The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Enhanced Detection of Focal Brain Responses Using Intersubject Averaging and Change-Distribution Analysis of Subtracted PET Images
Open accessAbstract
Intersubject averaging and change-distribution analysis of subtracted positron emission tomographic (PET) images were developed and tested. The purpose of these techniques is to increase the sensitivity and objectivity of functional mapping of the human brain with PET. To permit image averaging, all primary tomographic images were converted to anatomically standardized three-dimensional images using stereotactic anatomical localization and interslice interpolation. Image noise, measured in control-minus-control subtractions, was strongly suppressed by averaging. Signal-to-noise ratio, measured in stimulus-minus-control subtractions (hand vibration minus eyes-closed rest), rose steadily with averaging, confirming the accuracy of our method of anatomical standardization. Distribution analysis of CBF change images (outlier detection by gamma-2 statistic) was assessed as an omnibus test for state-dependent changes in regional neuronal activity. Sensitivity in detecting the somatosensory response rose steadily with averaging, increasing from 50% in individual images to 100% when three or more images were averaged. Specificity was 100% at all averaging levels. Although described here as a technique for functional brain mapping with H 215 O CBF images, image averaging, and change-distribution analysis are more generally applicable techniques, not limited to a single purpose or tracer.
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Fox, P. T., & Raichle, M. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1140 · Cited by 2,056
Self-citationMapping human visual cortex with positron emission tomography
Fox, P. T., Mintun, M. A., Raichle, M. E., Miezin, F. M., Allman, J. M., & Van Essen, D. C. (1986) · Nature · doi:10.1038/323806a0 · Cited by 422
Cited by
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Automated Talairach Atlas labels for functional brain mapping
Lancaster, J. L., Woldorff, M. G., Parsons, L. M., Liotti, M., Freitas, C. S., Rainey, L., Kochunov, P. V., Nickerson, D., Mikiten, S. A., & Fox, P. T. (2000) · Human Brain Mapping · doi:10.1002/1097-0193(200007)10:3<120::aid-hbm30>3.0.co;2-8 · Cited by 3,387
Self-citationMurphy, K., Birn, R. M., Handwerker, D. A., Jones, T. B., & Bandettini, P. A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.09.036 · Cited by 2,387
A three-dimensional statistical analysis for CBF activation studies in human brain
Worsley, K. J., Evans, A. C., Marrett, S., & Neelin, P. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.127 · Cited by 2,036
Meta-analysis of the functional neuroanatomy of single-word reading: method and validation
Turkeltaub, P. E., Eden, G. F., Jones, K. M., & Zeffiro, T. A. (2002) · NeuroImage · doi:10.1006/nimg.2002.1131 · Cited by 1,604
Metadata
- Authors
- Fox, P. T., Mintun, M. A., Reiman, E. M., & Raichle, M. E.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1988-10
- Volume
- 8
- Issue
- 5
- Pages
- 642-653
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2057468044
- Cited by
- 498
- References
- 2
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fox, P. T., Mintun, M. A., Reiman, E. M., & Raichle, M. E. (1988). Enhanced Detection of Focal Brain Responses Using Intersubject Averaging and Change-Distribution Analysis of Subtracted PET Images. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.1988.111
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