Cited by 286Nitric Oxide and Endothelin EffectsAcute Ischemic Stroke ManagementNeuroprotection in Cerebral Ischemia

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels

Open access

Yoshida, Tazuka, Limmroth, Volker, Irikura, Katsumi, Moskowitz, Michael A.·1994·Journal of Cerebral Blood Flow & Metabolism

DOI 10.1038/jcbfm.1994.123

Open this paper in CoChat — free account Open PDF

Abstract

We examined whether 7-nitroindazole (7-NI), a putative inhibitor of neuronal nitric oxide synthase (nNOS), decreases cerebral infarction 24 h after proximal middle cerebral artery (MCA) occlusion. In preliminary experiments, we determined that 7-NI (25, 50, and 100 mg/kg i.p.) decreased nitric oxide synthase (NOS) activity within cerebral cortex by 40–60% when measured up to 120 min, but not 240 min after administration. At 25 or 50 mg/kg, 7-NI did not alter the systemic arterial blood pressure or the dilation of pial arterioles after topical acetylcholine (10 and 100 μ M). To examine the effect of 7-NI on infarct size, 55 Sprague–Dawley halothaneanesthetized rats were subjected to proximal MCA occlusion (modified Tamura method). Five minutes after occlusion, 7-NI (25 or 50 mg/kg i.p.) or vehicle was injected. Animals treated with 25 or 50 mg/kg showed 25 and 27% reductions in infarct volume, respectively. Coadministration of l-arginine (300 mg/kg i.p.) plus 7-NI (25 mg/kg i.p.) reversed the effect. If, indeed, the effects of 7-NI are mediated by inhibition of nNOS activity, these results suggest that enzymatic products of the neuronal isoform promote ischemic injury and that they do so at least within the first few hours after permanent occlusion. The results also emphasize the importance of developing strategies to selectively inhibit the neuronal isoform inasmuch as we observed previously that administering the less selective NOS inhibitor, N ω -nitro-l-arginine (L-NA), in the same model either caused no change or increased the volume of ischemic injury.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/jcbfm.1994.123

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.
Bederson, J. B., Pitts, L. H., Tsuji, M., Nishimura, M. C., Davis, R. L., & Bartkowski, H. (1986) · Stroke · doi:10.1161/01.str.17.3.472 · Cited by 2,681
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.
Dawson, V. L., Dawson, T. M., London, E. D., Bredt, D. S., & Snyder, S. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.14.6368 · Cited by 2,174
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
Bredt, D. S., & Snyder, S. H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.9030 · Cited by 1,849
Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery Occlusion
Tamura, A., Graham, D., McCulloch, J., & Teasdale, G. M. (1981) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1981.6 · Cited by 1,432
Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.
Knowles, R. G., Palacios‐Callender, M., Palmer, R. M. J., & Moncada, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.5159 · Cited by 1,431

Flagged first, then by citations

Show all 34 references

Research works printed but not linked: 2

Morikawa E, 1992, Am J Physiol, 263, H1,632
Moskowitz MA, 1993, Microcirculatory Stasis in the Brain, 287

Sorted by citations

Items 101–200 of 286

Ischemic injury and faulty gene transcripts in the brain
Liu, P. K., Grossman, R. G., Hsu, C. Y., & Robertson, C. S. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01918-4 · Cited by 62
Mechanisms of Cerebral Ischemic Damage
Iadecola, C. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-479-5_1 · Cited by 62
Two pathways of nitric oxide production through glutamate receptors in the rat cerebellum in vivo
Yamada, K., & Nabeshima, T. (1997) · Neuroscience Research · doi:10.1016/s0168-0102(97)00032-1 · Cited by 61
Effects of Mild Hypothermia on Nitric Oxide Synthesis Following Contusion Trauma in the Rat
SAKAMOTO, K.-I., Fujisawa, H., KOIZUMI, H., Tsuchida, E., Ito, H., Sadamitsu, D., & Maekawa, T. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.349 · Cited by 61
Oxidative Damage to the c‐fos Gene and Reduction of Its Transcription After Focal Cerebral Ischemia
Cui, J., Holmes, E. H., & Liu, P. K. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731164.x · Cited by 61
“…levels are known to be elevated after brain injury of the ischemia–reperfusion type (Hall and Braughler, 1989; Rosenthal et al., 1992; Poiries, 1994; Yoshida et al., 1994; Zhang et al., 1994; O’Neill et al., 1996; Smith et al., 1996) and following administration of excitotoxic drugs (Schulz et…”
BackgroundMethodResultInfluential
In situ detection of AP sites and DNA strand breaks bearing 3'‐phosphate termini in ischemic mouse brain
Huang, D., Shenoy, A., Cui, J., Huang, W.-Y., & Liu, P. K. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.2.407 · Cited by 60
Sleep and nitric: oxide: effects of 7-nitro indazole, inhibitor of brain nitric oxide synthase
Dzoljic, M., de Vries, R., & van Leeuwen, R. (1996) · Brain Research · doi:10.1016/0006-8993(96)00102-3 · Cited by 59
“) decreased the NOS activity within cerebral cortex of rat by 40 -60% when measured up to 120 min but not 240 min after administration [32].”
Method
Time Course of Expression of Three Nitric Oxide Synthase Isoforms After Transient Middle Cerebral Artery Occlusion in Rats.
Masahiro, N. I. W. A., Inao, S., Takayasu, M., 河合達巳, Kajita, Y., Nihashi, T., Kabeya, R., Sugimoto, T., & Yoshida, J. (2001) · Neurologia medico-chirurgica · doi:10.2176/nmc.41.63 · Cited by 58
Inhibition of neuronal (type 1) nitric oxide synthase prevents hyperaemia and hippocampal lesions resulting from kainate-induced seizures
Montécot, C., Rondi‐Reig, L., Springhetti, V., Seylaz, J., & Pinard, E. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00566-6 · Cited by 57
Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia
O’Neill, M. J., Hicks, C. A., & Ward, M. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00387-1 · Cited by 57
Effect of nitric oxide synthase inhibitor on a hyperglycemic rat model of reversible focal ischemia: detection of excitatory amino acids release and hydroxyl radical formation
Wei, J., & Quast, M. J. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00089-4 · Cited by 56
NO produced by endothelial NO synthase is a mediator of delayed preconditioning-induced endothelial protection
Laude, K. M., Favre, J., Thuillez, C., & Richard, V. J. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00627.2002 · Cited by 56
“This dose was chosen on the basis that it effectively blocks brain nNOS in mice without functional evidence of eNOS inhibition (18) and also limits cerebral infarct size in rats (30).”
Background
Prolonged suppression of brain nitric oxide synthase activity by 7-nitroindazole protects against cerebral hypoxic–ischemic injury in neonatal rat
Ishida, A., Trescher, W. H., Lange, M. S., & Johnston, M. V. (2001) · Brain and Development · doi:10.1016/s0387-7604(01)00237-6 · Cited by 55
The potential of nitric oxide therapeutics in stroke
Willmot, M. R., & Bath, P. M. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.3.455 · Cited by 56
Nitric Oxide Synthase Expression after Human Brain Contusion
Gahm, C., Holmin, S., & Mathiesen, T. I. (2002) · Neurosurgery · doi:10.1097/00006123-200206000-00024 · Cited by 54
“Studies using selective nNOS inhibitors (30, 41, 45) or nNOS-knockout mice (10, 16) demonstrated reductions in cerebral ischemic damage.”
Method
Increased neurons containing neuronal nitric oxide synthase in the brain of a hypoxic-ischemic neonatal rat model
Higuchi, Y., Hattori, H., Hattori, R., & Furusho, K. (1996) · Brain and Development · doi:10.1016/0387-7604(96)00019-8 · Cited by 54
“In adult rats as well, recent data show that a selective nNOS inhibitor decreases the infarct volume and suggest that the effects of eNOS can be discriminated from those of nNOS [29].”
Inhibition of autophagy and glycolysis by nitric oxide during hypoxia–reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons
Benavides, G. A., Liang, Q., Dodson, M. B., Darley-Usmar, V. M., & Zhang, J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.006 · Cited by 53
“A pathological role for NO in brain ischemia-reperfusion has been suggested on the basis of both experiments in genetic models of NOS ablation and the use of NOS inhibitors (10-16).”
Method
Interaction between ATP-Sensitive K + Channels and Nitric Oxide on Pial Arterioles in Piglets
Bari, F., Errico, R. A., Louis, T. M., & Busija, D. W. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199611000-00010 · Cited by 52
Protection of prenylated flavonoids from mori cortex radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells
Lee, H. J., Lyu, D. H., Koo, U., Nam, K.-W., Hong, S. S., Kim, K. O., Kim, K. H., Lee, D., & Mar, W. (2012) · Archives of Pharmacal Research · doi:10.1007/s12272-012-0118-7 · Cited by 51
“For example, inhibitors of neuronal nitric oxide synthase (nNOS) have been shown to significantly reduce lesions produced in response to focal ischemia (Yoshida et al., 1994) and mice that are deficient in the nNOS gene exhibit significant protection against cerebral ischemia (Huang et al.”
Background
Effect of neuronal NO synthase inhibition on the cerebral vasodilatory response to somatosensory stimulation
Cholet, N., Bonvento, G., & Seylaz, J. (1996) · Brain Research · doi:10.1016/0006-8993(95)01387-3 · Cited by 51
NAD+ depletion or PAR polymer formation: which plays the role of executioner in ischaemic cell death?
Siegel, C., & McCullough, L. D. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02229.x · Cited by 53
Nitric oxide synthase activity and inhibition after neonatal hypoxia ischemia in the mouse brain
Muramatsu, K., Sheldon, R. A., Black, S. M., Täuber, M. G., & Ferriero, D. M. (2000) · Developmental Brain Research · doi:10.1016/s0165-3806(00)00088-2 · Cited by 50
Cerebral microvascular dilation during hypotension and decreased oxygen tension: a role for nNOS
Bauser‐Heaton, H. D., & Bohlen, H. G. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00190.2007 · Cited by 50
ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia
O’Neill, M. J., Murray, T. K., McCarty, D. R., Hicks, C. A., Dell, C. P., Patrick, K. E., Ward, M., Osborne, D. J., Wiernicki, T. R., Roman, C. R., et al. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02471-9 · Cited by 50
Nitric Oxide and the Cardiovascular System
Bohlen, H. G. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140052 · Cited by 54
Dynamic Cerebral Microcirculatory Changes in Transient Forebrain Ischemia in Rats: Involvement of Type I Nitric Oxide Synthase
Pinard, E., Engrand, N., & Seylaz, J. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200012000-00004 · Cited by 49
Nitric oxide is involved in ischemia-induced apoptosis in brain: a study in neuronal nitric oxide synthase null mice
Elibol, B., Söylemezoğlu, F., Ünal, I., Fujii, M., Hirt, L., Huang, P. L., Moskowitz, M. A., & Dalkara, T. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00159-2 · Cited by 49
Self-citation
The Association Between Neuronal Nitric Oxide Synthase and Neuronal Sensitivity in the Brain After Brain Injury
Liu, P. K., Robertson, C. S., & Valadka, A. B. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04071.x · Cited by 48
Role of Nitric Oxide in Pathogenesis Underlying Ischemic Cerebral Damage
Matsui, T., Nagafuji, T., Kumanishi, T., & Asano, T. (1999) · Cellular and Molecular Neurobiology · doi:10.1023/a:1006985112459 · Cited by 47
“Yoshida et al. (1994) demonstrated the beneficial effects of 7-NI on permanent MCAo.”
BackgroundMethod
Effects of 7-nitroindazole, NG-nitro-l-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-d-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions
Eblen, F., Löschmann, P. A., Wüllner, U., Turski, L., & Klockgether, T. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00795-4 · Cited by 47
Nitric oxide synthase in cerebral ischemia
Nagafuji, T., Sugiyama, M., Matsui, T., Muto, A., & Naito, S. (1995) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815009 · Cited by 47
Phosphinothricin induces epileptic activity via nitric oxide production through NMDA receptor activation in adult mice
篤史, 吉., Montécot, C., Sevestre, A., & Pichon, J. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03597-7 · Cited by 46
Ischemia-Reperfusion-Related Repair Deficit after Oxidative Stress: Implications of Faulty Transcripts in Neuronal Sensitivity after Brain Injury
Liu, P. K. (2003) · Journal of Biomedical Science · doi:10.1007/bf02255992 · Cited by 44
Limiting Neurological Damage After Stroke
Read, S. J., Hirano, T., Davis, S. M., & Donnan, G. A. (1999) · Drugs & Aging · doi:10.2165/00002512-199914010-00002 · Cited by 43
Blockade of neuronal nitric oxide synthase alters the baroreflex control of heart rate in the rabbit
Murakami, H., Liu, J., Yoneyama, H., Nishida, Y., Okada, K., Kosaka, H., Morita, H., & Zucker, I. H. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.1.r181 · Cited by 43
“It has been shown that 7-NI administered at 50 mg/kg decreased NOS activity within the forebrain to 45% after 30 min (33).”
Background
Influence of duration of focal cerebral ischemia and neuronal nitric oxide synthase on translocation of apoptosis-inducing factor to the nucleus
Li, X., Nemoto, M., Xu, Z., Yu, S.-W., Shimoji, M., Andrabi, S. A., Haince, J.-F., Poirier, G. G., Dawson, T. M., Dawson, V. L., et al. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.065 · Cited by 42
“Because comparable doses of 7-NI do not inhibit endothelial-dependent dilation to acetylcholine (Yoshida et al., 1994), the effects of 7-NI are considered to be selective for nNOS.”
Background
Developmental characteristics of neuronal nitric oxide synthase (nNOS) immunoreactive neurons in fetal to adolescent human brains
Ohyu, J., & Takashima, S. (1998) · Developmental Brain Research · doi:10.1016/s0165-3806(98)00107-2 · Cited by 42
Chapter 16 Mechanisms of NO neurotoxicity
Dalkara, T., Endres, M., & Moskowitz, M. A. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)63211-2 · Cited by 41
Self-citation
Nitric Oxide Production in the CA1 Field of the Gerbil Hippocampus After Transient Forebrain Ischemia
Lei, B., Adachi, N., Nagaro, T., & Arai, T. (1999) · Stroke · doi:10.1161/01.str.30.3.669 · Cited by 40
7-Nitroindazole, a selective inhibitor of nNOS, increases hippocampal extracellular glutamate concentration in status epilepticus induced by kainic acid in rats
Alabadí, J. A., Thibault, J.-L., Pinard, E., Seylaz, J., & Lasbennes, F. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01749-7 · Cited by 38
Chapter 14 Neurotoxic and Neuroprotective Roles of Nitric Oxide in Cerebral Ischaemia
Dalkara, T., & Moskowitz, M. A. (1996) · International review of neurobiology · doi:10.1016/s0074-7742(08)60726-6 · Cited by 38
Self-citation
Reduction of the Neurological Deficit in Mice with Traumatic Brain Injury by Nitric Oxide Synthase Inhibitors
Mésenge, C., VERRECCHIA, C., Allix, M., Boulu, R. G., & Plotkine, M. (1996) · Journal of Neurotrauma · doi:10.1089/neu.1996.13.209 · Cited by 37
Expressional Down-Regulation of Neuronal-Type Nitric Oxide Synthase I by Glucocorticoids in N1E-115 Neuroblastoma Cells
Schwarz, P. M., Gierten, B., Boissel, J., & Förstermann, U. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.2.258 · Cited by 37
“Similarly, the NOS inhibitor 7-nitroindazole, which exhibits a certain specificity for NOS I in vivo, reduced cerebral ischemic damage in rats caused by proximal middle cerebral artery occlusion (Yoshida et al., 1994).”
Background
A comparative study of the effects of two nitric oxide synthase inhibitors and two nitric oxide donors on temporary focal cerebral ischemia in the Wistar rat
Coert, B. A., Anderson, R. E., & Meyer, F. B. (1999) · Journal of neurosurgery · doi:10.3171/jns.1999.90.2.0332 · Cited by 37
Hippocampus and Nitric Oxide
Hu, Y. F., & Zhu, D. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800254-4.00006-4 · Cited by 36
Inducible Nitric Oxide Production and Expression of Transforming Growth Factor-β1 in Serum and CSF after Cerebral Ischaemic Stroke in Man
Krupiński, J., Yoram Vodovotz, B., Li, C., Słowik, A., Beevers, D., Flanders, K. C., Lip, G. Y. H., Kumar, P., & Szczudlik, A. (1998) · Nitric Oxide · doi:10.1006/niox.1998.0204 · Cited by 36
DY-9760e, a novel calmodulin antagonist, reduces brain damage induced by transient focal cerebral ischemia
Sato, T., MORISHIMA, Y., Sugimura, M., Uchida, T., & Shirasaki, Y. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00133-8 · Cited by 36
Rosuvastatin preconditioning provides neuroprotection against spinal cord ischemia in rats through modulating nitric oxide synthase expressions
Die, J., Wang, K., Fan, L., Jiang, Y., & Shi, Z. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.068 · Cited by 35
Changes in pro-oxidant and antioxidant enzyme levels during cerebral hypoperfusion in rats
Mracsko, E. Z., Hugyecz, M., Institóris, Á., Farkas, E., & Bari, F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.080 · Cited by 35
Elevated endogenous nitric oxide increases Ca2+ flux via L-type Ca2+ channels by S-nitrosylation in rat hippocampal neurons during severe hypoxia and in vitro ischemia
Tjong, Y.-W., Jian, K., Li, M., Chen, M., Gao, T., & Fung, M. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.09.020 · Cited by 35
“It has also been shown that blockade of the activity of nitric oxide synthases (NOSs) ameliorates neuronal injuries following severe hypoxia or ischemia in animal models [4,5], brain slices [6–8], and cultured neurons [9,10].”
Background
Maturation-dependent apoptotic cell death of oligodendrocytes in myelin-deficient rats
Grinspan, J. B., Coulalaglou, M., Beesley, J., Carpio, D. F., & Scherer, S. S. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19981201)54:5 · Cited by 33
Discovery and development of neuronal nitric oxide synthase inhibitors
Reif, D. W., McCarthy, D. J., CREGAN, E. F., & Macdonald, J. E. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00250-1 · Cited by 34
Relatively selective neuronal nitric oxide synthase inhibition by 7-nitroindazole in monkey isolated cerebral arteries
Ayajiki, K., Fujioka, H., Okamura, T., & Toda, N. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01068-8 · Cited by 34
Differential expression of alternatively spliced isoforms of neuronal nitric oxide synthase (nNOS) and N-methyl-d-aspartate receptors (NMDAR) in knockout mice deficient in nNOSα (nNOSαΔ/Δ mice)
Putzke, J., Seidel, B., Huang, P. L., & Wolf, G. L. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00220-5 · Cited by 34
Involvement of peroxynitrite and hydroxyradical generated from nitric oxide in hypoxia/reoxygenation injury in rat cerebrocortical slices
Oka, M., Hirouchi, M., Itoh, Y., & Ukai, Y. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00197-5 · Cited by 34
Tissue kallikrein alleviates glutamate‐induced neurotoxicity by activating ERK1
Liu, L., Zhang, R., Liu, K., Zhou, H., Tang, Y., Su, J., Yu, X., Yang, X., Tang, M., & Dong, Q. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22151 · Cited by 33
“…playing a detrimental role in ischemic damage and glutamate neurotoxicity and selective inhibition of nNOS with 7-NI has been reported to attenuate both ischemic injury and the excitotoxic lesions produced by NMDA (Dawson et al., 1991; Yoshida et al., 1994; Huang et al., 1994; Schulz et al., 1995).”
Background
Neuroprotective effects of the antioxidant LY231617 and NO synthase inhibitors in global cerebral ischaemia
Neill, M. J., Hicks, C. A., Ward, M., & Panetta, J. A. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00293-x · Cited by 33
Chronic inhibition of nitric oxide synthesis enhances both subventricular zone neurogenesis and olfactory learning in adult mice
Romero‐Grimaldi, C., Gheusi, G., Lledo, P., & Estrada, C. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05127.x · Cited by 32
“The relatively specific nNOS inhibitor 7-nitroindazole (7-NI) was also administered for 4 days, at doses reported to significantly decrease cerebral NOS activity (30 mg ⁄ kg, i.p.) (Yoshida et al., 1994).”
Background
Normobaric hyperoxia delays and attenuates early nitric oxide production in focal cerebral ischemic rats
Yuan, Z., Liu, W., Liu, B., Schnell, A., & Liu, K. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.07.010 · Cited by 30
“Moreover, pharmacologically selective nNOS inhibitors (Yoshida et al. 1994; Zhang et al. 1996b) or nNOS knockout (Ferriero et al. 1996; Panahian et al. 1996) attenuate the infarction volume after focal cerebral ischemia.”
BackgroundMethodInfluential
Nitric oxide reduces Ca2+ and Zn2+ influx through voltage-gated Ca2+ channels and reduces Zn2+ neurotoxicity
Snider, B. J., Choi, J., Turetsky, D. M., Canzoniero, L. M. T., Sensi, S. L., Sheline, C. T., Wang, X., Yu, S. P., & Choi, D. W. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00311-0 · Cited by 30
Neuroprotective and deleterious effects of nitric oxide on focal cerebral ischemia-induced neurone death
VERRECCHIA, C., Boulu, R. G., & Plotkine, M. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(95)00023-2 · Cited by 30
The neuronal nitric oxide synthase inhibitor, TRIM, as a neuroprotective agent: effects in models of cerebral ischaemia using histological and magnetic resonance imaging techniques
Haga, K. K., Gregory, L. J., Hicks, C. A., Ward, M., Beech, J. S., Bath, P. M., Williams, S., & O’Neill, M. J. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.063 · Cited by 30
Different roles of neuronal and endothelial nitric oxide synthases on ischemic nitric oxide production in gerbil striatum
Adachi, N., Lei, B., SOUTANI, M., & Arai, T. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01222-2 · Cited by 30
Modulation of Ischemic Excitatory Neurotransmitter and gamma-Aminobutyric Acid Release During Global Temporary Cerebral Ischemia by Selective Neuronal Nitric Oxide Synthase Inhibition
Kahn, R. A., Panah, M. H., & Weinberger, J. M. (1997) · Anesthesia & Analgesia · doi:10.1097/00000539-199705000-00009 · Cited by 30
Effects of Hypoxia-Ischemia and Inhibition of Nitric Oxide Synthase on Cerebral Energy Metabolism in Newborn Piglets
Groenendaal, F., de Graaf, R. A., van Vliet, G., & Nicolay, K. (1999) · Pediatric Research · doi:10.1203/00006450-199906000-00008 · Cited by 29
Effects of Mild Hypothermia on the Cortical Release of Excitatory Amino Acids and Nitric Oxide Synthesis Following Hypoxia
Fujisawa, H., KOIZUMI, H., Ito, H., Yamashita, K., & Maekawa, T. (1999) · Journal of Neurotrauma · doi:10.1089/neu.1999.16.1083 · Cited by 28
Influence of 7-nitroindazole on the anticonvulsive action of conventional antiepileptic drugs
Borowicz, K. K., Kleinrok, Z., & Czuczwar, S. J. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01034-0 · Cited by 28
Preferential Inhibition by a Novel Na+/Ca2+ Channel Blocker NS-7 of Severe to Mild Hypoxic Injury in Rat Cerebrocortical Slices: A Possible Involvement of a Highly Voltage-Dependent Blockade of Ca2+ Channel
Oka, M., Itoh, Y., & Ukai, Y. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39264-x · Cited by 28
Functional importance of neuronal nitric oxide synthase in the endothelium of rat basilar arteries
Benyó, Z., Lacza, Z., Hortobágyi, T., Görlach, C., & Wahl, M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02611-1 · Cited by 26
Perioperative Plasma Concentrations of Stable Nitric Oxide Products Are Predictive of Cognitive Dysfunction After Laparoscopic Cholecystectomy
Iohom, G., Szarvas, S., Larney, V., O’Brien, J., Buckley, E., Butler, M. D., & Shorten, G. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000132971.00206.4a · Cited by 26
iNOS contribution to the NMDA‐induced excitotoxic lesion in the rat striatum
Lecanu, L., VERRECCHIA, C., Margaill, I., Boulu, R. G., & Plotkine, M. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702119 · Cited by 26
“It has been shown that NO derived from neuronal NOS has a deleterious e ect during the early phase of ischaemic brain injury (Yoshida et al., 1994).”
Background
7-Nitroindazole reduces nitric oxide concentration in rat hippocampus after transient forebrain ischemia
Jiang, M. H., Kaku, T., Hada, J., & Hayashi, Y. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00555-5 · Cited by 26
The Role of Nitric Oxide in the Cerebrovascular Response to Hypercapnia
Smith, J. J., Lee, J. G., Hudetz, A. G., Hillard, C. J., Bosnjak, Z. J., & Kampine, J. P. (1997) · Anesthesia & Analgesia · doi:10.1097/00000539-199702000-00023 · Cited by 24
Involvement of NO in the convulsive behavior and oxidative damage induced by the intrastriatal injection of methylmalonate
Royes, L. F. F., Fighera, M. R., Furian, A. F., Oliveira, M. S., Fiorenza, N. G., Myskiw, J. D. C., Frussa‐Filho, R., & Mello, C. F. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.11.038 · Cited by 24
Proabsorptive and prosecretory roles for nitric oxide in cholera toxin induced secretion
Turvill, J. L., Mourad, F. H., & Farthing, M. J. G. (1999) · Gut · doi:10.1136/gut.44.1.33 · Cited by 24
7-Nitroindazole attenuates nitrotyrosine formation in the early phase of cerebral ischemia-reperfusion in mice
Hirabayashi, H., Takizawa, S., Fukuyama, N., Nakazawa, H. K., & Shinohara, Y. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00368-7 · Cited by 24
Roles of Apolipoprotein E (ApoE) and Inducible Nitric Oxide Synthase (iNOS) in Inflammation and Apoptosis in Preeclampsia Pathogenesis and Progression
Mao, L., Zhou, Q., Zhou, S., Wilbur, R. R., & Li, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058168 · Cited by 23
“A possible explanation could be that cNOS(eNOS and nNOS) is considered as the primary source of NO which plays an important role in the regulation of systemic blood pressure, blood flow and regional vascular tone in physiological condition [25,44].”
Background
Mechanisms mediating NG-nitro-l-arginine methyl ester-induced hypophagia in mice
Hui, S. G., & Chan, T. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00312-9 · Cited by 22
Nitric oxide inhibitors attenuate ischemic degeneration in the CA1 region of rat hippocampal slices
Izumi, Y., Benz, A. M., Clifford, D. B., & Zorumski, C. F. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12669-0 · Cited by 23
Nitric Oxide: Physiological Roles, Biosynthesis and Medical Uses
Adams, D. R., Brochwicz‐Lewinski, M., & BUTLER, A. R. (1999) · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products · doi:10.1007/978-3-7091-6351-1_1 · Cited by 23
Role of neuronal NO synthase in relationship between NO and opioids in hypoxia-induced pial artery dilation
Wilderman, M. J., & Armstead, W. M. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.4.h1807 · Cited by 22
7-Nitroindazole Inhibits Pial Arteriolar Vasodilation in a Rat Model of Pneumococcal Meningitis
Paul, R. H., Koedel, U., & Pfister, H. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199709000-00008 · Cited by 22
Effect of nitric oxide synthase modulation on resuscitation success in a swine ventricular fibrillation cardiac arrest model
Zhang, Y., Boddicker, K. A., Rhee, B. J., Davies, L. R., & Kerber, R. E. (2005) · Resuscitation · doi:10.1016/j.resuscitation.2005.03.015 · Cited by 22
Nitric Oxide Deficiency Contributes to Large Cerebral Infarct Size
Kidd, G. A., Dobrucki, L. W., Brovkovych, V. M., Bohr, D. F., & Maliñski, T. (2000) · Hypertension · doi:10.1161/01.hyp.35.5.1111 · Cited by 21
Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia
Hicks, C. A., Ward, M., Swettenham, J. B., & O’Neill, M. J. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00543-9 · Cited by 21
Dual Role for Nitric Oxide in Dynorphin Spinal Neurotoxicity
Hu, W., Li, F., Qiang, W., Liu, N., WANG, G.-Q., Xiao, J., LIU, J.-S., Liao, W.-H., & Jen, M.-F. (1999) · Journal of Neurotrauma · doi:10.1089/neu.1999.16.85 · Cited by 21
“…and iNOS (aminoguani-dine, AG) have been consistently demonstrated to ameliorate cerebral ischémie damage (Huang et al., 1994; Moore et al., 1994; Yoshida et al., 1994; Iadecola et al., 1995b, Zhang et al., 1996), traumatic brain injury (Mesenge et al., 1996), and striatal malonate lesion…”
Prior exposure to enriched environment reduces nitric oxide synthase after transient MCAO in rats
Yu, K., Wu, Y., Hu, Y., Zhang, Q., Xie, H., Liu, G., Chen, Y., Guo, Z., & Jia, J. (2013) · NeuroToxicology · doi:10.1016/j.neuro.2013.09.002 · Cited by 20
Neuroprotective effects of a dihydropyridine derivative, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (CV-159), on rat ischemic brain injury
Miyazaki, H., Tanaka, S., Fujii, Y., Shimizu, K., Nagashima, K., Kamibayashi, M., Uehara, T., Okuma, Y., & Nomura, Y. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00011-9 · Cited by 20
The Role of Nitric Oxide in the Cerebrovascular Response to Hypercapnia
Smith, J. J., Lee, J. G., Hudetz, A. G., Hillard, C. J., Bosnjak, Z. J., & Kampine, J. P. (1997) · Anesthesia & Analgesia · doi:10.1213/00000539-199702000-00023 · Cited by 20
Is neuroprotective efficacy of nNOS inhibitor 7-NI dependent on ischemic intracellular pH?
Coert, B. A., Anderson, R. E., & Meyer, F. B. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00580.2002 · Cited by 19
“The dosages used in this study were based on our previous study (17) and those of the literature (35, 67).”
BackgroundMethodInfluential
Nitric oxide and renal nerves: Comparison of effects on renal circulation and sodium excretion in anesthetized rats
Walkowska, A., Kompanowska‐Jezierska, E., & Sadowski, J. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00792.x · Cited by 19
Biology and chemistry of the inhibition of nitric oxide synthases by pteridine‐derivatives as therapeutic agents
Matter, H., & Kotsonis, P. (2004) · Medicinal Research Reviews · doi:10.1002/med.20005 · Cited by 19
“Furthermore the NOS-I selective inhibitor 7-nitroindazole showed reduced infarct sizes in animal models of focal ischemia, whereas non selective ligands did not show this effect.(37)”
Method
Oxygen Deprivation Produces Delayed Inhibition of Long-Term Potentiation by Activation of NMDA Receptors and Nitric Oxide Synthase
Izumi, Y., Katsuki, H., Benz, A. M., & Zorumski, C. F. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199801000-00010 · Cited by 19
Neuronal NOS Inhibitor That Reduces Oxidative DNA Lesions and Neuronal Sensitivity Increases the Expression of Intact c-fos Transcripts after Brain Injury
Cui, J., & Liu, P. K. (2001) · Journal of Biomedical Science · doi:10.1007/bf02258375 · Cited by 19
Intraventricular administration of nitric oxide synthase inhibitors prevents delayed neuronal death in gerbil hippocampal CA 1 neurons
Kohno, K., Ohta, S., Furuta, S., Kohno, K., Kumon, Y., & Sakaki, S. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12018-y · Cited by 19
Involvement of Nitric Oxide From Nerves on Diarrhea Induced by Castor Oil in Rats
Uchida, M., Kato, Y., Matsueda, K., Shoda, R., Muraoka, A., & Yamato, S. (2000) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.82.168 · Cited by 18
Nitric oxide and the cerebral-blood-flow response to somatosensory activation following deafferentation
Greenberg, J. H., Sohn, N., & Hand, P. J. (1999) · Experimental Brain Research · doi:10.1007/s002210050924 · Cited by 18
Der dreiwertige Neodymiumkomplex [(C5Me5)3Nd] ist ein Ein-Elektronen-Donor!
Evans, W. J., Nyce, G. W., Clark, R. D., Doedens, R. J., & Ziller, J. W. (1999) · Angewandte Chemie · doi:10.1002/(sici)1521-3757(19990614)111:12 · Cited by 7
Effect of chronic nNOS inhibition on blood pressure, vasoactivity, and arterial wall structure in Wistar rats
Čačányiová, S., Kristek, F., Gerová, M., Křenek, P., & Klimas, J. (2009) · Nitric Oxide · doi:10.1016/j.niox.2009.03.002 · Cited by 18
Chapter 23. Nitric Oxide Synthase Inhibitors
Macdonald, J. E. (1996) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(08)60462-5 · Cited by 18

Authors: Yoshida, T., Limmroth, V., Irikura, K., & Moskowitz, M. A.
Affiliations: Harvard University (US)
ORCID: Limmroth, Volker
Moskowitz, Michael A.
Venue: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications
Published: 1994-11
Volume: 14
Issue: 6
Pages: 924-929
ISSN: 0271-678X (ISSN-L)
1559-7016
DOI: 10.1038/jcbfm.1994.123
OpenAlex: W2047362612
Cited by: 286
References: 34
Citations by year: 2024: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 3
FWCI: 16.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns021558-09)
National Institute of Neurological Disorders and Stroke (NS-21558, NS 64361)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords: 7-nitroindazole, neuronal nitric oxide synthase, nitric oxide, cerebral ischemia, middle cerebral artery occlusion, infarct size, L-arginine, nitric oxide synthase inhibitors, L-NAME, cerebral vasodilation
MeSH terms: Acetylcholine, Administration, Topical, Amino Acid Oxidoreductases, Animals, Brain, Cerebral Infarction, Cerebrovascular Circulation, Indazoles, Male, Pia Mater, Rats, Sprague-Dawley, Nitric Oxide Synthase, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks