Cited by 1,287Gut microbiota and healthClostridium difficile and Clostridium perfringens researchOral microbiology and periodontitis research

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Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

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Wang, Tingting, Cai, Guoxiang, Qiu, Yunping, Fei, Na, Zhang, Menghui, Pang, Xiaoyan, Jia, Wei, Cai, Sanjun, Zhao, Liping·2012·The ISME Journal

DOI 10.1038/ismej.2011.109PMC PMC3260502

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Abstract

Despite a long-suspected role in the development of human colorectal cancer (CRC), the composition of gut microbiota in CRC patients has not been adequately described. In this study, fecal bacterial diversity in CRC patients (n=46) and healthy volunteers (n=56) were profiled by 454 pyrosequencing of the V3 region of the 16S ribosomal RNA gene. Both principal component analysis and UniFrac analysis showed structural segregation between the two populations. Forty-eight operational taxonomic units (OTUs) were identified by redundancy analysis as key variables significantly associated with the structural difference. One OTU closely related to Bacteroides fragilis was enriched in the gut microbiota of CRC patients, whereas three OTUs related to Bacteroides vulgatus and Bacteroides uniformis were enriched in that of healthy volunteers. A total of 11 OTUs belonging to the genera Enterococcus, Escherichia/Shigella, Klebsiella, Streptococcus and Peptostreptococcus were significantly more abundant in the gut microbiota of CRC patients, and 5 OTUs belonging to the genus Roseburia and other butyrate-producing bacteria of the family Lachnospiraceae were less abundant. Real-time quantitative PCR further validated the significant reduction of butyrate-producing bacteria in the gut microbiota of CRC patients by measuring the copy numbers of butyryl-coenzyme A CoA transferase genes (Mann-Whitney test, P<0.01). Reduction of butyrate producers and increase of opportunistic pathogens may constitute a major structural imbalance of gut microbiota in CRC patients.

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Global cancer statistics
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,044
Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA
Muyzer, G., de Waal, E. C., & Uitterlinden, A. G. (1993) · Applied and Environmental Microbiology · doi:10.1128/aem.59.3.695-700.1993 · Cited by 11,490
Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences
Li, W.-Z., & Godzik, A. (2006) · Bioinform. · doi:10.1093/bioinformatics/btl158 · Cited by 10,996
ARB: a software environment for sequence data
Ludwig, W. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh293 · Cited by 6,714
Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
The Ribosomal Database Project: improved alignments and new tools for rRNA analysis
Cole, J. R., Wang, Q., Cardenas, E., Fish, J., Chai, B., Farris, R. J., Kulam-Syed-Mohideen, A. S., McGarrell, D. M., Marsh, T. L., Garrity, G. M., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn879 · Cited by 4,873
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
THE POPULATION FREQUENCIES OF SPECIES AND THE ESTIMATION OF POPULATION PARAMETERS
Good, I. J. (1953) · Biometrika · doi:10.1093/biomet/40.3-4.237 · Cited by 3,427
de la Chapelle, A.
Beighton, P., & Beighton, G. (1997) · Springer eBooks · doi:10.1007/978-1-4471-0925-9_118 · Cited by 3,165
Introducing DOTUR, a Computer Program for Defining Operational Taxonomic Units and Estimating Species Richness
Schloss, P. D., & Handelsman, J. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.3.1501-1506.2005 · Cited by 2,529

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Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
Self-citation
What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases
Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G. A. D., Gasbarrini, A., & Mele, M. C. (2019) · Microorganisms · doi:10.3390/microorganisms7010014 · Cited by 3,462
The gut microbiota, bacterial metabolites and colorectal cancer
Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,925
Uniting the classification of cultured and uncultured bacteria and archaea using 16S rRNA gene sequences
Yarza, P., Yilmaz, P., Pruesse, E., Glöckner, F. O., Ludwig, W., SCHLEIFER, K. H., Whitman, W. B., Euzéby, J. P., Amann, R., & Rossello-Mora, R. A. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3330 · Cited by 2,651
The impact of dietary fiber on gut microbiota in host health and disease
Makki, K., Deehan, E. C., Walter, J., & Bäckhed, F. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.012 · Cited by 2,517
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.12.007 · Cited by 2,368
The role of the gut microbiota in nutrition and health
Flint, H. J., Scott, K. P., Louis, P., & Duncan, S. H. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.156 · Cited by 2,283
Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
Jia, W., Xie, G., & Jia, W. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.119 · Cited by 1,924
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Schwabe, R. F., & Jobin, C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3610 · Cited by 1,689
Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer
Mármol, I., Sánchez‐de‐Diego, C., Pradilla-Dieste, A., Cerrada, E., & Yoldi, M. R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010197 · Cited by 1,639
Gut microbiota in colorectal cancer: mechanisms of action and clinical applications
Wong, S. H., & Yu, J. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0209-8 · Cited by 1,392
Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota
Fusco, W. G., Bernabeu, M., Cintoni, M., Porcari, S., Rinninella, E., Kaitsas, F., Lener, E., Mele, M. C., Gasbarrini, A., Collado, M. C., et al. (2023) · Nutrients · doi:10.3390/nu15092211 · Cited by 1,397
The first 1000 cultured species of the human gastrointestinal microbiota
Rajilić-Stojanović, M., & de Vos, W. M. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12075 · Cited by 1,182
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Diet, microorganisms and their metabolites, and colon cancer
O'Keefe, S. J. D. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.165 · Cited by 1,100
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Schulthess, J., Pandey, S., Capitani, M., Rue-Albrecht, K. C., Arnold, I., Franchini, F., Chomka, A., Ilott, N. E., Johnston, D. G. W., Pires, E., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.018 · Cited by 1,037
Human Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer
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The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation
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Meta-analysis of gut microbiome studies identifies disease-specific and shared responses
(2017) · doi:10.1038/s41467-017-01973-8 · Cited by 986
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Zhang, X., Shen, D., Fang, Z., Jie, Z., Qiu, X., Zhang, C., Chen, Y., & Ji, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071108 · Cited by 946
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Health and disease markers correlate with gut microbiome composition across thousands of people
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Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer
Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752
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Gut microbiota in colorectal cancer development and therapy
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He, Y., Fu, L., Li, Y., Wang, W., Gong, M., Zhang, J., Dong, X., Huang, J., Wang, Q., Mackay, C. R., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.002 · Cited by 729
The Gut Microbiome Modulates Colon Tumorigenesis
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Nutrients, foods, and colorectal cancer prevention
Song, M., Garrett, W. S., & Chan, A. T. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.035 · Cited by 700
Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction
Litvak, Y., Byndloss, M. X., Tsolis, R. M., & Bäumler, A. J. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.07.003 · Cited by 658
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Zhang, X., Zhao, Y., Xu, J., Xue, Z., Zhang, M., Pang, X., Zhang, X., & Zhao, L. (2015) · Scientific Reports · doi:10.1038/srep14405 · Cited by 630
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Zhang, X., Zhao, Y., Zhang, M., Pang, X., Xu, J., Kang, C., Li, M., Zhang, C., Zhang, Z., Zhang, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042529 · Cited by 615
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Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity
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The human gut microbiome as a screening tool for colorectal cancer
Zackular, J. P., Rogers, M. A. M., Ruffin, M. T., & Schloss, P. D. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0129 · Cited by 551
Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers
Dai, Z., Coker, O. O., Nakatsu, G., Wu, W. K. K., Zhao, L., Chen, Z., Chan, F. K. L., Kristiansen, K., Sung, J. J. Y., Wong, S. H., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0451-2 · Cited by 545
Self-citation
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Watson, H., Mitra, S., Croden, F. C., Taylor, M., Wood, H. M., Perry, S. L., Spencer, J. A., Quirke, P., Toogood, G. J., Lawton, C. L., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-314968 · Cited by 506
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Flanagan, L., Schmid, J., Ebert, M., Soucek, P., Kunicka, T., Liska, V., Bruha, J., Neary, P., Dezeeuw, N., Tommasino, M., et al. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-014-2081-3 · Cited by 498
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Zhang, C., Li, S., Yang, L., Huang, P., Li, W., Wang, S., Zhao, G., Zhang, M., Pang, X., Yan, Z., et al. (2013) · Nature Communications · doi:10.1038/ncomms3163 · Cited by 461
Self-citation
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Guo, C., Guo, D., Fang, L., Sang, T., Wu, J., Guo, C., Wang, Y., Wang, Y., Chen, C., Chen, J., et al. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118231 · Cited by 480
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Axelrad, J. E., Lichtiger, S., & Yajnik, V. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i20.4794 · Cited by 431
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Zhang, J., Guo, Z., Xue, Z., Sun, Z., Zhang, M., Wang, L., Wang, G., Wang, F., Xu, J., Cao, H., et al. (2015) · The ISME Journal · doi:10.1038/ismej.2015.11 · Cited by 462
Self-citation
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Wu, N., Yang, X., Zhang, R., Li, J., Xiao, X., Hu, Y., Chen, Y., Yang, F., Lu, N., Wang, Z., et al. (2013) · Microbial Ecology · doi:10.1007/s00248-013-0245-9 · Cited by 454
Role of the intestinal microbiome in health and disease: from correlation to causation
de Vos, W. M., & de Vos, E. A. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00505.x · Cited by 440
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Xu, J. Y., Lian, F., Zhao, L., Zhao, Y., Chen, X., Zhang, X., Guo, Y., Zhang, C., Zhou, Q., Xue, Z., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.177 · Cited by 425
Self-citation
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Li, W., Wu, X., Hu, X., Wang, T., Liang, S., Duan, Y., Jin, F., & Qin, B. (2017) · Science China Life Sciences · doi:10.1007/s11427-016-9001-4 · Cited by 406
Self-citation
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Angelberger, S., Reinisch, W., Makristathis, A., Lichtenberger, C., Dejaco, C., Papay, P., Novacek, G., Trauner, M., Loy, A., & Berry, D. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.257 · Cited by 330
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Tsukuda, N., Yahagi, K., Hara, T., Watanabe, Y., Matsumoto, H., Mori, H., Higashi, K., Tsuji, H., Matsumoto, S., Kurokawa, K., et al. (2021) · The ISME Journal · doi:10.1038/s41396-021-00937-7 · Cited by 335
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Chen, H.-M., Yu, Y.-N., Wang, J.-L., Lin, Y.-W., Kong, X., Yang, C.-Q., Yang, L., Liu, Z.-J., Yuan, Y.-Z., Liu, F., et al. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.046607 · Cited by 321
Smoking and microbiome in oral, airway, gut and some systemic diseases
Huang, C., & Shi, G. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1971-7 · Cited by 288
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Cong, J., Liu, P., Han, Z., Ying, W., Li, C., Yang, Y., Wang, S., Yang, J., Cao, F., Shen, J., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.02.014 · Cited by 333
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Lucas, C., Barnich, N., & Nguyen, H. T. T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061310 · Cited by 330
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Moreno‐Indias, I., Cardona, F., Tinahones, F. J., & Queipo‐Ortuño, M. I. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00190 · Cited by 325
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Chen, L., Xu, Y., Chen, X., Fang, C., Zhao, L., & Chen, F. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01688 · Cited by 334
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Rosa, S. L. L., Leth, M. L., Michalak, L., Ejby, M., Pudlo, N. A., Glowacki, R. W. P., Pereira, G. V., Workman, C. T., Arntzen, M. Ø., Pope, P. B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08812-y · Cited by 308
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Scott, K. P., Antoine, J., Midtvedt, T., & van Hemert, S. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.25877 · Cited by 293
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Walsh, C. J., Guinane, C. M., O'Toole, P. W., & Cotter, P. D. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.03.035 · Cited by 274
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Hou, H., Chen, D., Zhang, K., Zhang, W., Liu, T., Wang, S., Dai, X., Wang, B., Zhong, W., & Cao, H. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.11.027 · Cited by 274
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Wirbel, J., Zych, K., Essex, M., Karcher, N., Kartal, E., Salazar, G., Bork, P., Sunagawa, S., & Zeller, G. (2021) · Genome Biology · doi:10.1186/s13059-021-02306-1 · Cited by 269
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Bultman, S. J. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500902 · Cited by 275
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Mira‐Pascual, L., Cabrera‐Rubio, R., Ocon, S. M., Costales, P., Parra, A., Suárez, A., Morís, F., Rodrigo, L., Mira, Á., & Collado, M. C. (2014) · Journal of Gastroenterology · doi:10.1007/s00535-014-0963-x · Cited by 269
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Pancu, D. F., Scurtu, A., Macasoi, I. G., Marti, D. T., Mioc, M., Şoica, C., Coricovac, D. E., Horhat, D. I., Poenaru, M., & Dehelean, C. A. (2021) · Antibiotics · doi:10.3390/antibiotics10040401 · Cited by 275
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Sun, J., & Kato, I. (2016) · Genes & Diseases · doi:10.1016/j.gendis.2016.03.004 · Cited by 257
“Others did not find differences in these alpha diversity indices.(9,10,15,16) With or without using additional quantitative PCR (qPCR), these studies have also found that specific bacterial groups were more common or less common in colorectal cancer cases than control specimens.”
Background
The NF-κB Signaling Pathway, the Microbiota, and Gastrointestinal Tumorigenesis: Recent Advances
Peng, C., Ouyang, Y., Lü, N., & Li, N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01387 · Cited by 266

Authors: Wang, T., Cai, G., Qiu, Y., Fei, N., Zhang, M., Pang, X., Jia, W., Cai, S., & Zhao, L.
Affiliations: Shanghai Jiao Tong University (CN)
Shanghai Medical College of Fudan University (CN)
University of North Carolina at Greensboro (US)
Corresponding author: Zhao, Liping
ORCID: Wang, Tingting
Cai, Guoxiang
Qiu, Yunping
Zhang, Menghui
Pang, Xiaoyan
Jia, Wei
Cai, Sanjun
Zhao, Liping
Venue: The ISME Journal
Publisher: Oxford University Press (OUP)
Published: 2011-08-18
Volume: 6
Issue: 2
Pages: 320-329
ISSN: 1751-7362 (ISSN-L)
1751-7370
DOI: 10.1038/ismej.2011.109
PMC: PMC3260502
OpenAlex: W2015567271
Cited by: 1,287
References: 65
Citations by year: 2026: 49 · 2025: 80 · 2024: 126 · 2023: 118 · 2022: 139 · 2021: 155 · 2020: 134 · 2019: 106 · 2018: 101 · 2017: 80 · 2016: 53 · 2015: 46 · 2014: 38 · 2013: 39 · 2012: 19
FWCI: 12.71
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The ISME Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (30730005)
National Science and Technology Major Project
National Key Research and Development Program of China
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: colorectal cancer, gut microbiota, microbial community structure, Bacteroides fragilis, Bacteroides vulgatus, Bacteroides uniformis, butyrate-producing bacteria, Lachnospiraceae, Roseburia, opportunistic pathogens, Enterococcus, Escherichia-Shigella, Klebsiella, Streptococcus, Peptostreptococcus, dysbiosis
MeSH terms: Acyl Coenzyme A, Adult, Aged, Bacteria, Feces, Female, Humans, Male, Middle Aged, RNA, Ribosomal, 16S, Colorectal Neoplasms, Reproducibility of Results, Coenzyme A-Transferases, Bacterial Physiological Phenomena, Principal Component Analysis, Gastrointestinal Tract, Biodiversity, Metagenome

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Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

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