Cited by 500Characterization and Applications of Magnetic NanoparticlesAdvanced MRI Techniques and ApplicationsNanoparticle-Based Drug Delivery

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Superparamagnetic Iron Oxide Nanoparticles: Diagnostic Magnetic Resonance Imaging and Potential Therapeutic Applications in Neurooncology and Central Nervous System Inflammatory Pathologies, a Review

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Weinstein, Jason S, Varallyay, Csanad G, Dosa, Edit, Gahramanov, Seymur, Hamilton, Bronwyn, Rooney, William D, Muldoon, Leslie L, Neuwelt, Edward A·2010·Journal of Cerebral Blood Flow & Metabolism

DOI 10.1038/jcbfm.2009.192PMC PMC2949106

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Abstract

Superparamagnetic iron oxide nanoparticles have diverse diagnostic and potential therapeutic applications in the central nervous system (CNS). They are useful as magnetic resonance imaging (MRI) contrast agents to evaluate: areas of blood-brain barrier (BBB) dysfunction related to tumors and other neuroinflammatory pathologies, the cerebrovasculature using perfusion-weighted MRI sequences, and in vivo cellular tracking in CNS disease or injury. Novel, targeted, nanoparticle synthesis strategies will allow for a rapidly expanding range of applications in patients with brain tumors, cerebral ischemia or stroke, carotid atherosclerosis, multiple sclerosis, traumatic brain injury, and epilepsy. These strategies may ultimately improve disease detection, therapeutic monitoring, and treatment efficacy especially in the context of antiangiogenic chemotherapy and antiinflammatory medications. The purpose of this review is to outline the current status of superparamagnetic iron oxide nanoparticles in the context of biomedical nanotechnology as they apply to diagnostic MRI and potential therapeutic applications in neurooncology and other CNS inflammatory conditions.

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Authors: Weinstein, J. S., Varallyay, C. G., Dosa, E., Gahramanov, S., Hamilton, B., Rooney, W. D., Muldoon, L. L., & Neuwelt, E. A.
Affiliations: Oregon Health & Science University (US)
Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
Corresponding author: Neuwelt, Edward A
ORCID: Gahramanov, Seymur
Hamilton, Bronwyn
Rooney, William D
Muldoon, Leslie L
Neuwelt, Edward A
Venue: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications
Published: 2009-09-16
Volume: 30
Issue: 1
Pages: 15-35
ISSN: 0271-678X (ISSN-L)
1559-7016
DOI: 10.1038/jcbfm.2009.192
PMC: PMC2949106
OpenAlex: W2059756358
Cited by: 500
References: 126
Citations by year: 2026: 12 · 2025: 15 · 2024: 21 · 2023: 24 · 2022: 21 · 2021: 20 · 2020: 18 · 2019: 32 · 2018: 41 · 2017: 37 · 2016: 33 · 2015: 41 · 2014: 41 · 2013: 51 · 2012: 41
FWCI: 2.66
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS 33618, R01NS053468, NS053468, R37NS044687, NS34608, R01NS033618, R01NS044687, R01NS034608, NS-44687)
National Institute of Biomedical Imaging and Bioengineering (R01EB007258)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: superparamagnetic iron oxide nanoparticles, MRI contrast agents, neuro-oncology, brain tumors, blood-brain barrier dysfunction, neuroinflammation, perfusion-weighted MRI, cerebrovascular imaging, cell tracking, cerebral ischemia, stroke, carotid atherosclerosis, multiple sclerosis, traumatic brain injury, epilepsy, anti-inflammatory therapy, nanomedicine
MeSH terms: Animals, Blood-Brain Barrier, Contrast Media, Electron Spin Resonance Spectroscopy, Ferric Compounds, Humans, Inflammation, Magnetic Resonance Imaging, Particle Size, Central Nervous System Neoplasms, Nanoparticles

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Superparamagnetic Iron Oxide Nanoparticles: Diagnostic Magnetic Resonance Imaging and Potential Therapeutic Applications in Neurooncology and Central Nervous System Inflammatory Pathologies, a Review

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