The metabolic topography of parkinsonism
Open accessAbstract
We used [ 18 F]fluorodeoxyglucose/positron emission tomography ( 18 F-FDG/PET) and a statistical model of regional covariation to study brain topographic organization in parkinsonism. We studied 22 patients with Parkinson's disease (PD), 20 age-matched normal volunteers, and 10 age- and severity-matched patients with presumed striatonigral degeneration (SND). We used FDG/PET to calculate global, regional, and normalized metabolic rates for glucose (GMR, rCMR glc , rCMR glc /GMR). Metabolic parameters in the three groups were compared using an analysis of variance, with a correction for multiple comparisons, and discriminant analysis. The scaled subprofile model (SSM) was applied to the combined rCMR glc dataset to identify topographic covariance profiles that distinguish PD patients from SND patients and normals. GMR, rCMR glc , and rCMR glc /GMR were normal in PD; caudate and lentiform rCMR glc /GMR was reduced in the SND group ( p < 0.01). SSM analysis of the combined group of patients and normals revealed a significant topographic profile characterized by increased metabolic activity in the lentiform nucleus and thalamus associated with decreased activity in the lateral frontal, paracentral, inferior parietal, and parietooccipital areas. Individual subject scores for this profile were significantly elevated in PD patients compared with normals and SND patients ( p < 0.001) and discriminated the three groups. In the PD group, subject scores for this factor correlated with individual subject Hoehn and Yahr (H&Y) scores ( p < 0.02), and with quantitative rigidity ( p < 0.01) and bradykinesia ( p < 0.03) ratings, but not with tremor ratings. SSM analysis of right-left metabolic asymmetries yielded a topographic contrast profile that accurately discriminated mildly affected PD patients (H&Y Stage I) from normals. Our findings demonstrate that abnormal topographic covariance profiles exist in parkinsonism. These profiles have potential clinical application as neuroimaging markers in parkinsonism.
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PET in IFN-alpha-treated patients revealed increased glucose metabolism in the basal ganglia, similar to Parkinson's disease.
“Indeed, positron emission tomography (PET) in interferon (IFN)-alpha-treated patients revealed increased glucose metabolism in the basal ganglia, similar to Parkinson’ s disease (Eidelberg et al., 1994, Spetsieris et al., 1995, Mentis et al., 2002), where it is believed to reflect increased oscillatory burst activity in relevant basal ganglia nuclei secondary to the loss of inhibitory nigral DA”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Eidelberg et al., 1994
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- Authors
- Eidelberg, D., Moeller, J. R., Dhawan, V., Spetsieris, P., Takikawa, S., Ishikawa, T., Chaly, T., Robeson, W., Margouleff, D., Przedborski, S., & Fahn, S.
- Affiliations
- Cornell University (US)
- New York State Psychiatric Institute (US)
- Columbia University (US)
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1994-09
- Volume
- 14
- Issue
- 5
- Pages
- 783-801
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2055710528
- Cited by
- 455
- References
- 72
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 12 · 2023: 14 · 2022: 18 · 2021: 10 · 2020: 7 · 2019: 12 · 2018: 16 · 2017: 17 · 2016: 13 · 2015: 10 · 2014: 12 · 2013: 13 · 2012: 20
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- Parkinson's disease, parkinsonism, striatonigral degeneration, brain glucose metabolism, caudate nucleus, lentiform nucleus, thalamus, Hoehn and Yahr stage, bradykinesia, rigidity, neuroimaging biomarkers
- MeSH terms
- Adult, Aged, Brain, Brain Diseases, Brain Mapping, Corpus Striatum, Female, Glucose, Humans, Male, Middle Aged, Parkinson Disease, Substantia Nigra, Tomography, Emission-Computed
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