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Cited by 340

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Measurement of absolute myocardial blood flow with H215O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect.

Open access
Iida, H, Kanno, I, Takahashi, A, Miura, S, Murakami, M, Takahashi, K, Ono, Y, Shishido, F, Inugami, A, Tomura, N·1988·Circulation

Abstract

An in vivo technique was developed for measuring the absolute myocardial blood flow with H215O and dynamic positron-emission tomography. This technique was based on a new model involving the concept of the tissue fraction, which was defined as the fraction of the tissue mass in the volume of the region of interest. The myocardium was imaged dynamically by positron-emission tomography, starting at the time of intravenous bolus injection of H215O. The arterial input function was measured continuously with a beta-ray detector. A separate image after C15O inhalation was also obtained for correction of the H215O radioactivity in the blood. The absolute myocardial blood flow and the tissue fraction were calculated for 15 subjects with a kinetic technique under region-of-interest analysis. These results seem consistent with their coronary angiographic findings. The mean value of the measured absolute myocardial blood flows in normal subjects was 0.95 +/- 0.09 ml/min/g. This technique detected a diffuse decrease of myocardial blood flow in patients with triple-vessel disease.

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Metadata

Authors
Iida, H., Kanno, I., Takahashi, A., Miura, S., Murakami, M., Takahashi, K., Ono, Y., Shishido, F., Inugami, A., & Tomura, N.
Venue
Circulation
Published
1988-07
Volume
78
Issue
1
Pages
104-115
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W1871634784
Cited by
340
References
4
FWCI
5.84
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Measurement of absolute myocardial blood flow with H215O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect. https://app.cochat.ai/papers/10.1161/01.cir.78.1.104
The paper
Iida, H., Kanno, I., Takahashi, A., Miura, S., Murakami, M., Takahashi, K., Ono, Y., Shishido, F., Inugami, A., & Tomura, N. (1988). Measurement of absolute myocardial blood flow with H215O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect. Circulation. https://doi.org/10.1161/01.cir.78.1.104

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.