Cited by 134Characterization and Applications of Magnetic NanoparticlesNanoparticle-Based Drug DeliveryGlioma Diagnosis and Treatment

Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors

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Iv, Michael, Telischak, Nicholas, Feng, Dan, Holdsworth, Samantha J, Yeom, Kristen W, Daldrup-Link, Heike E·2015·Nanomedicine

Abstract

Current neuroimaging provides detailed anatomic and functional evaluation of brain tumors, allowing for improved diagnostic and prognostic capabilities. Some challenges persist even with today's advanced imaging techniques, including accurate delineation of tumor margins and distinguishing treatment effects from residual or recurrent tumor. Ultrasmall superparamagnetic iron oxide nanoparticles are an emerging tool that can add clinically useful information due to their distinct physiochemical features and biodistribution, while having a good safety profile. Nanoparticles can be used as a platform for theranostic drugs, which have shown great promise for the treatment of CNS malignancies. This review will provide an overview of clinical ultrasmall superparamagnetic iron oxides and how they can be applied to the diagnostic and therapeutic neuro-oncologic setting.

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Crossref · 10.2217/nnm.14.203

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148 of 148 references verified0 citation errors · 0 not checkable

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  • Many iron oxide nanoparticles have been evaluated in preclinical and clinical trials, and several have reached the market.

    “Many iron oxide nanoparticles have been evaluated in preclinical and clinical trials, and several of them have reached the market (Table 1) [4, 22–26].”

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Authors
Iv, M., Telischak, N., Feng, D., Holdsworth, S. J., Yeom, K. W., & Daldrup-Link, H. E.
Affiliations
  • Stanford Medicine (US)
  • Lucile Packard Children's Hospital (US)
  • Stanford University (US)
Venue
Nanomedicine
Published
2015-03
Volume
10
Issue
6
Pages
993-1018
ISSN
  • 1743-5889 (ISSN-L)
  • 1748-6963
OpenAlex
W2017306186
Cited by
134
References
146
Citations by year
2026: 7 · 2025: 11 · 2024: 11 · 2023: 14 · 2022: 6 · 2021: 11 · 2020: 15 · 2019: 14 · 2018: 11 · 2017: 13 · 2016: 16 · 2015: 5
FWCI
1.17
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Nanomedicine (publishedVersion)
  • PubMed (publishedVersion)
  • ResearchSpace (University of Auckland) (submittedVersion, cc-by)
Funders
Stanford Department of Radiology
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
Keywords
ultrasmall superparamagnetic iron oxide, brain tumors, MRI contrast agents, theranostics, tumor margin delineation, tumor recurrence detection, tissue distribution, neuro-oncology, nanoparticle safety
MeSH terms
Animals, Brain Neoplasms, Ferric Compounds, Glioma, Humans, Magnetic Resonance Imaging, Neoplasm Transplantation, Prognosis, Nanomedicine, Rats, Ferrosoferric Oxide, Metal Nanoparticles, Patient Safety

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