Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy
Abstract
The safe and effective delivery of drugs is a major obstacle in the treatment of ischemic stroke. Exosomes hold great promise as an endogenous drug delivery nanosystem for the treatment of cerebral ischemia given their unique properties, including low immunogenicity, innate stability, high delivery efficiency, and ability to cross the blood-brain barrier (BBB). However, exosome insufficient targeting capability limits their clinical applications. In this study, the c(RGDyK) peptide has been conjugated to the exosome surface by an easy, rapid, and bio-orthogonal chemistry. In the transient middle cerebral artery occlusion (MCAO) mice model, The engineered c(RGDyK)-conjugated exosomes (cRGD-Exo) target the lesion region of the ischemic brain after intravenous administration. Furthermore, curcumin has been loaded onto the cRGD-Exo, and administration of these exosomes has resulted in a strong suppression of the inflammatory response and cellular apoptosis in the lesion region. The results suggest a targeting delivery vehicle for ischemic brain based on exosomes and provide a strategy for the rapid and large-scale production of functionalized exosomes.
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Modified exosomes provided a safe and effective delivery vehicle for ischemic stroke therapy in a mouse model.
“In a mouse model, the modified exosomes provided a safe and effective delivery vehicle for ischemic stroke therapy [71].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [71]
Exosome carriers conjugated to c(RGDyK) peptide or curcumin can target the lesion area of ischemic encephalopathy.
“Others reported that exosome carriers conjugated to the surface of c (RGDyK) peptide or curcumin can target the lesion area of ischemic encephalopathy.”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [71]
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Exosome-like Nanoparticles: A New Type of Nanocarrier
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Nanoconjugate formulations for enhanced drug delivery
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- Authors
- Tian, T., Zhang, H.-X., He, C.-P., Fan, S., Zhu, Y.-L., Qi, C., Huang, N.-P., Xiao, Z.-D., Lu, Z.-H., Tannous, B. A., & Gao, J.
- Affiliations
- Harvard University (US)
- Sun Yat-sen University (CN)
- Nanjing Medical University (CN)
- State Key Laboratory of Digital Medical Engineering (CN)
- Corresponding author
- Gao, Jun
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 150
- Pages
- 137-149
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2761425229
- Cited by
- 1,154
- References
- 72
- Citations by year
- 2026: 98 · 2025: 146 · 2024: 182 · 2023: 186 · 2022: 173 · 2021: 150 · 2020: 108 · 2019: 77 · 2018: 32 · 2017: 1
- FWCI
- 24.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81222013, 81673416, 81401092)
- Jiangsu Province (BE2016761)
- Natural Science Foundation of Jiangsu Province (BK20170107, BK20130886)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- exosomes, surface functionalization, targeted drug delivery, cerebral ischemia, ischemic stroke, RGD peptide conjugation, bioorthogonal chemistry, curcumin, middle cerebral artery occlusion, blood-brain barrier, neuroinflammation, apoptosis, exosome production
- MeSH terms
- Animals, Curcumin, Disease Models, Animal, HeLa Cells, Humans, Injections, Intravenous, Male, Mice, Inbred C57BL, Peptides, Pharmaceutical Vehicles, Infarction, Middle Cerebral Artery, Stroke, Cell Line, Tumor, Mice, Exosomes
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