The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Inflammatory Cytokines in Experimental and Human Stroke
Open accessAbstract
Inflammation is a hallmark of stroke pathology. The cytokines, tumor necrosis factor (TNF), interleukin (IL)-1, and IL-6, modulate tissue injury in experimental stroke and are therefore potential targets in future stroke therapy. The effect of these cytokines on infarct evolution depends on their availability in the ischemic penumbra in the early phase after stroke onset, corresponding to the therapeutic window (<4.5 hours), which is similar in human and experimental stroke. This review summarizes a large body of literature on the spatiotemporal and cellular production of TNF, IL-1, and IL-6, focusing on the early phase in experimental and human stroke. We also review studies of cytokines in blood and cerebrospinal fluid in stroke. Tumor necrosis factor and IL-1 are upregulated early in peri-infarct microglia. Newer literature suggests that IL-6 is produced by microglia, in addition to neurons. Tumor necrosis factor- and IL-1-producing macrophages infiltrate the infarct and peri-infarct with a delay. This information is discussed in the context of suggestions that neuronal sensitivity to ischemia may be modulated by cytokines. The fact that TNF and IL-1, and suppossedly also IL-6, are produced by microglia within the therapeutic window place these cells centrally in potential future stroke therapy.
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1 retracted
Rao, A. M., & Hatcher, J. F. (2007) · Brain Research · doi:10.1016/j.brainres.2006.11.080 · Cited by 60
RetractedPathobiology of ischaemic stroke: an integrated view
Dirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01401-0 · Cited by 3,943
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272 · cited 1×
“…allows the formation of gp130/gp130 homodimers that associates with Janusassociated kinases, activates signal transducer and activator of transcription and mitogen-activated protein kinase signaling pathways (Heinrich et al, 2003; Kamimura et al, 2003; Ernst and Jenkins, 2004; Bauer et al, 2007).”
BackgroundThresholds in cerebral ischemia - the ischemic penumbra.
Astrup, J., Siesjö, B. K., & Symon, L. (1981) · Stroke · doi:10.1161/01.str.12.6.723 · Cited by 2,820
Kriegler, M., Perez, C., DeFay, K., Albert, I., & Lu, S. D. (1988) · Cell · doi:10.1016/0092-8674(88)90486-2 · Cited by 1,102
Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke
Gelderblom, M., Leypoldt, F., Steinbach, K., Behrens, D., Choe, C.-U., Siler, D. A., Arumugam, T. V., Orthey, E., Gerloff, C., Tolosa, E., et al. (2009) · Stroke · doi:10.1161/strokeaha.108.534503 · Cited by 1,066
Schindler, R., Mancilla, J., Endres, S., Ghorbani, R., Clark, S., & Dinarello, C. (1990) · Blood · doi:10.1182/blood.v75.1.40.40 · Cited by 1,012
Interleukin-1 and neuronal injury
Allan, S. M., Tyrrell, P. J., & Rothwell, N. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1664 · Cited by 992
Bruce, A. J., Boling, W., Kindy, M. S., Peschon, J., Kraemer, P. J., Carpenter, M. K., Holtsberg, F. W., & Mattson, M. P. (1996) · Nature Medicine · doi:10.1038/nm0796-788 · Cited by 932
Viviani, B., Bartesaghi, S., Gardoni, F., Vezzani, A., Behrens, M. M., Bartfai, T., Binaglia, M., Corsini, E., Di Luca, M., Galli, C. L., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08692.2003 · Cited by 893
Research works printed but not linked: 14
- 10.1016/j.bbi.2010.09.017 · doi:10.1016/j.bbi.2010.09.017
- Dziewulska D, 2003, Clin Neuropathol, 22, 35
- Garcia JH, 1995, Am J Pathol, 147, 1477
- 10.1097/01.WCB.0000055177.50448.FA · doi:10.1097/01.wcb.0000055177.50448.fa
- Hossmann KA, 1996, Cell Mol Neurobiol, 26, 1057
- 10.1159/000094994 · doi:10.1159/000094994
- 10.1046/j.1468-1331.2003.00648.x · DOI
- Kamimura D, 2003, Rev Physiol Biochem Pharmacol, 149, 1
- Ohtaki H, 2003, Acta Neurochir, 86, 191
- 10.1007/s10072-001-8170-y · doi:10.1007/s10072-001-8170-y
- 10.1161/01.STR.0000221294.90068.c4 · doi:10.1161/01.str.0000221294.90068.c4
- 10.1111/j.1468-1331.2009.02609.x · doi:10.1111/j.1468-1331.2009.02609.x
- 10.1002/(SICI)1097-4547(20000115)59:2<238::AID-JNR10>3.0.CO;2-G · doi:10.1002/(sici)1097-4547(20000115)59:2<238::aid-jnr10>3.0.co;2-g
- 10.1016/j.neulet.2004.07.083 · doi:10.1016/j.neulet.2004.07.083
Cited by
Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy
Tian, T., Zhang, H.-X., He, C.-P., Fan, S., Zhu, Y.-L., Qi, C., Huang, N.-P., Xiao, Z.-D., Lu, Z.-H., Tannous, B. A., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.012 · Cited by 1,154
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
Qin, C., Yang, S., Chu, Y.-H., Zhang, H., Pang, X.-W., Chen, L., Zhou, L.-Q., Chen, M., Tian, D.-S., & Wang, W. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01064-1 · Cited by 939
Targeting Neutrophils in Ischemic Stroke: Translational Insights from Experimental Studies
Jickling, G. C., Liu, D., Ander, B. P., Stamova, B., Zhan, X., & Sharp, F. R. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.45 · Cited by 644
Glial Cells: Role of the Immune Response in Ischemic Stroke
Xu, S., Lu, J., Shao, A., Zhang, J. H., & Zhang, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00294 · Cited by 601
Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
Sierra, A., Abiega, O., Shahraz, A., & Neumann, H. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00006 · Cited by 574
Metadata
- Authors
- Lambertsen, K. L., Biber, K., & Finsen, B.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2012-06-27
- Volume
- 32
- Issue
- 9
- Pages
- 1677-1698
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W1998106951
- Cited by
- 732
- References
- 145
- FWCI
- 20.69
- Type
- journal article
- Language
- en
- Open access
- green
- Licence
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
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- Lambertsen, K. L., Biber, K., & Finsen, B. (2012). Inflammatory Cytokines in Experimental and Human Stroke. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.2012.88
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