β-Adrenergic Blockers Reduce the Risk of Fracture Partly by Increasing Bone Mineral Density: Geelong Osteoporosis Study
Abstract
Unlabelled This population-based study documented beta-blocker use in 59/569 cases with incident fracture and 112/775 controls. OR for fracture associated with beta-blocker use was 0.68 (95%CI, 0.49-0.96). Beta-blockers were associated with higher BMD at the total hip (2.5%) and UD forearm (3.6%) after adjusting for age, anthropometry, and thiazide use. Beta-blocker use is associated with reduced fracture risk and higher BMD. Introduction Animal data suggests that bone formation is under beta-adrenergic control and that beta-blockers stimulate bone formation and/or inhibit bone resorption. Materials and methods We evaluated the association between beta-blocker use, bone mineral density (BMD), and fracture risk in a population-based study in Geelong, a southeastern Australian city with a single teaching hospital and two radiological centers providing complete fracture ascertainment for the region. Beta-blocker use was documented for 569 women with radiologically confirmed incident fractures and 775 controls without incident fracture. Medication use and lifestyle factors were documented by questionnaire. Results Odds ratio for fracture associated with beta-blocker use was 0.68 (95% CI, 0.49-0.96) for any fracture. Adjusting for age, weight, medications, and lifestyle factors had little effect on the odds ratio. Beta-blocker use was associated with a higher BMD at the total hip (2.5%, p = 0.03) and ultradistal forearm (3.6%, p = 0.04) after adjustment for age, anthropometry, and…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A type I collagen α1 first-intron polymorphism and high homocysteine can affect fracture risk independently of BMD.
“A polymorphism of the first intron of the gene coding for the type I collagen α1 chain and increased levels of homocysteine can influence fracture risk independent of BMD”
From Pathogenesis of osteoporosis: concepts, conflicts, and prospects (2005) · cites this paper as [102]
Cites
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889 · see citing works
Leptin Regulates Bone Formation via the Sympathetic Nervous System
Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., Armstrong, D., Ducy, P., & Karsenty, G. (2002) · Cell · doi:10.1016/s0092-8674(02)01049-8 · Cited by 1,735 · see citing works
Prevention of spinal osteoporosis in oophorectomised women
Lindsay, R., Hart, D. M., Forrest, C., & Baird, C. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92592-1 · Cited by 706 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pathogenesis of osteoporosis: concepts, conflicts, and prospects
Raisz, L. G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27071 · Cited by 1,779 · see citing works
Koerner, A., Kratzsch, J., & Kiess, W. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.07.008 · Cited by 471 · see citing works
Regulation of bone remodeling by the central and peripheral nervous system
Elefteriou, F. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.016 · Cited by 229 · see citing works
Decreased Bone Formation and Osteopenia in Mice Lacking α-Calcitonin Gene-Related Peptide
Schinke, T., Liese, S., Priemel, M., Haberland, M., Schilling, A. F., Catala-Lehnen, P., Blicharski, D., Rueger, J. M., Gagel, R. F., Emeson, R. B., et al. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040915 · Cited by 177 · see citing works
β-Blocker Use, BMD, and Fractures in the Study of Osteoporotic Fractures
Reid, I. R., Gamble, G. D., Grey, A. B., Black, D. M., Ensrud, K. E., Browner, W. S., & Bauer, D. C. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041202 · Cited by 156 · see citing works
Risk of fractures in older adults using antihypertensive medications
Solomon, D. H., Mogun, H., Garneau, K., & Fischer, M. A. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.356 · Cited by 121 · see citing works
Bone: from a reservoir of minerals to a regulator of energy metabolism
Confavreux, C. B. (2011) · Kidney International · doi:10.1038/ki.2011.25 · Cited by 113 · see citing works
Ma, Y., Nyman, J. S., Tao, H., Moss, H. H., Yang, X., & Elefteriou, F. (2011) · Endocrinology · doi:10.1210/en.2010-0881 · Cited by 92 · see citing works
The role of calcitonin and α-calcitonin gene-related peptide in bone formation
Huebner, A. K., Keller, J., Catala-Lehnen, P., Perkovic, S., Streichert, T., Emeson, R. B., Amling, M., & Schinke, T. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.02.013 · Cited by 73 · see citing works
Levothyroxine Dose and Fracture Risk According to the Osteoporosis Status in Elderly Women
Ko, Y.-J., Kim, J. Y., Lee, J., Song, H.-J., Kim, J.-Y., Choi, N.-K., & Park, B.-J. (2014) · Journal of Preventive Medicine & Public Health · doi:10.3961/jpmph.2014.47.1.36 · Cited by 47 · see citing works
- Authors
- Pasco, J. A., Henry, M. J., Sanders, K. M., Kotowicz, M. A., Seeman, E., & Nicholson, G. C.
- Affiliations
- Barwon Health (AU)
- The University of Melbourne (AU)
- Corresponding author
- Pasco, Julie A
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-01-01
- Volume
- 19
- Issue
- 1
- Pages
- 19-24
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2046396082
- Cited by
- 260
- References
- 3
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 9 · 2016: 2 · 2015: 11 · 2014: 15 · 2013: 13 · 2012: 12
- FWCI
- 21.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Geelong Region Medical Research Foundation
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- beta-blockers, fracture risk, bone mineral density, osteoporosis, hip bone density, forearm bone mineral density, thiazide diuretics, women, Geelong Osteoporosis Study
- MeSH terms
- Adrenergic beta-Antagonists, Aged, Anthropometry, Bones of Upper Extremity, Australia, Bone and Bones, Cardiovascular Diseases, Female, Femur, Femur Neck, Humans, Lumbar Vertebrae, Middle Aged, Surveys and Questionnaires, Regression Analysis, Bone Density, Odds Ratio, Case-Control Studies, Fractures, Bone
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
