Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior
Open accessAbstract
The potential contribution of chronic inflammation to the development of neuropsychiatric disorders such as major depression has received increasing attention. Elevated biomarkers of inflammation, including inflammatory cytokines and acute-phase proteins, have been found in depressed patients, and administration of inflammatory stimuli has been associated with the development of depressive symptoms. Data also have demonstrated that inflammatory cytokines can interact with multiple pathways known to be involved in the development of depression, including monoamine metabolism, neuroendocrine function, synaptic plasticity, and neurocircuits relevant to mood regulation. Further understanding of mechanisms by which cytokines alter behavior have revealed a host of pharmacologic targets that may be unique to the impact of inflammation on behavior and may be especially relevant to the treatment and prevention of depression in patients with evidence of increased inflammation. Such targets include the inflammatory signaling pathways cyclooxygenase, p38 mitogen-activated protein kinase, and nuclear factor-κB, as well as the metabolic enzyme, indoleamine-2,3-dioxygenase, which breaks down tryptophan into kynurenine. Other targets include the cytokines themselves in addition to chemokines, which attract inflammatory cells from the periphery to the brain. Psychosocial stress, diet, obesity, a leaky gut, and an imbalance between regulatory and pro-inflammatory T cells also contribute to inflammation and may serve as a focus for preventative strategies relevant to both the development of depression and its recurrence. Taken together, identification of mechanisms by which cytokines influence behavior may reveal a panoply of personalized treatment options that target the unique contributions of the immune system to depression.
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Exposure to traumatic and stressful events results in HPA axis reactivity, activation of the immune system, and the release of pro-inflammatory cytokines.
“Indeed, exposure to traumatic and stressful events (including exposure to fear-and anxiety-provoking stimuli) results in HPA axis reactivity, activation of the immune system, and the release of pro-inflammatory cytokines (reviewed in Haroon et al (2012)).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Haroon et al, 2012
The “Stress Increases Inflammation” section (page not provided) reports that psychosocial stress activates inflammatory pathways and can increase IL-6, a pro-inflammatory cytokine. The “Stress” section links chronic stress to impaired HPA-axis regulation, but the cited passages do not establish HPA-axis reactivity specifically following traumatic events or fear- and anxiety-provoking stimuli. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIDO metabolizes tryptophan, an amino acid precursor to serotonin, thus depleting the availability of serotonin.
“In addition, IDO metabolizes tryptophan, an amino acid precursor to serotonin, thus depleting the availability of serotonin (128).”
From Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories (2023) · cites this paper as [128]
Experimental — accuracy not yet measuredImmune signaling contributes to the regulation of the hypothalamic-pituitary-adrenal (HPA) axis and other neurobiological processes that modulate affective behavior in the face of stressor exposure.
“Immune signaling contributes to the regulation of the hypothalamic-pituitary-adrenal (HPA) axis and other neurobiological processes that modulate affective behavior in the face of stressor exposure (Haroon et al, 2012).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Haroon et al, 2012
Low-grade inflammation may also facilitate the expression of behavioral co-morbidities, such as depression, that are characterized by alterations in stress pathways and neurotransmitter systems.
“Furthermore, low-grade inflammation may also facilitate the expression of behavioral co-morbidities, such as depression, that are characterized by alterations in stress pathways and neurotransmitter systems (Haroon et al, 2012).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Haroon et al, 2012
Proinflammatory cytokines communicate with the brain and affect neurotransmission, neuroendocrine activity, and brain structure and functions, thereby inducing emotional, cognitive, and behavioral changes.
“proinflammatory cytokines, such as interleukin (IL)-1β, interleukin (IL)-1 receptor antagonist (RA), interleukin (IL)- 6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ, have been recently shown to communicate with the brain and affect neurotransmission, neuroendocrine activity, and brain structure and functions, thereby inducing emotional, cognitive, and behavioral changes (Haroon et al.,”
From The interplay between stress, inflammation, and emotional attention: relevance for depression (2019) · cites this paper as Haroon et al., 2012
Cytokines can enter the brain through leaky regions in the blood-brain barrier or activated monocytes or macrophages recruited to the brain.
“cytokines can enter the brain through leaky regions in the blood-brain barrier (e.g., circumventricular organs) or activated monocytes/macrophages recruited to the brain.”
From The interplay between stress, inflammation, and emotional attention: relevance for depression (2019) · cites this paper as Haroon et al., 2012
Afferent vagus nerve fibers can be stimulated to transduce cytokine signals from the periphery into the brain, where the cytokine signals activate cytokine-producing glia cells.
“afferent vagus nerve fibers can be stimulated to transduce cytokine signals from the periphery into the brain, where the cytokine signals activate cytokine-producing glia cells.”
From The interplay between stress, inflammation, and emotional attention: relevance for depression (2019) · cites this paper as Haroon et al., 2012
Peripherally released cytokines communicate with the brain and are capable of eliciting changes in emotional processing that mimic affective-cognitive symptoms of depression.
“Peripherally released cytokines communicate with the brain and are capable of eliciting changes in emotional processing that mimic affective-cognitive symptoms of depression.”
From The interplay between stress, inflammation, and emotional attention: relevance for depression (2019) · cites this paper as Haroon et al., 2012
Cytokine release can be stimulated through brain blood vessel cells.
“cytokine release can be stimulated through brain blood vessel cells (e.g., endothelial cells).”
From The interplay between stress, inflammation, and emotional attention: relevance for depression (2019) · cites this paper as Haroon et al., 2012
Peripheral inflammation can access the brain and influence neural processes relevant to depression, including neuroplasticity, neurotransmitter systems, and neuroendocrine function.
“Research conducted over the last several decades has elucidated the mechanisms by which peripheral inflammation can access the brain to influence neural processes relevant for depression, including neuroplasticity, neurotransmitter systems, and neuroendocrine function (see Banks and Erickson, 2010; Haroon et al., 2012 for comprehensive reviews on this topic).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Haroon et al., 2012
Cytokines can influence neurocircuitry and neurotransmitter systems to produce behavioral alterations.
“Cytokines also have the capability of influencing neurocircuitry and neurotransmitter systems to produce behavioral alterations (Miller et al., 2009, Haroon et al., 2012).”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Haroon et al., 2012
Stress is a major environmental factor that may interact with cytokines and genetic predisposition to major depression.
“One of the major environmental factors that may interact with cytokines and genetic predisposition to major depression is stress (Haroon et al., 2012).”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Haroon et al., 2012
These metabolites can interact with neurotransmitter systems in the brain, particularly glutamate, and are thought to be involved in the behavioral effects of cytokines.
“These metabolites can then interact with neurotransmitter systems in the brain, particularly glutamate (see Section 3.3), and are thought to be involved in the behavioral effects of cytokines (Dantzer et al., 2011, Haroon et al., 2012).”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Haroon et al., 2012
Inflammatory cytokines activate IDO and KYN pathways in the brain that affect glutamate neurotransmission and may contribute to glutamate dysfunction in depression.
“Inflammatory cytokines activate IDO and KYN pathways in the brain that effect glutamate neurotransmission and may contribute to glutamate dysfunction in depression (McNally et al., 2008, Dantzer et al., 2011, Haroon et al., 2012).”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Haroon et al., 2012
An increased pro-inflammatory environment in ASD seems well supported.
“Although an increased pro-inflammatory environment seems well supported (Haroon et al, 2012)”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Haroon et al, 2012
Inflammation and immune signaling dysregulation can strongly influence neuropsychiatric behavior beyond ASD, with roles in bipolar disorder and PTSD, and perhaps most emphatically in schizophrenia.
“Inflammation and immune signaling dysregulation can strongly influence neuropsychiatric behavior beyond just ASD (Haroon et al, 2012;Meyer and Feldon, 2009), with evidence pointing toward roles in bipolar disorder and PTSD (Jones and Thomsen, 2013), and perhaps most emphatically in schizophrenia (Brown et al, 2004b;Meyer and Feldon, 2009;Michel et al, 2012;Patterson, 2009).”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Haroon et al, 2012
Neuroinflammatory signaling is increased by RSD and is argued to facilitate vulnerability toward mood disorders.
“In addition to activating neuronal fear/anxiety circuitry, neuroinflammatory signaling is increased by RSD (Kinsey et al, 2007;Wohleb et al, 2012) that is argued to facilitate vulnerability toward mood disorders (Haroon et al, 2012).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Haroon et al, 2012
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Cites
1 retracted
Mitra, A., Gao, L., & Zucker, I. H. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00127.2010 · Cited by 67 · see citing works
RetractedA human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies
Luppino, F. S., de Wit, L. M., Bouvy, P. F., Stijnen, T., Cuijpers, P., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.2 · Cited by 4,322 · see citing works
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848 · see citing works
Self-citationA Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
Anterior Cingulate Cortex, Error Detection, and the Online Monitoring of Performance
Carter, C. S., Braver, T. S., Barch, D. M., Botvinick, M. M., Noll, D., & Cohen, J. D. (1998) · Science · doi:10.1126/science.280.5364.747 · Cited by 3,273 · see citing works
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
Rhen, T., & Cidlowski, J. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050541 · Cited by 3,149 · see citing works
Clinical application of C-reactive protein for cardiovascular disease detection and prevention
Ridker, P. M. (2003) · Circulation · doi:10.1161/01.cir.0000053730.47739.3c · Cited by 2,513 · see citing works
Causal Relationship Between Stressful Life Events and the Onset of Major Depression
Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.837 · Cited by 2,486 · cited 2× · see citing works
“Stress Increases Inflammation Psychosocial stressors are well-established precipitants of episodes of major depression (Kendler et al, 1999).”
BackgroundFOXP3+ regulatory T cells in the human immune system
Sakaguchi, S., Miyara, M., Costantino, C. M., & Hafler, D. A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2785 · Cited by 2,443 · see citing works
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
Kalliomäki, M. A., Salminen, S., Arvilommi, H. S., Kero, P. O., Koskinen, P. J., & Isolauri, E. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04259-8 · Cited by 2,434 · see citing works
Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183 · see citing works
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144 · see citing works
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035 · see citing works
The HPA axis in major depression: classical theories and new developments
Pariante, C. M., & Lightman, S. L. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.006 · Cited by 2,009 · see citing works
Phenotypic and functional features of human Th17 cells
Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861 · see citing works
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · see citing works
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806 · see citing works
Astrocytes, from brain glue to communication elements: the revolution continues
Volterra, A., & Meldolesi, J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1722 · Cited by 1,763 · see citing works
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686 · see citing works
Immune-neuro-endocrine interactions: facts and hypotheses.
BESEDOVSKY, H. O., & REY, A. D. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-1-64 · Cited by 1,564 · see citing works
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525 · see citing works
Zhou, X., Bailey-Bucktrout, S. L., Jeker, L. T., Peñaranda, C., Martínez‐Llordella, M., Ashby, M., Nakayama, M., Rosenthal, W. L., & Bluestone, J. A. (2009) · Nature Immunology · doi:10.1038/ni.1774 · Cited by 1,374 · see citing works
Adverse childhood experiences and the risk of premature mortality
Brown, D. W., Anda, R. F., Tiemeier, H., Felitti, V. J., Edwards, V. J., Croft, J. B., & Giles, W. H. (2009) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2009.06.021 · Cited by 1,369 · see citing works
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365 · see citing works
Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer
Dhillon, N., Aggarwal, B. B., Newman, R. A., Wolff, R. A., Kunnumakkara, A. B., Abbruzzese, J. L., Ng, C. S., Badmaev, V., & Kurzrock, R. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0024 · Cited by 1,337 · see citing works
Astrocyte Control of Synaptic Transmission and Neurovascular Coupling
Haydon, P. G., & Carmignoto, G. (2006) · Physiological Reviews · doi:10.1152/physrev.00049.2005 · Cited by 1,326 · see citing works
O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278 · see citing works
David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267 · see citing works
Childhood maltreatment predicts adult inflammation in a life-course study
Danese, A., Pariante, C. M., Caspi, A., Taylor, A., & Poulton, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610362104 · Cited by 1,264 · cited 1× · see citing works
“Finally, epidemiologic data have indicated that increased inflammation in major depression may be especially associated with patients who have experienced childhood maltreatment (Danese et al, 2007).”
BackgroundWhy rejection hurts: a common neural alarm system for physical and social pain
Eisenberger, N. I., & Lieberman, M. D. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.05.010 · Cited by 1,246 · see citing works
Ziv, Y., Ron, N., Butovsky, O., Landa, G., Sudai, E., Greenberg, N., Cohen, H., Kipnis, J., & Schwartz, M. (2006) · Nature Neuroscience · doi:10.1038/nn1629 · Cited by 1,209 · see citing works
p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases
Kumar, S., Boehm, J. C., & Lee, J. C. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1177 · Cited by 1,199 · see citing works
Tracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154 · cited 21× · see citing works
“For example, treatment of mouse midbrain and striatal synaptosomes with IL-1b and TNF-a was shown to lead to a dose- and time-dependent increase in serotonin reuptake, which was reversed by the p38 antagonist, SB203580 (Zhu et al, 2006).”
BackgroundInfluentialGlucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147 · see citing works
Self-citationBailey, M. T., Dowd, S. E., Galley, J. D., Hufnagle, A. R., Allen, R. G., & Lyte, M. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.023 · Cited by 1,123 · see citing works
Paroxetine for the prevention of depression induced by high-dose interferon alfa.
Musselman, D. L., Lawson, D. H., Gumnick, J. F., Manatunga, A. K., Penna, S., Goodkin, R. S., Greiner, K., Nemeroff, C. B., & Miller, A. H. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103293441303 · Cited by 1,120 · see citing works
Self-citationHas the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?
Lee, Y. K., & Mazmanian, S. K. (2010) · Science · doi:10.1126/science.1195568 · Cited by 1,115 · see citing works
Tesmer, L. A., Lundy, S. K., Sarkar, S., & Fox, D. A. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00628.x · Cited by 1,097 · see citing works
Diurnal Cortisol Rhythm as a Predictor of Breast Cancer Survival
Sephton, S. E. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.12.994 · Cited by 1,082 · see citing works
Tyring, S., Gottlieb, A., Papp, K., Gordon, K., Leonardi, C., Wang, A., Lalla, D., Woolley, M., Jahreis, A., Zitnik, R., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(05)67763-x · Cited by 1,069 · cited 3× · see citing works
“Moreover, biologic therapies such as the TNF-a antagonist, etanercept, which is not believed to appreciably enter the brain, was shown to be effective in reducing depressive symptoms in patients with the peripheral immune disorder, psoriasis (see below) (Tyring et al, 2006).”
BackgroundMethodSubcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression
Lozano, A. M., Mayberg, H. S., Giacobbe, P., Hamani, C., Craddock, R. C., & Kennedy, S. H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.034 · Cited by 1,024 · see citing works
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999 · see citing works
The Relationship of Depression and Stressors to Immunological Assays: A Meta-Analytic Review
Zorrilla, E. P., Luborsky, L., McKay, J. R., Rosenthal, R., Houldin, A., Tax, A., McCorkle, R., Seligman, D. A., & Schmidt, K. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0597 · Cited by 995 · see citing works
Bezzi, P., Domercq, M., Brambilla, L., Galli, R., Schols, D., De Clercq, E., Vescovi, A., Bagetta, G., Kollias, G., Meldolesi, J., et al. (2001) · Nature Neuroscience · doi:10.1038/89490 · Cited by 964 · see citing works
Tikka, T., Fiebich, B. L., Goldsteins, G., Keinänen, R., & Koistinaho, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02580.2001 · Cited by 958 · see citing works
A mechanism converting psychosocial stress into mononuclear cell activation
Bierhaus, A., Wolf, J., Andrassy, M., Rohleder, N., Humpert, P. M., Petrov, D., Ferstl, R., von Eynatten, M., Wendt, T., Rudofsky, G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438019100 · Cited by 926 · see citing works
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works
Autonomic innervation and regulation of the immune system (1987–2007)
Nance, D. M., & Sanders, V. M. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.008 · Cited by 855 · see citing works
Pace, T. W. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., & Heim, C. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1630 · Cited by 810 · see citing works
Self-citationRegulation of learning and memory by meningeal immunity: a key role for IL-4
Derecki, N. C., Cardani, A. N., Yang, C. H., Quinnies, K. M., Crihfield, A., Lynch, K. R., & Kipnis, J. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091419 · Cited by 800 · see citing works
Müller, N., Schwarz, M. J., Dehning, S., Douhe, A., Cerovecki, A., Goldstein-Müller, B., Spellmann, I., Hetzel, G., Maino, K., Kleindienst, N., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001805 · Cited by 794 · see citing works
Steiner, J., Bielau, H., Brisch, R., Danos, P., Ullrich, O., Mawrin, C., Bernstein, H.-G., & Bogerts, B. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.10.013 · Cited by 791 · see citing works
Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus
Breder, C. D., Dinarello, C. A., & Saper, C. B. (1988) · Science · doi:10.1126/science.3258444 · Cited by 759 · see citing works
Harrison, N. A., Brydon, L., Walker, C., Gray, M. A., Steptoe, A., & Critchley, H. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.015 · Cited by 756 · see citing works
Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation
Grilli, M., Pizzi, M., Memo, M., & Spano, P. (1996) · Science · doi:10.1126/science.274.5291.1383 · Cited by 751 · see citing works
Pace, T. W. W., Negi, L. T., Adame, D. D., Cole, S. P., Sivilli, T. I., Brown, T. D., Issa, M. J., & Raison, C. L. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.011 · Cited by 748 · see citing works
Self-citationSocial regulation of gene expression in human leukocytes
Cole, S. W., Hawkley, L. C., Arevalo, J. M., Sung, C. Y., Rose, R. M., & Cacioppo, J. T. (2007) · Genome Biology · doi:10.1186/gb-2007-8-9-r189 · Cited by 745 · cited 1× · see citing works
“Of note, similar microarray data have been found in lonely vs non-lonely individuals, consistent with the notion that increased inflammation may be a mediator of the negative impact of social isolation on both mental and physical health (Cole et al, 2007).”
BackgroundCytokine Production and Treatment Response in Major Depressive Disorder
Lanquillon, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00134-7 · Cited by 735 · see citing works
Gao, H., Jiang, J., Wilson, B. C., Zhang, W., Hong, J., & Liu, B. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00928.x · Cited by 690 · see citing works
Ericsson, A. B., Kovacs, K., & Sawchenko, P. E. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-02-00897.1994 · Cited by 684 · see citing works
Central and autonomic nervous system interaction is altered by short-term meditation
Tang, Y.-Y., Ma, Y., Fan, Y., Feng, H., Wang, J., Feng, S., Lu, Q., Hu, B., Lin, Y., Li, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904031106 · Cited by 680 · see citing works
Henry, C. J., Huang, Y., Wynne, A., Hanke, M., Himler, J., Bailey, M. T., Sheridan, J. F., & Godbout, J. P. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-15 · Cited by 678 · see citing works
Depressive disorders and immunity: 20 years of progress and discovery
Irwin, M. R., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.01.010 · Cited by 676 · see citing works
Self-citationD'Mello, C., Le, T., & Swain, M. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3567-08.2009 · Cited by 675 · see citing works
Chiesa, A., & Serretti, A. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2010.08.011 · Cited by 650 · see citing works
Elevated inflammation levels in depressed adults with a history of childhood maltreatment
Danese, A., Moffitt, T. E., Pariante, C. M., Ambler, A., Poulton, R., & Caspi, A. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.4.409 · Cited by 641 · cited 1× · see citing works
“…with a current major depression and a documented history of childhood maltreatment were over two times more likely to show high peripheral blood concentrations of high-sensitivity (hs) CRP (43 mg/l) compared with depressed individuals without a history of childhood abuse (Danese et al, 2008).”
BackgroundRaison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.116 · Cited by 630 · see citing works
Self-citationBrain-immune communication pathways
Quan, N., & Banks, W. A. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.05.005 · Cited by 626 · see citing works
Pace, T. W. W., Hu, F., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.08.009 · Cited by 621 · see citing works
Self-citationGliogenesis and Glial Pathology in Depression
Rajkowska, G., & Miguel-Hidalgo, J. J. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780619326 · Cited by 612 · see citing works
Increased Levels of Glutamate in Brains from Patients with Mood Disorders
Hashimoto, K., Sawa, A., & Iyo, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.017 · Cited by 609 · see citing works
Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior
Koo, J. W., Russo, S. J., Ferguson, D., Nestler, E. J., & Duman, R. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910658107 · Cited by 607 · see citing works
Maes, M. H. J., Kubera, M., & Leunis, J. (2008) · PubMed · Cited by 607 · see citing works
Inflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward
Eisenberger, N. I., Berkman, E. T., Inagaki, T. K., Rameson, L. T., Mashal, N. M., & Irwin, M. R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.010 · Cited by 596 · see citing works
Association of the Mediterranean Dietary Pattern With the Incidence of Depression
Sánchez‐Villegas, A., Delgado‐Rodríguez, M., Alonso, Á., Schlatter, J., Lahortiga‐Ramos, F., Serra‐Majem, L., & Martínez‐González, M. Á. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.129 · Cited by 581 · see citing works
Frank, M. G., Baratta, M. V., Sprunger, D. B., Watkins, L. R., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.03.005 · Cited by 578 · see citing works
Gimeno, D., Kivimäki, M., Brunner, E. J., Elovainio, M., De Vogli, R., Steptoe, A., Kumari, M., Lowe, G. D. O., Rumley, A., Marmot, M. G., et al. (2009) · Psychological Medicine · doi:10.1017/s0033291708003723 · Cited by 561 · see citing works
Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities
Schwarcz, R. M., & Pellicciari, R. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034439 · Cited by 556 · see citing works
Miller, G. E., Chen, E., Sze, J., Marin, T., Arevalo, J. M. G., Doll, R., Ma, R., & Cole, S. W. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.017 · Cited by 552 · see citing works
Zhu, C.-B., Blakely, R. D., & Hewlett, W. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301029 · Cited by 549 · see citing works
Fatigue and Proinflammatory Cytokine Activity in Breast Cancer Survivors
Bower, J. E., Ganz, P. A., Aziz, N., & Fahey, J. L. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200207000-00010 · Cited by 538 · see citing works
A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression
Lin, P.-Y., Huang, S.-Y., & Su, K.-P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.018 · Cited by 530 · see citing works
Tikka, T., & Koıstınaho, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7527 · Cited by 530 · see citing works
Regulation of Endothelial Nitric Oxide Synthase by Tetrahydrobiopterin in Vascular Disease
Alp, N. J., & Channon, K. M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000110785.96039.f6 · Cited by 524 · see citing works
Zuany‐Amorim, C., Sawicka, E., Manlius, C., Moine, A. L., Brunet, L. R., Kemeny, D. M., Bowen, G., Rook, G. A. W., & Walker, C. (2002) · Nature Medicine · doi:10.1038/nm0602-625 · Cited by 514 · see citing works
Kipnis, J., Cohen, H., Cardon, M., Ziv, Y., & Schwartz, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402268101 · Cited by 510 · see citing works
Guillemin, G. J., Smythe, G., Takikawa, O., & Brew, B. J. (2005) · Glia · doi:10.1002/glia.20090 · Cited by 497 · see citing works
Interferon-alpha–induced changes in tryptophan metabolism
Capuron, L., Neurauter, G., Musselman, D. L., Lawson, D. H., Nemeroff, C. B., Fuchs, D., & Miller, A. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00173-2 · Cited by 493 · see citing works
Self-citationNeuropsychiatric Adverse Effects of Interferon-??: Recognition and Management
Raison, C. L., Demetrashvili, M., Capuron, L., & Miller, A. H. (2005) · CNS Drugs · doi:10.2165/00023210-200519020-00002 · Cited by 483 · see citing works
Self-citationLin, P.-Y., & Su, K.-P. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0712 · Cited by 481 · see citing works
Brown, R. P., & Gerbarg, P. L. (2005) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2005.11.711 · Cited by 471 · see citing works
Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults
Carpenter, L. L., Gawuga, C. E., Tyrka, A. R., Lee, J. K., Anderson, G. M., & Price, L. H. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.159 · Cited by 464 · see citing works
Meyers, C. A., Albitar, M. X., & Estey, E. H. (2005) · Cancer · doi:10.1002/cncr.21234 · Cited by 459 · see citing works
The metabolic topography of parkinsonism
Eidelberg, D., Moeller, J. R., Dhawan, V., Spetsieris, P., Takikawa, S., Ishikawa, T., Chaly, T., Robeson, W., Margouleff, D., Przedborski, S., et al. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.99 · Cited by 455 · see citing works
Kalliomäki, M. A., Salminen, S., Poussa, T. A., & Isolauri, E. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.608 · Cited by 453 · see citing works
Bonaccorso, S., Marino, V., Puzella, A., Pasquini, M., Biondi, M., Artini, M., Almerighi, C., Verkerk, R., Meltzer, H., & Maes, M. (2002) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200202000-00014 · Cited by 437 · see citing works
Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines
Johnson, J. D., Campisi, J., Sharkey, C. M., Kennedy, S. L., Nickerson, M., Greenwood, B. N., & Fleshner, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.090 · Cited by 424 · see citing works
Damsker, J. M., Hansen, A. M., & Caspi, R. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05133.x · Cited by 424 · see citing works
Mechanisms of glucocorticoid receptor signaling during inflammation
Smoak, K. A., & Cidlowski, J. A. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.06.010 · Cited by 420 · see citing works
Neural sensitivity to social rejection is associated with inflammatory responses to social stress
Slavich, G. M., Way, B. M., Eisenberger, N. I., & Taylor, S. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009164107 · Cited by 418 · see citing works
Indoleamine 2,3‐dioxygenase in T‐cell tolerance and tumoral immune escape
Katz, J. B., Muller, A. J., & Prendergast, G. C. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00610.x · Cited by 399 · see citing works
The methylation, neurotransmitter, and antioxidant connections between folate and depression.
Miller, A. L. (2008) · PubMed · Cited by 393 · see citing works
Self-citationEnhancement of recovery from psychiatric illness by methylfolate
Godfrey, P. S. A., Toone, B. K., Bottiglien, T., Laundy, M., Reynolds, E. H., Carney, M. W. P., Flynn, T. G., & Chanarin, I. (1990) · The Lancet · doi:10.1016/0140-6736(90)91942-4 · Cited by 389 · see citing works
Brydon, L., Harrison, N. A., Walker, C., Steptoe, A., & Critchley, H. D. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.12.007 · Cited by 381 · cited 20× · see citing works
“In conjunction with IL-6 and IL-23, IL-1b is the most effective inducer of IL-17 expression in naive T cells in humans (Boissier et al, 2008).”
BackgroundInfluentialNeuroinflammation and regulation of glial glutamate uptake in neurological disorders
Tilleux, S., & Hermans, E. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21325 · Cited by 381 · see citing works
Eickelberg, O., Roth, M., Lörx, R., Bruce, V., Rüdiger, J., Johnson, M., & Block, L.-H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.1005 · Cited by 378 · see citing works
Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes
Hamidi, M., Drevets, W. C., & Price, J. L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.006 · Cited by 369 · see citing works
Capuron, L., Schroecksnadel, S., Féart, C., Aubert, A., Higueret, D., Barberger-Gateau, P., Layé, S., & Fuchs, D. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.006 · Cited by 368 · see citing works
Raison, C. L., Borisov, A. S., Majer, M., Drake, D. F., Pagnoni, G., Woolwine, B. J., Vogt, G. J., Massung, B., & Miller, A. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.010 · Cited by 367 · see citing works
Self-citationAntoniades, C., Shirodaria, C., Warrick, N., Cai, S., de Bono, J., Lee, J., Leeson, P., Neubauer, S., Ratnatunga, C., Pillai, R., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.612325 · Cited by 365 · see citing works
Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression?
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.8.1189 · Cited by 364 · see citing works
Mead, G. E., Morley, W., Campbell, P., Greig, C. A., McMurdo, M., & Lawlor, D. A. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004366.pub4 · Cited by 364 · see citing works
Gilbody, S. M., Lewis, S. J., & Lightfoot, T. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj347 · Cited by 357 · see citing works
Neural Origins of Human Sickness in Interoceptive Responses to Inflammation
Harrison, N. A., Brydon, L., Walker, C., Gray, M. A., Steptoe, A., Dolan, R. J., & Critchley, H. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.007 · Cited by 345 · see citing works
Ursu, S., Stenger, V. A., Shear, M. K., Jones, M. R., & Carter, C. S. (2003) · Psychological Science · doi:10.1111/1467-9280.24411 · Cited by 341 · see citing works
Immune suppression and immune activation in depression
Blume, J., Douglas, S. D., & Evans, D. L. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.008 · Cited by 338 · see citing works
Coppen, A., & Bailey, J. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00153-1 · Cited by 337 · see citing works
Anisman, H., Merali, Z., & Hayley, S. P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.01.004 · Cited by 334 · see citing works
Indoleamine 2,3 dioxygenase and quinolinic acid Immunoreactivity in Alzheimer's disease hippocampus
Guillemin, G., Brew, B., Noonan, C. E., Takikawa, O., & Cullen, K. (2005) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2005.00655.x · Cited by 331 · see citing works
Glutamate‐mediated glial injury: Mechanisms and clinical importance
Matute, C., Domercq, M., & Sánchez‐Gómez, M. V. (2005) · Glia · doi:10.1002/glia.20275 · Cited by 330 · see citing works
Wolf, S. A., Steiner, B., Akpinarli, A., Kammertoens, T., Nassenstein, C., Braun, A., Blankenstein, T., & Kempermann, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801218 · Cited by 329 · see citing works
Bidirectional transport of interleukin-1 alpha across the blood-brain barrier
Banks, W. A., Kastin, A. J., & Durham, D. A. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90185-8 · Cited by 325 · see citing works
Plasticity of CD4+ FoxP3+ T cells
Zhou, X., Bailey-Bucktrout, S. L., Jeker, L. T., & Bluestone, J. A. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.007 · Cited by 317 · see citing works
Zhu, C.-B., Lindler, K. M., Owens, A. W., Daws, L. C., Blakely, R. D., & Hewlett, W. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.116 · Cited by 317 · see citing works
Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy
Sutcigil, L., Oktenli, C., Musabak, U., Bozkurt, A., Cansever, A., Uzun, O., Sanisoglu, S. Y., Yesilova, Z., Ozmenler, N., Ozsahin, A., et al. (2007) · Clinical and Developmental Immunology · doi:10.1155/2007/76396 · Cited by 315 · see citing works
Mechanism of inhibition of Raf-1 by protein kinase A
Häfner, S., Adler, H. S., Mischak, H., Janosch, P., Heidecker, G., Wolfman, A., Pippig, S., Lohse, M., Ueffing, M., & Kolch, W. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.6696 · Cited by 312 · see citing works
Stress, Food, and Inflammation: Psychoneuroimmunology and Nutrition at the Cutting Edge
Kiecolt-Glaser, J. K. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181dbf489 · Cited by 310 · cited 3× · see citing works
“…has been a dramatic shift toward a greater representation of n-6 (or omega 6) polyunsaturated fatty acids (PUFAs) in relation to n-3 fatty acids (Kiecolt-Glaser, 2010). n-3 fatty acids are found in large quantities in fish and fish oil extracts, and there is evidence that increased consumption…”
BackgroundInfluentialCapuron, L., Raison, C. L., Musselman, D. L., Lawson, D. H., Nemeroff, C. B., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.7.1342 · Cited by 308 · see citing works
Self-citationProinflammatory cytokines oppose opioid-induced acute and chronic analgesia
Hutchinson, M. R., Coats, B. D., Lewis, S. S., Zhang, Y., Sprunger, D. B., Rezvani, N., Baker, E. M., Jekich, B. M., Wieseler, J. L., Somogyi, A. A., et al. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.05.004 · Cited by 307 · see citing works
O'Connor, J., Lawson, M., André, C., Briley, E. M., Szegedi, S., Lestage, J., Castanon, N., Herkenham, M., Dantzer, R., & Kelley, K. (2009) · Journal of Immunology · doi:10.4049/jimmunol.0802722 · Cited by 305 · see citing works
Depression During Pegylated Interferon-Alpha Plus Ribavirin Therapy
Raison, C. L., Borisov, A. S., Broadwell, S. D., Capuron, L., Woolwine, B. J., Jacobson, I. M., Nemeroff, C. B., & Miller, A. H. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0106 · Cited by 298 · see citing works
Self-citationPapakostas, G. I., Mischoulon, D., Shyu, I., Alpert, J. E., & Fava, M. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09081198 · Cited by 297 · see citing works
Wong, M.-L., Dong, C., Maestre-Mesa, J., & Licinio, J. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.59 · Cited by 295 · see citing works
(1994) · PubMed · Cited by 294 · see citing works
Folate, vitamin B12, and homocysteine in major depressive disorder
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.3.426 · Cited by 287 · see citing works
Inflammatory Markers and Sleep Disturbance in Major Depression
Motivala, S. J., Sarfatti, A., Olmos, L., & Irwin, M. R. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000149259.72488.09 · Cited by 286 · see citing works
Neurocircuitry of illness-induced hyperalgesia
Watkins, L. R., Wiertelak, E. P., Goehler, L. E., Mooney-Heiberger, K., Martinez, J., Furness, L. E., Smith, K. P., & Maier, S. F. (1994) · Brain Research · doi:10.1016/0006-8993(94)91742-6 · Cited by 284 · see citing works
Maes, M., Lambrechts, J., Bosmans, E., Jacobs, J., Suy, E., Vandervorst, C., De Jonckheere, C., Minner, B., & Raus, J. (1992) · Psychological Medicine · doi:10.1017/s0033291700032712 · Cited by 275 · see citing works
Chronic Immune Stimulation Correlates with Reduced Phenylalanine Turnover
Neurauter, G., Schrocksnadel, K., Scholl-Burgi, S., Sperner-Unterweger, B., Schubert, C., Ledochowski, M., & Fuchs, D. (2008) · Current Drug Metabolism · doi:10.2174/138920008785821738 · Cited by 274 · see citing works
Quinolinic acid is a potent lipid peroxidant in rat brain homogenates
Rı́os, C., & Santamarı́a, A. (1991) · Neurochemical Research · doi:10.1007/bf00966592 · Cited by 272 · see citing works
Maes, M., Bosmans, E., Suy, E., Vandervorst, C., DeJonckheere, C., & Raus, J. (1991) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1991.tb03163.x · Cited by 268 · see citing works
Lavretsky, H., Alstein, L. L., Olmstead, R. E., Ercoli, L. M., Riparetti-Brown, M., St. Cyr, N., & Irwin, M. R. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31820ee9ef · Cited by 268 · see citing works
Morón, J. A., Zakharova, I., Ferrer, J. V., Merrill, G. A., Hope, B., Lafer, E. M., Lin, Z. C., Wang, J. B., Javitch, J. A., Galli, A., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08480.2003 · Cited by 262 · see citing works
Miller, A. H. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.08.006 · Cited by 261 · see citing works
Self-citationShelton, R. C., & Miller, A. H. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.004 · Cited by 257 · see citing works
Self-citationAssociation between adherence to the Mediterranean diet and oxidative stress
Dai, J., Jones, D. P., Goldberg, J., Ziegler, T. R., Bostick, R. M., Wilson, P. W., Manatunga, A. K., Shallenberger, L., Jones, L., & Vaccarino, V. (2008) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26528 · Cited by 256 · see citing works
Angiotensin II AT1 Receptor Blockade Ameliorates Brain Inflammation
Benicky, J., Sánchez-Lemus, E., Honda, M., Pang, T., Orecna, M., Wang, J., Leng, Y., Chuang, D.-M., & Saavedra, J. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.225 · Cited by 254 · see citing works
Barrientos, R. M., Sprunger, D. B., Campeau, S., Higgins, E. A., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00564-5 · Cited by 251 · see citing works
Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity
Gilbody, S. M., Lightfoot, T., & Sheldon, T. (2007) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2006.050385 · Cited by 251 · see citing works
TNFα Signaling in Depression and Anxiety: Behavioral Consequences of Individual Receptor Targeting
Simen, B. B., Duman, C. H., Simen, A. A., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.013 · Cited by 249 · see citing works
Molecular mechanisms of microglial activation
Zielasek, J., & Hartung, H. (1996) · Advances in Neuroimmunology · doi:10.1016/0960-5428(96)00017-4 · Cited by 244 · see citing works
CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson’s disease
Pabon, M. M., Bachstetter, A. D., Hudson, C. E., Gemma, C., & Bickford, P. C. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-9 · Cited by 241 · see citing works
Coppen, A. J., & Bailey, J. (2000) · PsycEXTRA Dataset · doi:10.1037/e323122004-002 · Cited by 236 · see citing works
Potter, M., Elmer, G., Bergeron, R., Albuquerque, E. X., Guidetti, P., Wu, H., & Schwarcz, R. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.39 · Cited by 235 · see citing works
Mendlewicz, J., Kriwin, P., Oswald, P., Souery, D., Alboni, S., & Brunello, N. (2006) · International Clinical Psychopharmacology · doi:10.1097/00004850-200607000-00005 · Cited by 229 · see citing works
Basal Ganglia Hypermetabolism and Symptoms of Fatigue during Interferon-α Therapy
Capuron, L., Pagnoni, G., Demetrashvili, M. F., Lawson, D. H., Fornwalt, F. B., Woolwine, B., Berns, G. S., Nemeroff, C. B., & Miller, A. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301362 · Cited by 229 · see citing works
Self-citationMinocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations
Alano, C. C., Kauppinen, T. M., Valls, A. V., & Swanson, R. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600554103 · Cited by 229 · see citing works
Intentional Weight Loss and Changes in Symptoms of Depression: A Systematic Review and Meta-Analysis
Fabricatore, A., Wadden, T., Higginbotham, A., Faulconbridge, L. F., Nguyen, A., Heymsfield, S., & Faith, M. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.2 · Cited by 228 · see citing works
Zhu, C.-B., Carneiro, A. M., Dostmann, W. R., Hewlett, W. A., & Blakely, R. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410858200 · Cited by 228 · see citing works
Bull, S. J., Huezo-Diaz, P., Binder, E. B., Cubells, J. F., Ranjith, G., Maddock, C., Miyazaki, C., Alexander, N., Hotopf, M., Cleare, A. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.48 · Cited by 228 · see citing works
Self-citationDhabhar, F. S., Burke, H. M., Epel, E. S., Mellon, S. H., Rosser, R., Reus, V. I., & Wolkowitz, O. M. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.05.010 · Cited by 225 · see citing works
Bondolfi, G., Jermann, F., der Linden, M. V., Gex-Fabry, M., Bizzini, L., Rouget, B. W., Myers-Arrazola, L., Gonzalez, C., Segal, Z., Aubry, J.-M., et al. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.07.007 · Cited by 223 · see citing works
Glutamate uptake by oligodendrocytes
Pitt, D., NAGELMEIER, I.-E., Wilson, H. C., & Raine, C. S. (2003) · Neurology · doi:10.1212/01.wnl.0000090564.88719.37 · Cited by 222 · see citing works
Fujigaki, H., Saito, K., Fujigaki, S., Takemura, M., Sudo, K., Ishiguro, H., & Seishima, M. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj072 · Cited by 222 · see citing works
Anterior Cingulate Activation and Error Processing During Interferon-Alpha Treatment
Capuron, L., Pagnoni, G., Demetrashvili, M., Woolwine, B. J., Nemeroff, C. B., Berns, G. S., & Miller, A. H. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.033 · Cited by 222 · see citing works
Self-citationAdaptive immunity affects learning behavior in mice
Brynskikh, A., Warren, T., Zhu, J., & Kipnis, J. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.12.008 · Cited by 221 · see citing works
Felger, J. C., Alagbe, O., Hu, F., Mook, D., Freeman, A. A., Sanchez, M. M., Kalin, N. H., Ratti, E., Nemeroff, C. B., & Miller, A. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.026 · Cited by 214 · see citing works
Self-citationFábry, Z., Fitzsimmons, K. M., Herlein, J. A., Moninger, T. O., Dobbs, M. B., & HART, M. N. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90281-3 · Cited by 207 · see citing works
Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase
Saxena, M., Williams, S., Taskén, K., & Mustelin, T. (1999) · Nature Cell Biology · doi:10.1038/13024 · Cited by 203 · see citing works
Cao, C., Matsumura, K., Yamagata, K., & Watanabe, Y. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.6.r1712 · Cited by 203 · see citing works
Depressive Symptoms and Change in Abdominal Obesity in Older Persons
Vogelzangs, N., Kritchevsky, S. B., Beekman, A. T. F., Newman, A. B., Satterfield, S., Simonsick, E. M., Yaffe, K., Harris, T. B., & Penninx, B. W. J. H. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.12.1386 · Cited by 200 · see citing works
Corona, A. W., Huang, Y., O’Connor, J. C., Dantzer, R., Kelley, K. W., Popovich, P. G., & Godbout, J. P. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-93 · Cited by 200 · see citing works
Emergence of Adverse Events Following Discontinuation of Treatment With Extended-Release Venlafaxine
D, M. F. M., Mulroy, R., Alpert, J. E., Nierenberg, A. A., & Rosenbaum, J. F. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.12.1760 · Cited by 198 · see citing works
Baune, B. T., Dannlowski, U., Domschke, K., Janssen, D. G. A., Jordan, M. A., Ohrmann, P., Bauer, J., Biroš, E., Arolt, V., Kugel, H., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.004 · Cited by 193 · see citing works
EISENBERGER, N. I., LIEBERMAN, M. D., & SATPUTE, A. B. (2005) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.5.2.169 · Cited by 184 · see citing works
Raison, C. L., Borisov, A. S., Woolwine, B. J., Massung, B., Vogt, G., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.58 · Cited by 183 · see citing works
Self-citationHutchinson, M. R., Northcutt, A. L., Chao, L. W., Kearney, J. J., Zhang, Y., Berkelhammer, D. L., Loram, L. C., Rozeske, R. R., Bland, S. T., Maier, S. F., et al. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.07.008 · Cited by 180 · see citing works
Exercise training and depression in older adults
Barbour, K. A., & Blumenthal, J. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.007 · Cited by 180 · see citing works
Resveratrol differentially modulates inflammatory responses of microglia and astrocytes
Lu, X., Ma, L., Ruan, L., Kong, Y., Mou, H., Zhang, Z., Wang, Z., Wang, J., & Le, Y. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-46 · Cited by 180 · see citing works
Monk, J. P., Phillips, G., Waite, R., Kuhn, J., Schaaf, L. J., Otterson, G. A., Guttridge, D., Rhoades, C., Shah, M., Criswell, T., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.2838 · Cited by 179 · see citing works
Social stress increases the susceptibility to endotoxic shock
Quan, N., Avitsur, R., Stark, J. L., He, L., Shah, M., Caligiuri, M., Padgett, D. A., Marucha, P. T., & Sheridan, J. F. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00273-9 · Cited by 177 · see citing works
Exercise, Inflammation, and Innate Immunity
Woods, J. A., Vieira‐Potter, V. J., & Keylock, K. T. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.011 · Cited by 176 · see citing works
Glucocorticoid receptor (GR) β has intrinsic, GRα-independent transcriptional activity
Kino, T., Manoli, I., Kelkar, S., Wang, Y., Su, Y. A., & Chrousos, G. P. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.110 · Cited by 175 · see citing works
Metabolic correlates of levodopa response in Parkinson’s disease
Feigin, A., Fukuda, M., DHAWAN, V. M., Przedborski, S., Jackson-Lewis, V. R., Mentis, M. J., Moeller, J. R., & Eidelberg, D. (2001) · Neurology · doi:10.1212/wnl.57.11.2083 · Cited by 174 · see citing works
Cohen, H., Ziv, Y., Cardon, M., Kaplan, Z., Matar, M. A., Gidron, Y., Schwartz, M., & Kipnis, J. (2006) · Journal of Neurobiology · doi:10.1002/neu.20249 · Cited by 173 · see citing works
Inhibition of the NF‐κB transcriptional activity by protein kinase A
Takahashi, N., Tetsuka, T., Uranishi, H., et al. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03157.x · Cited by 171 · see citing works
Raison, C. L., Lowry, C. A., & Rook, G. A. W. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.161 · Cited by 169 · see citing works
Self-citationMelck, D., Rueda, D., Galve-Roperh, I., De Petrocellis, L., Guzmán, M., & Di Marzo, V. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01639-7 · Cited by 168 · see citing works
Su, K., Huang, S., Peng, C., Lai, H., Huang, C., Chen, Y.-C., Aitchison, K. J., & Pariante, C. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.005 · Cited by 165 · see citing works
Capuron, L., Fornwalt, F. B., Knight, B. T., Harvey, P. D., Ninan, P. T., & Miller, A. H. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.02.017 · Cited by 164 · see citing works
Self-citationLi, Y., Xiao, B., Qiu, W., Yang, L., Hu, B., Tian, X., & Yang, H. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.10.018 · Cited by 163 · see citing works
Rational Design of Indoleamine 2,3-Dioxygenase Inhibitors
Röhrig, U. F., Awad, L., Grosdidier, A., Larrieu, P., Stroobant, V., Colau, D., Cerundolo, V., Simpson, A. J. G., Vogel, P., den Eynde, B. J. V., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm9014718 · Cited by 162 · see citing works
Shifting the imbalance from Th1/Th2 to Th17/treg: The changing rheumatoid arthritis paradigm
Boissier, M., Assier, É., Falgarone, G., & Bessis, N. (2008) · Joint Bone Spine · doi:10.1016/j.jbspin.2008.04.005 · Cited by 154 · see citing works
Kynurenic acid leads, dopamine follows: A new case of volume transmission in the brain?
Wu, H., Rassoulpour, A., & Schwarcz, R. M. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0562-y · Cited by 151 · see citing works
Yu, Y. W. ‐., Chen, T., Hong, C., Chen, H.-M., & Tsai, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300172 · Cited by 150 · see citing works
Prefrontal cortical hypometabolism during low-dose interferon alpha treatment
Juengling, F. D., Ebert, D., Gut, O., Engelbrecht, M. A., Rasenack, J., Nitzsche, E. U., Bauer, J., & Lieb, K. (2000) · Psychopharmacology · doi:10.1007/s002130000549 · Cited by 149 · see citing works
Quinolinic Acid Production by Macrophages Stimulated with IFN-γ, TNF-α, and IFN-α
PEMBERTON, L. A., KERR, S. J., SMYTHE, G., & BREW, B. J. (1997) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1997.17.589 · Cited by 149 · see citing works
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Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206 · see citing works
“that target cytokine activity in order to alleviate, and perhaps even prevent, depression (Capuron & Miller, 2011; Haroon et al., 2012; Hayley, 2011; Li et al., 2011; A. H. Miller et al., 2009; Rook et al., 2012).”
BackgroundCancer-related fatigue—mechanisms, risk factors, and treatments
Bower, J. E. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.127 · Cited by 1,666 · see citing works
Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., Haroon, E., & Miller, A. H. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.4 · Cited by 1,617 · see citing works
Self-citationInflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · see citing works
Miller, A. H., Haroon, E., Raison, C. L., & Felger, J. C. (2013) · Depression and Anxiety · doi:10.1002/da.22084 · Cited by 892 · see citing works
Self-citationInflammation: Depression Fans the Flames and Feasts on the Heat
Kiecolt-Glaser, J. K., Derry, H. M., & Fagundes, C. P. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15020152 · Cited by 844 · see citing works
Pinto-Sanchez, M. I., Hall, G. B., Ghajar, K., Nardelli, A., Bolino, C., Lau, J. T., Martin, F.-P., Cominetti, O., Welsh, C., Rieder, A., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.05.003 · Cited by 821 · see citing works
Review: microglia of the aged brain: primed to be activated and resistant to regulation
Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792 · see citing works
Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond
Michopoulos, V., Powers, A., Gillespie, C. F., Ressler, K. J., & Jovanovic, T. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.146 · Cited by 786 · see citing works
Neuroinflammation and psychiatric illness
Najjar, S., Pearlman, D. M., Alper, K., Najjar, A., & Devinsky, O. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-43 · Cited by 733 · see citing works
Nusslock, R., & Miller, G. E. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.017 · Cited by 672 · see citing works
The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders
Réus, G. Z., Fries, G. R., Stertz, L., Badawy, M., Passos, I. C., Barichello, T., Kapczinski, F., & Quevedo, J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.018 · Cited by 594 · see citing works
Wohleb, E. S., Powell, N. D., Godbout, J. P., & Sheridan, J. F. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1671-13.2013 · Cited by 563 · see citing works
Hassamal, S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1130989 · Cited by 578 · see citing works
The Emerging Field of Human Social Genomics
Slavich, G. M., & Cole, S. W. (2013) · Clinical Psychological Science · doi:10.1177/2167702613478594 · Cited by 523 · see citing works
The Role of the Immune System in Autism Spectrum Disorder
Meltzer, A., & Van de Water, J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.158 · Cited by 533 · see citing works
Is depression an inflammatory disorder?
Raison, C. L., & Miller, A. H. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0232-0 · Cited by 524 · see citing works
Self-citationElevated C-Reactive Protein Levels, Psychological Distress, and Depression in 73 131 Individuals
Wium-Andersen, M. K., Ørsted, D. D., Nielsen, S. F., & Nordestgaard, B. G. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.102 · Cited by 489 · see citing works
Cattaneo, A., Gennarelli, M., Uher, R., Breen, G., Farmer, A., Aitchison, K. J., Craig, I. W., Anacker, C., Zunsztain, P. A., McGuffin, P., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.191 · Cited by 436 · see citing works
Sharma, S., & Fulton, S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.48 · Cited by 424 · see citing works
Kynurenines in CNS disease: regulation by inflammatory cytokines.
Campbell, B. M., Charych, E., Lee, A. W., & Möller, T. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00012 · Cited by 409 · see citing works
Treatment-resistant depression and peripheral C-reactive protein.
Chamberlain, S. R., Cavanagh, J., de Boer, P., Mondelli, V., Jones, D. N. C., Drevets, W. C., Cowen, P. J., Harrison, N. A., Pointon, L., Pariante, C. M., et al. (2019) · British Journal of Psychiatry · doi:10.1192/bjp.2018.66 · Cited by 400 · see citing works
McKim, D. B., Weber, M. D., Niraula, A., Sawicki, C. M., Liu, X., Jarrett, B. L., Ramirez-Chan, K., Wang, Y., Roeth, R. M., Sucaldito, A. D., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.64 · Cited by 365 · see citing works
Mac Giollabhui, N., Ng, T. H., Ellman, L. M., & Alloy, L. B. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00867-4 · Cited by 361 · see citing works
High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation
Dutheil, S., Ota, K. T., Wohleb, E. S., Rasmussen, K., & Duman, R. S. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.357 · Cited by 355 · see citing works
Palma-Gudiel, H., Córdova-Palomera, A., Leza, J. C., & Fañanás, L. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.016 · Cited by 347 · see citing works
Connecting inflammation with glutamate agonism in suicidality
Erhardt, S., Lim, C. K., Linderholm, K. R., Janelidze, S., Lindqvist, D., Samuelsson, M., Lundberg, K., Postolache, T. T., Träskman-Bendz, L., Guillemin, G. J., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.248 · Cited by 345 · see citing works
Breath of Life: The Respiratory Vagal Stimulation Model of Contemplative Activity
Gerritsen, R. J. S., & Band, G. P. H. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00397 · Cited by 342 · see citing works
Neuroplastic changes in depression: A role for the immune system
Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319 · see citing works
Wohleb, E. S., McKim, D. B., Shea, D. T., Powell, N. D., Tarr, A. J., Sheridan, J. F., & Godbout, J. P. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.029 · Cited by 300 · see citing works
Kopschina Feltes, P., Doorduin, J., Klein, H. C., Juárez-Orozco, L. E., Dierckx, R. A., Moriguchi-Jeckel, C. M., & de Vries, E. F. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117711708 · Cited by 279 · see citing works
Cortisol and Inflammatory Biomarkers Predict Poor Treatment Response in First Episode Psychosis
Mondelli, V., Ciufolini, S., Belvederi Murri, M., Bonaccorso, S., Di Forti, M., Giordano, A., Marques, T. R., Zunszain, P. A., Morgan, C., Murray, R. M., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv028 · Cited by 286 · see citing works
Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal
Weber, M. D., Godbout, J. P., & Sheridan, J. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.102 · Cited by 283 · see citing works
Cross talk: the microbiota and neurodevelopmental disorders
Kelly, J. R., Minuto, C., Cryan, J. F., Clarke, G., & Dinan, T. G. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00490 · Cited by 271 · see citing works
Savitz, J., Drevets, W. C., Smith, C. M., Victor, T. A., Wurfel, B. E., Bellgowan, P. S., Bodurka, J., Teague, T. K., & Dantzer, R. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.194 · Cited by 272 · see citing works
Cytokines in bipolar disorder: A systematic review and meta-analysis
Munkholm, K., Vinberg, M., & Vedel Kessing, L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.06.010 · Cited by 256 · see citing works
The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)
Raison, C. L., & Miller, A. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.2 · Cited by 253 · see citing works
Self-citationNajjar, S., Pearlman, D. M., Devinsky, O., Najjar, A., & Zagzag, D. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-142 · Cited by 248 · see citing works
Oxidative Stress, Inflammation, and Neuroprogression in Chronic PTSD
Miller, M. W., Lin, A. P., Wolf, E. J., & Miller, D. R. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000167 · Cited by 237 · see citing works
Hippocampal gene expression changes underlying stress sensitization and recovery
Gray, J. D., Rubin, T. G., Hunter, R. G., & McEwen, B. S. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.175 · Cited by 242 · see citing works
Inflammation-Associated Co-morbidity Between Depression and Cardiovascular Disease
Halaris, A. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_28 · Cited by 233 · see citing works
Zou, W., Feng, R., & Yang, Y. (2018) · PLOS ONE · doi:10.1371/journal.pone.0197267 · Cited by 224 · see citing works
The role of cytokines in the pathophysiology of suicidal behavior
Ganança, L., Oquendo, M. A., Tyrka, A. R., Cisneros-Trujillo, S., Mann, J. J., & Sublette, M. E. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.10.008 · Cited by 217 · see citing works
Monteiro, S., Roque, S., de Sá-Calçada, D., Sousa, N., Correia-Neves, M., & Cerqueira, J. J. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00006 · Cited by 216 · see citing works
Molecular mechanisms in the regulation of adult neurogenesis during stress
Egeland, M., Zunszain, P. A., & Pariante, C. M. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3855 · Cited by 203 · see citing works
A meta-analysis of cytokine concentrations in eating disorders
Dalton, B., Bartholdy, S., Robinson, L., Solmi, M., Ibrahim, M. A. A., Breen, G., Schmidt, U., & Himmerich, H. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.06.002 · Cited by 197 · see citing works
A meta-analysis of chemokines in major depression
Eyre, H. A., Air, T., Pradhan, A., Johnston, J., Lavretsky, H., Stuart, M. J., & Baune, B. T. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.02.006 · Cited by 188 · see citing works
The interplay between stress, inflammation, and emotional attention: relevance for depression
Maydych, V. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00384 · Cited by 193 · see citing works
Mithaiwala, M. N., Santana-Coelho, D., Porter, G. A., & O’Connor, J. C. (2021) · Cells · doi:10.3390/cells10061548 · Cited by 190 · see citing works
Role of Adiposity-Driven Inflammation in Depressive Morbidity
Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182 · see citing works
Felger, J. C., Li, L., Marvar, P. J., Woolwine, B. J., Harrison, D. G., Raison, C. L., & Miller, A. H. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.010 · Cited by 176 · see citing works
Self-citationDooley, L. N., Kuhlman, K. R., Robles, T. F., Eisenberger, N. I., Craske, M. G., & Bower, J. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.006 · Cited by 176 · see citing works
The link between inflammation, bugs, the intestine and the brain in alcohol dependence
Leclercq, S., de Timary, P., Delzenne, N. M., & Stärkel, P. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.15 · Cited by 174 · see citing works
The role of depressive subtypes within the neuroinflammation hypothesis of major depressive disorder
Woelfer, M., Kasties, V., Kahlfuss, S., & Walter, M. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2018.03.034 · Cited by 171 · see citing works
Miller, G. E., Murphy, M. L. M., Cashman, R., Ma, R., Ma, J., Arevalo, J. M. G., Kobor, M. S., & Cole, S. W. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.05.016 · Cited by 166 · see citing works
Kraynak, T. E., Marsland, A. L., Wager, T. D., & Gianaros, P. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.013 · Cited by 165 · see citing works
Kéri, S., Szabó, C., & Kelemen, O. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.03.020 · Cited by 165 · see citing works
Marques, A. H., Bjørke-Monsen, A.-L., Teixeira, A. L., & Silverman, M. N. (2015) · Brain Research · doi:10.1016/j.brainres.2014.10.051 · Cited by 166 · see citing works
Herbert, J., & Lucassen, P. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.12.001 · Cited by 150 · see citing works
Neuroinflammation in suicide: Toward a comprehensive model
Courtet, P., Giner, L., Seneque, M., Guillaume, S., Olie, E., & Ducasse, D. (2016) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1054879 · Cited by 146 · see citing works
Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation
Miller, A. H., Haroon, E., & Felger, J. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.167 · Cited by 152 · see citing works
Self-citationArloth, J., Bogdan, R., Weber, P., Frishman, G., Menke, A., Wagner, K. V., Balsevich, G., Schmidt, M. V., Karbalai, N., Czamara, D., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.034 · Cited by 142 · see citing works
Okubo, R., Koga, M., Katsumata, N., Odamaki, T., Matsuyama, S., Oka, M., Narita, H., Hashimoto, N., Kusumi, I., Xiao, J., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.011 · Cited by 149 · see citing works
The neurobiological correlates of childhood adversity and implications for treatment
Tyrka, A. R., Burgers, D. E., Philip, N. S., Price, L. H., & Carpenter, L. L. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12143 · Cited by 142 · see citing works
Diet, gut microbiota and cognition
Proctor, C., Thiennimitr, P., Chattipakorn, N., & Chattipakorn, S. C. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-016-9917-8 · Cited by 144 · see citing works
Farzi, A., Reichmann, F., & Holzer, P. (2015) · Acta Physiologica · doi:10.1111/apha.12445 · Cited by 145 · see citing works
Filipović, D., Todorović, N., Bernardi, R. E., & Gass, P. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1218-9 · Cited by 138 · see citing works
Differential effects of metformin on age related comorbidities in older men with type 2 diabetes
Wang, C.-P., Lorenzo, C., Habib, S. L., Jo, B., & Espinoza, S. E. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.01.013 · Cited by 134 · see citing works
Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat
McKim, D. B., Patterson, J. M., Wohleb, E. S., Jarrett, B. L., Reader, B. F., Godbout, J. P., & Sheridan, J. F. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.010 · Cited by 137 · see citing works
Fuertig, R., Azzinnari, D., Bergamini, G., Cathomas, F., Sigrist, H., Seifritz, E., Vavassori, S., Luippold, A., Hengerer, B., Ceci, A., et al. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.12.020 · Cited by 135 · see citing works
Salk, R. H., Petersen, J. L., Abramson, L. Y., & Hyde, J. S. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.03.071 · Cited by 134 · see citing works
“Many have also suggested that lifestyle changes (e.g., greater sugar consumption, pro-inflammatory diets, increased self-focus) have increased rates of depression (e.g., Haroon et al., 2012; Hidaka, 2012; Lopresti et al., 2013).”
BackgroundThe neuroimmunology of social-stress-induced sensitization
Biltz, R. G., Sawicki, C. M., Sheridan, J. F., & Godbout, J. P. (2022) · Nature Immunology · doi:10.1038/s41590-022-01321-z · Cited by 132 · see citing works
Depression and Inflammation: An Intricate Relationship
Dantzer, R. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.025 · Cited by 124 · see citing works
The role of dopamine in inflammation-associated depression: mechanisms and therapeutic implications
Felger, J. C. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_13 · Cited by 115 · see citing works
Hygiene and other early childhood influences on the subsequent function of the immune system
Rook, G. A. W., Lowry, C. A., & Raison, C. L. (2015) · Brain Research · doi:10.1016/j.brainres.2014.04.004 · Cited by 109 · see citing works
Self-citationLasselin, J., Lekander, M., Axelsson, J., & Karshikoff, B. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.06.005 · Cited by 106 · see citing works
Barnum, C. J., Pace, T. W., Hu, F., Neigh, G. N., & Tansey, M. G. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-9 · Cited by 107 · see citing works
Miller, A. H., & Raison, C. L. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.22 · Cited by 101 · see citing works
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Aguliar-Valles, A., Kim, J., Jung, S., Woodside, B., & Luheshi, G. N. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.137 · Cited by 97 · see citing works
Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses
Zhu, X., Sakamoto, S., Ishii, C., Smith, M. D., Ito, K., Obayashi, M., Unger, L., Hasegawa, Y., Kurokawa, S., Kishimoto, T., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01447-8 · Cited by 99 · see citing works
Waddington, Dynamic Systems, and Epigenetics
Tronick, E., & Hunter, R. G. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00107 · Cited by 96 · see citing works
Larouche, E., Hudon, C., & Goulet, S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.058 · Cited by 93 · see citing works
The connection between microbiome and schizophrenia
Golofast, B., & Vales, K. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.011 · Cited by 92 · see citing works
Lotrich, F. E., Albusaysi, S., & Ferrell, R. E. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.263 · Cited by 92 · see citing works
Hostinar, C. E., Nusslock, R., & Miller, G. E. (2018) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2016.1266647 · Cited by 90 · see citing works
Role of Inflammation in Depression: Implications for Phenomenology, Pathophysiology and Treatment
Raison, C. L., & Miller, A. H. (2013) · Modern Trends in Psychiatry · doi:10.1159/000343966 · Cited by 88 · see citing works
Self-citationSu, W.-J., Zhang, T., Jiang, C.-L., & Wang, W. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00412 · Cited by 84 · see citing works
Systematic review of evidence to support the theory of psychobiotics
Romijn, A. R., & Rucklidge, J. J. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv025 · Cited by 81 · see citing works
Martín-Hernández, D., Caso, J. R., Javier Meana, J., Callado, L. F., Madrigal, J. L. M., García-Bueno, B., & Leza, J. C. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1294-2 · Cited by 80 · see citing works
Woo, Y., Seo, H.-J., McIntyre, R., & Bahk, W.-M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010080 · Cited by 79 · see citing works
Keenan, K., Hipwell, A. E., Class, Q. A., & Mbayiwa, K. (2018) · Developmental Psychobiology · doi:10.1002/dev.21773 · Cited by 77 · see citing works
Mehta, D., Raison, C. L., Woolwine, B. J., Haroon, E., Binder, E. B., Miller, A. H., & Felger, J. C. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.04.004 · Cited by 74 · see citing works
Self-citationMean platelet volume in bipolar disorder:The search for an ideal biomarker
Mert, D. G., & Terzi, H. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s112374 · Cited by 67 · see citing works
Farzi, A., Reichmann, F., Meinitzer, A., Mayerhofer, R., Jain, P., Hassan, A. M., Fröhlich, E. E., Wagner, K., Painsipp, E., Rinner, B., et al. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.08.011 · Cited by 68 · see citing works
Neutrophil/Lymphocyte, Platelet/Lymphocyte, and Monocyte/Lymphocyte Ratios in Mood Disorders
Marazziti, D., Torrigiani, S., Carbone, M. G., Mucci, F., Flamini, W., Ivaldi, T., & Dell'Osso, L. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867328666210922160116 · Cited by 61 · see citing works
Blanco, C., Markowitz, J. C., Hellerstein, D. J., Nezu, A. M., Wall, M., Olfson, M., Chen, Y., Levenson, J., Onishi, M., Varona, C., et al. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-4994-5 · Cited by 59 · see citing works
Cyclooxygenase-2 inhibition reduces stress-induced affective pathology
Gamble-George, J. C., Baldi, R., Halladay, L., Kocharian, A., Hartley, N., Silva, C. G., Roberts, H., Haymer, A., Marnett, L. J., Holmes, A., et al. (2016) · eLife · doi:10.7554/elife.14137 · Cited by 55 · see citing works
Effects of acute systemic inflammation on the interplay between sad mood and affective cognition.
Benson, S., Brinkhoff, A., Lueg, L., Roderigo, T., Kribben, A., Wilde, B., Witzke, O., Engler, H., Schedlowski, M., & Elsenbruch, S. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0043-0 · Cited by 53 · see citing works
Dooley, L. N., Ganz, P. A., Cole, S. W., Crespi, C. M., & Bower, J. E. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.02.059 · Cited by 50 · see citing works
Psychological Stress: A Predisposing and Exacerbating Factor in Periodontitis
Spector, A. M., Postolache, T. T., Akram, F., Scott, A. J., Wadhawan, A., & Reynolds, M. A. (2020) · Current Oral Health Reports · doi:10.1007/s40496-020-00282-2 · Cited by 47 · see citing works
- Authors
- Haroon, E., Raison, C. L., & Miller, A. H.
- Affiliations
- Emory University (US)
- Corresponding author
- Miller, Andrew H
- Venue
- Neuropsychopharmacology
- Published
- 2011-09-14
- Volume
- 37
- Issue
- 1
- Pages
- 137-162
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3238082
- OpenAlex
- W1998878650
- Cited by
- 1,000
- References
- 293
- Citations by year
- 2026: 58 · 2025: 51 · 2024: 71 · 2023: 64 · 2022: 73 · 2021: 80 · 2020: 67 · 2019: 55 · 2018: 70 · 2017: 69 · 2016: 77 · 2015: 88 · 2014: 74 · 2013: 58 · 2012: 37
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Abbott Laboratories
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- H. Lundbeck A/S
- National Institutes of Health (UL1TR000454)
- National Institute of Mental Health (R01MH083746, R01MH75102, R01MH087604, K23MH091254, R01MH075102)
- National Center for Research Resources (UL1RR025008, M01RR000039, M01-RR-0039)
- National Center for Advancing Translational Sciences
- National Center for Complementary and Integrative Health (R01AT004698)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- chronic inflammation, major depressive disorder, inflammatory cytokines, acute phase proteins, monoamine metabolism, neuroendocrine function, synaptic plasticity, cyclooxygenase, p38 MAPK, NF-κB, indoleamine 2,3-dioxygenase, kynurenine, chemokines, psychosocial stress, diet, obesity, leaky gut, T cell imbalance, depression recurrence prevention
- MeSH terms
- Animals, Mental Disorders, Humans, Inflammation, Neuropharmacology, Psychoneuroimmunology, Psychopharmacology
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