Cited by 1,287Gut microbiota and healthClostridium difficile and Clostridium perfringens researchOral microbiology and periodontitis research

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Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

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Wang, Tingting, Cai, Guoxiang, Qiu, Yunping, Fei, Na, Zhang, Menghui, Pang, Xiaoyan, Jia, Wei, Cai, Sanjun, Zhao, Liping·2012·The ISME Journal

DOI 10.1038/ismej.2011.109PMC PMC3260502

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Abstract

Despite a long-suspected role in the development of human colorectal cancer (CRC), the composition of gut microbiota in CRC patients has not been adequately described. In this study, fecal bacterial diversity in CRC patients (n=46) and healthy volunteers (n=56) were profiled by 454 pyrosequencing of the V3 region of the 16S ribosomal RNA gene. Both principal component analysis and UniFrac analysis showed structural segregation between the two populations. Forty-eight operational taxonomic units (OTUs) were identified by redundancy analysis as key variables significantly associated with the structural difference. One OTU closely related to Bacteroides fragilis was enriched in the gut microbiota of CRC patients, whereas three OTUs related to Bacteroides vulgatus and Bacteroides uniformis were enriched in that of healthy volunteers. A total of 11 OTUs belonging to the genera Enterococcus, Escherichia/Shigella, Klebsiella, Streptococcus and Peptostreptococcus were significantly more abundant in the gut microbiota of CRC patients, and 5 OTUs belonging to the genus Roseburia and other butyrate-producing bacteria of the family Lachnospiraceae were less abundant. Real-time quantitative PCR further validated the significant reduction of butyrate-producing bacteria in the gut microbiota of CRC patients by measuring the copy numbers of butyryl-coenzyme A CoA transferase genes (Mann-Whitney test, P<0.01). Reduction of butyrate producers and increase of opportunistic pathogens may constitute a major structural imbalance of gut microbiota in CRC patients.

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Self-citation

Authors: Wang, T., Cai, G., Qiu, Y., Fei, N., Zhang, M., Pang, X., Jia, W., Cai, S., & Zhao, L.
Affiliations: Shanghai Jiao Tong University (CN)
Shanghai Medical College of Fudan University (CN)
University of North Carolina at Greensboro (US)
Corresponding author: Zhao, Liping
ORCID: Wang, Tingting
Cai, Guoxiang
Qiu, Yunping
Zhang, Menghui
Pang, Xiaoyan
Jia, Wei
Cai, Sanjun
Zhao, Liping
Venue: The ISME Journal
Publisher: Oxford University Press (OUP)
Published: 2011-08-18
Volume: 6
Issue: 2
Pages: 320-329
ISSN: 1751-7362 (ISSN-L)
1751-7370
DOI: 10.1038/ismej.2011.109
PMC: PMC3260502
OpenAlex: W2015567271
Cited by: 1,287
References: 65
Citations by year: 2026: 49 · 2025: 80 · 2024: 126 · 2023: 118 · 2022: 139 · 2021: 155 · 2020: 134 · 2019: 106 · 2018: 101 · 2017: 80 · 2016: 53 · 2015: 46 · 2014: 38 · 2013: 39 · 2012: 19
FWCI: 12.71
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The ISME Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (30730005)
National Science and Technology Major Project
National Key Research and Development Program of China
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: colorectal cancer, gut microbiota, microbial community structure, Bacteroides fragilis, Bacteroides vulgatus, Bacteroides uniformis, butyrate-producing bacteria, Lachnospiraceae, Roseburia, opportunistic pathogens, Enterococcus, Escherichia-Shigella, Klebsiella, Streptococcus, Peptostreptococcus, dysbiosis
MeSH terms: Acyl Coenzyme A, Adult, Aged, Bacteria, Feces, Female, Humans, Male, Middle Aged, RNA, Ribosomal, 16S, Colorectal Neoplasms, Reproducibility of Results, Coenzyme A-Transferases, Bacterial Physiological Phenomena, Principal Component Analysis, Gastrointestinal Tract, Biodiversity, Metagenome

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Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

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