Bone: from a reservoir of minerals to a regulator of energy metabolism
Open accessAbstract
Besides locomotion, organ protection, and calcium-phosphorus homeostasis, the three classical functions of the skeleton, bone remodeling affects energy metabolism through uncarboxylated osteocalcin, a recently discovered hormone secreted by osteoblasts. This review traces how energy metabolism affects osteoblasts through the central control of bone mass involving leptin, serotoninergic neurons, the hypothalamus, and the sympathetic nervous system. Next, the role of osteocalcin (insulin secretion, insulin sensitivity, and pancreas β-cell proliferation) in the regulation of energy metabolism is described. Then, the connections between insulin signaling on osteoblasts and the release of uncarboxylated osteocalcin during osteoclast bone resorption through osteoprotegerin are reported. Finally, the understanding of this new bone endocrinology will provide some insights into bone, kidney, and energy metabolism in patients with chronic kidney disease.
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Undercarboxylated osteocalcin has lower affinity to minerals due to acidification during osteoclast resorption, and is carried by bloodstream to other organs.
“The undercarboxylated form shows lower affinity to minerals, due to acidification of bone matrix during osteoclast bone resorption, and then it is ferried by the bloodstream, reaching other organs [204, 205].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [205]
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- Authors
- Confavreux, C. B.
- Affiliations
- Inserm (FR)
- Corresponding author
- Confavreux, Cyrille B.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 79
- Issue
- 121
- Pages
- S14-S19
- ISSN
- 0085-2538 (ISSN-L)
- PMC
- PMC3257050
- OpenAlex
- W2008654911
- Cited by
- 113
- References
- 32
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 7 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 5 · 2015: 12 · 2014: 13 · 2013: 11 · 2012: 10
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Association pour la Recherche sur le Cancer
- Philippe Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- uncarboxylated osteocalcin, energy metabolism, osteoblasts, leptin, serotonergic neurons, hypothalamus, sympathetic nervous system, insulin secretion, insulin sensitivity, beta-cell proliferation, osteoprotegerin, osteoclast resorption, bone remodeling, chronic kidney disease, calcium and phosphorus homeostasis
- MeSH terms
- Bone and Bones, Energy Metabolism, Humans, Insulin, Minerals, Serotonin, Osteocalcin, Leptin, Osteoprotegerin
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