The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
The chronobiology, etiology and pathophysiology of obesity
Open accessAbstract
The effect of CD on human health is an emerging issue. Many records link CD with diseases such as cancer, cardiovascular, cognitive impairment and obesity, all of them conducive to premature aging. The amount of sleep has declined by 1.5 h over the past century, accompanied by an important increase in obesity. Shift work, sleep deprivation and exposure to bright light at night increase the prevalence of adiposity. Animal models have shown that mice with Clock gene disruption are prone to developing obesity and MetS. This review summarizes the latest developments with regard to chronobiology and obesity, considering (1) how molecular clocks coordinate metabolism and the specific role of the adipocyte; (2) CD and its causes and pathological consequences; (3) the epidemiological evidence of obesity as a chronobiological illness; and (4) theories of circadian disruption and obesity. Energy intake and expenditure, relevance of sleep, fat intake from a circadian perspective and psychological and genetic aspects of obesity are examined. Finally, ideas about the use of chronobiology in the treatment of obesity are discussed. Such knowledge has the potential to become a valuable tool in the understanding of the relationship between the chronobiology, etiology and pathophysiology of obesity.
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Cited by
Beccuti, G., & Pannain, S. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3283479109 · Cited by 507
Spaeth, A. M., Dinges, D. F., & Goel, N. (2013) · Sleep · doi:10.5665/sleep.2792 · Cited by 457
Garaulet, M., Ortega, F. B., Ruiz, J. R., Rey-López, J. P., Béghin, L., Manios, Y., Cuenca-García, M., Plada, M., Diethelm, K., Kafatos, A., et al. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.149 · Cited by 422
Self-citationTiming of food intake and obesity: a novel association
Garaulet, M., & Gómez-Abellán, P. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.01.001 · Cited by 362
Self-citationIs Social Jetlag Associated with an Adverse Endocrine, Behavioral, and Cardiovascular Risk Profile?
Rutters, F., Lemmens, S. G., Adam, T. C., Bremmer, M. A., Elders, P. J., Nijpels, G., & Dekker, J. M. (2014) · Journal of Biological Rhythms · doi:10.1177/0748730414550199 · Cited by 274
Metadata
- Authors
- Garaulet, M., Ordovás, J. M., & Madrid, J. A.
- Venue
- International Journal of Obesity
- Published
- 2010-06-22
- Volume
- 34
- Issue
- 12
- Pages
- 1667-1683
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2044551188
- Cited by
- 281
- References
- 28
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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