Cited by 179Epigenetics and DNA MethylationSchizophrenia research and treatmentGenetics and Neurodevelopmental Disorders

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DNA methylation of the BDNF gene and its relevance to psychiatric disorders

Ikegame, Tempei, Bundo, Miki, Murata, Yui, Kasai, Kiyoto, Kato, Tadafumi, Iwamoto, Kazuya·2013·Journal of Human Genetics

DOI 10.1038/jhg.2013.65

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Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor, which is important for neuronal survival, development and synaptic plasticity. Accumulating evidence suggests that epigenetic modifications of BDNF are associated with the pathophysiology of psychiatric disorders, such as schizophrenia and mood disorders. Patients with psychiatric disorders generally show decreased neural BDNF levels, which are often associated with increased DNA methylation at the specific BDNF promoters. Importantly, observed DNA methylation changes are consistent across tissues including brain and peripheral blood, which suggests potential usefulness of these findings as a biomarker of psychiatric disorders. Here we review DNA methylation characteristics of BDNF promoters of cellular, animal and clinical samples and discuss future perspectives.

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Brain and cognitive correlates of FKBP5: methylation patterns in schizophrenia
Latorre-Guardia, M., Almodóvar-Payá, C., París-Gómez, I., Guardiola-Ripoll, M., Canales-Rodríguez, E. J., Fuentes‐Claramonte, P., García‐León, M. Á., Garcia‐Ruiz, B., Sotero-Moreno, A., Guerrero‐Pedraza, A., et al. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111959
BDNF promoter methylation and genetic variation in late-life depression
Januar, V, Ancelin, M.-L., Ritchie, K., Saffery, R., & Ryan, J. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.114 · Cited by 139

Authors: Ikegame, T., Bundo, M., Murata, Y., Kasai, K., Kato, T., & Iwamoto, K.
Affiliations: The University of Tokyo (JP)
RIKEN Center for Brain Science (JP)
Japan Science and Technology Agency (JP)
Corresponding author: Iwamoto, Kazuya
ORCID: Ikegame, Tempei
Bundo, Miki
Kasai, Kiyoto
Kato, Tadafumi
Iwamoto, Kazuya
Venue: Journal of Human Genetics
Publisher: Springer Science and Business Media LLC
Published: 2013-06-06
Volume: 58
Issue: 7
Pages: 434-438
ISSN: 1434-5161 (ISSN-L)
1435-232X
DOI: 10.1038/jhg.2013.65
OpenAlex: W1996375332
Cited by: 179
References: 69
Citations by year: 2026: 8 · 2025: 12 · 2024: 14 · 2023: 16 · 2022: 14 · 2021: 11 · 2020: 8 · 2019: 13 · 2018: 13 · 2017: 12 · 2016: 20 · 2015: 21 · 2014: 15 · 2013: 2
FWCI: 1.82
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Human Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology (CREST)
Core Research for Evolutional Science and Technology
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: brain-derived neurotrophic factor, DNA methylation, epigenetics, mental illness, schizophrenia, mood disorders, promoter methylation, biomarkers, peripheral blood, brain, neurotrophic factors, synaptic plasticity
MeSH terms: Animals, Autopsy, Brain, Disease Models, Animal, Humans, Neurons, Promoter Regions, Genetic, Schizophrenia, DNA Methylation, Brain-Derived Neurotrophic Factor

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DNA methylation of the BDNF gene and its relevance to psychiatric disorders

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