The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels
Open accessAbstract
We examined whether 7-nitroindazole (7-NI), a putative inhibitor of neuronal nitric oxide synthase (nNOS), decreases cerebral infarction 24 h after proximal middle cerebral artery (MCA) occlusion. In preliminary experiments, we determined that 7-NI (25, 50, and 100 mg/kg i.p.) decreased nitric oxide synthase (NOS) activity within cerebral cortex by 40–60% when measured up to 120 min, but not 240 min after administration. At 25 or 50 mg/kg, 7-NI did not alter the systemic arterial blood pressure or the dilation of pial arterioles after topical acetylcholine (10 and 100 μ M). To examine the effect of 7-NI on infarct size, 55 Sprague–Dawley halothaneanesthetized rats were subjected to proximal MCA occlusion (modified Tamura method). Five minutes after occlusion, 7-NI (25 or 50 mg/kg i.p.) or vehicle was injected. Animals treated with 25 or 50 mg/kg showed 25 and 27% reductions in infarct volume, respectively. Coadministration of l-arginine (300 mg/kg i.p.) plus 7-NI (25 mg/kg i.p.) reversed the effect. If, indeed, the effects of 7-NI are mediated by inhibition of nNOS activity, these results suggest that enzymatic products of the neuronal isoform promote ischemic injury and that they do so at least within the first few hours after permanent occlusion. The results also emphasize the importance of developing strategies to selectively inhibit the neuronal isoform inasmuch as we observed previously that administering the less selective NOS inhibitor, N ω -nitro-l-arginine (L-NA), in the same model either caused no change or increased the volume of ischemic injury.
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“In recent years, several studies have linked nitric oxide as a key mediator in numerous neurodegenerative diseases, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD) and ischemic brain injury (stroke).”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [145]
In the citing paper
“This dual action makes it a contributing player in pathophysiology, but also makes the development of effective treatments for neurodegenerative diseases particularly difficult [141,142,143,144,145].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [145]
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Citations
Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
Bederson, J. B., Pitts, L. H., Tsuji, M., Nishimura, M. C., Davis, R. L., & Bartkowski, H. (1986) · Stroke · doi:10.1161/01.str.17.3.472 · Cited by 2,681
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.
Dawson, V. L., Dawson, T. M., London, E. D., Bredt, D. S., & Snyder, S. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.14.6368 · Cited by 2,174
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
Bredt, D. S., & Snyder, S. H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.9030 · Cited by 1,849
Tamura, A., Graham, D., McCulloch, J., & Teasdale, G. M. (1981) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1981.6 · Cited by 1,432
Knowles, R. G., Palacios‐Callender, M., Palmer, R. M. J., & Moncada, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.5159 · Cited by 1,431
Research works printed but not linked: 2
- Morikawa E, 1992, Am J Physiol, 263, H1,632
- Moskowitz MA, 1993, Microcirculatory Stasis in the Brain, 287
Cited by
Sorted by citations
Items 201–286 of 286
Harukuni, I., Traystman, R. J., & Kirsch, J. R. (1999) · Critical Care Medicine · doi:10.1097/00003246-199911000-00030 · Cited by 18
Neither l -Arginine nor L-NAME Affects Neurological Outcome After Global Ischemia in Cats
Kirsch, J. R., Bhardwaj, A., Martin, L. J., Hanley, D. F., & Traystman, R. J. (1997) · Stroke · doi:10.1161/01.str.28.11.2259 · Cited by 18
Vannucchi, M. G., Bizzoco, E., Corsani, L., Gianfriddo, M., Pedata, F., & Faussone‐Pellegrini, M. S. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.029 · Cited by 17
Engelhardt, T., Lowe, P. R., Galley, H. F., & Webster, N. R. (2006) · British Journal of Anaesthesia · doi:10.1093/bja/ael010 · Cited by 17
Hu, W.-H., Lee, F.-C., Wan, X. S. T., Chen, Y., & Jen, M.-F. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(95)12246-x · Cited by 16
Fibroblast Growth Factor Protects Nitric Oxide-Induced Apoptosis in Neuronal SHSY-5Y Cells
Wagle, A., & Singh, J. P. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38986-4 · Cited by 16
“, 1999), L-nitroarginine, and 7-nitroindazole significantly reduces infarct size in various models of cerebral ischemia (Yoshida et al., 1994).”
Sorrenti, V., Giacomo, C. D., Campisi, A., Perez-Polo, J. R., & Vanella, A. (1999) · Neurochemical Research · doi:10.1023/a:1020906030328 · Cited by 16
“(32) who postulate that changes in vascular hemodinamics, platelets and leukocytes caused by L-NA and L-NAME obscured the consequences of nNOS inhibition and increased infarct size in their models.”
BackgroundAge-dependent redox status in the brain stem of NO-deficient hypertensive rats
Majzúnová, M., Pakanová, Z., Kvasnicka, P., Bališ, P., Čačányiová, S., & Dovinová, I. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0366-4 · Cited by 15
Mild Hypothermia Inhibits Exogenous Glutamate-Induced Increases in Nitric Oxide Synthesis
Shima, H., Fujisawa, H., Suehiro, E., Uetsuka, S., Maekawa, T., & Suzuki, M. (2003) · Journal of Neurotrauma · doi:10.1089/089771503770802862 · Cited by 15
“Recent evidence has indicated that the NO produced by nNOS and iNOS is neurotoxic, whereas the NO produced by eNOS is cerebroprotective (Huang et al., 1994, 1996; Iadecola, 1997; Yoshida et al., 1994; Zhang et al., 1995).”
Sporer, B., Martens, K. H., Koedel, U., & Haberl, R. L. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199710000-00009 · Cited by 15
Spanggord, H., Sheldon, R. A., & Ferriero, D. M. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12848-2 · Cited by 15
Transcripts of damaged genes in the brain during cerebral oxidative stress
Liu, P. K., & Arora, T. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10454 · Cited by 14
“…animals treated with 7-nitroindazole (7NI; an inhibitor of nNOS) are protected against neuronal death after experimental brain injury of the ischemia/reperfusion type (Kamii et al., 1994; Huang et al., 1994; Yoshida et al., 1994; O’Neill et al., 1996; Panahian et al., 1996; Iadecola et al., 1997).”
MethodBauser‐Heaton, H. D., Song, J. H., & Bohlen, H. G. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01074.2007 · Cited by 14
Vannucchi, M. G., Corsani, L., Gianfriddo, M., Pedata, F., & Faussone‐Pellegrini, M. S. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.044 · Cited by 14
Neuroprotective Agents: Is Effective on Toxicity in Glial Cells?
Dağcı, T., Yılmaz, Ö., Taşkıran, D., & Peker, G. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9082-4 · Cited by 14
“In vitro studies have shown that 7-NI evidently inhibit neuronal NOS (nNOS) (Yoshida et al., 1994).”
BackgroundGroenendaal, F., Mishra, O. P., McGowan, J. E., Hoffman, D. J., & Delivoria‐Papadopoulos, M. (1997) · Pediatric Research · doi:10.1203/00006450-199708000-00008 · Cited by 14
Palmer, C. (1997) · Springer eBooks · doi:10.1007/978-1-4899-0197-2_12 · Cited by 13
Introduction and Historical Notes
Beal, M. F. (2004) · Springer eBooks · doi:10.1007/978-1-4419-8959-8_1 · Cited by 13
7-Nitroindazole: A selective inhibitor of penile erection: An in vivo study in a rat animal model
Spiess, P. E., Dion, S., Zvara, P., Merlin, S. L., Chan, P. T. K., & Brock, G. B. (1996) · Urology · doi:10.1016/s0090-4295(99)80389-6 · Cited by 13
Nitric Oxide and the Cardiovascular System
Bohlen, H. G. (2015) · Comprehensive physiology · doi:10.1002/j.2040-4603.2015.tb00628.x · Cited by 12
Robertson, S. C., & Loftus, C. M. (1998) · Neurosurgery · doi:10.1097/00006123-199801000-00023 · Cited by 12
Segawa, D., Hatori, N., Yoshizu, H., Uriuda, Y., Shimizu, M., & Tanaka, S. (1998) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(98)70375-7 · Cited by 12
Free Radical-Mediated Cerebral Damage After Hypoxia/Ischemia and Stroke
Matsuyama, T. (1997) · Humana Press eBooks · doi:10.1007/978-1-59259-472-6_7 · Cited by 12
Sinz, E. H., Kochanek, P. M., Dixon, C. E., Clark, R. S. B., Carcillo, J. A., Watkins, S. C., Schiding, J. K., Carlos, T. M., & Billiar, T. R. (1998) · Critical Care Medicine · doi:10.1097/00003246-199801001-00044 · Cited by 12
Nitric Oxide Synthase Inhibitors
Resink, A., Dawson, V. L., & Dawson, T. M. (1996) · CNS Drugs · doi:10.2165/00023210-199606050-00002 · Cited by 11
Lee, S. Y., & Hur, S. J. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.05.003 · Cited by 10
Helps, S. C., & Sims, N. R. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9160-5 · Cited by 10
“[38] showed that reductions in infarct volume following permanent MCA occlusion were achieved when 7-nitroindazole was injected intraperitoneally at either 25 or 50 mg/kg.”
MethodEngelhardt, T., Lowe, P. R., Galley, H. F., & Webster, N. R. (2006) · European Journal of Anaesthesiology · doi:10.1017/s0265021505002188 · Cited by 10
“Although 7-NI is not isoform selective for nNOS in some in vitro studies [15], it appears to have acceptable in vivo isoform selectivity for nNOS, possibly due to a preferred uptake into neuronal cells, which may also explain the absence of haemodynamic effects [16,17].”
BackgroundHandy, R. L. C., & Moore, P. K. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(98)01239-5 · Cited by 10
Zagvazdin, Y., Sancesario, G., Fitzgerald, M. E. C., & Reiner, A. J. (1998) · Pharmacological Research · doi:10.1006/phrs.1998.0374 · Cited by 10
Zhang, W., Shibamoto, T., Cui, S., Takano, H., & Kurata, Y. (2009) · Shock · doi:10.1097/shk.0b013e31817c05bc · Cited by 9
“The 7-NI does not influence the endotheliumdependent vasodilation of acetylcholine (29) nor does it cause an increase in arterial blood pressure in vivo (28), as observed in the present study, indicating that eNOS function is preserved.”
ResultAcupuncture Attenuates Blood Pressure via Inducing the Expression of nNOS
Wang, L., Yang, N., Shi, G., Wang, Y., Li, Q., Yang, J., & Liu, C. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/9945277 · Cited by 8
“As a relatively selective inhibitor of nNOS, 7-NI was demonstrated in numerous studies to suppress the level of nNOS in the brain [44, 45].”
BackgroundMishima, K., Pu, F. C. R. M. F. R., Kaneko, T., Egashira, N., Iwasaki, K., & Fujiwara, M. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(02)00404-5 · Cited by 8
Gültürk, S., Kozan, R., Bostanci, M. Ö., Sefil, F., & Bağırıcı, F. (2008) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2008-1668 · Cited by 8
Effect of low doses of L-NAME on methamphetamine-induced dopaminergic depletion in the rat striatum
Abekawa, T., Ohmori, T., Honda, M., Ito, K., & Koyama, T. (2001) · Journal of Neural Transmission · doi:10.1007/s007020100000 · Cited by 8
“…by relatively low doses of LNAME (3mg/kg, i.p., 1, or 15mg/kg, i.v., 1) enhances ischemic lesion (Kamii et al., 1996; Stagliano et al., 1997), whereas 7-NI (25mg/kg, i.p., 1 or 50mg/kg, i.p., 1) attenuates ischemic brain damage (Kamii et al., 1996; Stagliano et al., 1997; Yoshida et al., 1994).”
BackgroundMargaill, I., Allix, M., Charriaut‐Marlangue, C., Boulu, R. G., & Plotkine, M. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb15076.x · Cited by 8
Neurotoxic Actions and Mechanisms of Nitric Oxide
Gonzalez‐Zulueta, M., Dawson, V. L., & Dawson, T. M. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50044-7 · Cited by 8
Nitric Oxide in Cerebrovascular Regulation and Ischemia
Dalkara, T., & Moskowitz, M. A. (1997) · KARGER eBooks · doi:10.1159/000061570 · Cited by 7
Self-citationJiang, M. H., & Hada, J. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.03.014 · Cited by 7
Liu, G., Lu, D., Wu, J., Wang, S., Duan, A., Ren, Y., Zhang, Y. L., Meng, L., Shou, R., Li, H., et al. (2024) · Nitric Oxide · doi:10.1016/j.niox.2024.11.005 · Cited by 6
Thomas, J. E. (1997) · Neurosurgical FOCUS · doi:10.3171/foc.1997.3.3.6 · Cited by 6
“Recent evidence indicates that the neuronal form of NOS may be deleterious in ischemic conditions, whereas the endothelial type may be protective by means of its vasodilatory effect; the development of relatively selective NOS inhibitors is needed to shed more light on these interactions.[9,80] Upregulation of gene ex…”
BackgroundPark, S., Bivona, B. J., & Harrison‐Bernard, L. M. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00433.2017 · Cited by 5
“Inhibition of neuronal NOS does not alter the acetylcholine-induced dilation of rat pial arterioles (39) or mouse retinal arterioles (7).”
BackgroundLack of iNOS induction in a severe model of transient focal cerebral ischemia in rats
Lerouet, D., Jafarian-Tehrani, M., Louin, G., Palmier, B., Bonnefont‐Rousselot, D., Plotkine, M., & Margaill, I. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.05.001 · Cited by 5
BROŽÍČKOVÁ, C., Mikulecká, A., & Otáhal, J. (2014) · Physiological Research · doi:10.33549/physiolres.932781 · Cited by 5
“Inhibition of nNOS by 7-NI or other, more selective nNOS inhibitors was reported to increase (Zagvazdin et al. 1996), decrease (Kakoki et al. 2001) or not to change blood pressure (Yoshida et al. 1994, Zagvazdin et al. 1996).”
BackgroundMethodThe Role of Nitric Oxide in Cerebral Ischemia
Dalkara, T., & Moskowitz, M. A. (1997) · Primer on Cerebrovascular Diseases · doi:10.1016/b978-012743170-3.50059-5 · Cited by 5
Self-citationHow Selective Is 7-Nitroindazole, An Inhibitor of Neuronal Nitric Oxide Synthase?
Zagvazdin, Y., Reiner, A. J., & Benter, I. F. (1998) · Anesthesia & Analgesia · doi:10.1097/00000539-199803000-00056 · Cited by 5
Biphasic modulation by nitric oxide of caspase activation due to malonate injection in rat striatum
Paucard, A., Palmier, B., Croci, N., Taillieu, F., Plotkine, M., & Margaill, I. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.10.038 · Cited by 5
Therapeutic effects of nitric oxide synthase inhibition in neuronal injury
Beal, M. F. (1996) · Elsevier eBooks · doi:10.1016/b978-012525445-8/50008-4 · Cited by 5
Anti-inflammatory modulators in stroke
O’Neill, M. J., Astles, P. C., Allan, S. M., & Anthony, D. C. (2004) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2004.08.006 · Cited by 4
Gas Mediators in the Nervous System: Nitric Oxide, Hydrogen Sulfide and Carbon Monoxide
NOMENOĞLU, T., & Demirel-Yılmaz, E. (2017) · Turkiye Klinikleri Journal of Neurology · doi:10.5336/neuro.2017-58770 · Cited by 4
Zhang, H., Zhang, Y., Wang, X., Liu, J., & Zhang, W. (2024) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12453 · Cited by 4
Nitric Oxide Synthase Inhibitors I: Substrate Analogs and Heme Ligands
Parkinson, J. F. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57077-3_6 · Cited by 4
Regulation of Vulnerability to NMDA Excitotoxicity During Postnatal Maturation
Marks, J. D. (2009) · Contemporary clinical neuroscience · doi:10.1007/978-1-60327-579-8_1 · Cited by 3
Nitric Oxide and Cerebral Ischemia
Kirsch, J. R., Hurn, P. D., & Traystman, R. J. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50029-0 · Cited by 3
THERAPEUTIC ADVANCES IN ACUTE ISCHAEMIC STROKE
Bhalla, A., & Rudd, A. G. (1999) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.1999.tb11728.x · Cited by 3
Nitric Oxide and Oxidative Damage in the CNS
Dawson, D. A. (1997) · Springer eBooks · doi:10.1007/978-1-4899-0197-2_11 · Cited by 3
Neuroprotection by Free Radical Scavengers and Other Antioxidants
Phillis, J. W. (2002) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-06274-6_9 · Cited by 3
[Progress in the studies on neuronal nitric oxide synthase inhibitors].
Zhang, C.-Z., Dong, L., Mu, F.-H., Yang, X., & Sun, W. (2014) · PubMed · Cited by 2
Oxidative Stress and Nitric Oxide in Cerebral Ischemic Reperfusion Injury
Ma, J., Liu, Z., & Shi, Z. (2018) · Springer series in translational stroke research · doi:10.1007/978-3-319-90194-7_7 · Cited by 2
Togashi, H., Ueno, K.-I., Mori, K., Matsumoto, M., Itoh, Y., Shinohara, K., & Yoshioka, M. (1999) · Springer eBooks · doi:10.1007/978-4-431-67929-5_5 · Cited by 2
Nitric Oxide in Brain Ischemia/Reperfusion Injury
Sasaki, M., Dawson, T. M., & Dawson, V. L. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57077-3_24 · Cited by 2
Contribution of NO/ONOO− pathway to the deleterious effect of traumatic brain injury in mice
Mésenge, C., VERRECCHIA, C., Charriaut‐Marlangue, C., Margaill, I., Boulu, R. G., & Plotkine, M. (2000) · Drug Discovery Today · doi:10.1016/s1359-6446(00)01554-3 · Cited by 2
Synaptic and Neuroglial Pathobiology in Acute and Chronic Neurological Disorders
Martin, L. J. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-105-3_25 · Cited by 1
Immunological Aspects of Ischaemic Stroke
Stoll, G., Jander, S., Siebler, M., & Schroeter, M. (2000) · CNS Drugs · doi:10.2165/00023210-200014030-00004 · Cited by 1
“[130-132] Similarly, the iNOS inhibitor aminoguanidine attenuated post-ischaemic iNOS activity and reduced infarct size after Immunology of Ischaemic Stroke 223”
Dalkara, T., Huang, P. L., & Moskowitz, M. A. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50043-5 · Cited by 1
Self-citationFree Radicals and Acute Brain Injury: Mechanisms of Oxidative Stress and Therapeutic Potentials
Bayır, H., & Kagan, V. E. (2001) · Springer eBooks · doi:10.1007/978-1-4615-1721-4_6 · Cited by 1
Choi, C. W., Hwang, J. H., Chang, Y. S., & Park, W. S. (2004) · Korean Journal of Pediatrics · Cited by 1
XVIIIth International Symposium on Cerebral Blood Flow and Metabolism
(1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x9701701s01 · Cited by 1
Stroke: Mechanisms of Excitotoxicity and Approaches for Therapy
O’Neill, M. J., Lodge, D., & McCulloch, J. (2007) · doi:10.1002/9780470101001.hcn058
Involvement of Nitric Oxide in Simulated Retinal Ischemia
Jin, D., Ishikawa, M., Yoshitomi, T., & Izumi, Y. (2014) · Institutional Repositories DataBase (IRDB)
Neuronal nitric oxide synthase in the cerebrovascular endothelium
Benyó, Z., Lacza, Z., Hortobágyi, T., Görlach, C., Sándor, P., & Wahl, M. (2002) · International Congress Series · doi:10.1016/s0531-5131(02)00208-x
Stagliano, N. E., & Huang, P. L. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-002-5_20
Molecular mechanisms of neuronal survival; Roles of kinases in ischemic cell death
Gotoh, Y. (2002) · Springer eBooks · doi:10.1007/978-4-431-68430-5_7
“Inhibitors of neuronal NOS (nNOS) have been shown to significantly reduce lesions after focal ischemia [91].”
BackgroundCharron, C. (2007) · uO Research (University of Ottawa) · doi:10.20381/ruor-19832
Nitric oxide reactivity and toxicity in brain tissue in vitro
Keynes, R. G. (2004) · OpenGrey (Institut de l'Information Scientifique et Technique)
Experimental findings with important clinical implications for stroke treatment
Dalkara, T., Hirt, L., & Moskowitz, M. A. (2003) · CRC Press eBooks · doi:10.1201/b14341-19
Self-citationThe NO Signaling Pathway in the Brain: Neural Injury, Neurological Disorders, and Aggression
Sasaki, M., Dawson, V. L., & Dawson, T. M. (2003) · Humana Press eBooks · doi:10.1385/1-59259-019-5:151
INTRODUCTIONAND HISTORICAL NOTES EXCITOTOXICITY IN NEUROLOGIC DISEASES
Beal, M. F. (2004)
Cold, G. E., & Dahl, B. L. (2002) · Springer eBooks · doi:10.1007/978-3-662-04845-0_12
Nantermet, P. G., Shalen, E. F., Venkatraman, S., Zhu, H., & Mark, R. J. (2010) · Burger's Medicinal Chemistry and Drug Discovery · doi:10.1002/0471266949.bmc250
Neurochemical Aspects of Ischemic Injury
Farooqui, A. A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6652-0_2
“As stated above, ischemic/reperfusion injury is accompanied with the activation of many enzymes including cPLA2, PLC, NOS, protein kinases, calpains, calcinurin, and endonucleases (Fig.”
BackgroundInfluentialThe NO Signaling Pathway in the Brain
Sasaki, M., Dawson, V. L., & Dawson, T. M. (2000) · doi:10.1007/978-1-59259-019-3_6
Metadata
- Authors
- Yoshida, T., Limmroth, V., Irikura, K., & Moskowitz, M. A.
- Affiliations
- Harvard University (US)
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1994-11
- Volume
- 14
- Issue
- 6
- Pages
- 924-929
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2047362612
- Cited by
- 286
- References
- 34
- Citations by year
- 2024: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 16.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns021558-09)
- National Institute of Neurological Disorders and Stroke (NS-21558, NS 64361)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- 7-nitroindazole, neuronal nitric oxide synthase, nitric oxide, cerebral ischemia, middle cerebral artery occlusion, infarct size, L-arginine, nitric oxide synthase inhibitors, L-NAME, cerebral vasodilation
- MeSH terms
- Acetylcholine, Administration, Topical, Amino Acid Oxidoreductases, Animals, Brain, Cerebral Infarction, Cerebrovascular Circulation, Indazoles, Male, Pia Mater, Rats, Sprague-Dawley, Nitric Oxide Synthase, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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