The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Cerebral Hemodynamics in Normal Aging: Central Artery Stiffness, Wave Reflection, and Pressure Pulsatility
Open accessAbstract
Blood ejected from the left ventricle perfuses the brain via central elastic arteries, which stiffen with advancing age and may elevate the risk of end-organ damage. The purpose of this study was to determine the impact of central arterial aging on cerebral hemodynamics. Eighty-three healthy participants aged 22 to 80 years underwent the measurements of cerebral blood flow (CBF) and CBF velocity (CBFV) using magnetic resonance imaging (MRI) and transcranial Doppler, respectively. The CBF pulsatility was determined by the relative amplitude of CBFV to the mean value (CBFV%). Central arterial stiffness (carotid-femoral pulse wave velocity), wave reflection (carotid augmentation index), and pressure were measured using applanation tonometry. Total volume of white-matter hyperintensity (WMH) was quantified from MR images. Total CBF decreased with age while systolic and pulsatile CBFV% increased and diastolic CBFV% decreased. Women showed greater total CBF and lower cerebrovascular resistance than men. Diastolic CBFV% was lower in women than in men. Age- and sex-related differences in CBF pulsatility were independently associated with carotid pulse pressure and arterial wave reflection. In older participants, higher pulsatility of CBF was associated with the greater total volume of WMH. These findings indicate that central arterial aging has an important role in age-related differences in cerebral hemodynamics.
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Cited by
Toth, P., Tarantini, S., Csiszar, A., & Ungvari, Z. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00581.2016 · Cited by 522
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Distribution of cardiac output to the brain across the adult lifespan
Xing, C.-Y., Tarumi, T., Liu, J., Zhang, Y., Turner, M., Riley, J., Tinajero, C. D., Yuan, L.-J., & Zhang, R. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16676826 · Cited by 160
Self-citation
Metadata
- Authors
- Tarumi, T., Khan, M. A., Liu, J., Tseng, B. M., Parker, R., Riley, J., Tinajero, C., & Zhang, R.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2014-03-19
- Volume
- 34
- Issue
- 6
- Pages
- 971-978
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2059969387
- Cited by
- 218
- References
- 10
- FWCI
- 9.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tarumi, T., Khan, M. A., Liu, J., Tseng, B. M., Parker, R., Riley, J., Tinajero, C., & Zhang, R. (2014). Cerebral Hemodynamics in Normal Aging: Central Artery Stiffness, Wave Reflection, and Pressure Pulsatility. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/jcbfm.2014.44
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