Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury
Open accessAbstract
Amyloid-beta (Abeta) peptides, found in Alzheimer's disease brain, accumulate rapidly after traumatic brain injury (TBI) in both humans and animals. Here we show that blocking either beta- or gamma-secretase, enzymes required for production of Abeta from amyloid precursor protein (APP), can ameliorate motor and cognitive deficits and reduce cell loss after experimental TBI in mice. Thus, APP secretases are promising targets for treatment of TBI.
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The rapid accumulation of Aβ after TBI is well documented in both humans and experimental animal models.
“The rapid accumulation of Aβ after TBI is well documented in both humans and experimental animal models.12–17”
From Controlled Cortical Impact Results in an Extensive Loss of Dendritic Spines that Is Not Mediated by Injury-Induced Amyloid-Beta Accumulation (2013) · cites this paper as [14]
CCI causes a rapid and significant increase in the production of the Alzheimer disease-related protein Aβ in mice.
“We have shown previously that CCI causes a rapid and significant increase in the production of the Alzheimer disease-related protein Aβ in mice.14,22”
From Controlled Cortical Impact Results in an Extensive Loss of Dendritic Spines that Is Not Mediated by Injury-Induced Amyloid-Beta Accumulation (2013) · cites this paper as [14]
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- Authors
- Loane, D. J., Pocivavsek, A., Moussa, C. E.-H., Thompson, R., Matsuoka, Y., Faden, A. I., Rebeck, G. W., & Burns, M. P.
- Affiliations
- Georgetown University Medical Center (US)
- Corresponding author
- Burns, Mark P
- Venue
- Nature Medicine
- Published
- 2009-03-15
- Volume
- 15
- Issue
- 4
- Pages
- 377-379
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC2844765
- OpenAlex
- W1989349429
- Cited by
- 246
- References
- 29
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 9 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 13 · 2019: 15 · 2018: 18 · 2017: 22 · 2016: 14 · 2015: 21 · 2014: 14 · 2013: 21 · 2012: 26
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (K01AG030378)
- National Institute of Neurological Disorders and Stroke (R03NS057635, R03NS57635)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24HD050845)
- Topics
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- traumatic brain injury, amyloid precursor protein, beta-secretase, gamma-secretase, amyloid-beta, neuroprotection, neuronal cell death, motor impairment, cognitive impairment, therapeutic target
- MeSH terms
- Animals, Brain Injuries, Cognition, Disease Models, Animal, Humans, Motor Activity, Aspartic Acid Endopeptidases, Mice, Amyloid Precursor Protein Secretases
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