The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21
Open accessAbstract
Delayed ischemic preconditioning effectively protects kidneys from ischemia-reperfusion injury but the mechanism underlying renal protection remains poorly understood. Here we examined the in vivo role of microRNA miR-21 in the renal protection conferred by delayed ischemic preconditioning in mice. A 15 minute renal ischemic preconditioning significantly increased the expression of miR-21 by 4 hours and substantially attenuated ischemia-reperfusion injury induced 4 days later. A locked nucleic acid-modified anti-miR-21 given at the time of ischemic preconditioning knocked down miR-21 and significantly exacerbated subsequent ischemia-reperfusion injury in the mouse kidney. Knockdown of miR-21 resulted in significant upregulation of programmed cell death protein 4, a pro-apoptotic target gene of miR-21, and substantially increased tubular cell apoptosis. Hypoxia inducible factor-1α in the kidney was activated after ischemic preconditioning and blockade of its activity with a decoy abolished the up-regulation of miR-21 in cultured human renal epithelial cells treated with the inducer cobalt chloride. In the absence of ischemic preconditioning, knockdown of miR-21 alone did not significantly affect ischemia-reperfusion injury in the mouse kidney. Thus, upregulation of miR-21 contributes to the protective effect of delayed ischemic preconditioning against subsequent renal ischemia-reperfusion injury.
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Anti-Apoptotic Effect of MicroRNA-21 after Contusion Spinal Cord Injury in Rats
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Metadata
- Authors
- Xu, X., Kriegel, A. J., Liu, Y., Usa, K., Mladinov, D., Liu, H., Fang, Y., Ding, X., & Liang, M.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 82
- Issue
- 11
- Pages
- 1167-1175
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W1965191283
- Cited by
- 172
- References
- 10
- FWCI
- 12.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xu, X., Kriegel, A. J., Liu, Y., Usa, K., Mladinov, D., Liu, H., Fang, Y., Ding, X., & Liang, M. (2012). Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21. Kidney International. https://doi.org/10.1038/ki.2012.241
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