Effects of sodium nitrite on ischemia–reperfusion injury in the rat kidney
Abstract
Reactive oxygen and nitrogen species play a key role in the pathophysiology of renal ischemia-reperfusion (I/R) injury. Recent studies have shown that nitrite (NO(2)(-)) serves as an endogenous source of nitric oxide (NO), particularly in the presence of hypoxia and acidosis. Nanomolar concentrations of NO(2)(-) reduce injury following I/R in the liver and heart in vivo. The purpose of this study was to evaluate the role of NO(2)(-) in renal I/R injury. Male Sprague-Dawley rats underwent a unilateral nephrectomy followed by 45 min of ischemia of the contralateral kidney or sham surgery under isoflurane anesthesia. Animals received normal saline, sodium NO(2)(-), or sodium nitrate (NO(3)(-); 1.2 nmol/g body wt ip) at 22.5 min after induction of ischemia or 15 min before ischemia. A separate set of animals received saline, NO(2)(-), or NO(3)(-) (0.12, 1.2, or 12 nmol/g body wt iv) 45 min before ischemia. Serum creatinine and blood urea nitrogen were increased following I/R injury but were not significantly different among treatment groups at 24 and 48 h after acute renal injury. Interestingly, NO(3)(-) administration appeared to worsen renal injury. Histological scoring for loss of brush border, tubular necrosis, and red blood cell extravasation showed no significant differences among the treatment groups. The results indicate that, contrary to the protective effects of NO(2)(-) in I/R injury of the liver and heart, NO(2)(-) does not provide protection in renal I/R injury and suggest a unique metabolism of NO(2)(-) in the kidney.
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Nitrite therapy is protective against ischemia-reperfusion injury in the kidney, depending on route of administration.
“Several other studies extended the idea that nitrite therapy is protective against ischemia-reperfusion injury in different organs including the brain [157] and kidney (depending on route of administration) [158, 159].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [159]
Nitrite therapy is protective against ischemia-reperfusion injury in the kidney, depending on route of administration.
“Several other studies extended the idea that nitrite therapy is protective against ischemia-reperfusion injury in different organs including the brain [157] and kidney (depending on route of administration) [158, 159].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [158]
Cites
Hospital-acquired renal insufficiency
Nash, K., Hafeez, A., & Hou, S. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.32766 · Cited by 1,955 · see citing works
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807 · see citing works
Self-citationOxygen free radicals in ischemic acute renal failure in the rat.
Paller, M. S., Hoidal, J. R., & Ferris, T. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111524 · Cited by 1,080 · see citing works
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674 · cited 7× · see citing works
“2, and 12 nmol/g body wt of NO2 , resulting in a 2, 20, and 200 M final circulating concentrations, respectively (assuming rat blood volume of 6 ml/100 g), were used in these experiments based on previous studies in mouse hepatic and cardiac I/R injury (10).”
BackgroundMethodResultInfluentialSelf-citationWebb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608 · cited 9× · see citing works
“Similarly, NO2 was protective in an isolated cardiac I/R injury model (49), in hypoxia-induced pulmonary vasoconstriction (18), and in a hemorrhagic model of stroke (40).”
BackgroundInfluentialPlasma nitrite reflects constitutive nitric oxide synthase activity in mammals
Kleinbongard, P., Dejam, A., Lauer, T., Rassaf, T., Schindler, A., Picker, O., Scheeren, T., Gödecke, A., Schrader, J., Schulz, R., et al. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00406-4 · Cited by 586 · see citing works
Measurement of Nitric Oxide and Peroxynitrite Generation in the Postischemic Heart
Wang, P., & Zweier, J. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.29223 · Cited by 538 · see citing works
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
Huang, Z. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24650 · Cited by 520 · see citing works
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
Bryan, N. S., Fernandez, B. O., Bauer, S. M., Garcia-Saura, M. F., Milsom, A. B., Rassaf, T., Maloney, R. E., Bharti, A., Rodriguez, J., & Feelisch, M. (2005) · Nature Chemical Biology · doi:10.1038/nchembio734 · Cited by 518 · see citing works
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation
Crawford, J. H. (2006) · Blood · doi:10.1182/blood-2005-07-2668 · Cited by 497 · see citing works
Reactive oxygen species and acute renal failure.
Nath, K. A., & Norby, S. M. (2000) · American Journal of Medicine · doi:10.1016/s0002-9343(00)00612-4 · Cited by 421 · see citing works
Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase
Godber, B. L. J., Doel, J. J., Sapkota, G. P., Blake, D. R., Stevens, C. R., Eisenthal, R., & Harrison, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7757 · Cited by 411 · see citing works
Bryan, N. S., Rassaf, T., Maloney, R. E., Rodriguez, C. M., Saijo, F., Rodriguez, J. R., & Feelisch, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306706101 · Cited by 400 · see citing works
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation
Gladwin, M. T., Crawford, J. H., & Patel, R. P. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.11.032 · Cited by 378 · see citing works
Self-citationNO-dependent protein nitration: a cell signaling event or an oxidative inflammatory response?
Schopfer, F. J. (2003) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2003.10.006 · Cited by 369 · see citing works
Oxidative and nitrosative stress in acute renal ischemia
Noiri, E., Nakao, A., Uchida, K., Tsukahara, H., Ohno, M., Fujita, T., Brodsky, S. V., & Goligorsky, M. S. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.281.5.f948 · Cited by 366 · see citing works
Erythrocytes are the major intravascular storage sites of nitrite in human blood
Dejam, A. (2005) · Blood · doi:10.1182/blood-2005-02-0567 · Cited by 350 · see citing works
Nagababu, E., Ramasamy, S., Abernethy, D. R., & Rifkind, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307572200 · Cited by 349 · see citing works
Nitrite‐derived nitric oxide: a possible mediator of ‘acidic–metabolic’ vasodilation
Modin, A., Björne, H., Herulf, M., Alving, K., Weitzberg, E., & Lundberg, J. O. N. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00771.x · Cited by 346 · see citing works
Noiri, E., Peresleni, T., Miller, F. W., & Goligorsky, M. S. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118681 · Cited by 341 · see citing works
NO Generation From Nitrite and Its Role in Vascular Control
Lundberg, J. O., & Weitzberg, E. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000161048.72004.c2 · Cited by 341 · see citing works
Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.
Doyle, M. P., Pickering, R. A., DeWeert, T. M., Hoekstra, J. W., & Pater, D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43285-1 · Cited by 334 · see citing works
Nitric oxide: a mediator in rat tubularhypoxia/reoxygenation injury.
Yu, L., Gengaro, P. E., Niederberger, M., Burke, T. J., & Schrier, R. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.5.1691 · Cited by 318 · see citing works
Nitric oxide in acute renal failure: NOS versus NOS
Goligorsky, M. S., Brodsky, S. V., & Noiri, E. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00233.x · Cited by 284 · see citing works
Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator
Hunter, C. J., Dejam, A., Blood, A. B., Shields, H., Kim-Shapiro, D. B., Machado, R. F., Tarekegn, S., Mulla, N., Hopper, A. O., Schechter, A. N., et al. (2004) · Nature Medicine · doi:10.1038/nm1109 · Cited by 281 · see citing works
Characterization of the Magnitude and Kinetics of Xanthine Oxidase-catalyzed Nitrite Reduction
Li, H., Samouilov, A., Liu, X., & Zweier, J. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011648200 · Cited by 280 · see citing works
Pluta, R. M. (2005) · JAMA · doi:10.1001/jama.293.12.1477 · Cited by 261 · see citing works
The Reaction between Nitrite and Deoxyhemoglobin
Huang, K. T., Keszler, A., Patel, N., Patel, R. P., Gladwin, M. T., Kim-Shapiro, D. B., & Hogg, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501496200 · Cited by 253 · see citing works
Self-citationNitrite in saliva increases gastric mucosal blood flow and mucus thickness
Björne, H., Petersson, J., Phillipson, M., Weitzberg, E., Holm, L., & Lundberg, J. O. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19019 · Cited by 246 · see citing works
Luchsinger, B. P., Rich, E. N., Gow, A. J., Williams, E. M., Stamler, J. S., & Singel, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0233287100 · Cited by 202 · see citing works
Jaruga, B., Hong, F., Kim, W., & Gao, B. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00184.2004 · Cited by 169 · see citing works
Attenuation of renal ischemia-reperfusion injury in inducible nitric oxide synthase knockout mice
Ling, H., Edelstein, C. L., Gengaro, P. E., Meng, X., Lucia, S. M., Knotek, M., Wangsiripaisan, A., Shi, Y., & Schrier, R. W. (1999) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1999.277.3.f383 · Cited by 160 · see citing works
Singri, N., Ahya, S. N., & Levin, M. L. (2003) · JAMA · doi:10.1001/jama.289.6.747 · Cited by 152 · see citing works
Nitric oxide synthesis in the kidney: isoforms, biosynthesis, and functions in health
Kone, B. C. (2004) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2004.04.002 · Cited by 112 · see citing works
Crawford, J. H., Chacko, B. K., Pruitt, H. M., Piknova, B., Hogg, N., & Patel, R. P. (2004) · Blood · doi:10.1182/blood-2004-03-0880 · Cited by 111 · see citing works
Self-citationGoligorsky, M. S., Brodsky, S. V., & Noiri, E. (2004) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2004.04.003 · Cited by 106 · see citing works
Outcomes in acute renal failure.
Liaño, F., & Pascual, J. (1998) · PubMed · Cited by 102 · see citing works
Schneider, R., Raff, U., Vornberger, N., Schmidt, M., Freund, R., Reber, M., Schramm, L., Gambaryan, S. P., Wanner, C., Schmidt, H. H. H. W., et al. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00063.x · Cited by 91 · see citing works
Effect of hypoxia on proximal tubules isolated from nitric oxide synthase knockout mice
Ling, H., Gengaro, P. E., Edelstein, C. L., Martin, P., Wangsiripaisan, A., Nemenoff, R. A., & Schrier, R. W. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00913.x · Cited by 88 · see citing works
Chiu, T. T., Santiskulvong, C., & Rozengurt, E. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00200.2004 · Cited by 86 · see citing works
Ms, C., Chin, P. S., Vemulapalli, S., Watkins, R. W., & Sybertz, E. J. (1993) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00169160 · Cited by 81 · see citing works
Wang, W., Mitra, A., Poole, B., Falk, S. A., Lucia, M. S., Tayal, S., & Schrier, R. W. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00136.2004 · Cited by 81 · see citing works
Effect of sodium nitrate loading on electrolyte transport by the renal tubule
Kahn, T., Bosch, J., Levitt, M., & Goldstein, M. B. (1975) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1975.229.3.746 · Cited by 72 · see citing works
Nitrosyl-Heme Complexes Are Formed in the Ischemic Heart
Tiravanti, E., Samouilov, A., & Zweier, J. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311908200 · Cited by 67 · see citing works
An evaluation of antioxidant effects on recovery from postischemic acute renal failure.
Zager, R. A., Fuerstenberg, S. M., Baehr, P. H., Myerson, D., & Torok‐Storb, B. (1994) · Journal of the American Society of Nephrology · doi:10.1681/asn.v481588 · Cited by 66 · see citing works
Xanthine oxidase produces O2-. in posthypoxic injury of renal epithelial cells
Greene, E. L., & Paller, M. S. (1992) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1992.263.2.f251 · Cited by 66 · see citing works
Xanthine oxidase: evidence against a causative role in renal reperfusion injury
Joannidis, M., Gstraunthaler, G. J. A., & Pfaller, W. (1990) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1990.258.2.f232 · Cited by 56 · see citing works
Kurata, H., Takaoka, M., Kubo, Y., Katayama, T., Tsutsui, H., Takayama, J., Ohkita, M., & Matsumura, Y. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.05.026 · Cited by 51 · see citing works
Matsumura, Y., Nishiura, M., Deguchi, S., Hashimoto, N., Ogawa, T., & Seo, R. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37904-2 · Cited by 43 · see citing works
Rodríguez-Peña, A. B., García‐Criado, F. J., Eleno, N., Arévalo, M. A., & López-Novoa, J. M. (2004) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00560.x · Cited by 42 · see citing works
Nitrite-derived nitric oxide formation following ischemia-reperfusion injury in kidney
Okamoto, M., Tsuchiya, K., Kanematsu, Y., Izawa, Y., Yoshizumi, M., Kagawa, S., & Tamaki, T. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00036.2004 · Cited by 36 · see citing works
Effects of xanthine oxidase inhibition on ischemic acute renal failure in the rat
Zager, R. A., & Gmur, D. J. (1989) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1989.257.6.f953 · Cited by 30 · see citing works
Jeong, G. Y., Chung, K. Y., Lee, W. J., Kim, Y. S., & Sung, S. H. (2004) · Transplantation Proceedings · doi:10.1016/j.transproceed.2004.08.119 · Cited by 25 · see citing works
Raff, U., Schneider, R., Gambaryan, S. P., Seibold, S., Reber, M., Vornberger, N., Freund, R., Schramm, L., Wanner, C., & Galle, J. C. (2005) · Nephron Physiology · doi:10.1159/000086647 · Cited by 17 · see citing works
Impact des nitrates inorganiques sur l’aspect morphofonctionnel du rein chez le rat
Zaki, A., Chaoui, A. A., Chait, A., Aboussaouira, T., Zarrouk, K., & Himmi, T. (2005) · Therapies · doi:10.2515/therapie:2005010 · Cited by 4 · see citing works
Protective effect of FK409, a nitric oxide donor, on ischemic acute renal failure in rat
Nishiura, M., Deguchi, S., Seo, R., Ogawa, T., & Matsumura, Y. (1998) · The Japanese Journal of Pharmacology · doi:10.1016/s0021-5198(19)40394-6 · Cited by 2 · see citing works
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Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435 · see citing works
Gladwin, M. T., Raat, N. J. H., Shiva, S., Dezfulian, C., Hogg, N., Kim-Shapiro, D. B., & Patel, R. P. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00407.2006 · Cited by 329 · see citing works
Self-citationMitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury
Szeto, H. H., Liu, S., Soong, Y., Wu, D., Darrah, S. F., Cheng, F.-Y., Zhao, Z., Ganger, M. T., Tow, C., & Seshan, S. V. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010080808 · Cited by 308 · see citing works
Nitrite in nitric oxide biology: Cause or consequence?
Bryan, N. S. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.019 · Cited by 260 · see citing works
Jung, K.-H., Chu, K., Ko, S.-Y., Lee, S.-T., Sinn, D.-I., Park, D.-K., Kim, J.-M., Song, E.-C., Kim, M., & Roh, J.-K. (2006) · Stroke · doi:10.1161/01.str.0000245116.40163.1c · Cited by 253 · see citing works
Tripatara, P., Patel, N. S. A., Webb, A., Rathod, K., Lecomte, F. M. J., Mazzon, E., Cuzzocrea, S., Yaqoob, M. M., Ahluwalia, A., & Thiemermann, C. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006050450 · Cited by 226 · see citing works
Chatterjee, P. K. (2007) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0183-5 · Cited by 221 · see citing works
Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics
DEZFULIAN, C., RAAT, N., SHIVA, S., & GLADWIN, M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.05.001 · Cited by 198 · see citing works
Dietary Nitrate, Nitric Oxide, and Cardiovascular Health
Bondonno, C. P., Croft, K. D., & Hodgson, J. M. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.811212 · Cited by 141 · see citing works
Inorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113 · see citing works
Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes.
Vaghasiya, J., Sheth, N., Bhalodia, Y., & Manek, R. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2010.08.007 · Cited by 113 · see citing works
Carlström, M., & Montenegro, M. F. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12818 · Cited by 97 · see citing works
Nitrite mediates cytoprotection after ischemia/reperfusion by modulating mitochondrial function
Shiva, S., & Gladwin, M. T. (2009) · Basic Research in Cardiology · doi:10.1007/s00395-009-0009-3 · Cited by 91 · see citing works
Özbek, E., İlbey, Y. Ö., Özbek, M., Şimşek, A., Cekmen, M. B., & Somay, A. (2009) · Journal of Endourology · doi:10.1089/end.2009.0035 · Cited by 82 · see citing works
Isbell, T. S., Gladwin, M. T., & Patel, R. P. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00759.2007 · Cited by 82 · see citing works
Self-citationEffects of nitrite on modulating ROS generation following ischemia and reperfusion
Raat, N. J. H., Shiva, S., & Gladwin, M. T. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.02.002 · Cited by 79 · see citing works
Castiglione, N., Rinaldo, S., Giardina, G., Stelitano, V., & Cutruzzolà, F. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4196 · Cited by 79 · see citing works
Yang, T., Zhang, X., Tarnawski, L., Peleli, M., Zhuge, Z., Terrando, N., Harris, R. A., Olofsson, P. S., Larsson, E., Persson, A. E. G., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.06.002 · Cited by 80 · see citing works
Milsom, A. B., Patel, N. S. A., Mazzon, E., Tripatara, P., Storey, A., Mota-Filipe, H., Sepodes, B., Webb, A. J., Cuzzocrea, S., Hobbs, A. J., et al. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.10.010 · Cited by 67 · see citing works
Fadıllıoğlu, E., Kurçer, Z., Parlakpınar, H., Iraz, M., & Gürsul, C. (2008) · Archives of Pharmacal Research · doi:10.1007/s12272-001-1216-3 · Cited by 66 · see citing works
Rassaf, T., Ferdinandy, P., & Schulz, R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12291 · Cited by 62 · see citing works
Prathapasinghe, G. A., Siow, Y. L., Xu, Z., & Karmin, O. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00040.2008 · Cited by 60 · see citing works
Khatri, J., Mills, C. E., Maskell, P., Odongerel, C., & Webb, A. J. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12913 · Cited by 58 · see citing works
Nitrite as a mediator of ischemic preconditioning and cytoprotection
Murillo, D., Kamga, C., Mo, L., & Shiva, S. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.01.003 · Cited by 57 · see citing works
Augmentation of nitrite therapy in cerebral ischemia by NMDA receptor inhibition
Jung, K., Chu, K., Lee, S., Park, H.-K., Kim, J.-H., Kang, K., Kim, M., Lee, S. K., & Roh, J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.081 · Cited by 48 · see citing works
Exaggerated liver injury induced by renal ischemia reperfusion in diabetes: Effect of exenatide
Vaghasiya, J. D., Sheth, N. R., Bhalodia, Y. S., & Jivani, N. P. (2010) · Saudi Journal of Gastroenterology · doi:10.4103/1319-3767.65187 · Cited by 45 · see citing works
Nitrite Reduces Acute Lung Injury and Improves Survival in a Rat Lung Transplantation Model
Sugimoto, R., Okamoto, T., Nakao, A., Zhan, J., Wang, Y., Kohmoto, J., Tokita, D., Farver, C. F., Tarpey, M. M., Billiar, T. R., et al. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2012.04169.x · Cited by 40 · see citing works
Tawfik, M. K. (2012) · PubMed · Cited by 41 · see citing works
Nitric oxide production pathways in erythrocytes and plasma
Chen, K., & Popel, A. S. (2009) · Biorheology · doi:10.3233/bir-2009-0531 · Cited by 40 · see citing works
Sinha, S. S., Shiva, S., & Gladwin, M. T. (2008) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2008.05.001 · Cited by 37 · see citing works
Samal, A. A., Honavar, J., Brandon, A. P., Bradley, K. M., Doran, S. F., Liu, Y., Dunaway, C. W., Steele, C. H., Postlethwait, E. M., Squadrito, G. L., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.007 · Cited by 35 · see citing works
Self-citationSpeir, R. W., Stallings, J. D., Andrews, J. M., Gelnett, M. S., Brand, T. C., & Salgar, S. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126622 · Cited by 35 · see citing works
Kumar, P., Yang, Z., Lever, J. M., Chávez, M. D., Fatima, H., Crossman, D. K., Maynard, C. L., George, J. F., & Mitchell, T. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166442 · Cited by 32 · see citing works
Nitrite therapy for protection against ischemia-reperfusion injury
Lefer, D. J. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00470.2005 · Cited by 30 · see citing works
Hamburger, T., Broecker-Preuss, M., Hartmann, M., Schade, F. U., de Groot, H., & Petrat, F. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.01.024 · Cited by 28 · see citing works
Kelpke, S. S., Chen, B., Bradley, K. M., Teng, X., Chumley, P., Brandon, A., Yancey, B., Moore, B., Head, H., Viera, L., et al. (2012) · Kidney International · doi:10.1038/ki.2012.116 · Cited by 28 · see citing works
Self-citationRenovascular effects of inorganic nitrate following ischemia-reperfusion of the kidney
Zhang, G., Han, H., Zhuge, Z., Dong, F., Jiang, S., Wang, W., Guimarães, D. D., Schiffer, T. A., Lai, E. Y., Carvalho, L. R. R. A., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101836 · Cited by 27 · see citing works
Inhalation of NO during myocardial ischemia reduces infarct size and improves cardiac function
Neye, N., Enigk, F., Shiva, S., Habazettl, H., Plesnila, N., Kuppe, H., Gladwin, M. T., & Kuebler, W. M. (2012) · Intensive Care Medicine · doi:10.1007/s00134-012-2605-1 · Cited by 26 · see citing works
Portella, R. D. L., Bickta, J., & Shiva, S. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6260 · Cited by 21 · see citing works
Low dose nitrite improves reoxygenation following renal ischemia in rats
Cantow, K., Flemming, B., Wiegard, M., Persson, P. B., & Seeliger, E. (2017) · Scientific Reports · doi:10.1038/s41598-017-15058-5 · Cited by 21 · see citing works
Ötünçtemur, A., Özbek, E., Çakır, S. S., Dursun, M., Cekmen, M. B., Polat, E. C., Özcan, L., Somay, A., & Özbay, N. (2015) · International braz j urol · doi:10.1590/s1677-5538.ibju.2015.02.14 · Cited by 20 · see citing works
The novel nitric oxide donor PDNO attenuates ovine ischemia-reperfusion induced renal failure
Nilsson, K. F., Sandin, J. A., Gustafsson, L. E., & Frithiof, R. (2017) · Intensive Care Medicine Experimental · doi:10.1186/s40635-017-0143-4 · Cited by 19 · see citing works
Tong, F., Tang, X., Luo, L., Li, X., Xia, W., Lu, C. T., & Liu, D. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.04.118 · Cited by 17 · see citing works
Dietary sources of nitrite as a modulator of ischemia/reperfusion injury
Garg, H. K., & Bryan, N. S. (2009) · Kidney International · doi:10.1038/ki.2009.13 · Cited by 17 · see citing works
Colburn, T. D., Ferguson, S. K., Holdsworth, C. T., Craig, J. C., Musch, T. I., & Poole, D. C. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00367.2016 · Cited by 16 · see citing works
Sodium nitrite-derived nitric oxide protects rat testes against ischemia/reperfusion injury
Han, J., Lee, J., Lee, D., & Park, J. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_76_18 · Cited by 16 · see citing works
Schatlo, B., Henning, E. C., Pluta, R. M., Latour, L. L., Golpayegani, N., Merrill, M. J., Lewin, N., Chen, Y., & Oldfield, E. H. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600542 · Cited by 16 · see citing works
Mechanisms of Nitrite Reduction in Ischemia in the Cardiovascular System
Webb, A., & Ahluwalia, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00017-4 · Cited by 15 · see citing works
The macrophage stimulating anti-cancer agent, RRx-001, protects against ischemia-reperfusion injury
Cabrales, P., Caroen, S. Z., Oronsky, A. L., Carter, C. A., Trepel, J. B., Summers, T. A., Reid, T. R., Oronsky, N. C., Lybeck, M., & Oronsky, B. T. (2017) · Expert Review of Hematology · doi:10.1080/17474086.2017.1324779 · Cited by 15 · see citing works
Eobania vermiculata as a potential indicator of nitrate contamination in soil
Cofone, R., Carraturo, F., Capriello, T., Libralato, G., Siciliano, A., Giudice, C. D., Maio, N., Guida, M., & Ferrandino, I. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111082 · Cited by 15 · see citing works
Preserving vessel function during ischemic disease: new possibilities of inorganic nitrite therapy
Kevil, C. G., & Patel, R. P. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.9.1175 · Cited by 14 · see citing works
Self-citationEffect of photobiomodulation on ischemia/reperfusion-induced renal damage in diabetic rats
Asghari, A., Takhtfooladi, M. A., & Hoseinzadeh, H. A. (2016) · Lasers in Medical Science · doi:10.1007/s10103-016-2073-x · Cited by 12 · see citing works
Role of nitrates in the adaptation of fish to hypoxic conditions
Si, D., Żukow, W., Dzierżanowski, M., Mieszkowski, J., Muszkieta, R., & Klimczyk, M. (2016) · Water Resources · doi:10.1134/s0097807816120046 · Cited by 8 · see citing works
Shiva, S., Frizzell, S. A., & Gladwin, M. T. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00019-8 · Cited by 7 · see citing works
El-Gohary, O. A., & Said, M. A. (2016) · Benha Medical Journal · doi:10.4103/1110-208x.194384 · Cited by 6 · see citing works
Jeddi, S., Gheibi, S., Kashfi, K., & Ghasemi, A. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119870 · Cited by 6 · see citing works
Exenatide protects renal ischemia reperfusion injury in type 2 diabetes mellitus
Vaghasiya, J. D., Sheth, N. R., Bhalodia, Y. S., Malaviya, S., & Jivani, N. P. (2010) · International Journal of Diabetes in Developing Countries · doi:10.4103/0973-3930.70863 · Cited by 4 · see citing works
Cherif-Sayadi, A., Tka, K. H. A., Zaoualí, M. A., Béjaoui, M., Abdallah, N. H., Bouhlel, A., & Abdennebi, H. B. (2017) · Libyan Journal of Medicine · doi:10.1080/19932820.2017.1308780 · Cited by 3 · see citing works
Hydroxyproline increases inflammation and Uropathogenic E. coli (UPEC) infection in female rats
Kumar, P., Yang, Z., Fatima, H., & Mitchell, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-73246-6 · Cited by 3 · see citing works
Si, D., & Sataieva, T. (2015) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.5281/zenodo.13902 · Cited by 2 · see citing works
Lee, J. W., Hwang, E. T., & Han, J. S. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5514537 · Cited by 2 · see citing works
Nitrite and Nitrate in Ischemia–Reperfusion Injury
Lefer, D. J., Bryan, N. S., & Organ, C. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_16 · Cited by 2 · see citing works
Nitrite and Nitrate in Ischemia-Reperfusion Injury
Lavu, M., Gundewar, S., & Lefer, D. J. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-616-0_14 · Cited by 2 · see citing works
Colburn, T. D. (2016) · K-State Research Exchange (Kansas State University) · Cited by 2 · see citing works
Vaghasiya, J. D., Sheth, N. R., Bhalodia, Y. S., & Jivani, N. (2009) · Journal of Young Pharmacists · doi:10.4103/0975-1483.55748 · Cited by 1 · see citing works
Zeid, A. A., & Shafik, N. M. (2012) · Cited by 1 · see citing works
Investigation on nitrate induced histological alterations in vas deferens of rats
Rajini, S. V., Srushti, R., Sanchana, M., & Sarjan, H. N. (2025) · Journal of Trace Elements and Minerals · doi:10.1016/j.jtemin.2025.100245 · Cited by 1 · see citing works
Mohamed, M. E., Hammadi, S. H., & Hamid, M. H. A.-E. (2014) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2014.47018 · Cited by 1 · see citing works
El‐Saka, M. H., Madi, N. M., & Fard, G. A. (2014) · Bulletin of Egyptian Society for Physiological Sciences · doi:10.21608/besps.2014.34789 · Cited by 1 · see citing works
Nitric Oxide Regulation in Redox Signaling
Vitturi, D. A., Krzywanski, D. M., Postlethwait, E. M., & Patel, R. P. (2009) · Wiley eBooks · doi:10.1002/9783527627585.ch12
Self-citationNitric oxide mediated cardiovascular benefits of dietary nitrate and polyphenols
Bondonno, C. P. (2012) · UWA Profiles and Research Repository (University of Western Australia)
- Authors
- Basireddy, M., Isbell, T. S., Teng, X., Patel, R. P., & Agarwal, A.
- Affiliations
- University of Alabama at Birmingham (US)
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2006-04
- Volume
- 290
- Issue
- 4
- Pages
- F779-F786
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2137137628
- Cited by
- 72
- References
- 56
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2018: 2 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 8
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Renal Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL070146, R01HL70146)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK059600, R01 DK-59600, R21DK067472)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- sodium nitrite, renal ischemia-reperfusion injury, nitric oxide, sodium nitrate, reactive oxygen species, reactive nitrogen species, kidney, renal protection, tubular necrosis, hypoxia, acidosis, nitrite metabolism
- MeSH terms
- Animals, Male, Nitric Oxide, Sodium Nitrite, Reperfusion Injury, Rats, Sprague-Dawley, Reactive Oxygen Species, Reactive Nitrogen Species, Rats
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