Sodium nitrite protects against kidney injury induced by brain death and improves post-transplant function
Open accessAbstract
Renal injury induced by brain death is characterized by ischemia and inflammation, and limiting it is a therapeutic goal that could improve outcomes in kidney transplantation. Brain death resulted in decreased circulating nitrite levels and increased infiltrating inflammatory cell infiltration into the kidney. Since nitrite stimulates nitric oxide signaling in ischemic tissues, we tested whether nitrite therapy was beneficial in a rat model of brain death followed by kidney transplantation. Nitrite, administered over 2 h of brain death, blunted the increased inflammation without affecting brain death-induced alterations in hemodynamics. Kidneys were transplanted after 2 h of brain death and renal function followed over 7 days. Allografts collected from nitrite-treated brain-dead rats showed significant improvement in function over the first 2 to 4 days after transplantation compared with untreated brain-dead animals. Gene microarray analysis after 2 h of brain death without or with nitrite therapy showed that the latter significantly altered the expression of about 400 genes. Ingenuity Pathway Analysis indicated that multiple signaling pathways were affected by nitrite, including those related to hypoxia, transcription, and genes related to humoral immune responses. Thus, nitrite therapy attenuates brain death-induced renal injury by regulating responses to ischemia and inflammation, ultimately leading to better post-transplant kidney function.
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Nitrite supplementation preserves or increases antioxidant capacity in the heart after acute nitrite exposure under basal conditions.
“Nitrite supplementation also preserves or increases antioxidant capacity in the heart after an acute nitrite exposure under basal conditions (43, 89, 113, 148)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [89]
Nitrite lessens inflammation caused by ischemia in various organs.
“Nitrite also lessens inflammation caused by ischemia in various organs (89, 125, 140, 146, 147, 176, 197)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [89]
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- Authors
- Kelpke, S. S., Chen, B., Bradley, K. M., Teng, X., Chumley, P., Brandon, A., Yancey, B., Moore, B., Head, H., Viera, L., Thompson, J. A., Crossman, D. K., Bray, M. S., Eckhoff, D. E., Agarwal, A., & Patel, R. P.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Patel, Rakesh P.
- ORCID
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 82
- Issue
- 3
- Pages
- 304-313
- ISSN
- 0085-2538 (ISSN-L)
- PMC
- PMC3412933
- OpenAlex
- W1981237798
- Cited by
- 28
- References
- 48
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 2
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL092624, R01HL092624)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079337, R21DK071300, 5R1 DK071300)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR048311)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Organ Donation and Transplantation
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Keywords
- sodium nitrite, brain death, kidney transplantation, renal ischemia, renal inflammation, nitric oxide signaling, allograft function, hypoxia, humoral immune response, gene expression profiling
- MeSH terms
- Allopurinol, Animals, Benzoates, Brain Death, Hemodynamics, Imidazoles, Inflammation, Kidney, Male, Nitrites, Rats, Inbred Lew, Sodium Nitrite, Lipid Peroxidation, Signal Transduction, Reperfusion Injury, Gene Expression, Kidney Transplantation, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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