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Roux-en-Y gastric bypass surgery changes food reward in rats
Open accessAbstract
Context Roux-en-Y gastric bypass surgery (RYGB) is currently the most effective treatment for morbid obesity, and clinical studies suggest that RYGB patients change food preferences and the desire to eat.Objective To examine hedonic reactions to palatable foods and food choice behavior in an established rat model of RYGB.Methods and design Male Sprague-Dawley (SD) rats and selected line obesity-prone rats that were rendered obese on a high-fat diet underwent RYGB or sham surgery and were tested for 'liking' and 'wanting' of palatable foods at different caloric densities 4-6 months after surgery.Results Compared with sham-operated (obese) and age-matched lean control rats, RYGB rats of both models exhibited more positive orofacial responses to low concentrations of sucrose but fewer to high concentrations. These changes in 'liking' by RYGB rats were translated into a shift of the concentration-response curve in the brief access test, with more vigorous licking of low concentrations of sucrose and corn oil, but less licking of the highest concentrations. The changes in hedonic evaluation also resulted in lower long-term preference/acceptance of high-fat diets compared with sham-operated (obese) rats. Furthermore, the reduced 'wanting' of a palatable reward in the incentive runway seen in sham-operated obese SD rats was fully restored after RYGB to the level found in lean control rats.Conclusions The results suggest that RYGB leads to a shift in hedonic evaluation, favoring low over high calorie foods and restores obesity-induced alterations in 'liking' and 'wanting'. It remains to be determined whether these effects are simply due to weight loss or specific changes in gut-brain communication. Given the emerging evidence for modulation of cortico-limbic brain structures involved in reward mechanisms by gut hormones, RYGB-induced changes in the secretion of these hormones could potentially be mediating these effects.
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“multiple studies have shown that following RYGB, patients show changes in food preference away from a high-fat and/or high-sugar diet and evidence a lower recognition threshold for sucrose compared with control subjects [2, 9–12].”
From Taste and Odor Preferences Following Roux-En-Y Surgery in Humans (2018) · cites this paper as [2]
In the citing paper
“These results are consistent with previous findings [2, 8, 12] suggesting that RYGB surgery decreases the reward value of palatable food.”
From Taste and Odor Preferences Following Roux-En-Y Surgery in Humans (2018) · cites this paper as [2]
In the citing paper
“bariatric surgery has been shown to produce significant and long-lasting weight loss [1, 2] and is now considered the most effective method for the treatment of morbid obesity.”
From Taste and Odor Preferences Following Roux-En-Y Surgery in Humans (2018) · cites this paper as [2]
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Cites
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Berridge, K. C., & Kringelbach, M. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1099-6 · Cited by 1,254
The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats
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Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus
Schauer, P. R., Burguera, B., Ikramuddin, S., Cottam, D., Gourash, W., Hamad, G., Eid, G. M., Mattar, S., Ramanathan, R., Barinas-Mitchel, E., et al. (2003) · Annals of Surgery · doi:10.1097/01.sla.0000089851.41115.1b · Cited by 1,183
Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
During, M. J., Cao, L., Zuzga, D. S., Francis, J. S., Fitzsimons, H. L., Jiao, X., Bland, R. J., Klugmann, M., Banks, W. A., Drucker, D. J., et al. (2003) · Nature Medicine · doi:10.1038/nm919 · Cited by 851
Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology
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Mechanisms underlying weight loss after bariatric surgery
Miras, A. D., & le Roux, C. W. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.119 · Cited by 360
Gut-Brain Cross-Talk in Metabolic Control
Clemmensen, C., Müller, T. D., Woods, S. C., Berthoud, H., Seeley, R. J., & Tschöp, M. H. (2017) · Cell · doi:10.1016/j.cell.2017.01.025 · Cited by 309
Self-citationAll Bariatric Surgeries Are Not Created Equal: Insights from Mechanistic Comparisons
Stefater, M. A., Wilson, H., Chambers, A. P., Sandoval, D. A., & Seeley, R. J. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1044 · Cited by 289
The importance of the gut microbiota after bariatric surgery
Aron‐Wisnewsky, J., Dore, J. M., & Clément, K. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.161 · Cited by 271
Taste of Fat: A Sixth Taste Modality?
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Metadata
- Authors
- Shin, A. C., Zheng, H., Pistell, P. J., & Berthoud, H.-R.
- Affiliations
- Pennington Biomedical Research Center (US)
- Corresponding author
- Berthoud, H-R
- Venue
- International Journal of Obesity
- Published
- 2010-08-31
- Volume
- 35
- Issue
- 5
- Pages
- 642-651
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- PMC
- PMC2997148
- OpenAlex
- W2040476968
- Cited by
- 133
- References
- 60
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 8 · 2021: 8 · 2020: 3 · 2019: 8 · 2018: 9 · 2017: 13 · 2016: 12 · 2015: 14 · 2014: 12 · 2013: 14 · 2012: 18
- FWCI
- 14.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK071082, R01DK047348, P30DK072476)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- Roux-en-Y gastric bypass, food reward, food liking, desire to eat, food choice, obesity, high-fat diet, sucrose, gut-brain signaling, gastrointestinal hormones, bariatric surgery
- MeSH terms
- Animals, Body Weight, Food Preferences, Male, Obesity, Morbid, Reward, Gastric Bypass, Weight Loss, Rats, Sprague-Dawley, Rats
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