Cited by 118Gut microbiota and healthNutritional Studies and DietProbiotics and Fermented Foods

Associations between Pro- and Anti-Inflammatory Gastro-Intestinal Microbiota, Diet, and Cognitive Functioning in Dutch Healthy Older Adults: The NU-AGE Study

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van Soest, Annick P. M., Hermes, Gerben D. A., Berendsen, Agnes A. M., van de Rest, Ondine, Zoetendal, Erwin G., Fuentes, Susana, Santoro, Aurelia, Franceschi, Claudio +2 more·2020·Nutrients

Abstract

Dietary modulation of the gastro-intestinal microbiota is a potential target in improving healthy ageing and age-related functional outcomes, including cognitive decline. We explored the association between diet, gastro-intestinal microbiota and cognition in Dutch healthy older adults of the ‘New dietary strategies addressing the specific needs of the elderly population for healthy aging in Europe’ (NU-AGE) study. The microbiota profile of 452 fecal samples from 226 subjects was determined using a 16S ribosomal RNA gene-targeted microarray. Dietary intake was assessed by 7-day food records. Cognitive functioning was measured with an extensive cognitive test battery. We observed a dietary and microbial pro- to anti-inflammatory gradient associated with diets richer in animal- or plant-based foods. Fresh fruits, nuts, seeds and peanuts, red and processed meat and grain products were most strongly associated to microbiota composition. Plant-rich diets containing fresh fruits, nuts, seeds and peanuts were positively correlated with alpha-diversity, various taxa from the Bacteroidetes phylum and anti-inflammatory species, including those related to Faecalibacterium prausnitzii and Eubacterium rectale and E. biforme. Animal product-rich diets associated with pro-inflammatory species, including those related to Ruminococcus gnavus and Collinsella spp.. Cognition was neither associated with microbiota composition nor alpha-diversity. In conclusion, diets richer in animal- and plant-based foods were related to a pro- and anti-inflammatory microbial profile, while cognition was associated with neither.

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  • The phenomenon of age-related gut microbiota change exists simultaneously in species such as Drosophila, fish, mice, rats, and humans.

    “Moreover, this phenomenon exists simultaneously in species such as Drosophila,219 fish,220 mice,221 rats,222 and humans.223”

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  1. [38]Lewis R. Kupke T. The Lafayette Clinic Repeatable Neuropsychological Test Battery: Its Development and Research Applications Proceedings of the Annual Meeting of the Southeastern Psychological Association Hollywood, FL, USA 4–7 May 1977

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Authors
van Soest, A. P. M., Hermes, G. D. A., Berendsen, A. A. M., van de Rest, O., Zoetendal, E. G., Fuentes, S., Santoro, A., Franceschi, C., de Groot, L. C. P. G. M., & de Vos, W. M.
Affiliations
  • Division of Human Nutrition and Health, Wageningen University & Research, 6708WE Wageningen, The Netherlands
  • Wageningen University & Research (NL)
  • National Institute for Public Health and the Environment (NL)
  • University of Bologna (IT)
  • N. I. Lobachevsky State University of Nizhny Novgorod (RU)
  • Laboratory of Microbiology, Wageningen University & Research, 6708WE Wageningen, The Netherlands
Venue
Nutrients
Publisher
MDPI AG
Published
2020-11-12
Volume
12
Issue
11
Pages
3471
ISSN
2072-6643 (ISSN-L)
OpenAlex
W3103664997
Cited by
118
References
89
Citations by year
2026: 8 · 2025: 22 · 2024: 26 · 2023: 38 · 2022: 19 · 2021: 5
FWCI
5.02
Type
journal article
Language
en
Open access
Locations
  • Nutrients (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Työväentutkimus Vuosikirja (submittedVersion)
  • Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
  • Rivm (National Institute for Public Health and the Environment) (submittedVersion)
  • Rivm (National Institute for Public Health and the Environment) (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
Funders
  • Seventh Framework Programme (266486)
  • Horizon 2020 Framework Programme (818368)
  • Spinoza award of The Netherlands Organization for Scientific Research 2008 (n/a)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
gut microbiota, diet, cognitive function, older adults, healthy aging, inflammation, plant-based diet, animal-based diet, alpha diversity, Faecalibacterium prausnitzii, Ruminococcus gnavus, Bacteroidetes, red and processed meat, fresh fruits, nuts and seeds, cognitive decline
MeSH terms
Gastrointestinal Microbiome, Aged, Bacteria, Cognition, Feces, Female, Humans, Male, Netherlands, RNA, Ribosomal, 16S, Diet, Mediterranean, Healthy Volunteers

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