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What is the Correct Value for the Brain-Blood Partition Coefficient for Water?
Abstract
A knowledge of the brain-blood partition coefficient (γ) for water is usually required for the measurement of CBF with [15 O]water. The currently accepted value for whole-brain Λ, 0.95–0.96 ml/g, calculated from brain and blood water content data, is incorrect because in the calculation, the blood water content was not adjusted for the density of blood. The correct value is 0.90 ml/g. Variations in brain or blood water content affect Λ. Thus, Λ changes during development of the brain and varies regionally in it, even among different gray matter structures, owing to variation in brain water content. In addition, Λ would be expected to vary with the hematocrit, owing to changes in blood water content. The impact of using an incorrect value for Λ will depend on the sensitivity of the CBF measurement technique used to errors in Λ.
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Citations
Cited by
Biophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals
Kim, S.-G., & Ogawa, S. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.23 · Cited by 547
Cruz Hernández, J. C., Bracko, O., Kersbergen, C. J., Muse, V., Haft-Javaherian, M., Berg, M., Park, L., Vinarcsik, L. K., Ivasyk, I., Rivera, D. A., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0329-4 · Cited by 508
Chalela, J. A., Alsop, D. C., Gonzalez-Atavales, J. B., Maldjian, J. A., Kasner, S. E., & Detre, J. A. (2000) · Stroke · doi:10.1161/01.str.31.3.680 · Cited by 481
Methodology of brain perfusion imaging
Barbier, E. L., Lamalle, L., & Décorps, M. (2001) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1073 · Cited by 404
Iida, H., Kanno, I., Takahashi, A., Miura, S., Murakami, M., Takahashi, K., Ono, Y., Shishido, F., Inugami, A., & Tomura, N. (1988) · Circulation · doi:10.1161/01.cir.78.1.104 · Cited by 340
Metadata
- Authors
- Herscovitch, P., & Raichle, M. E.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1985-03
- Volume
- 5
- Issue
- 1
- Pages
- 65-69
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W1976099054
- Cited by
- 705
- References
- 0
- FWCI
- 7.80
- Type
- journal article
- Language
- en
- Open access
- closed
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