The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin C
Open accessAbstract
The Chronic Kidney Disease in Children study is a cohort of about 600 children with chronic kidney disease (CKD) in the United States and Canada. The independent variable for our observations was a measurement of glomerular filtration rate (GFR) by iohexol disappearance (iGFR) at the first two visits one year apart and during alternate years thereafter. In a previous report, we had developed GFR estimating equations utilizing serum creatinine, blood urea nitrogen, height, gender and cystatin C measured by an immunoturbidimetric method; however the correlation coefficient of cystatin C and GFR (-0.69) was less robust than expected. Therefore, 495 samples were re-assayed using immunonephelometry. The reciprocal of immunonephelometric cystatin C was as well correlated with iGFR as was height/serum creatinine (both 0.88). We developed a new GFR estimating equation using a random 2/3 of 965 person-visits and applied it to the remaining 1/3 as a validation data set. In the validation data set, the correlation of the estimated GFR with iGFR was 0.92 with high precision and no bias; 91% and 45% of eGFR values were within 30% and 10% of iGFR, respectively. This equation works well in children with CKD in a range of GFR from 15 to 75 ml/min per 1.73 m2. Further studies are needed to establish the applicability to children of normal stature and muscle mass, and higher GFR.
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Cites
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New Equations to Estimate GFR in Children with CKD
Schwartz, G. J., Mun[Combining Tilde]oz, A., Schneider, M. F., Mak, R. H., Kaskel, F., Warady, B. A., & Furth, S. L. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008030287 · Cited by 3,777
Self-citationSchwartz, G. J., Haycock, G. B., Edelmann, C. M., & Spitzer, A. (1976) · Pediatrics · doi:10.1542/peds.58.2.259 · Cited by 2,379
Self-citationSchwartz, G. J., Brion, L. P., & Spitzer, A. (1987) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)36251-4 · Cited by 1,726
Self-citationHaycock, G. B., Schwartz, G. J., & Wisotsky, D. H. (1978) · The Journal of Pediatrics · doi:10.1016/s0022-3476(78)80601-5 · Cited by 1,675
Self-citationSerum cystatin C is superior to serum creatinine as a marker of kidney function: A meta-analysis
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Self-citationKnight, E. L., Verhave, J. C., Spiegelman, D., Hillege, H. L., De Zeeuw, D., Curhan, G. C., & De Jong, P. E. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00517.x · Cited by 1,039
Measurement and Estimation of GFR in Children and Adolescents
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Pierce, C. B., Muñoz, A., Ng, D. K., Warady, B. A., Furth, S. L., & Schwartz, G. J. (2021) · Kidney International · doi:10.1016/j.kint.2020.10.047 · Cited by 420
Self-citationKidney damage causally affects the brain cortical structure: A Mendelian randomization study
Chen, X., Kong, J., Pan, J., Huang, K., Zhou, W., Diao, X., Cai, J., Zheng, J., Yang, X., Xie, W., et al. (2021) · eBioMedicine · doi:10.1016/j.ebiom.2021.103592 · Cited by 267
Yu, Z., Coresh, J., Qi, G., Grams, M., Boerwinkle, E., Snieder, H., Teumer, A., Pattaro, C., Köttgen, A., Chatterjee, N., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.04.044 · Cited by 135
Metadata
- Authors
- Schwartz, G. J., Schneider, M. F., Maier, P. S., Moxey-Mims, M., Dharnidharka, V. R., Warady, B. A., Furth, S. L., & Muñoz, A.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 82
- Issue
- 4
- Pages
- 445-453
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W1982428643
- Cited by
- 566
- References
- 42
- FWCI
- 17.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schwartz, G. J., Schneider, M. F., Maier, P. S., Moxey-Mims, M., Dharnidharka, V. R., Warady, B. A., Furth, S. L., & Muñoz, A. (2012). Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin C. Kidney International. https://doi.org/10.1038/ki.2012.169
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