans found that this ratio is increased in obesity [38, 39].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [38]
In the citing paper
“Indeed, previous studies of the gut microbiota during dietary interventions for weight loss have not reported an increase in Proteobacteria but a shift in taxa such as Bacteroidetes (Ley et al., 2006), Eubacterium/Roseburia (Duncan et al., 2008), and Eubacterium rectale (Cotillard et al., 2013).”
From Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015) · cites this paper as Duncan et al., 2008
In the citing paper
“based on most human studies, the obesity-associated decrease in the ratio of Bacteroidetes to Firmicutes (B:F) remains controversial.24 25”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [25]
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Metadata
- Authors
- Duncan, S. H., Lobley, G. E., Holtrop, G., Ince, J., Johnstone, A. M., Louis, P., & Flint, H. J.
- Affiliations
- University of Aberdeen (GB)
- Biomathematics and Statistics Scotland (GB)
- Corresponding author
- Flint, H J
- Venue
- International Journal of Obesity
- Published
- 2008-09-09
- Volume
- 32
- Issue
- 11
- Pages
- 1720-1724
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2047703946
- Cited by
- 1,222
- References
- 22
- Citations by year
- 2026: 16 · 2025: 25 · 2024: 53 · 2023: 64 · 2022: 92 · 2021: 85 · 2020: 95 · 2019: 76 · 2018: 97 · 2017: 77 · 2016: 97 · 2015: 75 · 2014: 88 · 2013: 79 · 2012: 84
- FWCI
- 16.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Scottish Government
- World Cancer Research Fund
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, obesity, weight loss, Bacteroidetes, Firmicutes, butyrate-producing bacteria, diet, body mass index, fecal bacteria, colonic microbiota
- MeSH terms
- Colon, Feces, Humans, Male, Obesity, Weight Loss, Body Mass Index, Diet, Carbohydrate-Restricted
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