Collagen Turnover in Wound Repair––A Macrophage Connection
Open accessAbstract
In this issue, Rohani et al. (2015) report on the role of macrophage-derived stromelysin-2 (matrix metalloproteinase (MMP)-10) in promoting the turnover of extracellular matrix (ECM) during cutaneous wound repair. They provide evidence that MMP-10 specifically enhances collagenolytic activity of murine MMP-13 produced by M2-like macrophages. These results emphasize the important role of macrophage-derived MMP-10 in regulating tissue remodeling and scar formation during wound healing.
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The M1/M2 polarization paradigm consists of an overlap as both phenotypes have been shown to stimulate fibroblast migration and differentiation, as well as collagen production.
“The M1/M2 polarization paradigm consists of an overlap as both phenotypes have been shown to stimulate fibroblast migration and differentiation, as well as collagen production (Figure 1D).[ 69 , 70 , 71 ]”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [69]
MMP-10 regulates collagenolytic activity of M2 macrophages, which is critical for scar resolution.
“Interestingly, a recent study revealed the important role of MMP-10 in regulating the collagenolytic activity of M2 macrophages, which is critical for scar resolution [41, 78].”
From Transition from inflammation to proliferation: a critical step during wound healing (2016) · cites this paper as [41]
Cites
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528 · see citing works
Inflammation in Wound Repair: Molecular and Cellular Mechanisms
Eming, S. A., Krieg, T., & Davidson, J. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700701 · Cited by 2,429 · see citing works
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903356 · Cited by 1,205 · cited 1× · see citing works
“In general, macrophages have a role in all phases of wound healing, and depletion of macrophages results in delayed wound repair, reduced granulation tissue formation, and delayed re-epithelialization and scar deposition (Lucas et al., 2010).”
BackgroundMacrophages in skin injury and repair.
Delavary, B. M., van der Veer, W. M., van Egmond, M., Niessen, F., & Beelen, R. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.01.001 · Cited by 794 · see citing works
The Activity of Collagenase-1 Is Required for Keratinocyte Migration on a Type I Collagen Matrix
Pilcher, B. K., Dumin, J. A., Sudbeck, B. D., Krane, S. M., Welgus, H. G., & Parks, W. C. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.6.1445 · Cited by 613 · see citing works
Wound Macrophages as Key Regulators of Repair
Brancato, S. K., & Albina, J. E. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.08.003 · Cited by 508 · see citing works
Fallowfield, J. A., Mizuno, M., Kendall, T. J., Constandinou, C. M., Benyon, R. C., Duffield, J. S., & Iredale, J. P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5288 · Cited by 479 · see citing works
Matrix metalloproteinases in inflammation
Nissinen, L. M., & Kähäri, V. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.03.007 · Cited by 446 · see citing works
Self-citationMMP-8 Is the Predominant Collagenase in Healing Wounds and Nonhealing Ulcers
Nwomeh, B. C., Liang, H.-X., Cohen, I. K., & Yager, D. R. (1999) · Journal of Surgical Research · doi:10.1006/jsre.1998.5495 · Cited by 357 · cited 5× · see citing works
“Collagenases identified in normally healing human cutaneous wounds are MMP-1 and MMP-8 (Saarialho-Kere et al., 1992; Inoue et al., 1995; Nwomeh et al., 1999).”
BackgroundInfluentialVaalamo, M., Mattila, L., Johansson, N., Kariniemi, A., Karjalainen‐Lindsberg, M., Kähäri, V., & Saarialho‐Kere, U. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12276722 · Cited by 287 · see citing works
Self-citationIncreased inflammation delays wound healing in mice deficient in collagenase‐2 (MMP‐8)
Gutiérrez‐Fernández, A., Inada, M., Balbı́n, M., Fueyo, A., Pitiot, A. S., Astudillo, A., Hirose, K., Hirata, M., Shapiro, S. D., Noël, A., et al. (2007) · The FASEB Journal · doi:10.1096/fj.06-7860com · Cited by 281 · see citing works
Yeast Nuclear Extract Contains Two Major Forms of RNA Polymerase II Mediator Complexes
Liu, Y., Ranish, J. A., Aebersold, R. H., & Hahn, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009586200 · Cited by 255 · see citing works
Balbı́n, M., Fueyo, A., Knäuper, V., López, J. M., Álvarez, J., Sánchez, L. M., Quesada, V., Bordallo, J., Murphy, G., & López-Otı́n, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007674200 · Cited by 239 · see citing works
Saarialho‐Kere, U., Pentland, A. P., Birkedal‐Hansen, H., Parks, W. C., & Welgus, H. G. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117351 · Cited by 237 · see citing works
Hattori, N., Mochizuki, S., Kishi, K., Nakajima, T., Takaishi, H., D'Armiento, J. M., & Okada, Y. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081080 · Cited by 231 · see citing works
Ravanti, L., Häkkinen, L., Larjava, H., Saarialho‐Kere, U., Foschi, M., Han, J., & Kähäri, V. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37292 · Cited by 211 · see citing works
Self-citationProteinases in cutaneous wound healing
Toriseva, M., & Kähäri, V. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8388-4 · Cited by 206 · see citing works
Self-citationTreatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis
Siller-López, F., Sandoval-Rodriguez, A. S., Salgado, S., Salazar, A., Bueno‐Topete, M. R., Garcı́a, J., Vera-Cruz, J. M., Gálvez, J., Hernández‐Cañaveral, I., & Ramos, M. H. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.12.045 · Cited by 173 · see citing works
Saarialho-Kere, U. K., Chang, E. S., Welgus, H. G., & Parks, W. C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116073 · Cited by 170 · see citing works
Krampert, M., Bloch, W., Sasaki, T., Bugnon, P., Rülicke, T., Wolf, E., Aumailley, M., Parks, W. C., & Werner, S. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-02-0109 · Cited by 145 · see citing works
Inoue, M., Kratz, G., Hægerstrand, A., & Ståhle‐Bäckdahl, M. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12605917 · Cited by 137 · see citing works
Toriseva, M., Laato, M. K., Carpén, O., Ruohonen, S. T., Savontaus, E., Inada, M., Krane, S. M., & Kähäri, V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042596 · Cited by 115 · see citing works
Self-citationStromelysin-2 is Upregulated During Normal Wound Repair and is Induced by Cytokines
Rechardt, O., Vaalamo, M., Höök‐Nikanne, J., Saarialho‐Kere, U., Elomaa, O., Pääkkönen, K., Jahkola, T., Hembry, R. M., Häkkinen, L., & Kere, J. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00135.x · Cited by 111 · see citing works
MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages
Rohani, M. G., McMahan, R. S., Razumova, M. V., Hertz, A. L., Cieslewicz, M., Pun, S. H., Regnier, M., Wang, Y., Birkland, T. P., & Parks, W. C. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.167 · Cited by 101 · see citing works
Ravanti, L., Toriseva, M., Penttinen, R. P. K., Crombleholme, T. M., Foschi, M., Han, J., & Kähäri, V. (2001) · PubMed · Cited by 73 · see citing works
Self-citationMatrix Metalloproteinase-13 Promotes Recovery from Experimental Liver Cirrhosis in Rats
Endo, H., Niioka, M., Sugioka, Y., Itoh, J., Kameyama, K., Okazaki, I., Ala‐aho, R., Kähäri, V., & Watanabe, T. (2011) · Pathobiology · doi:10.1159/000328841 · Cited by 68 · see citing works
Self-citationRavanti, L., Toriseva, M., Penttinen, R. P. K., Crombleholme, T. M., Foschi, M., Han, J., & Kähäri, V. (2001) · The FASEB Journal · doi:10.1096/fj.00-0588fje · Cited by 37 · see citing works
Self-citation
Flagged first, then by citations
2 of the 30 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Transition from inflammation to proliferation: a critical step during wound healing
Landén, N. X., Li, D., & Ståhle, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2268-0 · Cited by 1,980 · see citing works
“, matrix metalloproteinases (MMPs), to degrade provisional matrix [40, 41]; while depositing collagen and other extracellular matrix (ECM) components, e.”
BackgroundMacrophages as a therapeutic target to promote diabetic wound healing
Sharifiaghdam, M., Shaabani, E., Majidi, R. F., Smedt, S. C. D., Braeckmans, K., & Fraire, J. C. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.07.016 · Cited by 596 · see citing works
Extracellular matrix regulation of fibroblast function: redefining our perspective on skin aging
Cole, M. A., Quan, T., Voorhees, J. J., & Fisher, G. J. (2018) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-018-0459-1 · Cited by 365 · see citing works
Cai, J., Feng, J., Liu, K., Zhou, S., & Lu, F. (2017) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000004028 · Cited by 113 · see citing works
Nanopolyphenols: a review of their encapsulation and anti-diabetic effects
Rambaran, T. F. (2020) · SN Applied Sciences · doi:10.1007/s42452-020-3110-8 · Cited by 82 · see citing works
ten Brink, T., Damanik, F., Rotmans, J. I., & Moroni, L. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202301939 · Cited by 71 · see citing works
Zhang, C., Niu, J., Chong, Y.-S., Huang, Y., Chu, Y., Xie, S.-Y., Jiang, Z., & Peng, L. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.09.005 · Cited by 71 · see citing works
Direct and Indirect Roles of Macrophages in Hypertrophic Scar Formation
Feng, Y., Sun, Z., Liu, S., Wu, J., Zhao, B.-H., Lv, G., Du, Y., Yu, S., Yang, M., Yuan, F., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01101 · Cited by 68 · see citing works
Jo, Y., Kweon, H., Kim, D. W., Kim, M.-K., Kim, S., Kim, J.-Y., Chae, W., Hong, S., Park, Y.-H., Lee, S. Y., et al. (2017) · Scientific Reports · doi:10.1038/srep42441 · Cited by 56 · see citing works
Song, H., Zhang, L., Luo, Y., Zhang, S., & Лі, Б. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13317 · Cited by 34 · see citing works
Evaluation of Dermal Toxicity and Wound Healing Activity of Cnestis ferruginea Vahl ex DC
Ankomah, A. D., Boakye, Y. D., Agana, T. A., Boamah, V. E., Ossei, P. P. S., Adu, F., & Agyare, C. (2022) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/2022/5268613 · Cited by 31 · see citing works
Involvement of DPP IV/CD26 in cutaneous wound healing process in mice
Batičić, L., Pugel, E. P., Detel, D., & Varljen, J. (2016) · Wound Repair and Regeneration · doi:10.1111/wrr.12498 · Cited by 29 · see citing works
Oargă, D. P., Cornea‐Cipcigan, M., & Cordea, M. I. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1390419 · Cited by 29 · see citing works
Shao, Y., Zhou, S., Zhou, S., Long, J., Jin, L., Shi, X., Zhou, L., Zhang, Y., & Fan, D. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.114488 · Cited by 25 · see citing works
Recent Developments in Extracellular Matrix Remodeling for Fat Grafting
Bi, X., Li, Y., Dong, Z., Zhao, J., Wu, W., Zou, J., Guo, L., Lu, F., & Gao, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.767362 · Cited by 27 · see citing works
MMP-13 is involved in oral cancer cell metastasis
Huang, S.-H., Law, C., Kuo, P.-H., Hu, R., Yang, C.-C., Chung, T.-W., Li, J.-M., Lin, L., Liu, Y., Liao, E., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7942 · Cited by 24 · see citing works
RetractedRenal Mononuclear Phagocytes in Lupus Nephritis
Davidson, A. (2021) · ACR Open Rheumatology · doi:10.1002/acr2.11269 · Cited by 22 · see citing works
Lei, Z., Cao, Z., Yang, Z., Ao, M., Jin, W., & Yu, L. (2018) · Planta Medica · doi:10.1055/a-0725-8456 · Cited by 21 · see citing works
Fluoroquinolone-Mediated Tendinopathy and Tendon Rupture
Duman, E., Müller-Deubert, S. M., Pattappa, G., Stratos, I., Sieber, S. A., Clausen‐Schaumann, H., Sarafian, V. S., Shukunami, C., Rudert, M., & Docheva, D. (2025) · Pharmaceuticals · doi:10.3390/ph18020184 · Cited by 19 · see citing works
Rare earth cerium oxide nanoparticles attenuated liver fibrosis in bile duct ligation mice model
Godugu, C., Khurana, A., & Saifi, M. A. (2022) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.127102 · Cited by 19 · see citing works
Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials
Karkanitsa, M. L., Fathi, P., Ngo, T. B., & Sadtler, K. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.730938 · Cited by 18 · see citing works
Donato, A. C., Belluzzi, E., Mattiuzzo, E., Venerando, R., Cadamuro, M., Ruggieri, P., Vindigni, V., & Brun, P. (2022) · Polymers · doi:10.3390/polym14091817 · Cited by 16 · see citing works
Efficacy of Aeschynomene indica L. leaves for wound healing and isolation of active constituent
Lei, Z.-Y., Chen, J., Cao, Z., Ao, M., & Yu, L. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.08.008 · Cited by 16 · see citing works
Impact of Epigenetics, Diet, and Nutrition-Related Pathologies on Wound Healing
Hajj, J. P., Sizemore, B., & Singh, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910474 · Cited by 19 · see citing works
Chai, H., Wang, Z., Ju, J., & Sun, J. (2025) · Advanced NanoBiomed Research · doi:10.1002/anbr.202500147 · Cited by 7 · see citing works
Degradation and release of tannic acid from an injectable tissue regeneration bead matrix in vivo
Baldwin, A., Hartl, M. J., Tschaikowsky, M., Balzer, B. N., & Booth, B. W. (2021) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34990 · Cited by 7 · see citing works
Isoprenaline Induces Periostin Expression in Gastric Cancer
Liu, G.-X., Xi, H., Sun, X.-Y., Geng, Z.-J., Yang, S.-W., Lu, Y.-J., Wei, B., & Chen, L. (2016) · Yonsei Medical Journal · doi:10.3349/ymj.2016.57.3.557 · Cited by 6 · see citing works
Helmy, N. A., Aziz, E. A. A., Raouf, M. A. E., Korany, R. M. S., Mansour, D. A., Baraka, S. M., Hassan, A. A., Gomaa, E., Faisal, M. M., Basha, W. A. A., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0315673 · Cited by 5 · see citing works
Ha, S., Vetrivel, P., Kim, S. M., Bhosale, P. B., Kim, H., Pak, J. E., Heo, J., Kim, Y., & Kim, G. S. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12641 · Cited by 5 · see citing works
Mardiyantoro, F., Prasetyaningrum, N., & Rahmastuti, H. T. (2020) · Majalah Kedokteran Gigi Indonesia · doi:10.22146/majkedgiind.39830 · Cited by 4 · see citing works
The aging epidermal skin niche
Zhuang, L., & Kaur, P. (2020) · Advances in stem cells and their niches · doi:10.1016/bs.asn.2020.06.002 · Cited by 3 · see citing works
Lu, S., Lu, A., & Paslin, D. A. (2020) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000655468.08618.fc · Cited by 3 · see citing works
Ying, K., Xin, W., Xu, Y., Lv, D., Zhu, H., Li, Y., Xu, W., Yan, C., Li, Y., Cheng, H., et al. (2024) · Advanced Science · doi:10.1002/advs.202308166 · Cited by 2 · see citing works
Phytotherapeutic insights into wound healing: unveiling the potential of Agrimonia eupatoria L.
Čoma, M., Fialová, S. B., Mučaji, P., & Gál, P. (2025) · Phytochemistry Reviews · doi:10.1007/s11101-025-10203-9 · Cited by 1 · see citing works
The effects of the recipient site on fat graft survival in a murine model
Tutak, F. N., & Bakırhan, E. G. (2022) · European Journal of Plastic Surgery · doi:10.1007/s00238-022-01979-6 · Cited by 1 · see citing works
Manjunatha, B. S., Handge, K. T., Shah, V., Al-Thobaiti, Y. E., & Pateel, D. G. S. (2024) · World Journal of Methodology · doi:10.5662/wjm.v15.i2.94514
- Authors
- Nissinen, L. M., & Kähäri, V.-M.
- Affiliations
- University of Turku (FI)
- Corresponding author
- Kähäri, Veli-Matti
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 135
- Issue
- 10
- Pages
- 2350-2352
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2194612341
- Cited by
- 37
- References
- 30
- Citations by year
- 2025: 4 · 2024: 6 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 5
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- collagen turnover, wound healing, macrophages, MMP-10, stromelysin-2, MMP-13, collagen degradation, extracellular matrix remodeling, M2 macrophages, scar formation, skin wound healing
- MeSH terms
- Animals, Female, Humans, Male, Skin, Wounds and Injuries, Collagenases, Matrix Metalloproteinase 10
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