The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Age-Dependent Effect of Apolipoprotein E4 on Functional Outcome after Controlled Cortical Impact in Mice
Abstract
The apolipoprotein E4 ( APOE4) gene leads to increased brain amyloid beta (Aβ) and poor outcome in adults with traumatic brain injury (TBI); however, its role in childhood TBI is controversial. We hypothesized that the transgenic expression of human APOE4 worsens the outcome after controlled cortical impact (CCI) in adult but not immature mice. Adult and immature APOE4 mice had worse motor outcome after CCI ( P<0.001 versus wild type (WT)), but the Morris water maze performance was worse only in adult APOE4 mice ( P=0.028 at 2 weeks, P=0.019 at 6 months versus WT), because immature APOE4 mice had performance similar to WT for up to 1 year after injury. Brain lesion size was similar in adult APOE4 mice but was decreased ( P=0.029 versus WT) in injured immature APOE4 mice. Microgliosis was similar in all groups. Soluble brain Aβ 40 was increased at 48 hours after CCI in adult and immature APOE4 mice and in adult WT ( P<0.05), and was dynamically regulated during the chronic period by APOE4 in adults but not immature mice. The data suggest age-dependent effects of APOE4 on cognitive outcome after TBI, and that therapies targeting APOE4 may be more effective in adults versus children with TBI.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Recently, several studies have shown that APOE4 is associated with increased innate immune reactivity and enhanced cytokine secretion in primary microglia and peripheral macrophages in various animal models as well as human subjects [31–42].”
From 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner (2020) · cites this paper as [35]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The role of apolipoprotein E in Alzheimer's disease
Kim, J., Basak, J. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.026 · Cited by 1,661
Shibata, M., Yamada, S., Kumar, S. R., Calero, M., Bading, J., Frangione, B., Holtzman, D. M., Miller, C. A., Strickland, D. K., Ghiso, J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10498 · Cited by 1,413
Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
Bales, K. R., Verina, T., Dodel, R. C., Du, Y., Altstiel, L., Bender, M., Hyslop, P., Johnstone, E. M., Little, S. P., Cummins, D. J., et al. (1997) · Nature Genetics · doi:10.1038/ng1197-263 · Cited by 830
apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain
Deane, R., Sagare, A., Hamm, K., Parisi, M., Lane, S., Finn, M. B., Holtzman, D. M., & Zlokovic, B. V. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36663 · Cited by 771
Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?
Johnson, V. E., Stewart, W., & Smith, D. H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2808 · Cited by 587
Lynch, J. R., Tang, W., Wang, H., Vitek, M. P., Bennett, E. R., Sullivan, P. M., Warner, D. S., & Laskowitz, D. T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306923200 · Cited by 394
Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury
Chen, Y., Lomnitski, L., Michaelson, D. M., & Shohami, E. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00007-9 · Cited by 214
Buttini, M., Yu, G.-Q., Shockley, K., Huang, Y., Jones, B., Masliah, E., Mallory, M., Yeo, T., Longo, F. M., & Mucke, L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10539.2002 · Cited by 183 · cited 1×
“…2001), and APOE4 is associated with age-related decreases in synaptophysin-immunoreactive presynaptic terminals, decreased choline acetyltransferase activity, and reduced cholinergic fibers in mutant hAPP mice expressing APOE4 under the direction of neuron-specific enolase (Buttini et al, 2002).”
BackgroundHartman, R. E., Wozniak, D. F., Nardi, A., Olney, J. W., Sartorius, L., & Holtzman, D. M. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7715 · Cited by 157
Research works printed but not linked: 32
- 10.1542/peds.2004-1728 · DOI
- 10.1038/sj.jcbfm.9600258 · DOI
- 10.1111/j.1469-8749.2005.tb01042.x · DOI
- 10.1016/S0197-4580(98)00091-8 · DOI
- 10.1016/S0306-4522(00)00069-5 · DOI
- 10.1016/S0306-4522(03)00436-6 · DOI
- 10.1523/JNEUROSCI.22-23-10083.2002 · DOI · Paper page
- 10.1080/02699050701739549 · DOI
- 10.1073/pnas.050004797 · DOI · Paper page
- 10.1161/STROKEAHA.108.530402 · DOI
- 10.1001/jama.1997.03550020068040 · DOI
- 10.1097/01.CCM.0000080484.72004.C4 · DOI
- 10.1038/nm.1940 · DOI · Paper page
- 10.1016/S0002-9440(10)65184-X · DOI · Paper page
- 10.1523/JNEUROSCI.5572-08.2009 · DOI · Paper page
- 10.1212/WNL.45.3.555 · DOI · Paper page
- 10.1002/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M · DOI
- 10.1089/neu.2008.0767 · DOI
- 10.1074/jbc.M313003200 · DOI
- 10.1002/(SICI)1096-9861(19990830)411:3<390::AID-CNE3>3.0.CO;2-# · DOI
- 10.1111/j.1365-2990.1996.tb01128.x · DOI
- 10.1073/pnas.201279298 · DOI
- 10.1016/S0306-4522(00)00438-3 · DOI · Paper page
- 10.1542/peds.2005-2588 · DOI
- 10.1007/s11064-009-9960-5 · DOI
- 10.1038/nm0995-852 · DOI
- 10.1093/brain/awh595 · DOI
- 10.1016/S0140-6736(97)04318-3 · DOI
- 10.1523/JNEUROSCI.3478-07.2007 · DOI
- 10.1016/j.neurobiolaging.2007.11.014 · DOI · Paper page
- 10.1155/JBB/2006/58406 · DOI
- 10.1203/01.PDR.0000090927.53818.DE · DOI
Cited by
Sorted by citations
The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease
Brothers, H. M., Gosztyla, M. L., & Robinson, S. R. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00118 · Cited by 314
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner
Wong, M. Y., Lewis, M., Doherty, J. J., Shi, Y., Cashikar, A. G., Amelianchik, A., Tymchuk, S., Sullivan, P. M., Qian, M., Covey, D. F., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01869-3 · Cited by 121
Apolipoprotein E Genotype Affects Size of ApoE Complexes in Cerebrospinal Fluid
Heinsinger, N. M., Gachechiladze, M. A., & Rebeck, G. W. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw067 · Cited by 74
Castranio, E. L., Wolfe, C. M., Nam, K. N., Letronne, F., Fitz, N. F., Lefterov, I., & Koldamova, R. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0569-2 · Cited by 23
Beneficial effect of amyloid beta after controlled cortical impact
Mannix, R. C., Zhang, J., Berglass, J., Qui, J., & Whalen, M. J. (2013) · Brain Injury · doi:10.3109/02699052.2013.771797 · Cited by 19
Self-citation
Metadata
- Authors
- Mannix, R. C., Zhang, J., Park, J., Zhang, X., Bilal, K., Walker, K., Tanzi, R. E., Tesco, G., & Whalen, M. J.
- Affiliations
- Division of Emergency Medicine, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
- Neuroscience Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
- Department of Neuroscience, Tufts University, Boston, Massachusetts, USA
- Department of Neurology, MIND Institute, Massachusetts General Hospital, Charlestown, Massachusetts, USA
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2010-06-30
- Volume
- 31
- Issue
- 1
- Pages
- 351-361
- ISSN
- 0271-678X
- 1559-7016
- Cited by
- 62
- References
- 9
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Age-Dependent Effect of Apolipoprotein E4 on Functional Outcome after Controlled Cortical Impact in Mice. https://app.cochat.ai/papers/10.1038/jcbfm.2010.99
- The paper
- Mannix, R. C., Zhang, J., Park, J., Zhang, X., Bilal, K., Walker, K., Tanzi, R. E., Tesco, G., & Whalen, M. J. (2011). Age-Dependent Effect of Apolipoprotein E4 on Functional Outcome after Controlled Cortical Impact in Mice. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.2010.99
