The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Comparison of Bolus and Infusion Methods for Receptor Quantitation: Application to [18F]Cyclofoxy and Positron Emission Tomography
Abstract
Positron emission tomography studies with the opiate antagonist [18 F]cyclofoxy ([18 F]CF) were performed in baboons. Bolus injection studies demonstrated initial uptake dependent on blood flow. The late uptake showed highest binding in caudate nuclei, amygdala, thalamus, and brainstem and the least accumulation in cerebellum. By 60 min postinjection, regional brain radioactivity cleared at the same rate as metabolite-corrected plasma, i.e., transient equilibrium was achieved. Compartmental modeling methods were applied to time-activity curves from brain and metabolite-corrected plasma. Individual rate constants were estimated with poor precision. The model estimate of the total volume of distribution ( V T), representing the ratio of tissue radioactivity to metabolite-corrected plasma at equilibrium, was reliably determined. The apparent volume of distribution ( V a), the concentration ratio of tissue to metabolite-corrected plasma during transient equilibrium, was compared with the fitted V T values to determine if single-scan methods could provide accurate receptor measurements. V a significantly overestimated V T and produced artificially high image contrast. These differences were predicted by compartment model theory and were caused by a plasma clearance rate that was close to the slowest tissue clearance rate. To develop a simple method to measure V T, an infusion protocol consisting of bolus plus continuous infusion (B/I) of CF was designed and applied in a separate set of studies. The V a values from the B/I studies agreed with the V T values from both B/I and bolus studies. This infusion approach can produce accurate receptor measurements and has the potential to shorten scan time and simplify the acquisition and processing of scan and blood data.
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Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000
Logan, J., Fowler, J. S., Volkow, N. D., Wolf, A. P., Dewey, S. L., Schlyer, D. J., MacGregor, R. R., Hitzemann, R., Bendriem, B., Gatley, S. J., et al. (1990) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1990.127 · Cited by 1,479
Frackowiak, R. S. J., Lenzi, G.-L., Jones, T., & Heather, J. D. (1980) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-198012000-00001 · Cited by 1,242
Quantitation in Positron Emission Computed Tomography: 1. Effect of Object Size
Hoffman, E. J., Huang, S.-C., & Phelps, M. E. (1979) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-197906000-00001 · Cited by 1,143
Mintun, M. A., Raichle, M. E., Kilbourn, M. R., Wooten, G. F., & Welch, M. J. (1984) · Annals of Neurology · doi:10.1002/ana.410150302 · Cited by 955
Quantitative Analysis of D2 Dopamine Receptor Binding in the Living Human Brain by PET
Farde, L., Hall, H., Ehrin, E., & Sedvall, G. (1986) · Science · doi:10.1126/science.2867601 · Cited by 831
Parameter Estimation in Engineering and Science.
Folks, J. L., Beck, J. V., & Arnold, K. J. (1978) · Journal of the Royal Statistical Society. Series A (General) · doi:10.2307/2344460 · Cited by 610
Tracer kinetic methods in medical physiology
Lassen, N. A., & Perl, W. (1979) · Raven Press eBooks · Cited by 495
Farde, L., Eriksson, L., Blomquist, G., & Halldin, C. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.98 · Cited by 448
Analysis of Emission Tomographic Scan Data: Limitations Imposed by Resolution and Background
Kessler, R. M., Ellis, J. R., & Eden, M. (1984) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-198406000-00028 · Cited by 430
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Breier, A., Su, T.-P., Saunders, R., Carson, R. E., Kolachana, B. S., de Bartolomeis, A., Weinberger, D. R., Weisenfeld, N., Malhotra, A. K., Eckelman, W. C., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2569 · Cited by 1,154
Self-citationImaging synaptic density in the living human brain
Finnema, S. J., Nabulsi, N. B., Eid, T., Detyniecki, K., Lin, S.-F., Chen, M.-K., Dhaher, R., Matuskey, D., Baum, E., Holden, D., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6667 · Cited by 575
Self-citationMartinez, D., Slifstein, M., Broft, A., Mawlawi, O., Hwang, D.-R., Huang, Y., Cooper, T., Kegeles, L., Zarahn, E., Abi-Dargham, A., et al. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000048520.34839.1a · Cited by 569
Cigarette Smoking Saturates Brain α4β2 Nicotinic Acetylcholine Receptors
Brody, A. L., Mandelkern, M. A., London, E. D., Olmstead, R. E., Farahi, J., Scheibal, D., Jou, J., Allen, V., Tiongson, E., Chefer, S. I., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.907 · Cited by 367
Greenwald, M. K., Johanson, C.-E., Moody, D. E., Woods, J. H., Kilbourn, M. R., Koeppe, R. A., Schuster, C. R., & Zubieta, J.-K. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300251 · Cited by 320
Metadata
- Authors
- Carson, R. E., Channing, M. A., Blasberg, R. G., Dunn, B. B., Cohen, R. M., Rice, K. C., & Herscovitch, P.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1993-01
- Volume
- 13
- Issue
- 1
- Pages
- 24-42
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2046045427
- Cited by
- 375
- References
- 32
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Comparison of Bolus and Infusion Methods for Receptor Quantitation: Application to [18F]Cyclofoxy and Positron Emission Tomography. https://app.cochat.ai/papers/10.1038/jcbfm.1993.6
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- Carson, R. E., Channing, M. A., Blasberg, R. G., Dunn, B. B., Cohen, R. M., Rice, K. C., & Herscovitch, P. (1993). Comparison of Bolus and Infusion Methods for Receptor Quantitation: Application to [18F]Cyclofoxy and Positron Emission Tomography. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.1993.6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
