The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Co-occurrence of antibiotic and metal resistance genes revealed in complete genome collection
Open accessAbstract
The high frequency of antibiotic resistance is a global public health concern. More seriously, widespread metal pressure in the environment may facilitate the proliferation of antibiotic resistance via coselection of antibiotic resistance genes (ARGs) and metal resistance genes (MRGs). Given the lack of comprehensive understanding of the ARG and MRG coselection, in this study both abundance relationship and genetic linkage between ARGs and MRGs were rigorously investigated by performing a genomic analysis of a large complete genome collection. Many more ARGs were enriched in human-associated bacteria compared with those subjected to less anthropogenic interference. The signatures of ARG and MRG co-occurrence were much more frequent and the distance linkages between ARGs and MRGs were much more intimate in human pathogens than those less human-associated bacteria. Moreover, the co-occurrence structures in the habitat divisions were significantly different, which could be attributed to their distinct gene transfer potentials. More exogenous ARGs and MRGs on the genomes of human pathogens indicated the importance of recent resistance acquisition in resistome development of human commensal flora. Overall, the study emphasizes the potential risk associated with ARG and MRG coselection of both environmental and medical relevance.
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Cites
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An omics-based framework for assessing the health risk of antimicrobial resistance genes
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Self-citationSorinolu, A. J., Tyagi, N., Kumar, A., & Munir, M. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2020.129032 · Cited by 113
Peng, S., Zheng, H., Herrero-Fresno, A., Olsen, J. E., Dalsgaard, A., & Ding, Z. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.148259 · Cited by 51
Metal bioavailability and the soil microbiome
Sullivan, T. S., & Gadd, G. M. (2019) · Advances in Agronomy · doi:10.1016/bs.agron.2019.01.004 · Cited by 50
Heavy metal co-resistance with antibiotics amongst bacteria isolates from an open dumpsite soil
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Zhang, K., Guo, J., Luo, H., Chen, W., Chen, J., Mo, Y., & Zou, Z. (2023) · Journal of Environmental Chemical Engineering · doi:10.1016/j.jece.2022.109122 · Cited by 11
Metadata
- Authors
- Li, L.-G., Xia, Y., & Zhang, T.
- Venue
- The ISME Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-12-13
- Volume
- 11
- Issue
- 3
- Pages
- 651-662
- ISSN
- 1751-7362 (ISSN-L)
- 1751-7370
- OpenAlex
- W2563315795
- Cited by
- 528
- References
- 71
- FWCI
- 14.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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