MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G

Chen, Yang; Liu, Wei; Chao, Tengfei; Zhang, Yu; Yan, Xingqi; Gong, Yanhua; Qiang, Boqin; Yuan, Jiangang; Sun, Maosheng; Peng, Xiaozhong

doi:10.1016/j.canlet.2008.06.034

Cited by 219MicroRNA in disease regulationCancer-related molecular mechanisms researchGlioma Diagnosis and Treatment

MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G

Chen, Yang, Liu, Wei, Chao, Tengfei, Zhang, Yu, Yan, Xingqi, Gong, Yanhua, Qiang, Boqin, Yuan, Jiangang +2 more·2008·Cancer Letters

DOI 10.1016/j.canlet.2008.06.034

Open this paper in CoChat — free account

Abstract

MicroRNAs have been linked to different cancer-related processes. The microRNA miR-21 appears to function as an anti-apoptosis factor in glioblastomas. However, the functional target genes of miR-21 are largely unknown in glioblastomas. In this study, bioinformatics analysis was used to identify miR-21 target sites in various genes. Luciferase activity assay showed that a number of genes involved in apoptosis, PDCD4, MTAP, and SOX5, carry putative miR-21 binding sites. Expression of PDCD4 protein correlates inversely with expression of miR-21 in a number of human glioblastoma cell lines such as T98G, A172, U87, and U251. Inhibition of miR-21 increases endogenous levels of PDCD4 in cell line T98G and over-expression miR-21 inhibits PDCD4-dependent apoptosis. Together, these results indicate that miR-21 expression plays a key role in regulating cellular processes in glioblastomas and may serve as a target for effective therapies.

Integrity signals

Registry

Crossref · 10.1016/j.canlet.2008.06.034

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

miR-21 has been shown to be a strong antiapoptotic factor.
“In particular, miRNA-21 (miR-21) has been shown to be a strong antiapoptotic factor [5, 9–11].”
From MicroRNA‐21 protects neurons from ischemic death (2010) · cites this paper as [9]
PDCD4, HNRNPK, and RECK are tumor suppressor genes and direct targets of miR-21-5p.
“Previous studies have proven that PDCD4, HNRNPK and RECK are TSGs among the direct targets of miR-21-5p (13,(27)(28)(29).”
From Functional interaction between miR-505-3p and miR-21 contributes to GBM suppression (2026) · cites this paper as [27]

Real-time quantification of microRNAs by stem-loop RT-PCR
Chen, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni178 · Cited by 4,931 · see citing works
MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer
Meng, F., Henson, R., Wehbe–Janek, H., Ghoshal, K., Jacob, S. T., & Patel, T. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.022 · Cited by 2,773 · see citing works
MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells
Chan, J. A., Krichevsky, A. M., & Kosik, K. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0137 · Cited by 2,557 · see citing works
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
Asangani, I. A., Rasheed, S. A. K., Nikolova, D. A., Leupold, J. H., Colburn, N. H., Post, S., & Allgayer, H. (2008) · Oncogene · doi:10.1038/sj.onc.1210856 · Cited by 1,882 · see citing works
miR-21-mediated tumor growth
Si, M.-L., Zhu, S., Wu, H., Lu, Z., Wu, F., & Mo, Y.-Y. (2007) · Oncogene · doi:10.1038/sj.onc.1210083 · Cited by 1,600 · see citing works
Programmed Cell Death 4 (PDCD4) Is an Important Functional Target of the MicroRNA miR-21 in Breast Cancer Cells
Frankel, L. B., Christoffersen, N. R., Jacobsen, A., Lindow, M., Krogh, A., & Lund, A. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707224200 · Cited by 1,141 · see citing works
MicroRNA-21 Targets the Tumor Suppressor Gene Tropomyosin 1 (TPM1)
Zhu, S., Si, M.-L., Wu, H., & Mo, Y.-Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611393200 · Cited by 1,090 · see citing works
Involvement of Human Micro-RNA in Growth and Response to Chemotherapy in Human Cholangiocarcinoma Cell Lines
Meng, F., Henson, R., Lang, M., Wehbe, H., Maheshwari, S., Mendell, J. T., Jiang, J., Schmittgen, T. D., & Patel, T. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.02.057 · Cited by 984 · see citing works
S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth
Dorrello, N. V., Peschiaroli, A., Guardavaccaro, D., Colburn, N. H., Sherman, N. E., & Pagano, M. (2006) · Science · doi:10.1126/science.1130276 · Cited by 731 · see citing works
OncomiRs: the discovery and progress of microRNAs in cancers
Cho, W. C. S. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-60 · Cited by 719 · see citing works
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene
Lu, Z., Liu, M., Stribinskis, V, Klinge, C. M., Ramos, K. S., Colburn, N. H., & Li, Y. (2008) · Oncogene · doi:10.1038/onc.2008.72 · Cited by 711 · see citing works
MOLECULAR PATHOLOGY OF MALIGNANT GLIOMAS
Louis, D. N. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100043 · Cited by 647 · see citing works
Arginine Methylation of STAT1 Modulates IFNα/β-Induced Transcription
Mowen, K. A., Tang, J., Zhu, W. Z., Schurter, B. T., Shuai, K., Herschman, H. R., & David, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00269-0 · Cited by 484 · see citing works
Messenger RNA regulation: to translate or to degrade
Shyu, A., Wilkinson, M., & van Hoof, A. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601977 · Cited by 447 · see citing works
miR-21 Gene Expression Triggered by AP-1 Is Sustained through a Double-Negative Feedback Mechanism
Fujita, S., Ito, T., Mizutani, T., Minoguchi, S., Yamamichi, N., Sakurai, K., & Iba, H. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.03.015 · Cited by 432 · see citing works
MicroRNA-21 Knockdown Disrupts Glioma Growth <i>In vivo</i> and Displays Synergistic Cytotoxicity with Neural Precursor Cell–Delivered S-TRAIL in Human Gliomas
Corsten, M. F., Miranda, R., Kasmieh, R., Krichevsky, A. M., Weissleder, R., & Shah, K. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1045 · Cited by 406 · see citing works
SoxD Proteins Influence Multiple Stages of Oligodendrocyte Development and Modulate SoxE Protein Function
Stolt, C. C., Schlierf, A., Lommes, P., Hillgärtner, S., Werner, T., Kosian, T., Sock, E., Kessaris, N., Richardson, W. D., Lefebvre, V., et al. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.08.011 · Cited by 299 · see citing works
Trends in the biochemical pharmacology of 5′-deoxy-5′-methylthioadenosine
Williams-Ashman, H. G., Seidenfeld, J., & Galletti, P. (1982) · Biochemical Pharmacology · doi:10.1016/0006-2952(82)90171-x · Cited by 253 · see citing works
Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death
Shibahara, K., Asano, M., Ishida, Y., Aoki, T., Koike, T., & Honjo, T. (1995) · Gene · doi:10.1016/0378-1119(95)00607-9 · Cited by 223 · see citing works
Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: sox genes and BMP signaling
Chimal‐Monroy, J., Rodríguez‐León, J., Montero, J. A., Gañán, Y., Macias, D., Merino, R., & Hurlé, J. M. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00066-6 · Cited by 221 · see citing works
Modification of miR gene expression pattern in human colon cancer cells following exposure to 5-fluorouracil in vitro
Rossi, L., Bonmassar, E., & Faraoni, I. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.07.001 · Cited by 184 · see citing works
Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers.
Nobori, T., Takabayashi, K., Tran, P. T., Orvis, L., Batova, A., Yu, A. L.-T., & Carson, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.6203 · Cited by 113 · see citing works
Frequent loss of PDCD4 expression in human glioma: Possible role in the tumorigenesis of glioma
Gao, F., Zhang, P., Zhou, C., Li, J., Wang, Q., Zhu, F., Ma, C., Sun, W., & Zhang, L. (2007) · Oncology Reports · doi:10.3892/or.17.1.123 · Cited by 100 · see citing works
Programmed cell death protein 4 (pdcd4): A novel target for antineoplastic therapy?
Lankat–Buttgereit, B., & Göke, R. (2003) · Biology of the Cell · doi:10.1016/j.biolcel.2003.09.003 · Cited by 94 · see citing works
Improving the prediction of human microRNA target genes by using ensemble algorithm
Yan, X., Chao, T., Tu, K., Zhang, Y., Xie, L., Gong, Y., Yuan, J., Qiang, B., & Peng, X. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.03.022 · Cited by 57 · see citing works
Self-citation

Flagged first, then by citations

1 of the 26 references couldn’t be matched to a known paper.

Sorted by citations

MicroRNAs in Development and Disease
Sayed, D. H., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,074 · see citing works
MicroRNAs
Bhaskaran, M., & Mohan, M. (2013) · Veterinary Pathology · doi:10.1177/0300985813502820 · Cited by 614 · see citing works
Exploring miRNA based approaches in cancer diagnostics and therapeutics
Mishra, S., Yadav, T., & Rani, V. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.10.003 · Cited by 494 · see citing works
The role of SOX family members in solid tumours and metastasis
Grimm, D. G., Bauer, J. W., Wise, P. M., Krüger, M., Simonsen, U., Wehland, M., Infanger, M., & Corydon, T. J. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.03.004 · Cited by 487 · see citing works
Apoptosis and the target genes of microRNA-21
Buscaglia, L. E. B., & Li, Y. (2011) · 癌症：英文版 · doi:10.5732/cjc.011.10132 · Cited by 374 · see citing works
Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status
Zhou, X., Ren, Y., Moore, L. M., Mei, M., You, Y., Xu, P., Wang, B., Wang, G., Jia, Z., Pu, P., et al. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2009.126 · Cited by 358 · see citing works
Physical exercise as an epigenetic modulator of brain plasticity and cognition
Fernandes, J., Arida, R. M., & Gómez‐Pinilla, F. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.06.012 · Cited by 326 · see citing works
Clinicopathological and Prognostic Value of MicroRNA-21 and MicroRNA-155 in Colorectal Cancer
Shibuya, H., Iinuma, H., Shimada, R., Horiuchi, A., & Watanabe, T. (2010) · Oncology · doi:10.1159/000323283 · Cited by 244 · see citing works
MicroRNA‐21 protects neurons from ischemic death
Buller, B., Liu, X., Wang, X., Zhang, R. L., Zhang, L., Hozeska‐Solgot, A., Chopp, M., & Zhang, Z. G. (2010) · The FEBS Journal · doi:10.1111/j.1742-4658.2010.07818.x · Cited by 242 · see citing works
miR-21: an oncomir on strike in prostate cancer
Folini, M., Gandellini, P., Longoni, N., Profumo, V., Callari, M., Pennati, M., Colecchia, M., Supino, R., Veneroni, S., Salvioni, R., et al. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-12 · Cited by 229 · see citing works
MicroRNAs in glioblastoma multiforme pathogenesis and therapeutics
Shea, A. A., Harish, V., Afzal, Z., Chijioke, J., Kedir, H., Dusmatova, S., Roy, A., Ramalinga, M., Harris, B. T., Blancato, J. K., et al. (2016) · Cancer Medicine · doi:10.1002/cam4.775 · Cited by 207 · see citing works
MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4 (PDCD4) in HeLa cervical carcinoma cells
Yao, Q., Xu, H. M., Zhang, Q.-Q., Zhou, H., & Qu, L. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.08.044 · Cited by 204 · see citing works
Metastamirs: a stepping stone towards improved cancer management
White, N. M. A., Fatoohi, E., Metias, M., Jung, K., Stephan, C., & Yousef, G. M. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.173 · Cited by 185 · see citing works
Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo
Gaur, A. B., Holbeck, S. L., Colburn, N. H., & Israel, M. A. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor033 · Cited by 180 · see citing works
Genome-wide expression profiling identifies deregulated miRNAs in malignant astrocytoma
Rao, S. A., Santosh, V., & Somasundaram, K. (2010) · Modern Pathology · doi:10.1038/modpathol.2010.135 · Cited by 179 · see citing works
Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21
Xu, X., Kriegel, A. J., Liu, Y., Usa, K., Mladinov, D., Liu, H., Fang, Y., Ding, X., & Liang, M. (2012) · Kidney International · doi:10.1038/ki.2012.241 · Cited by 171 · see citing works
MicroRNA Profiling and Head and Neck Cancer
Liu, X., Chen, Z., Yu, J., Xia, J., & Zhou, X. C. (2009) · Comparative and Functional Genomics · doi:10.1155/2009/837514 · Cited by 165 · see citing works
Label-free ultrasensitive detection of breast cancer miRNA-21 biomarker employing electrochemical nano-genosensor based on sandwiched AgNPs in PANI and N-doped graphene
Salahandish, R., Ghaffarinejad, A., Omidinia, E., Zargartalebi, H., Majidzadeh‐A, K., Naghib, S. M., & Sanati‐Nezhad, A. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.08.025 · Cited by 165 · see citing works
MicroRNAs in liver cancer: a model for investigating pathogenesis and novel therapeutic approaches
Callegari, E., Gramantieri, L., Domenicali, M., D’Abundo, L., Sabbioni, S., & Negrini, M. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.136 · Cited by 164 · see citing works
Silencing of MicroRNA-21 Confers Radio-Sensitivity through Inhibition of the PI3K/AKT Pathway and Enhancing Autophagy in Malignant Glioma Cell Lines
Gwak, H., Kim, T. H., Jo, G. H., Kim, Y., Kwak, H., Kim, J. H., Yin, J., Yoo, H., Lee, S. H., & Park, J. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047449 · Cited by 155 · see citing works
MiR‐195, miR‐196b, miR‐181c, miR‐21 expression levels and O‐6‐methylguanine‐DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients
Lakomý, R., Šáňa, J., Hankeová, S., Fadrus, P., Křen, L., Lžičařová, E., Svoboda, M., Doleželová, H., Smrčka, M., Vyzula, R., et al. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02092.x · Cited by 155 · see citing works
Anti-Apoptotic Effect of MicroRNA-21 after Contusion Spinal Cord Injury in Rats
Hu, J.-Z., Huang, J.-H., Zeng, L., Wang, G., Cao, M., & Lu, H.-B. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2012.2748 · Cited by 128 · see citing works
Current Progress on Understanding MicroRNAs in Glioblastoma Multiforme
Karsy, M., Arslan, E., & Moy, F. (2012) · Genes & Cancer · doi:10.1177/1947601912448068 · Cited by 151 · see citing works
miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma
Wang, Z. (2012) · Oncology Reports · doi:10.3892/or.2012.1682 · Cited by 146 · see citing works
MicroRNA involvement in glioblastoma pathogenesis
Nováková, J., Slabý, O., Vyzula, R., & Michálek, J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.06.034 · Cited by 141 · see citing works
The use of hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma
Zhi, F., Chen, X., Wang, S., Xia, X., Shi, Y., Guan, W., Shao, N., Qu, H., Yang, C., Zhang, Y., et al. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.02.003 · Cited by 141 · see citing works
Self-citation
Radiation-Induced Micro-RNA Modulation in Glioblastoma Cells Differing in DNA-Repair Pathways
Chaudhry, M. A., Sachdeva, H., & Omaruddin, R. A. (2010) · DNA and Cell Biology · doi:10.1089/dna.2009.0978 · Cited by 131 · see citing works
Clinicopathological and prognostic significance of PDCD4 and microRNA-21 in human gastric cancer
Mori (2010) · International Journal of Oncology · doi:10.3892/ijo_00000590 · Cited by 124 · see citing works
Pdcd4, a colon cancer prognostic that is regulated by a microRNA
Allgayer, H. (2009) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2009.09.001 · Cited by 123 · see citing works
Oncogenic role of microRNAs in brain tumors
Pang, J. C., Kwok, W. K., Chen, Z., & Ng, H. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0525-0 · Cited by 120 · see citing works
MicroRNAs as regulators of death receptors signaling
Garofalo, M., Condorelli, G. L., Croce, C. M., & Condorelli, G. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.105 · Cited by 120 · see citing works
Micro‐RNA‐21 regulates TGF‐β‐induced myofibroblast differentiation by targeting PDCD4 in tumor‐stroma interaction
Yao, Q., Cao, S., Li, C., Mengesha, A., Kong, B., & Wei, M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25506 · Cited by 120 · see citing works
Model-guided quantitative analysis of microRNA-mediated regulation on competing endogenous RNAs using a synthetic gene circuit
Yuan, Y., Liu, B., Xie, P., Zhang, M. Q., Li, Y., Xie, Z., & Wang, X. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413896112 · Cited by 114 · see citing works
MicroRNA roles in beta-catenin pathway
Huang, K., Zhang, J., Han, L., You, Y., Jiang, T., Pu, P., & Kang, C. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-252 · Cited by 113 · see citing works
mirConnX: condition-specific mRNA-microRNA network integrator
Huang, G., Athanassiou, C. G., & Benos, P. V. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr276 · Cited by 112 · see citing works
Overexpression of miR-21 Promotes an In vitro Metastatic Phenotype by Targeting the Tumor Suppressor RHOB
Connolly, E. C., Doorslaer, K. V., Rogler, L. E., & Rogler, C. E. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0465 · Cited by 112 · see citing works
The Clinical Utility of miR-21 as a Diagnostic and Prognostic Marker for Renal Cell Carcinoma
Faragalla, H., Youssef, Y. M., Scorilas, A., Khalil, B., White, N. M. A., Mejia‐Guerrero, S., Khella, H. W. Z., Jewett, M. A. S., Evans, A. J., Lichner, Z., et al. (2012) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2012.02.003 · Cited by 110 · see citing works
MicroRNA expression profile of MCF-7 human breast cancer cells and the effect of green tea polyphenon-60.
Fix, L. N., Shah, M., Efferth, T., Farwell, M. A., & Zhang, B. (2010) · PubMed · Cited by 110 · see citing works
Emerging functions of microRNAs in glioblastoma
Lawler, S. E., & Chiocca, E. A. (2009) · Journal of Neuro-Oncology · doi:10.1007/s11060-009-9843-2 · Cited by 108 · see citing works
Regulation of Breast Cancer and Bone Metastasis by MicroRNAs
Vimalraj, S., Miranda, P. J., Ramyakrishna, B., & Selvamurugan, N. (2013) · Disease Markers · doi:10.1155/2013/451248 · Cited by 108 · see citing works
NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age
Gray, G. K., McFarland, B. C., Nozell, S. E., & Benveniste, E. N. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.964211 · Cited by 108 · see citing works
MiR-21 is involved in cervical squamous cell tumorigenesis and regulates CCL20
Yao, T., & Lin, Z. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.09.018 · Cited by 107 · see citing works
Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs 143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy
Drebber, U. (2011) · International Journal of Oncology · doi:10.3892/ijo.2011.1036 · Cited by 107 · see citing works
The role of microRNAs in glioma initiation and progression
Zhang, Y. (2011) · Frontiers in bioscience · doi:10.2741/3952 · Cited by 108 · see citing works
Self-citation
Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3
Kang (2010) · Oncology Reports · doi:10.3892/or_00000846 · Cited by 107 · see citing works
MicroRNA‐21 Expression is regulated by β‐catenin/STAT3 Pathway and Promotes Glioma Cell Invasion by Direct Targeting RECK
Han, L., Yue, X., Zhou, X., Lan, F., You, G., Zhang, W. J., Zhang, K., Zhang, C., Cheng, J., Yu, S., et al. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00344.x · Cited by 103 · see citing works
Expression of 19 microRNAs in glioblastoma and comparison with other brain neoplasia of grades I–III
Visani, M., de Biase, D., Marucci, G., Cerasoli, S., Nigrisoli, E., Reggiani, M. L. B., Albani, F., Baruzzi, A., Pession, A., & the PERNO study group (2013) · Molecular Oncology · doi:10.1016/j.molonc.2013.12.010 · Cited by 103 · see citing works
MicroRNA-21 (miR-21) Post-Transcriptionally Downregulates Tumor Suppressor PDCD4 and Promotes Cell Transformation, Proliferation, and Metastasis in Renal Cell Carcinoma
Li, X., Xin, S., He, Z., Che, X., Wang, J., Xiao, X., Chen, J., & Song, X. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000362946 · Cited by 94 · see citing works
Down-regulation of MicroRNA-21 Is Involved in the Propofol-induced Neurotoxicity Observed in Human Stem Cell–derived Neurons
Twaroski, D. M., Yan, Y., Olson, J. M. G., Bosnjak, Z. J., & Bai, X. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000345 · Cited by 89 · see citing works
Ginsenoside Rh2 inhibits glioma cell proliferation by targeting microRNA-128
Wu, N., Wu, G.-C., Hu, R., Li, M., & Feng, H. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.220 · Cited by 92 · see citing works
Belonging to a network—microRNAs, extracellular vesicles, and the glioblastoma microenvironment
Godlewski, J. A., Krichevsky, A. M., Johnson, M. D., Chiocca, E. A., & Bronisz, A. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou292 · Cited by 91 · see citing works
microRNAs (miRNAs) in Glioblastoma Multiforme (GBM)—Recent Literature Review
Makowska, M., Smolarz, B., & Romanowicz, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043521 · Cited by 96 · see citing works
Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma
Bhatti, I. K., Lee, A., James, V. H., Hall, R. I., Lund, J. N., Tufarelli, C., Lobo, D. N., & Larvin, M. (2010) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-010-1381-x · Cited by 90 · see citing works
MiR-21 expression in the tumor cell compartment holds unfavorable prognostic value in gliomas
Hermansen, S. K., Dahlrot, R. H., Nielsen, B. S., Hansen, S., & Kristensen, B. W. (2012) · Journal of Neuro-Oncology · doi:10.1007/s11060-012-0992-3 · Cited by 89 · see citing works
The regulatory roles of non-coding RNAs in nerve injury and regeneration
Yu, B., Zhou, S., Yi, S., & Gu, X. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.006 · Cited by 87 · see citing works
Extracellular vesicles shed by glioma cells: pathogenic role and clinical value
Chistiakov, D. A., & Chekhonin, V. P. (2014) · Tumor Biology · doi:10.1007/s13277-014-2262-9 · Cited by 87 · see citing works
Role of microRNAs in gliomagenesis: targeting miRNAs in glioblastoma multiforme therapy
Nikaki, A. V., Piperi, C., & Papavassiliou, A. G. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2012.710199 · Cited by 84 · see citing works
microRNAs in Gliomas: Small Regulators of a Big Problem
Silber, J., James, C. D., & Hodgson, J. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8087-9 · Cited by 80 · see citing works
MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma
Costa, P. M., Cardoso, A. L., Nóbrega, C., Pereira de Almeida, L. F., Bruce, J. N., Canoll, P., & Pedroso de Lima, M. C. (2013) · Human Molecular Genetics · doi:10.1093/hmg/dds496 · Cited by 80 · see citing works
M i R ‐21 Modulates h TERT Through a STAT 3‐Dependent Manner on Glioblastoma Cell Growth
Wang, Y., Sun, G., Luo, H., Wang, X., Lan, F., Yue, X., Fu, L., Pu, P., Kang, C., Liu, N., et al. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00349.x · Cited by 78 · see citing works
<i>Retracted:</i> Micro<scp>RNA</scp>‐21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting <scp>SPRY</scp>1 via the <scp>PTEN</scp>/<scp>PI</scp>3K/<scp>AKT</scp> signaling pathway
Chai, C., Song, L., Han, S., Li, X., & Li, M. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12785 · Cited by 89 · see citing works
Retracted
Combination of quercetin and hyperoside inhibits prostate cancer cell growth and metastasis via regulation of microRNA-21
Yang, F., Liu, M., Li, W., Che, J., WANG, G.-C., & Zheng, J. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2813 · Cited by 74 · see citing works
Overexpression of microRNA-21 regulating PDCD4 during tumorigenesis of liver fluke-associated cholangiocarcinoma contributes to tumor growth and metastasis
Chusorn, P., Namwat, N., Loilome, W., Techasen, A., Pairojkul, C., Khuntikeo, N., Dechakhamphu, A., Talabnin, C., Chan-on, W., Ong, C. K., et al. (2013) · Tumor Biology · doi:10.1007/s13277-013-0688-0 · Cited by 71 · see citing works
The many roles of microRNAs in brain tumor biology
Turner, J. D., Williamson, R., Almefty, K. K., Nakaji, P., Porter, R., Tse, V., & Kalani, M. Y. S. (2009) · Neurosurgical FOCUS · doi:10.3171/2009.10.focus09207 · Cited by 71 · see citing works
Epigenetic regulation of matrix metalloproteinases and their collagen substrates in cancer
Chernov, A. V., & Strongin, A. Y. (2011) · bmc · doi:10.1515/bmc.2011.017 · Cited by 69 · see citing works
The role of MiRNA-21 in gliomas: Hope for a novel therapeutic intervention?
Aloizou, A.-M., Pateraki, G., Siokas, V., Mentis, A.-F. A., Liampas, I., Lazopoulos, G., Kovatsi, L., Mitsias, P. D., Bogdanos, D. P., Paterakis, K., et al. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2020.11.001 · Cited by 69 · see citing works
MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications
Šáňa, J., Hajdúch, M., Michálek, J., Vyzula, R., & Slabý, O. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01317.x · Cited by 69 · see citing works
Grade-Specific Expression Profiles of miRNAs/mRNAs and Docking Study in Human Grade I–III Astrocytomas
Li, D., Chen, P., Li, X., Zhang, L., Xiong, W., Zhou, M., Xiao, L., Fang, Z., Li, X., Wu, M., et al. (2011) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2011.0064 · Cited by 66 · see citing works
MicroRNA-21 suppression impedes medulloblastoma cell migration
Grunder, E., D’Ambrosio, R., Fiaschetti, G., Abela, L., Arcaro, A., Zuzak, T. J., Ohgaki, H., Lv, S., Shalaby, T., & Grotzer, M. A. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.06.041 · Cited by 65 · see citing works
Targeting strategies on miRNA-21 and PDCD4 for glioblastoma
Wang, G., Wang, J. J., Tang, H., & To, S. S. T. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.07.001 · Cited by 63 · see citing works
Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer
Huang, Y., Liu, Y., Yu, L., Chen, J., Hou, J., Cui, L., Ma, D., & Wang-kun, L. (2014) · Tumor Biology · doi:10.1007/s13277-014-2630-5 · Cited by 63 · see citing works
Possible role of Toxoplasma gondii in brain cancer through modulation of host microRNAs
Thirugnanam, S., Rout, N., & Munirathinam, G. (2013) · Infectious Agents and Cancer · doi:10.1186/1750-9378-8-8 · Cited by 63 · see citing works
Clock-controlled mir-142-3p can target its activator, Bmal1
Tan, X., Zhang, P., Zhou, L., Yin, B., Pan, H., & Peng, X. (2012) · BMC Molecular Biology · doi:10.1186/1471-2199-13-27 · Cited by 62 · see citing works
Self-citation
Glioma-initiating cells and molecular pathology: implications for therapy
Natsume, A., Kinjo, S., Yuki, K., Kato, T., Ohno, M., Motomura, K., Iwami, K., & Wakabayashi, T. (2011) · Brain Tumor Pathology · doi:10.1007/s10014-010-0011-3 · Cited by 61 · see citing works
Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression
Walters, R. W., Bradrick, S. S., & Gromeier, M. (2009) · RNA · doi:10.1261/rna.1795410 · Cited by 61 · see citing works
Targeting epigenetic mechanisms and microRNAs by aspirin and other non steroidal anti-inflammatory agents - implications for cancer treatment and chemoprevention
Yiannakopoulou, E. C. (2014) · Cellular Oncology · doi:10.1007/s13402-014-0175-7 · Cited by 60 · see citing works
Cryptocaryols A–H, α-Pyrone-Containing 1,3-Polyols from Cryptocarya sp. Implicated in Stabilizing the Tumor Suppressor Pdcd4
Grkovic, T., Blees, J. S., Colburn, N. H., Schmid, T., Thomas, C. L., Henrich, C. J., McMahon, J. B., & Gustafson, K. R. (2011) · Journal of Natural Products · doi:10.1021/np100918z · Cited by 60 · see citing works
MicroRNA and extracellular vesicles in glioblastoma: small but powerful
Rooj, A. K., Mineo, M., & Godlewski, J. A. (2016) · Brain Tumor Pathology · doi:10.1007/s10014-016-0259-3 · Cited by 59 · see citing works
MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2
Ho, C., Bar, E. E., Giannini, C., Marchionni, L., Karajannis, M. A., Zagzag, D., Gutmann, D. H., Eberhart, C. G., & Rodriguez, F. J. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos269 · Cited by 59 · see citing works
Role of MicroRNAs in Malignant Glioma
Wang, B., & Ma, J. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.156141 · Cited by 55 · see citing works
The critical roles of miR-21 in anti-cancer effects of curcumin.
Chen, J., TieFeng, X., & Chen, C. (2015) · PubMed Central · doi:10.3978/j.issn.2305-5839.2015.09.20 · Cited by 55 · see citing works
Identification of microRNAs associated with glioma diagnosis and prognosis
Ye, X., Wei, W., Zhang, Z., He, C., Yang, R., Zhang, J., Wu, Z., Huang, Q., & Jiang, Q. (2017) · Oncotarget · doi:10.18632/oncotarget.14445 · Cited by 55 · see citing works
MiR-21 in extracellular vesicles contributes to the growth of fertilized eggs and embryo development in mice
Lv, C., Yu, W.-X., Wang, Y., Yi, D.-J., Zeng, M.-H., & Xiao, H. (2018) · Bioscience Reports · doi:10.1042/bsr20180036 · Cited by 55 · see citing works
miR-21 Modulates Cell Apoptosis by Targeting Multiple Genes in Renal Cell Carcinoma
Zhang, A., Liu, Y., Shen, Y., Xu, Y., & Li, X.-T. (2011) · Urology · doi:10.1016/j.urology.2011.03.030 · Cited by 54 · see citing works
The Modulation of MicroRNAs by Type I IFN through the Activation of Signal Transducers and Activators of Transcription 3 in Human Glioma
Ohno, M., Natsume, A., Kondo, Y., Iwamizu, H., Motomura, K., Toda, H., Ito, M., Kato, T., & Wakabayashi, T. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0319 · Cited by 54 · see citing works
MiR-29c inhibits glioma cell proliferation, migration, invasion and angiogenesis
Fan, Y.-C., Mei, P.-J., Chen, C., Miao, F., Zhang, H., & Li, Z.-L. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1223-2 · Cited by 53 · see citing works
Human miR-31 targets radixin and inhibits migration and invasion of glioma cells
Lin, B. (2011) · Oncology Reports · doi:10.3892/or.2011.1555 · Cited by 53 · see citing works
MicroRNA-34a and microRNA-21 play roles in the chemopreventive effects of 3,6-dihydroxyflavone on 1-methyl-1-nitrosourea-induced breast carcinogenesis
Hui, C., Fu, Y., Lijia, Y., Yi, L., Hongxia, X., Zhou, Y. G., Jundong, Z., Zhang, Q., & Mi, M. (2012) · Breast Cancer Research · doi:10.1186/bcr3194 · Cited by 53 · see citing works
Microarray-based Transcriptional and Epigenetic Profiling of Matrix Metalloproteinases, Collagens, and Related Genes in Cancer
Chernov, A. V., Baranovskaya, S., Golubkov, V. S., Wakeman, D. R., Snyder, E. Y., Williams, R. M., & Strongin, A. Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.088153 · Cited by 52 · see citing works
MicroRNAs as Regulators of Neural Stem Cell-Related Pathways in Glioblastoma Multiforme
González‐Gómez, P., Sánchez, P., & Mira, H. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8196-y · Cited by 52 · see citing works
Targeting miR-21 in glioma: a small RNA with big potential
Moore, L. M., & Zhang, W. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.527334 · Cited by 51 · see citing works
MicroRNAs dysregulation in epilepsy
Li, M., Li, X., Zheng, X., Yu, J., & Tan, L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.09.049 · Cited by 51 · see citing works
microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKKβ-mTORC1 axis to regulate renal cancer cell invasion
Bera, A., Das, F., Ghosh‐Choudhury, N., Kasinath, B. S., Abboud, H. E., & Choudhury, G. G. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.06.022 · Cited by 51 · see citing works
MicroRNAs in neural cell development and brain diseases
Feng, W., & Feng, Y. (2011) · Science China Life Sciences · doi:10.1007/s11427-011-4249-8 · Cited by 50 · see citing works
microRNA-214-mediated UBC9 expression in glioma
Zhao, Z., Tan, X., Zhao, A.-N., Zhu, L., Yin, B., Yuan, J., Qiang, B., & Peng, X. (2012) · BMB Reports · doi:10.5483/bmbrep.2012.45.11.097 · Cited by 50 · see citing works
Self-citation
MicroRNA in Human Glioma
Li, M., Li, J., Liu, L., Li, W., Yang, Y., & Yuan, J. X. (2013) · Cancers · doi:10.3390/cancers5041306 · Cited by 50 · see citing works
Self-citation
Noncoding RNAs in Glioblastoma: Emerging Biological Concepts and Potential Therapeutic Implications
Shahzad, U., Krumholtz, S. L., Rutka, J. T., & Das, S. (2021) · Cancers · doi:10.3390/cancers13071555 · Cited by 49 · see citing works
Differential response of miRNA-21 and its targets after traumatic brain injury in aging mice
Sandhir, R., Gregory, E. J., & Berman, N. E. J. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.09.009 · Cited by 46 · see citing works
Designing small multiple-target artificial RNAs
Guire, V. D., Caron, M., Scott, N., Ménard, C., Gaumont‐Leclerc, M., Chartrand, P., Major, F., & Ferbeyre, G. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq354 · Cited by 44 · see citing works
MicroRNA-21a-5p Functions on the Regulation of Melanogenesis by Targeting Sox5 in Mouse Skin Melanocytes
Wang, P., Zhao, Y., Fan, R., Chen, T., & Dong, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17070959 · Cited by 44 · see citing works

MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells
Papagiannakopoulos, T., Shapiro, A., & Kosik, K. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1305 · Cited by 705 · see citing works
Targeting strategies on miRNA-21 and PDCD4 for glioblastoma
Wang, G., Wang, J. J., Tang, H., & To, S. S. T. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.07.001 · Cited by 63 · see citing works
MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells
Chan, J. A., Krichevsky, A. M., & Kosik, K. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0137 · Cited by 2,557 · see citing works
Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo
Gaur, A. B., Holbeck, S. L., Colburn, N. H., & Israel, M. A. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor033 · Cited by 180 · see citing works
Programmed Cell Death 4 (PDCD4) Is an Important Functional Target of the MicroRNA miR-21 in Breast Cancer Cells
Frankel, L. B., Christoffersen, N. R., Jacobsen, A., Lindow, M., Krogh, A., & Lund, A. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707224200 · Cited by 1,141 · see citing works

Authors: Chen, Y., Liu, W., Chao, T., Zhang, Y., Yan, X., Gong, Y., Qiang, B., Yuan, J., Sun, M., & Peng, X.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author: Sun, Maosheng
Peng, Xiaozhong
ORCID: Chen, Yang
Liu, Wei
Chao, Tengfei
Zhang, Yu
Gong, Yanhua
Peng, Xiaozhong
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2008-12
Volume: 272
Issue: 2
Pages: 197-205
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2008.06.034
OpenAlex: W2091108445
Cited by: 217
References: 26
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 10 · 2018: 7 · 2017: 13 · 2016: 10 · 2015: 17 · 2014: 24 · 2013: 19 · 2012: 20
FWCI: 8.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
Keywords: miR-21, PDCD4, glioblastoma, microRNA binding sites, apoptosis, MTAP, SOX5, T98G cells, tumor suppressor regulation, miRNA inhibitors
MeSH terms: Base Sequence, Brain Neoplasms, Glioblastoma, Humans, Blotting, Northern, Blotting, Western, Down-Regulation, Gene Expression Regulation, Neoplastic, RNA-Binding Proteins, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, In Situ Nick-End Labeling, MicroRNAs, Cell Line, Tumor, Apoptosis Regulatory Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks