The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Exploring the “Hair Growth–Wound Healing Connection”: Anagen Phase Promotes Wound Re-Epithelialization
Open accessAbstract
When the skin is damaged, a variety of cell types must migrate, proliferate, and differentiate to reform a functional barrier to the external environment. Recent studies have shown that progenitor cells residing in hair follicles (HFs) are able to contribute to this re-epithelialization of wounds in vivo. However, the influence of the hair cycle on wound healing has not previously been addressed. Here, we have exploited spontaneous postnatal hair-cycle synchronicity in mice to systematically examine the influence of the different hair-cycle stages on murine skin wound healing. We report significant acceleration of healing during the anagen phase of HF cycling in vivo, associated with alterations in epithelial, endothelial, and inflammatory cell types. Intriguingly, gene profiling data reveal a clear correlation between the transcription of genes beneficial for wound healing and those upregulated during the anagen phase of the hair cycle in unwounded skin. These findings, which demonstrate a previously unappreciated association between HF cycling and wound healing, reveal numerous molecular correlates for further investigation.
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“Indeed, the pattern and stage of hair growth in different regions of the mouse skin can significantly affect rates of skin healing in mouse tissue (114).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [114]
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Cites
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Defining the Epithelial Stem Cell Niche in Skin
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Identifying biological themes within lists of genes with EASE
Hosack, D. A., Dennis, G., Sherman, B. T., Lane, H. C., & Lempicki, R. A. (2003) · Genome biology · doi:10.1186/gb-2003-4-10-r70 · Cited by 1,961
Controls of Hair Follicle Cycling
Stenn, K. S., & Paus, R. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.449 · Cited by 1,543
Self-citationMüller-Röver, S., Foitzik, K., Paus, R., Handjiski, B., van der Veen, C., Eichmüller, S., McKay, I. A., & Stenn, K. S. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01377.x · Cited by 1,375
Self-citationIto, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R. J., & Cotsarelis, G. (2005) · Nature Medicine · doi:10.1038/nm1328 · Cited by 1,317
MIF Signal Transduction Initiated by Binding to CD74
Leng, L., Metz, C. N., Fang, Y., Xu, J., Donnelly, S., Baugh, J., Delohery, T., Chen, Y., Mitchell, R. A., & Bucala, R. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030286 · Cited by 1,154
The Hair Follicle as a Dynamic Miniorgan
Schneider, M. R., Schmidt-Ullrich, R., & Paus, R. (2009) · Current Biology · doi:10.1016/j.cub.2008.12.005 · Cited by 1,119
Self-citationDominant role of the niche in melanocyte stem-cell fate determination
Nishimura, E. K., Jordan, S. A., Oshima, H., Yoshida, H., Osawa, M., Moriyama, M., Jackson, I. J., Barrandon, Y., Miyachi, Y., & Nishikawa, S. (2002) · Nature · doi:10.1038/416854a · Cited by 906
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Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562
Epithelialization in Wound Healing: A Comprehensive Review
Pastar, I., Stojadinović, O., Yin, N. C., Ramirez, H. A., Nusbaum, A. G., Sawaya, A. P., Patel, S. B., Khalid, L., Isseroff, R. R., & Tomic‐Canic, M. (2014) · Advances in Wound Care · doi:10.1089/wound.2013.0473 · Cited by 1,604
Wound Healing and Skin RegenerationPreprint
Takeo, M., Lee, W., & Ito, M. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a023267 · Cited by 715
Smart Bandage for Monitoring and Treatment of Chronic Wounds
Mostafalu, P., Tamayol, A., Rahimi, R., Ochoa, M., Khalilpour, A., Kiaee, G., Yazdi, I. K., Bagherifard, S., Dokmeci, M. R., Ziaie, B., et al. (2018) · Small · doi:10.1002/smll.201703509 · Cited by 497
How UV Light Touches the Brain and Endocrine System Through Skin, and Why
Slominski, A. T., Zmijewski, M. A., Plonka, P. M., Szaflarski, J. P., & Paus, R. (2018) · Endocrinology · doi:10.1210/en.2017-03230 · Cited by 452
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Metadata
- Authors
- Ansell, D. M., Kloepper, J. E., Thomason, H. A., Paus, R., & Hardman, M. J.
- Affiliations
- University of Manchester (GB)
- University of Lübeck (DE)
- Corresponding author
- Hardman, Matthew J.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 131
- Issue
- 2
- Pages
- 518-528
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2109605961
- Cited by
- 171
- References
- 59
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 11 · 2023: 9 · 2022: 11 · 2021: 11 · 2020: 14 · 2019: 16 · 2018: 16 · 2017: 15 · 2016: 11 · 2015: 5 · 2014: 10 · 2013: 8 · 2012: 8
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Manchester Biomedical Research Centre
- Biotechnology and Biological Sciences Research Council
- Topics
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- hair cycle, anagen phase, wound healing, re-epithelialization, skin wound healing, gene expression profiling, inflammatory cells, endothelial cells
- MeSH terms
- Animals, Cell Cycle, Cell Movement, Epithelial Cells, Female, Mice, Inbred C57BL, Regeneration, Skin, Skin Physiological Phenomena, Wound Healing, Hair Follicle, Neovascularization, Physiologic, Models, Animal, Mice
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