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Superparamagnetic Iron Oxide Nanoparticles: Diagnostic Magnetic Resonance Imaging and Potential Therapeutic Applications in Neurooncology and Central Nervous System Inflammatory Pathologies, a Review
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Superparamagnetic iron oxide nanoparticles have diverse diagnostic and potential therapeutic applications in the central nervous system (CNS). They are useful as magnetic resonance imaging (MRI) contrast agents to evaluate: areas of blood-brain barrier (BBB) dysfunction related to tumors and other neuroinflammatory pathologies, the cerebrovasculature using perfusion-weighted MRI sequences, and in vivo cellular tracking in CNS disease or injury. Novel, targeted, nanoparticle synthesis strategies will allow for a rapidly expanding range of applications in patients with brain tumors, cerebral ischemia or stroke, carotid atherosclerosis, multiple sclerosis, traumatic brain injury, and epilepsy. These strategies may ultimately improve disease detection, therapeutic monitoring, and treatment efficacy especially in the context of antiangiogenic chemotherapy and antiinflammatory medications. The purpose of this review is to outline the current status of superparamagnetic iron oxide nanoparticles in the context of biomedical nanotechnology as they apply to diagnostic MRI and potential therapeutic applications in neurooncology and other CNS inflammatory conditions.
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“Many iron oxide nanoparticles have been evaluated in preclinical and clinical trials, and several of them have reached the market (Table 1) [4, 22–26].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [23]
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Metadata
- Authors
- Weinstein, J. S., Varallyay, C. G., Dosa, E., Gahramanov, S., Hamilton, B., Rooney, W. D., Muldoon, L. L., & Neuwelt, E. A.
- Affiliations
- Oregon Health & Science University (US)
- Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
- Corresponding author
- Neuwelt, Edward A
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2009-09-16
- Volume
- 30
- Issue
- 1
- Pages
- 15-35
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- PMC
- PMC2949106
- OpenAlex
- W2059756358
- Cited by
- 500
- References
- 126
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 21 · 2023: 24 · 2022: 21 · 2021: 20 · 2020: 18 · 2019: 32 · 2018: 41 · 2017: 37 · 2016: 33 · 2015: 41 · 2014: 41 · 2013: 51 · 2012: 41
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS 33618, R01NS053468, NS053468, R37NS044687, NS34608, R01NS033618, R01NS044687, R01NS034608, NS-44687)
- National Institute of Biomedical Imaging and Bioengineering (R01EB007258)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- superparamagnetic iron oxide nanoparticles, MRI contrast agents, neuro-oncology, brain tumors, blood-brain barrier dysfunction, neuroinflammation, perfusion-weighted MRI, cerebrovascular imaging, cell tracking, cerebral ischemia, stroke, carotid atherosclerosis, multiple sclerosis, traumatic brain injury, epilepsy, anti-inflammatory therapy, nanomedicine
- MeSH terms
- Animals, Blood-Brain Barrier, Contrast Media, Electron Spin Resonance Spectroscopy, Ferric Compounds, Humans, Inflammation, Magnetic Resonance Imaging, Particle Size, Central Nervous System Neoplasms, Nanoparticles
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