Link Between Increased Satiety Gut Hormones and Reduced Food Reward After Gastric Bypass Surgery for Obesity
Open accessAbstract
CONTEXT: Roux-en-Y gastric bypass (RYGB) surgery is an effective long-term intervention for weight loss maintenance, reducing appetite, and also food reward, via unclear mechanisms. OBJECTIVE: To investigate the role of elevated satiety gut hormones after RYGB, we examined food hedonic-reward responses after their acute post-prandial suppression. DESIGN: These were randomized, placebo-controlled, double-blind, crossover experimental medicine studies. PATIENTS: Two groups, more than 5 months after RYGB for obesity (n = 7-11), compared with nonobese controls (n = 10), or patients after gastric banding (BAND) surgery (n = 9) participated in the studies. INTERVENTION: Studies were performed after acute administration of the somatostatin analog octreotide or saline. In one study, patients after RYGB, and nonobese controls, performed a behavioral progressive ratio task for chocolate sweets. In another study, patients after RYGB, and controls after BAND surgery, performed a functional magnetic resonance imaging food picture evaluation task. MAIN OUTCOME MEASURES: Octreotide increased both appetitive food reward (breakpoint) in the progressive ratio task (n = 9), and food appeal (n = 9) and reward system blood oxygen level-dependent signal (n = 7) in the functional magnetic resonance imaging task, in the RYGB group, but not in the control groups. RESULTS: Octreotide suppressed postprandial plasma peptide YY, glucagon-like peptide-1, and fibroblast growth factor-19 after RYGB. The reduction in plasma peptide YY with octreotide positively correlated with the increase in brain reward system blood oxygen level-dependent signal in RYGB/BAND subjects, with a similar trend for glucagon-like peptide-1. CONCLUSIONS: Enhanced satiety gut hormone responses after RYGB may be a causative mechanism by which anatomical alterations of the gut in obesity surgery modify behavioral and brain reward responses to food.
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Compared to normal-weight control groups, those who have obesity have higher levels of reward-based eating.
“Some research has also suggested that, compared to normal-weight control groups, those who have obesity have higher levels of reward-based eating (45, 48–51).”
From Behavioral Interventions to Attenuate Driven Overeating and Weight Regain After Bariatric Surgery (2022) · cites this paper as [51]
The Results (Behavioral responses; page unavailable) found no significant difference in food-reward breakpoint between the post-bypass group and nonobese controls under saline. The Discussion (page unavailable) states that the study included no unoperated obese control group, so it does not establish whether people with obesity generally have higher reward-based eating than normal-weight controls. (LLM, conf=0.75)
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- Authors
- Goldstone, A. P., Miras, A. D., Scholtz, S., Jackson, S., Neff, K. J., Pénicaud, L., Geoghegan, J., Chhina, N., Durighel, G., Bell, J. D., Meillon, S., & le Roux, C. W.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- University College Dublin (IE)
- Corresponding author
- Goldstone, Anthony P.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2016-02
- Volume
- 101
- Issue
- 2
- Pages
- 599-609
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC4880130
- OpenAlex
- W2177986650
- Cited by
- 121
- References
- 46
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 6 · 2023: 12 · 2022: 12 · 2021: 16 · 2020: 14 · 2019: 8 · 2018: 18 · 2017: 12 · 2016: 8 · 2015: 1
- FWCI
- 13.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- WestminsterResearch (University of Westminster) (acceptedVersion)
- WestminsterResearch (University of Westminster) (acceptedVersion, cc-by)
- HAL (submittedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by)
- Funders
- Wellcome Trust (087745/Z/08/Z)
- Imperial College Healthcare Charity
- National Institute for Health and Care Research
- Imperial College London
- Imperial College Healthcare NHS Trust
- Science Foundation Ireland (12/YI/B2480)
- Medical Research Council
- NIHR Imperial Biomedical Research Centre
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- Roux-en-Y gastric bypass, bariatric surgery, food reward, octreotide, somatostatin analogues, peptide YY, glucagon-like peptide-1, FGF19, brain reward system, gastric banding
- MeSH terms
- Adult, Appetite, Cacao, Double-Blind Method, Female, Food, Gastrointestinal Hormones, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Obesity, Oxygen, Photic Stimulation, Reward, Satiation, Octreotide, Gastric Bypass, Cross-Over Studies
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