Differences emerge in visceral adipose tissue accumulation after selection for innate cardiovascular fitness
Open accessAbstract
Cardiorespiratory fitness (CRF) has been reported to be inversely associated with visceral adipose tissue (VAT) accumulation, independent of body weight. However, the confounding effect of physical activity on the association between CRF and VAT remains inadequately addressed. On the basis of maximal oxygen uptake (VO(2 max)), 143 sedentary, overweight women were dichotomized into high-fit (HF) and low-fit (LF) groups. Body composition and VAT were measured using dual-energy X-ray absorptiometry and computed tomography, respectively, and activity-related energy expenditure (AEE) was calculated using the doubly labeled water technique. No differences were observed between HF and LF for body mass index (HF 28.2 ± 1.3; LF 28.3 ± 1.31 kg m(-2)), total body weight (HF 77.5 ± 6.8; LF 77.9 ± 7.3 kg), total fat mass (HF 33.5 ± 5.1; LF 33.9 ± 4.4 kg) or AEE (HF 439.9 ± 375.4; LF 517.9 ± 298.7 kcal day(-1)). Significant differences in visceral adiposity (HF 68.5 ± 30.4; LF 91.2 ± 31.8 cm(2); P<0.001) and insulin sensitivity (HF 5.1 ± 1.8; LF 3.1 ± 2.4 S(I) × 10(-4) min(-1) μIU(-1) ml(-1); P<0.01) were observed between the HF and LF groups, independent of age, race and AEE. This study affirms previous findings that CRF is an important determinant of the accumulation of VAT, and this relationship is independent of physical activity.
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- Authors
- Brock, D. W., Irving, B. A., Gower, B., & Hunter, G. R.
- Affiliations
- University of Vermont (US)
- Mayo Clinic (US)
- University of Alabama at Birmingham (US)
- Corresponding author
- Brock, D W
- Venue
- International Journal of Obesity
- Published
- 2010-07-20
- Volume
- 35
- Issue
- 2
- Pages
- 309-312
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- PMC
- PMC2982865
- OpenAlex
- W2047933996
- Cited by
- 12
- References
- 22
- Citations by year
- 2024: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2015: 3 · 2013: 2 · 2012: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Civil War Book Review (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (T32-HL007457-25, T32HL007457, R01HL084151)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK49779, R01DK049779, P30-DK56336, P30DK056336)
- National Center for Research Resources (M01RR00032, KL2RR084151, M01RR000032)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- visceral adipose tissue, cardiorespiratory fitness, VO2max, insulin sensitivity, physical activity, overweight women, body composition, fat mass
- MeSH terms
- Adult, Energy Metabolism, Female, Humans, Obesity, Oxygen Consumption, Physical Fitness, Exercise, Absorptiometry, Photon, Body Mass Index, Intra-Abdominal Fat
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