The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis
Open accessAbstract
Primary focal segmental glomerulosclerosis (FSGS) is a disease with poor prognosis and high unmet therapeutic need. Here, we evaluated the safety and pharmacokinetics of single-dose infusions of fresolimumab, a human monoclonal antibody that inactivates all forms of transforming growth factor-β (TGF-β), in a phase I open-label, dose-ranging study. Patients with biopsy-confirmed, treatment-resistant, primary FSGS with a minimum estimated glomerular filtration rate (eGFR) of 25 ml/min per 1.73 m(2), and a urine protein to creatinine ratio over 1.8 mg/mg were eligible. All 16 patients completed the study in which each received one of four single-dose levels of fresolimumab (up to 4 mg/kg) and was followed for 112 days. Fresolimumab was well tolerated with pustular rash the only adverse event in two patients. One patient was diagnosed with a histologically confirmed primitive neuroectodermal tumor 2 years after fresolimumab treatment. Consistent with treatment-resistant FSGS, there was a slight decline in eGFR (median decline baseline to final of 5.85 ml/min per 1.73 m(2)). Proteinuria fluctuated during the study with the median decline from baseline to final in urine protein to creatinine ratio of 1.2 mg/mg with all three Black patients having a mean decline of 3.6 mg/mg. The half-life of fresolimumab was ∼14 days, and the mean dose-normalized Cmax and area under the curve were independent of dose. Thus, single-dose fresolimumab was well tolerated in patients with primary resistant FSGS. Additional evaluation in a larger dose-ranging study is necessary.
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Levey, A. S., Coresh, J., Bolton, K., Culleton, B. F., Harvey, K. S., Ikizler, T. A., Johnson, C. A., Kausz, A., Kimmel, P. L., Kusek, J. W., et al. (2002) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 11,633
Levey, A. S., Coresh, J., Balk, E., Kausz, A. T., Levin, A., Steffes, M. W., Hogg, R. J., Perrone, R. D., Lau, J., & Eknoyan, G. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-2-200307150-00013 · Cited by 4,615
Peterson, J. C., Adler, S., Burkart, J. M., Greene, T., Hebert, L. A., Hunsicker, L. G., King, A. J., Klahr, S., Massry, S. G., Seifter, J. L., et al. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-123-10-199511150-00003 · Cited by 1,342
Jafar, T. H., Schmid, C. H., Landa, M., Giatras, I., Toto, R., Remuzzi, G., Maschio, G., Brenner, B. M., Kamper, A., Zucchelli, P., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-135-2-200107170-00007 · Cited by 1,092
Self-citationPathologic classification of focal segmental glomerulosclerosis: a working proposal
D'Agati, V. D., Fogo, A. B., Bruijn, J. A., & Jennette, J. C. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2003.10.024 · Cited by 776
Apoptosis in podocytes induced by TGF-β and Smad7
Schiffer, M., Bitzer, M., Roberts, I. S. D., Kopp, J. B., ten Dijke, P., Mundel, P., & Böttinger, E. P. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12367 · Cited by 598
Morris, J. C., Tan, A. R., Olencki, T. E., Shapiro, G. I., Dezube, B. J., Reiss, M., Hsu, F. J., Berzofsky, J. A., & Lawrence, D. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090353 · Cited by 487
The Notch pathway in podocytes plays a role in the development of glomerular disease
Niranjan, T., Bielesz, B., Gruenwald, A., Ponda, M. P., Kopp, J. B., Thomas, D. B., & Susztak, K. (2008) · Nature Medicine · doi:10.1038/nm1731 · Cited by 427
Cattran, D. C., Appel, G. B., Hebert, L. A., Hunsicker, L. G., Pohl, M. A., Hoy, W. E., Maxwell, D. R., & Kunis, C. L. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00778.x · Cited by 326
A randomized trial of cyclosporine in steroid-resistant idiopathic nephrotic syndrome
Ponticelli, C., Rizzoni, G., Edefonti, A., Altieri, P., Rivolta, E., Rinaldi, S., Ghio, L., Lusvarghi, E., Gusmano, R., Locatelli, F., et al. (1993) · Kidney International · doi:10.1038/ki.1993.194 · Cited by 288
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Metadata
- Authors
- Trachtman, H., Fervenza, F. C., Gipson, D. S., Heering, P., Jayne, D. R. W., Peters, H., Rota, S., Remuzzi, G., Rump, L. C., Sellin, L. K., Heaton, J. P. W., Streisand, J. B., Hard, M. L., Ledbetter, S. R., & Vincenti, F.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 79
- Issue
- 11
- Pages
- 1236-1243
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2112988722
- Cited by
- 263
- References
- 34
- FWCI
- 13.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Trachtman, H., Fervenza, F. C., Gipson, D. S., Heering, P., Jayne, D. R. W., Peters, H., Rota, S., Remuzzi, G., Rump, L. C., Sellin, L. K., Heaton, J. P. W., Streisand, J. B., Hard, M. L., Ledbetter, S. R., & Vincenti, F. (2011). A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis. Kidney International. https://doi.org/10.1038/ki.2011.33
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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