Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors
Open accessAbstract
Current neuroimaging provides detailed anatomic and functional evaluation of brain tumors, allowing for improved diagnostic and prognostic capabilities. Some challenges persist even with today's advanced imaging techniques, including accurate delineation of tumor margins and distinguishing treatment effects from residual or recurrent tumor. Ultrasmall superparamagnetic iron oxide nanoparticles are an emerging tool that can add clinically useful information due to their distinct physiochemical features and biodistribution, while having a good safety profile. Nanoparticles can be used as a platform for theranostic drugs, which have shown great promise for the treatment of CNS malignancies. This review will provide an overview of clinical ultrasmall superparamagnetic iron oxides and how they can be applied to the diagnostic and therapeutic neuro-oncologic setting.
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Many iron oxide nanoparticles have been evaluated in preclinical and clinical trials, and several have reached the market.
“Many iron oxide nanoparticles have been evaluated in preclinical and clinical trials, and several of them have reached the market (Table 1) [4, 22–26].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [26]
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- Authors
- Iv, M., Telischak, N., Feng, D., Holdsworth, S. J., Yeom, K. W., & Daldrup-Link, H. E.
- Affiliations
- Stanford Medicine (US)
- Lucile Packard Children's Hospital (US)
- Stanford University (US)
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2015-03
- Volume
- 10
- Issue
- 6
- Pages
- 993-1018
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2017306186
- Cited by
- 134
- References
- 146
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 11 · 2023: 14 · 2022: 6 · 2021: 11 · 2020: 15 · 2019: 14 · 2018: 11 · 2017: 13 · 2016: 16 · 2015: 5
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by
- Locations
- Nanomedicine (publishedVersion)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion, cc-by)
- Funders
- Stanford Department of Radiology
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Keywords
- ultrasmall superparamagnetic iron oxide, brain tumors, MRI contrast agents, theranostics, tumor margin delineation, tumor recurrence detection, tissue distribution, neuro-oncology, nanoparticle safety
- MeSH terms
- Animals, Brain Neoplasms, Ferric Compounds, Glioma, Humans, Magnetic Resonance Imaging, Neoplasm Transplantation, Prognosis, Nanomedicine, Rats, Ferrosoferric Oxide, Metal Nanoparticles, Patient Safety
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