Cited by 500Characterization and Applications of Magnetic NanoparticlesAdvanced MRI Techniques and ApplicationsNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.

Superparamagnetic Iron Oxide Nanoparticles: Diagnostic Magnetic Resonance Imaging and Potential Therapeutic Applications in Neurooncology and Central Nervous System Inflammatory Pathologies, a Review

Open access

Weinstein, Jason S, Varallyay, Csanad G, Dosa, Edit, Gahramanov, Seymur, Hamilton, Bronwyn, Rooney, William D, Muldoon, Leslie L, Neuwelt, Edward A·2010·Journal of Cerebral Blood Flow & Metabolism

DOI 10.1038/jcbfm.2009.192PMC PMC2949106

Open this paper in CoChat — free account

Abstract

Superparamagnetic iron oxide nanoparticles have diverse diagnostic and potential therapeutic applications in the central nervous system (CNS). They are useful as magnetic resonance imaging (MRI) contrast agents to evaluate: areas of blood-brain barrier (BBB) dysfunction related to tumors and other neuroinflammatory pathologies, the cerebrovasculature using perfusion-weighted MRI sequences, and in vivo cellular tracking in CNS disease or injury. Novel, targeted, nanoparticle synthesis strategies will allow for a rapidly expanding range of applications in patients with brain tumors, cerebral ischemia or stroke, carotid atherosclerosis, multiple sclerosis, traumatic brain injury, and epilepsy. These strategies may ultimately improve disease detection, therapeutic monitoring, and treatment efficacy especially in the context of antiangiogenic chemotherapy and antiinflammatory medications. The purpose of this review is to outline the current status of superparamagnetic iron oxide nanoparticles in the context of biomedical nanotechnology as they apply to diagnostic MRI and potential therapeutic applications in neurooncology and other CNS inflammatory conditions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/jcbfm.2009.192

Cites

126 of 126 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Magnetic iron oxide nanoparticles: Synthesis, stabilization, vectorization, physicochemical characterizations and biological applications
Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852
Response criteria for phase II studies of supratentorial malignant glioma.
Macdonald, D. R., Cascino, T. L., Schold, S. C., & Cairncross, J. G. (1990) · Journal of Clinical Oncology · doi:10.1200/jco.1990.8.7.1277 · Cited by 2,409
Comparison of Magnetic Properties of MRI Contrast Media Solutions at Different Magnetic Field Strengths
Rohrer, M., Bauer, H., Mintorovitch, J., Requardt, M., & Weinmann, H. (2005) · Investigative Radiology · doi:10.1097/01.rli.0000184756.66360.d3 · Cited by 1,681
Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders.
(1989) · Stroke · doi:10.1161/01.str.20.10.1407 · Cited by 1,543
Recent advances in iron oxide nanocrystal technology for medical imaging☆
Corot, C., Robert, P., Idée, J., & Port, M. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.013 · Cited by 1,461
Perfusion imaging with NMR contrast agents
Rosen, B. R., Belliveau, J. W., Vevea, J. M., & Brady, T. J. (1990) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910140211 · Cited by 1,141
Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas
Brandsma, D., Stalpers, L. J. A., Taal, W., Sminia, P., & van den Bent, M. J. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70125-6 · Cited by 1,120
Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging.
Weissleder, R., Elizondo, G., WITTENBERG, J., Rabito, C. A., Bengele, H. H., & Josephson, L. (1990) · Radiology · doi:10.1148/radiology.175.2.2326474 · Cited by 1,027
Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings.
Aronen, H. J., Gazit, I. E., Louis, D. N., Buchbinder, B. R., Pardo, F. S., Weisskoff, R. M., Harsh, G. R., Cosgrove, G. R., Halpern, E. F., & Hochberg, F. H. (1994) · Radiology · doi:10.1148/radiology.191.1.8134596 · Cited by 905
Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors
Chertok, B., Moffat, B. A., David, A. E., Yu, F., Bergemann, C., Ross, B. D., & Yang, V. C.-M. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.08.050 · Cited by 901
Acute axonal injury in multiple sclerosis: Correlation with demyelination and inflammation
Bitsch, A. (2000) · Brain · doi:10.1093/brain/123.6.1174 · Cited by 898
Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats
Moseley, M. E., Kucharczyk, J. R., Mintorovitch, J., Cohen, Y., Kurhanewicz, J. V., Derugin, N., Asgari, H. S., & Norman, D. M. (2024) · American Journal of Neuroradiology · doi:10.3174/ajnr.45-12.s8 · Cited by 890
Inflammation and glial responses in ischemic brain lesions
Stoll, G. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00034-3 · Cited by 811
Intracranial Thermotherapy using Magnetic Nanoparticles Combined with External Beam Radiotherapy: Results of a Feasibility Study on Patients with Glioblastoma Multiforme
Maier-Hauff, K., Rothe, R., Scholz, R., Gneveckow, U., Wust, P., Thiesen, B., Feussner, A., von Deimling, A., Waldöfner, N., Felix, R., et al. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9195-0 · Cited by 772
Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging
Thorek, D. L. J., Chen, A. K., Czupryna, J., & Tsourkas, A. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-005-9002-7 · Cited by 770
Dynamic imaging with lanthanide chelates in normal brain: Contrast due to magnetic susceptibility effects
Villringer, A., Rosen, B. R., Belliveau, J. W., Ackerman, J. L., Lauffer, R. B., Buxton, R. B., Chao, Y. S., Wedeenand, V. J., & Brady, T. J. (1988) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910060205 · Cited by 701
Inflammation and Stroke: Putative Role for Cytokines, Adhesion Molecules and iNOS in Brain Response to Ischemia
del Zoppo, G., Ginis, I., Hallenbeck, J. M., Iadecola, C., Wang, X., & Feuerstein, G. Z. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00247.x · Cited by 660
Magnetic field and tissue dependencies of human brain longitudinal 1 H 2 O relaxation in vivo
Rooney, W. D., Johnson, G., Li, X., Cohen, E. R., Kim, S., Uǧurbil, K., & SPRINGER, C. S. J. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21122 · Cited by 651
Self-citation
Glial Neoplasms: Dynamic Contrast-enhanced T2*-weighted MR Imaging
Knopp, E. A., Cha, S., Johnson, G., Mazumdar, A., Golfinos, J. G., Zagzag, D., Miller, D. C., Kelly, P. J., & Kricheff, I. I. (1999) · Radiology · doi:10.1148/radiology.211.3.r99jn46791 · Cited by 592
Outwitting the Blood-Brain Barrier for Therapeutic Purposes: Osmotic Opening and Other Means
KrolI, R. A., Neuwelt, E. A., & Neuwelt, E. A. (1998) · Neurosurgery · doi:10.1097/00006123-199805000-00082 · Cited by 585
Self-citation
Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI
Arbab, A. S., Yocum, G. T., Kalish, H. R., Jordan, E. K., Anderson, S. A., Khakoo, A. Y., Read, E. J., & Frank, J. A. (2004) · Blood · doi:10.1182/blood-2004-02-0655 · Cited by 529
Intracranial Mass Lesions: Dynamic Contrast-enhanced Susceptibility-weighted Echo-planar Perfusion MR Imaging
Cha, S., Knopp, E. A., Johnson, G., Wetzel, S. G., Litt, A. W., & Zagzag, D. (2002) · Radiology · doi:10.1148/radiol.2231010594 · Cited by 515
Correlation of MR imaging-determined cerebral blood volume maps with histologic and angiographic determination of vascularity of gliomas.
Sugahara, T., Korogi, Y., Kochi, M., Ikushima, I., Hirai, T., Okuda, T., Shigematsu, Y., Liang, L., Ge, Y., Ushio, Y., et al. (1998) · American Journal of Roentgenology · doi:10.2214/ajr.171.6.9843274 · Cited by 456
Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected].
Lev, M. H., Özsunar, Y., Henson, J. W., Rasheed, A. A., Barest, G. D., Harsh, G. R., Fitzek, M. M., Chiocca, E. A., Rabinov, J. D., Csavoy, A. N., et al. (2004) · PubMed Central · Cited by 409
Molecular Imaging: Looking at Problems, Seeing Solutions
Herschman, H. R. (2003) · Science · doi:10.1126/science.1090585 · Cited by 381
Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice
Schilling, M., Besselmann, M., Leonhard, C., Mueller, M., Ringelstein, E. B., & Kiefer, R. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00082-7 · Cited by 375
Post-mortem studies in glioblastoma patients treated with thermotherapy using magnetic nanoparticles
van Landeghem, F. K. H., Maier-Hauff, K., Jordan, A., Hoffmann, K., Gneveckow, U., Scholz, R., Thiesen, B., Brück, W., & von Deimling, A. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.044 · Cited by 354
Fast and quiet MRI using a swept radiofrequency
Idiyatullin, D., Corum, C. A., Park, J., & Garwood, M. (2006) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2006.05.014 · Cited by 353
Proliferating resident microglia after focal cerebral ischaemia in mice
Denes, A., Vidyasagar, R., Feng, J., Narvainen, J., McColl, B. W., Kauppinen, R. A., & Allan, S. M. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600495 · Cited by 342
Iron misregulation in the brain: a primary cause of neurodegenerative disorders
Ke, Y., & Qian, Z. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00353-3 · Cited by 341
Preclinical Safety and Pharmacokinetic Profile of Ferumoxtran-10, an Ultrasmall Superparamagnetic Iron Oxide Magnetic Resonance Contrast Agent
Bourrinet, P., Bengele, H. H., Bonnemain, B., Dencausse, A., Idée, J., Jacobs, P. M., & Lewis, J. M. (2006) · Investigative Radiology · doi:10.1097/01.rli.0000197669.80475.dd · Cited by 335
Cellular MR Imaging
Modo, M., Hoehn, M., & Bulte, J. W. M. (2005) · Molecular Imaging · doi:10.1162/15353500200505145 · Cited by 298
Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study.
Floris, S., Blezer, E., Schreibelt, G., Döpp, E. D., van der Pol, S. V. D., Schadee-Eestermans, I., Nicolay, K., Dijkstra, C. D., & de Vries, H. D. (2004) · Brain : a journal of neurology · doi:10.1093/brain/awh068 · Cited by 295
Principles of cerebral perfusion imaging by bolus tracking
Østergaard, L. (2005) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20460 · Cited by 290
In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide
McAteer, M. A., Sibson, N. R., Mühlen, C. V. Z., Schneider, J. E., Lowe, A., Warrick, N., Channon, K. M., Anthony, D. C., & Choudhury, R. P. (2007) · Nature Medicine · doi:10.1038/nm1631 · Cited by 289
Hepatic MR imaging with ferumoxides: a multicenter clinical trial of the safety and efficacy in the detection of focal hepatic lesions.
Ros, P. R., Freeny, P. C., Harms, S. E., Seltzer, S. E., Davis, P. L., Chan, T., Stillman, A. E., Muroff, L. R., Runge, V. M., & Nissenbaum, M. A. (1995) · Radiology · doi:10.1148/radiology.196.2.7617864 · Cited by 277
Recurrent seizures induced by cortical iron injection: A model of posttraumatic epilepsy
Willmore, L. J., Sypert, G. W., & Munson, J. B. (1978) · Annals of Neurology · doi:10.1002/ana.410040408 · Cited by 268
Ultrasmall superparamagnetic iron oxides (USPIOs): a future alternative magnetic resonance (MR) contrast agent for patients at risk for nephrogenic systemic fibrosis (NSF)?
Neuwelt, E. A., Hamilton, B. E., Varallyay, C. G., Rooney, W. R., Edelman, R. D., Jacobs, P. M., & Watnick, S. G. (2009) · Kidney International · doi:10.1038/ki.2008.496 · Cited by 267
Self-citation
Chlorotoxin, a scorpion‐derived peptide, specifically binds to gliomas and tumors of neuroectodermal origin
Lyons, S. A., O'Neal, J., & Sontheimer, H. W. (2002) · Glia · doi:10.1002/glia.10083 · Cited by 263
Capacity of human monocytes to phagocytose approved iron oxide MR contrast agents in vitro
Metz, S., Bonaterra, G. A., Rudelius, M., Settles, M., Rummeny, E., & Daldrup-Link, H. E. (2004) · European Radiology · doi:10.1007/s00330-004-2405-2 · Cited by 246
Use of chlorotoxin for targeting of primary brain tumors.
Soroceanu, L., Gillespie, G. Y., Khazaeli, M. B., & Sontheimer, H. W. (1998) · PubMed · Cited by 237
Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemia
Tanaka, R., Komine‐Kobayashi, M., Mochizuki, H., YAMADA, M., Furuya, T., Migita, M., Shimada, T., Mizuno, Y., & Urabe, T. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00954-5 · Cited by 237
MR imaging of cerebral ischemia: findings in the first 24 hours.
Yuh, W. T. C., Crain, M. R., Loes, D. J., Greene, G. M., Ryals, T. J., & Satō, Y. (1991) · PubMed Central · Cited by 233
Macrophage Imaging in Central Nervous System and in Carotid Atherosclerotic Plaque Using Ultrasmall Superparamagnetic Iron Oxide in Magnetic Resonance Imaging
Corot, C., Petry, K. G., Trivedi, R. A., Saleh, A., Jonkmanns, C., Bas, J. L., Blezer, E. L. A., Rausch, M., Brochet, B., Foster‐Gareau, P., et al. (2004) · Investigative Radiology · doi:10.1097/01.rli.0000135980.08491.33 · Cited by 229
In vivo MRI of brain inflammation in human ischaemic stroke
Saleh, A., Schroeter, M., Jonkmanns, C., Hartung, H., Mödder, U., & Jander, S. (2004) · Brain · doi:10.1093/brain/awh191 · Cited by 228
Imaging of iron oxide nanoparticles by MR and light microscopy in patients with malignant brain tumours
Neuwelt, E. A., Várallyay, P., Bagó, A. G., Muldoon, L. L., Nesbit, G. M., & Nixon, R. A. (2004) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2004.00557.x · Cited by 218
Self-citation
Positive contrast visualization of iron oxide‐labeled stem cells using inversion‐recovery with ON‐resonant water suppression (IRON)
Stuber, M., Gilson, W. D., Schär, M., Kedziorek, D., Hofmann, L. V., Shah, S., Vonken, E.-J. P. A., Bulte, J. W. M., & Kraitchman, D. L. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21399 · Cited by 215
Comparison of Transfection Agents in Forming Complexes with Ferumoxides, Cell Labeling Efficiency, and Cellular Viability
Arbab, A. S., Yocum, G. T., Wilson, L. B., Ashari, P., Jordan, E. K., Kalish, H. R., & Frank, J. A. (2004) · Molecular Imaging · doi:10.1162/153535004773861697 · Cited by 213
New developments in MRI for target volume delineation in radiotherapy
Khoo, V. S., & Joon, D. L. (2006) · British Journal of Radiology · doi:10.1259/bjr/41321492 · Cited by 207
Targeting of Hematopoietic Progenitor Cells with MR Contrast Agents
Daldrup-Link, H. E., Rudelius, M., Oostendorp, R. A. J., Settles, M., Piontek, G., Metz, S., Rosenbrock, H., Keller, U., Heinzmann, U., Rummeny, E. J., et al. (2003) · Radiology · doi:10.1148/radiol.2283020322 · Cited by 200
Imaging, Distribution, and Toxicity of Superparamagnetic Iron Oxide Magnetic Resonance Nanoparticles in the Rat Brain and Intracerebral Tumor
Muldoon, L. L., Manninger, S., Pinkston, K. E., & Neuwelt, E. A. (2005) · Neurosurgery · doi:10.1093/neurosurgery/57.4.785 · Cited by 190
Self-citation
Survival analysis in patients with glioblastoma multiforme: Predictive value of choline‐to‐n‐acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume
Oh, J., Henry, R. G., Pirzkall, A., Lü, Y., Li, X., Catalaa, I., Chang, S. M., Dillon, W. P., & Nelson, S. J. (2004) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20039 · Cited by 189
THE POTENTIAL OF FERUMOXYTOL NANOPARTICLE MAGNETIC RESONANCE IMAGING, PERFUSION, AND ANGIOGRAPHY IN CENTRAL NERVOUS SYSTEM MALIGNANCY: A PILOT STUDY
Neuwelt, E. A., Várallyay, C. G., Manninger, S., Solymosi, D., Haluska, M., Hunt, M. A., Nesbit, G., Stevens, A., Jerosch-Herold, M., Jacobs, P. M., et al. (2007) · Neurosurgery · doi:10.1227/01.neu.0000255350.71700.37 · Cited by 184
Self-citation
Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement
Vellinga, M. M., Oude Engberink, R. D., Seewann, A., Pouwels, P. J. W., Wattjes, M. P., van der Pol, S. M. A., Pering, C., Polman, C. H., de Vries, H. E., Geurts, J. J. G., et al. (2008) · Brain · doi:10.1093/brain/awn009 · Cited by 183
MR imaging of relapsing multiple sclerosis patients using ultra-small-particle iron oxide and compared with gadolinium.
Dousset, V., Brochet, B., Deloire, M. S. A., Lagoarde, L., Barroso, B., Caillé, J. M., & Petry, K. G. (2006) · PubMed Central · Cited by 182
Cell Tagging with Clinically Approved Iron Oxides: Feasibility and Effect of Lipofection, Particle Size, and Surface Coating on Labeling Efficiency
Matuszewski, L., ten Persigehl, T., Wall, A., Schwindt, W., Tombach, B., Fobker, M., Poremba, C., Ebert, W., Heindel, W. L., & Bremer, C. (2005) · Radiology · doi:10.1148/radiol.2351040094 · Cited by 179
Phagocytic Response in Photochemically Induced Infarction of Rat Cerebral Cortex
Schroeter, M., Jander, S., Huitinga, I., Witte, O. W., & Stoll, G. (1997) · Stroke · doi:10.1161/01.str.28.2.382 · Cited by 169
Systemic Inflammatory Response Depends on Initial Stroke Severity but Is Attenuated by Successful Thrombolysis
Audebert, H. J., Rott, M. M., Eck, T., & Haberl, R. L. (2004) · Stroke · doi:10.1161/01.str.0000137607.61697.77 · Cited by 169
MRI‐based monitoring of inflammation and tissue damage in acute and chronic relapsing EAE
Rausch, M., HIESTAND, P. C., Kindler, D., Cannet, C., & Rudin, M. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10541 · Cited by 163
Imaging, Distribution, and Toxicity of Superparamagnetic Iron Oxide Magnetic Resonance Nanoparticles in the Rat Brain and Intracerebral Tumor
Muldoon, L. L., Manninger, S., Pinkston, K. E., et al. (2005) · Neurosurgery · doi:10.1227/01.neu.0000175731.25414.4c · Cited by 159
Self-citation
Capillary ultrastructure in human metastatic brain tumors
Long, D. M. (1979) · Journal of neurosurgery · doi:10.3171/jns.1979.51.1.0053 · Cited by 158
Preclinical Safety Assessment and Pharmacokinetics of Gadodiamide Injection, a New Magnetic Resonance Imaging Contrast Agent
Harpur, E. S., Worah, D. M., Hals, P., Holtz, E., Furuhama, K., & NOMURA, H. (1993) · Investigative Radiology · doi:10.1097/00004424-199303001-00004 · Cited by 157
Physiology and pathology of the blood-brain barrier: implications for microbial pathogenesis, drug delivery and neurodegenerative disorders
Banks, W. A. (1999) · Journal of NeuroVirology · doi:10.3109/13550289909021284 · Cited by 155
Quantitative Assessment of Core/Penumbra Mismatch in Acute Stroke
Schaefer, P. W., Barak, E. R., Kamalian, S., Gharai, L. R., Schwamm, L. H., González, R. G., & Lev, M. H. (2008) · Stroke · doi:10.1161/strokeaha.107.513358 · Cited by 154
In vivo “hot spot” MR imaging of neural stem cells using fluorinated nanoparticles
Ruı́z-Cabello, J., Walczak, P., Kedziorek, D., Chacko, V. P., Schmieder, A. H., Wickline, S. A., Lanza, G. M., & Bulte, J. W. M. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21783 · Cited by 153
In vivo tracking of stem cells in brain and spinal cord injury
Syková, E., & Jendelová, P. (2007) · Progress in brain research · doi:10.1016/s0079-6123(06)61026-1 · Cited by 152
Comparison of two superparamagnetic viral-sized iron oxide particles ferumoxides and ferumoxtran-10 with a gadolinium chelate in imaging intracranial tumors.
Várallyay, P., Nesbit, G. M., Muldoon, L. L., Nixon, R. R., Delashaw, J. B., Cohen, J. I., Petrillo, A., Rink, D., & Neuwelt, E. A. (2002) · PubMed Central · Cited by 149
Self-citation
Dynamic patterns of USPIO enhancement can be observed in macrophages after ischemic brain damage
Rausch, M., Sauter, A., Froehlich, J. M., Neubacher, U., Radue, E. W., & Rudin, M. (2001) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1290 · Cited by 144
Field strength dependence of R1 and R relaxivities of human whole blood to prohance, vasovist, and deoxyhemoglobin
Blockley, N. P., Jiang, L., Gardener, A. G., Ludman, C. N., Francis, S., & Gowland, P. A. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21792 · Cited by 140
Clinical investigation survival prediction in high-grade gliomas by MRI perfusion before and during early stage of RT
Cao, Y., Tsien, C. I., Nagesh, V., Junck, L., Haken, R. K. T., Ross, B. D., Chenevert, T. L., & Lawrence, T. S. (2005) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2005.09.001 · Cited by 140
Assessment of Inflammatory Burden Contralateral to the Symptomatic Carotid Stenosis Using High-Resolution Ultrasmall, Superparamagnetic Iron Oxide–Enhanced MRI
Tang, T. Y., Howarth, S. P. S., Miller, S. R., Trivedi, R. A., Graves, M. J., King-Im, J. U., Li, Z. Y., Brown, A. P., Kirkpatrick, P. J., Gaunt, M. E., et al. (2006) · Stroke · doi:10.1161/01.str.0000236063.47539.99 · Cited by 137
Delivery of Virus-sized Iron Oxide Particles to Rodent CNS Neurons
Neuwelt, E. A., Weissleder, R., Nilaver, G., Kroll, R. A., Roman-Goldstein, S., Szumowski, J., Pagel, M. A., Jones, R. S., Remsen, L. G., McCormick, C. I., et al. (1994) · Neurosurgery · doi:10.1227/00006123-199404000-00048 · Cited by 135
Self-citation
Inflammatory Response After Ischemic Stroke
Nighoghossian, N., Wiart, M., Cakmak, S., Berthezène, Y., Derex, L., Cho, T., Nemoz, C., Chapuis, F. R., Tisserand, G. L., Pialat, J., et al. (2006) · Stroke · doi:10.1161/01.str.0000254548.30258.f2 · Cited by 130
Comparison of SPIO and USPIO for in Vitro Labeling of Human Monocytes: MR Detection and Cell Function
Engberink, R. D. O., van der Pol, S. M. A., Döpp, E. A., de Vries, H. E., & Blezer, E. L. A. (2007) · Radiology · doi:10.1148/radiol.2432060120 · Cited by 127
Iron Oxide Particle-Enhanced MRI Suggests Variability of Brain Inflammation at Early Stages After Ischemic Stroke
Saleh, A., Schroeter, M., Ringelstein, A., Hartung, H., Siebler, M., Mödder, U., & Jander, S. (2007) · Stroke · doi:10.1161/strokeaha.107.481788 · Cited by 124
Magnetic Labeling of Activated Microglia in Experimental Gliomas
Fleige, G., Nolte, C., Synowitz, M., Seeberger, F., Kettenmann, H., & Zimmer, C. (2001) · Neoplasia · doi:10.1038/sj.neo.7900176 · Cited by 116
Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: Clinical implications for ultrasmall superparamagnetic iron oxide‐enhanced magnetic resonance imaging
Rausch, M., HIESTAND, P. C., Foster, C. A., Kindler, D., Cannet, C., & Rudin, M. (2004) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20057 · Cited by 109
In vivo tracking of superparamagnetic iron oxide nanoparticle–labeled mesenchymal stem cell tropism to malignant gliomas using magnetic resonance imaging
Wu, X., Hu, J., Zhou, L., Mao, Y. Q., Yang, B., Gao, L., Xie, R., Xu, F., Zhang, D., Liu, J., et al. (2008) · Journal of neurosurgery · doi:10.3171/jns/2008/108/2/0320 · Cited by 108
Pharmacokinetic Study of Ferumoxytol: A New Iron Replacement Therapy in Normal Subjects and Hemodialysis Patients
Landry, R., Jacobs, P. M., Davis, R., Shenouda, M., & Bolton, W. K. (2005) · American Journal of Nephrology · doi:10.1159/000087212 · Cited by 108
Imaging Inflammation in Acute Brain Ischemia
Jander, S., Schroeter, M., & Saleh, A. (2007) · Stroke · doi:10.1161/01.str.0000250048.42916.ad · Cited by 101
Cell tracking using magnetic resonance imaging
Hoehn, M., Wiedermann, D., Justicia, C., Ramos‐Cabrer, P., Kruttwig, K., Farr, T. D., & Himmelreich, U. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.139451 · Cited by 93
Central nervous system inflammatory response after cerebral infarction as detected by magnetic resonance imaging
Saleh, A., Wiedermann, D., Schroeter, M., Jonkmanns, C., Jander, S., & Hoehn, M. (2004) · NMR in Biomedicine · doi:10.1002/nbm.881 · Cited by 88
Sensitivity of magnetic resonance imaging of dendritic cells for in vivo tracking of cellular cancer vaccines
Verdijk, P., Scheenen, T. W. J., Lesterhuis, W. J., Gambarota, G., Veltien, A. A., Walczak, P., Scharenborg, N. M., Bulte, J. W. M., Punt, C. J. A., Heerschap, A., et al. (2006) · International Journal of Cancer · doi:10.1002/ijc.22385 · Cited by 86
Detecting and Treating Cancer with Nanotechnology
Hartman, K. B., Wilson, L. J., & Rosenblum, M. G. (2008) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256264 · Cited by 85
Early macrophage MRI of inflammatory lesions predicts lesion severity and disease development in relapsing EAE
Brochet, B., Deloire, M. S. A., Touil, T., Anne, O., Caillé, J. M., Dousset, V., & Petry, K. G. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.03.028 · Cited by 81
Cerebral blood volume mapping by MR imaging in the initial evaluation of brain tumors.
Kremer, S., Grand, S., Remy, C. T., Estève, F., Lefournier, V., Pasquier, B., Hoffmann, D., Benabid, A., & Bas, J. F. L. (2002) · PubMed · Cited by 81
Dynamic MRI Using Iron Oxide Nanoparticles to Assess Early Vascular Effects of Antiangiogenic versus Corticosteroid Treatment in a Glioma Model
Várallyay, C. G., Muldoon, L. L., Gahramanov, S., Wu, Y. J., Goodman, J. A., Li, X., Pike, M. M., & Neuwelt, E. A. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.162 · Cited by 80
Self-citation
An exploratory study of ferumoxtran-10 nanoparticles as a blood-brain barrier imaging agent targeting phagocytic cells in CNS inflammatory lesions.
Manninger, S., Muldoon, L. L., Nesbit, G. M., Murillo, T. P., Jacobs, P. M., & Neuwelt, E. A. (2005) · PubMed Central · Cited by 77
Self-citation
Quantitative measurements of capillary transport in human brain tumors by computed tomography
Groothuis, D. R., Vriesendorp, F. J., Kupfer, B., Warnke, P. C., Lapin, G. D., Kuruvilla, A., Vick, N. A., Mikhael, M. A., & Patlak, C. S. (1991) · Annals of Neurology · doi:10.1002/ana.410300411 · Cited by 76
The safety and efficacy of ferumoxytol therapy in anemic chronic kidney disease patients
Spinowitz, B., Schwenk, M. H., Jacobs, P. M., Bolton, W. K., Kaplan, M. R., Charytan, C., & Galler, M. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00598.x · Cited by 74
Endogenous and Exogenous CNS Derived Stem / Progenitor Cell Approaches for Neurotrauma
Kulbatski, I., Mothe, A. J., Nomura, H., & Tator, C. H. (2005) · Current Drug Targets · doi:10.2174/1389450053345037 · Cited by 74
Neuronal repair and replacement in spinal cord injury
Bareyre, F. M. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.05.004 · Cited by 74
Association of Total Dose Intensity of Chemotherapy in Primary Central Nervous System Lymphoma (Human Non-Acquired Immunodeficiency Syndrome) and Survival
Kraemer, D. F., Fortin, D., Doolittle, N. D., & Neuwelt, E. A. (2001) · Neurosurgery · doi:10.1097/00006123-200105000-00013 · Cited by 70
Self-citation
In vivo leukocyte labeling with intravenous ferumoxides/protamine sulfate complex and in vitro characterization for cellular magnetic resonance imaging
Wu, Y. J., Muldoon, L. L., Várallyay, C. G., Markwardt, S., Jones, R. E., & Neuwelt, E. A. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00215.2007 · Cited by 69
Self-citation
Liposome‐enhanced MRI of neointimal lesions in the ApoE‐KO mouse
Mulder, W. J. M., Douma, K., Koning, G. A., van Zandvoort, M. A. M. J., Lutgens, E., Daemen, M. J. A. P., Nicolay, K., & Strijkers, G. J. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20883 · Cited by 66
Contrast-Enhanced Magnetic Resonance Imaging of Central Nervous System Tumors
Essig, M., Weber, M. D., von Tengg‐Kobligk, H., Knopp, M. V., Yuh, W. T. C., & Giesel, F. L. (2006) · Topics in Magnetic Resonance Imaging · doi:10.1097/01.rmr.0000245464.36148.dc · Cited by 66
Dynamic changes of magnetic resonance imaging abnormalities in relation to inflammation and glial responses after photothrombotic cerebral infarction in the rat brain
Schroeter, M., Franke, C., Stoll, G., & Hoehn, M. (2001) · Acta Neuropathologica · doi:10.1007/s004010000262 · Cited by 65
Present Status of Magnetic Resonance Imaging and Spectroscopy in Animal Stroke Models
Weber, R., Ramos‐Cabrer, P., & Hoehn, M. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600241 · Cited by 64
Functionalized magnetonanoparticles for MRI diagnosis and localization in epilepsy
Akhtari, M., Bragin, A., Cohen, M. S., Moats, R. A., Brenker, F. E., Lynch, M. D., Vinters, H. V., & Engel, J. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01615.x · Cited by 63
Compartmental study of diffusion and relaxation measured in vivo in normal and ischemic rat brain and trigeminal nerve
Does, M. D., & Gore, J. C. (2000) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200006)43:6 · Cited by 62
Cellular multiparametric MRI of neural stem cell therapy in a rat glioma model
Brekke, C., Williams, S., Price, J., Thorsen, F. A., & Modo, M. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.06.006 · Cited by 59
Double-echo perfusion-weighted MR imaging: basic concepts and application in brain tumors for the assessment of tumor blood volume and vascular permeability
Uematsu, H., & Maeda, M. (2005) · European Radiology · doi:10.1007/s00330-005-2807-9 · Cited by 58
Magnetic resonance imaging‐based detection of glial brain tumors in mice after antiangiogenic treatment
Claes, A., Gambarota, G., Hamans, B. C., van Tellingen, O., Wesseling, P., Maass, C., Heerschap, A., & Leenders, W. P. J. (2007) · International Journal of Cancer · doi:10.1002/ijc.23306 · Cited by 55
Feridex Preloading Permits Tracking of CNS-Resident Macrophages after Transient Middle Cerebral Artery Occlusion
Henning, E. C., Ruetzler, C., Gaudinski, M. R., Hu, T. C., Latour, L. L., Hallenbeck, J. M., & Warach, S. J. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.48 · Cited by 55
Quantitative measurement of tissue perfusion and diffusion in vivo
Chenevert, T. L., Pipe, J. G., Williams, D. M., & Brunberg, J. A. (1991) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910170123 · Cited by 54
Safety profile of ultrasmall superparamagnetic iron oxide ferumoxtran‐10: Phase II clinical trial data
Sharma, R., Saini, S., Ros, P. R., Hahn, P. F., Small, W. C., de Lange, E. E., Stillman, A. E., Edelman, R. R., Runge, V. M., Outwater, E. K., et al. (1999) · Journal of Magnetic Resonance Imaging · doi:10.1002/(sici)1522-2586(199902)9:2 · Cited by 53
Evaluation with α−[11C]Methyl‐ l ‐tryptophan Positron Emission Tomography for Reoperation after Failed Epilepsy Surgery
Juhász, C., Chugani, D. C., Padhye, U. N., Muzik, O., Shah, A. K., Asano, E., Mangner, T. J., Chakraborty, P. K., Sood, S., & Chugani, H. T. (2004) · Epilepsia · doi:10.1111/j.0013-9580.2004.30303.x · Cited by 52
Time-dependency in brain lesion enhancement with gadodiamide injection
Åkeson, P., Nordström, C., & Holtås, S. (1997) · Acta Radiologica · doi:10.1080/02841859709171236 · Cited by 50
Single-dose contrast agent for intraoperative MR imaging of intrinsic brain tumors by using ferumoxtran-10.
Hunt, M. A., Bagó, A. G., & Neuwelt, E. A. (2005) · PubMed · Cited by 48
Self-citation
Comparison of lipid‐rich necrotic core size in symptomatic and asymptomatic carotid atherosclerotic plaque: Initial results
Cappendijk, V. C., Kessels, A. G. H., Heeneman, S., Cleutjens, K. B. J. M., Schurink, G. W. H., Welten, R. J. T. J., Mess, W. H., van Suylen, R. J., Leiner, T., Daemen, M. J. A. P., et al. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21359 · Cited by 47
Differences between Relapsing-Remitting and Chronic Progressive Multiple Sclerosis as Determined with Quantitative MR Imaging
Miki, Y., Grossman, R. I., Udupa, J. K., van Buchem, M. A., Wei, L., Phillips, M. D., Patel, U. J., McGowan, J. C., & Kolson, D. L. (1999) · Radiology · doi:10.1148/radiology.210.3.r99mr44769 · Cited by 46
Trafficking of superparamagnetic iron oxide particles (Combidex) from brain to lymph nodes in the rat
Muldoon, L. L., Várallyay, P., Kraemer, D. F., Kiwic, G., Pinkston, K. E., Walker-Rosenfeld, S. L., & Neuwelt, E. A. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2003.00512.x · Cited by 44
Self-citation
Computer-assisted quantitation of enhancing lesions in multiple sclerosis: correlation with clinical classification.
Miki, Y., Grossman, R. I., Udupa, J. K., Samarasekera, S., van Buchem, M. A., Cooney, B. S., Pollack, S. N., Kolson, D. L., Constantinescu, C. S., Polansky, M., et al. (1997) · PubMed Central · Cited by 43
Ultrasmall Superparamagnetic Iron Oxide–enhanced MR Imaging of Atherosclerotic Plaque in Hyperlipidemic Rabbits
Ruehm, S. G., Corot, C., VOGT, P. R., Cristina, H., & Debatin, J. F. (2002) · Academic Radiology · doi:10.1016/s1076-6332(03)80422-1 · Cited by 42
Measurement of tissue blood flow using intravascular relaxation agents and resonance imaging
Gore, J. C., & Majumdar, S. (1990) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910140210 · Cited by 41
Visualisation of the kinetics of macrophage infiltration during experimental autoimmune encephalomyelitis by magnetic resonance imaging
Baeten, K., Hendriks, J. J. A., Hellings, N., Theunissen, E., Vanderlocht, J., Ryck, L. D., Gelan, J., Stinissen, P., & Adriaensens, P. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.11.008 · Cited by 34
Contrast enhancement of brain tumors at different MR field strengths: comparison of 0.5 T and 2.0 T.
Chang, K. H., David Chakravarthi, G., Han, M., Cha, S. H., Kim, H. D., & Han, M. C. (1994) · PubMed Central · Cited by 30
Differential permeability and quantitative MR imaging of a human lung carcinoma brain xenograft in the nude rat.
Barnett, P. A., Roman-Goldstein, S., Ramsey, F., McCormick, C. I., Sexton, G. J., Szumowski, J., & Neuwelt, E. A. (1995) · Europe PMC (PubMed Central) · Cited by 28
Self-citation
Imaging and nanomedicine for diagnosis and therapy in the central nervous system: report of the eleventh annual Blood-Brain Barrier Disruption Consortium meeting.
Muldoon, L. L., Tratnyek, P. G., Jacobs, P. M., Doolittle, N. D., Christoforidis, G. A., Frank, J. A., Lindau, M., Lockman, P. R., Manninger, S., Qiang, Y., et al. (2006) · PubMed Central · Cited by 28
Self-citation
Susceptibility Contrast Magnetic Resonance Imaging Determination of Fractional Tumor Blood Volume: A Noninvasive Imaging Biomarker of Response to the Vascular Disrupting Agent ZD6126
Robinson, S. P., Howe, F. A., Griffiths, J. R., Ryan, A. J., & Waterton, J. C. (2007) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2007.06.061 · Cited by 26
Mitochondrial DNA deletions in acute brain injury
McDonald, R. P. A., Horsburgh, K. J., Graham, D. I., & Nicoll, J. A. R. (1999) · Neuroreport · doi:10.1097/00001756-199906230-00014 · Cited by 24
Positive contrast MR‐lymphography using inversion recovery with ON‐resonant water suppression (IRON)
Korosoglou, G., Tang, L., Kedziorek, D., Cosby, K., Gilson, W. D., Vonken, E.-J. P. A., Schär, M., Sosnovik, D. E., Kraitchman, D. L., Weiss, R. G., et al. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21337 · Cited by 22
Assessment of dynamic susceptibility contrast cerebral blood flow response to amphetamine challenge: A human pharmacological magnetic resonance imaging study at 1.5 and 4 T
Rose, S. E., Janke, A. L., Strudwick, M. W., McMahon, K. L., Chalk, J. B., Snyder, P., & De zubicaray, G. I. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20749 · Cited by 20
Ferumoxtran-10 enhancement in orthotopic xenograft models of human brain tumors: an indirect marker of tumor proliferation?
Kremer, S., Pinel, S., Védrine, P., Bressenot, A., Robert, P., Bracard, S., & Plénat, F. (2007) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9260-8 · Cited by 11
Treatment of iron deficiency anaemia with saccharated iron oxide given by the intravenous route.
CAMERON, D. G., Bensley, E. H., Wood, P. A., & Grayston (1951) · PubMed Central · Cited by 9
Is the disruption of the blood-brain barrier a prerequisite for cellular infiltration in autoimmune encephalitis?
Bendszus, M. (2005) · Brain · doi:10.1093/brain/awh389 · Cited by 6

Research works printed but not linked: 15

Barnett PA, 1995, Am J Pathol, 146, 436
Cameron DG, 1951, Can Med Assoc J, 64, 27
Chang KH, 1994, AJNR Am J Neuroradiol, 15, 1413
Dousset V, 2006, AJNR Am J Neuroradiol, 27, 1000
Hunt MA, 2005, AJNR Am J Neuroradiol, 26, 1084
Kraemer DF, 2001, Neurosurgery, 48, 1033
Kremer S, 2002, J Neuroradiol, 29, 105
Lev MH, 2004, AJNR Am J Neuroradiol, 25, 214
Manninger SP, 2005, AJNR Am J Neuroradiol, 26, 2290
Miki Y, 1997, AJNR Am J Neuroradiol, 18, 705
Moseley ME, 1990, AJNR Am J Neuroradiol, 11, 423
Muldoon LL, 2006, AJNR Am J Neuroradiol, 27, 715
Soroceanu L, 1998, Cancer Res, 58, 4871
Varallyay P, 2002, AJNR Am J Neuroradiol, 23, 510
Yuh WT, 1991, AJNR Am J Neuroradiol, 12, 621

Sorted by citations

Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181
Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers
Wahajuddin, M., & Arora, S. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s30320 · Cited by 1,148
Therapeutic efficacy of nanoparticles and routes of administration
Chenthamara, D., Sadhasivam, S., Ramakrishnan, S. G., Krishnaswamy, S., Essa, M. M., Lin, F., & Qoronfleh, M. W. (2019) · Biomaterials Research · doi:10.1186/s40824-019-0166-x · Cited by 1,103
Engaging neuroscience to advance translational research in brain barrier biology
Neuwelt, E. A., Bauer, B., Fahlke, C. M., Fricker, G., Iadecola, C., Janigro, D., Leybaert, L., Molnár, Z., O’Donnell, M. E., Povlishock, J. T., et al. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn2995 · Cited by 594
Self-citation
Exceedingly small iron oxide nanoparticles as positive MRI contrast agents
Wei, H., Bruns†, O. T., Kaul, M. G., Hansen, E. C., Barch, M., Wiśniowska, A. E., Chen, O., Chen, Y., Li, N., Okada, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620145114 · Cited by 500

See all 500

Authors: Weinstein, J. S., Varallyay, C. G., Dosa, E., Gahramanov, S., Hamilton, B., Rooney, W. D., Muldoon, L. L., & Neuwelt, E. A.
Affiliations: Oregon Health & Science University (US)
Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
Corresponding author: Neuwelt, Edward A
ORCID: Gahramanov, Seymur
Hamilton, Bronwyn
Rooney, William D
Muldoon, Leslie L
Neuwelt, Edward A
Venue: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications
Published: 2009-09-16
Volume: 30
Issue: 1
Pages: 15-35
ISSN: 0271-678X (ISSN-L)
1559-7016
DOI: 10.1038/jcbfm.2009.192
PMC: PMC2949106
OpenAlex: W2059756358
Cited by: 500
References: 126
Citations by year: 2026: 12 · 2025: 15 · 2024: 21 · 2023: 24 · 2022: 21 · 2021: 20 · 2020: 18 · 2019: 32 · 2018: 41 · 2017: 37 · 2016: 33 · 2015: 41 · 2014: 41 · 2013: 51 · 2012: 41
FWCI: 2.66
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS 33618, R01NS053468, NS053468, R37NS044687, NS34608, R01NS033618, R01NS044687, R01NS034608, NS-44687)
National Institute of Biomedical Imaging and Bioengineering (R01EB007258)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: superparamagnetic iron oxide nanoparticles, MRI contrast agents, neuro-oncology, brain tumors, blood-brain barrier dysfunction, neuroinflammation, perfusion-weighted MRI, cerebrovascular imaging, cell tracking, cerebral ischemia, stroke, carotid atherosclerosis, multiple sclerosis, traumatic brain injury, epilepsy, anti-inflammatory therapy, nanomedicine
MeSH terms: Animals, Blood-Brain Barrier, Contrast Media, Electron Spin Resonance Spectroscopy, Ferric Compounds, Humans, Inflammation, Magnetic Resonance Imaging, Particle Size, Central Nervous System Neoplasms, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Superparamagnetic Iron Oxide Nanoparticles: Diagnostic Magnetic Resonance Imaging and Potential Therapeutic Applications in Neurooncology and Central Nervous System Inflammatory Pathologies, a Review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks