Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management

Inhibition of mouse melanoma cell proliferation by corticotropin-releasing hormone and its analogs.

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Identification of 7(8) and 8(9) unsaturated adrenal steroid metabolites produced by patients with 7-dehydrosterol-Δ7-reductase deficiency (Smith–Lemli–Opitz syndrome)

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Metabolism of cholesterol, vitamin D3 and 20-hydroxyvitamin D3 incorporated into phospholipid vesicles by human CYP27A1

Tieu, E. W., Li, W., Chen, J., Baldisseri, D. M., Slominski, A. T., & Tuckey, R. C. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.11.012 · Cited by 56

Vitamin D receptor polymorphisms and survival in patients with cutaneous melanoma: a population-based study

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Novel vitamin D analogs as potential therapeutics: metabolism, toxicity profiling, and antiproliferative activity.

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Protective role of vitamin D signaling in skin cancer formation

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Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice

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Anti‐inflammatory effects of melatonin in multiple sclerosis

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Relationship of 25-hydroxyvitamin D3 side chain structure to biological activity.

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Roles of Solar UVB and Vitamin D in Reducing Cancer Risk and Increasing Survival.

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Tumor suppression in skin and other tissues via cross-talk between vitamin D- and p53-signaling

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RORα is not a receptor for melatonin (response to DOI 10.1002/bies.201600018)

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Vitamin D Receptor, UVR, and Skin Cancer: A Potential Protective Mechanism

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Synthesis and photochemical transformation of 3β,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity

Zmijewski, M. A., Li, W., Chen, J., Kim, T.-K., Zjawiony, J. K., Sweatman, T. W., Miller, D. D., & Slominski, A. T. (2011) · Steroids · doi:10.1016/j.steroids.2010.10.009 · Cited by 51

Vitamin D analogs 17, 20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity

Slominski, A. T., Li, W., Bhattacharya, S. K., Smith, R. A., Johnson, P. L., Chen, J., Nelson, K. E., Tuckey, R. C., Miller, D., Jiao, Y., et al. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.425 · Cited by 51

Antiapoptotic action of 1α,25-dihydroxyvitamin D3 in primary human melanocytes

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Antitumor Effects of Vitamin D Analogs on Hamster and Mouse Melanoma Cell Lines in Relation to Melanin Pigmentation

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NF-κB inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the β-catenin pathway

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Kinetics of vitamin D3 metabolism by cytochrome P450scc (CYP11A1) in phospholipid vesicles and cyclodextrin

Tuckey, R. C., Nguyen, M. N., & Slominski, A. T. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.05.006 · Cited by 49

1,25‐dihydroxyvitamin D3 and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells

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Metabolism of vitamin D2 to 17, 20,24-trihydroxyvitamin D2 by cytochrome p450scc (CYP11A1)

Nguyen, M. N., Slominski, A., Li, W., Ng, Y. R., & Tuckey, R. C. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.025619 · Cited by 48

Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes

Piotrowska, A., Wierzbicka, J., Ślebioda, T., Woźniak, M., Tuckey, R. C., Slominski, A. T., & Żmijewski, M. A. (2016) · Steroids · doi:10.1016/j.steroids.2016.04.002 · Cited by 48

1,25(OH)2D3 attenuates TGF-β1/β2-induced increased migration and invasion via inhibiting epithelial–mesenchymal transition in colon cancer cells

Chen, S., Zhu, J., Zuo, S., Ma, J., Zhang, J., Chen, G., Wang, X., Pan, Y., Liu, Y., & Wang, P. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.10.146 · Cited by 47

CYP24A1 as a Potential Target for Cancer Therapy

Sakaki, T., Yasuda, K., Kittaka, A., Yamamoto, K., & Chen, T. C. (2014) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/18715206113139990307 · Cited by 47

Ligand-Specific Structural Changes in the Vitamin D Receptor in Solution

Singarapu, K. K., Zhu, J. G., Tonelli, M., Rao, H., Assadi‐Porter, F. M., Westler, W. M., DeLuca, H. F., & Markley, J. L. (2011) · Biochemistry · doi:10.1021/bi201637p · Cited by 46

Kinetic analysis of human CYP 24A1 metabolism of vitamin D via the C24‐oxidation pathway

Tieu, E. W., Tang, E. K. Y., & Tuckey, R. C. (2014) · FEBS Journal · doi:10.1111/febs.12862 · Cited by 46

New vitamin D analogs as potential therapeutics in melanoma

Szyszka, P., Zmijewski, M. A., & Slominski, A. T. (2012) · Expert Review of Anticancer Therapy · doi:10.1586/era.12.40 · Cited by 46

Vitamin D and Death by Sunshine

Dixon, K. M., Tongkao‐on, W., Sequeira, V. B., Carter, S. E., Song, E., Rybchyn, M. S., Gordon‐Thomson, C., & Mason, R. S. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14011964 · Cited by 45

The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer Metastasis

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The Synthesis of Vitamin D Metabolites by Human Melanoma Cells*

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RXRα Ablation in Epidermal Keratinocytes Enhances UVR-Induced DNA Damage, Apoptosis, and Proliferation of Keratinocytes and Melanocytes

Wang, Z., Coleman, D. J., Bajaj, G., Liang, X., Ganguli‐Indra, G., & Indra, A. K. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.290 · Cited by 44

Rat CYP24A1 acts on 20-hydroxyvitamin D3 producing hydroxylated products with increased biological activity

Tieu, E. W., Tang, E. K. Y., Chen, J., Li, W., Nguyen, M. N., Janjetovic, Z., Slominski, A., & Tuckey, R. C. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.09.032 · Cited by 44

CYP24A1 Expression Inversely Correlates with Melanoma Progression: Clinic-Pathological Studies

Brożyna, A. A., Jochymski, C., Janjetović, Z., Jóźwicki, W., Tuckey, R. C., & Slominski, A. T. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151019000 · Cited by 44

Lumisterol is metabolized by CYP11A1: discovery of a new pathway

Tuckey, R. C., Slominski, A. T., Cheng, C. Y. S., Chen, J., Kim, T.-K., Xiao, M., & Li, W. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.08.004 · Cited by 43

Vitamin D, its Precursors, and Metabolites do not Affect Melanization of Cultured Human Melanocytes

Mansur, C. P., Gordon, P. R., Ray, S., Holick, M. F., & Gilchrest, B. A. (1988) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12463282 · Cited by 42

Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1

Tang, E. K. Y., Chen, J., Janjetovic, Z., Tieu, E. W., Slominski, A. T., Li, W., & Tuckey, R. C. (2013) · Drug Metabolism and Disposition · doi:10.1124/dmd.113.050955 · Cited by 42

Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives

Zmijewski, M. A., Li, W., Zjawiony, J. K., Sweatman, T. W., Chen, J., Miller, D. D., & Slominski, A. T. (2008) · Photochemical & Photobiological Sciences · doi:10.1039/b809005j · Cited by 41

Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D3, Producing 1α,20,23-Trihydroxyvitamin D3, Which Has Altered Biological Activity

Tang, E. K. Y., Li, W., Janjetovic, Z., Nguyen, M. N., Wang, Z., Slominski, A., & Tuckey, R. C. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.034389 · Cited by 40

Vitamin D receptor variants and the malignant melanoma risk: A population-based study

Gapska, P., Scott, R. J., Serrano‐Fernández, P., Mirecka, A., Rassoud, I., Górski, B., Cybulski, C., Huzarski, T., Byrski, T., Nagay, L., et al. (2009) · Cancer Epidemiology · doi:10.1016/j.canep.2009.06.006 · Cited by 39

Adjuvant therapy with high dose vitamin D following primary treatment of melanoma at high risk of recurrence: a placebo controlled randomised phase II trial (ANZMTG 02.09 Mel-D)

Saw, R. P. M., Armstrong, B. K., Mason, R. S., Morton, R. L., Shannon, K. F., Spillane, A. J., Stretch, J. R., & Thompson, J. F. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-780 · Cited by 39

1,25-Dihydroxyvitamin D3 induces biphasic NF-κB responses during HL-60 leukemia cells differentiation through protein induction and PI3K/Akt-dependent phosphorylation/degradation of IκB

Tse, A. K., Wan, E. C. K., Shen, X., Zhu, G., Cheung, H., Yang, M., & Fong, W. F. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.02.022 · Cited by 38

Retinoic acid receptor-related receptor alpha (RORalpha) is a prognostic marker for hepatocellular carcinoma

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Antiproliferative and Apoptosis-Inducing Effects of Lipophilic Vitamins on Human Melanoma A375 Cells in Vitro

Ishibashi, M., Arai, M., Tanaka, S., Onda, K., & Hirano, T. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.35.10 · Cited by 36

Molecular Pathogenesis of Sporadic Melanoma and Melanoma-Initiating Cells

Kong, Y., Kumar, S. M., & Xu, X. (2010) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2009-0418-rar.1 · Cited by 36

Skin Under the Sun: When Melanin Pigment Meets Vitamin D

Slominski, A. T., & Postlethwaite, A. E. (2014) · Endocrinology · doi:10.1210/en.2014-1918 · Cited by 35

Activation of vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling pathways through 1,25(OH)2D3in melanoma cell lines and other skin-derived cell lines

Sertznig, P., Seifert, M., Tilgen, W., & Reichrath, J. (2009) · Dermato-Endocrinology · doi:10.4161/derm.1.4.9629 · Cited by 35

Vitamin D and melanoma

Field, S., Davies, J., Bishop, D. T., & Newton‐Bishop, J. (2013) · Dermato-Endocrinology · doi:10.4161/derm.25244 · Cited by 34

Natural metabolites of 1alpha,25-dihydroxyvitamin D(3) retain biologic activity mediated through the vitamin D receptor.

Harant, H., Spinner, D., Reddy, G. S., & Lindley, I. J. D. (2000) · PubMed · Cited by 34

Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma

Mandelcorn-Monson, R. L., Marrett, L. D., Kricker, A., Armstrong, B. K., Orlow, I., Goumas, C., Paine, S., Rosso, S., Thomas, N. E., Millikan, R. C., et al. (2011) · Cancer Epidemiology · doi:10.1016/j.canep.2011.03.003 · Cited by 33

Regulation of proliferation of prostate epithelial cells by 1,25-dihydroxyvitamin D3 is accompanied by an increase in insulin-like growth factor binding protein-3

Sprenger, C., Peterson, A., Lance, R., Ware, J. L., Drivdahl, R. H., & Plymate, S. R. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1700609 · Cited by 33

Protection from Ultraviolet Damage and Photocarcinogenesis by Vitamin D Compounds

Gordon‐Thomson, C., Tongkao‐on, W., Song, E. J., Carter, S. E., Dixon, K. M., & Mason, R. S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0437-2_17 · Cited by 33

CYP24A1andCYP27B1Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence

Hibler, E. A., Klimentidis, Y. C., Jurutka, P. W., Kohler, L. N., Lance, P., Roe, D. J., Thompson, P. A., & Jacobs, E. T. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1068818 · Cited by 32

Vitamin D and melanoma incidence and mortality

Berwick, M., & Erdei, E. O. (2012) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12015 · Cited by 31

Antiproliferative activity of vitamin D compounds in combination with cytostatics.

Pełczyńska, M., Świtalska, M., Maciejewska, M., Jaroszewicz, I., Kutner, A., & Opolski, A. (2006) · PubMed · Cited by 31

Attenuated RORC Expression in the Presence of EMT Progression in Somatotroph Adenomas following Treatment with Somatostatin Analogs Is Associated with Poor Clinical Recovery

Lekva, T., Berg, J. P., Heck, A., Fougner, S. L., Olstad, O. K., Ringstad, G. A., Bollerslev, J., & Ueland, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066927 · Cited by 30

The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-β1 in NCI-H929 multiple myeloma cells

Park, W., Seol, J. H., Kim, E. Y., Binderup, L., Koeffler, H., Kim, B. C., & Lee, Y. (2002) · International Journal of Oncology · doi:10.3892/ijo.20.3.533 · Cited by 30

Expression of 25-hydroxyvitamin D-1alpha-hydroxylase (1alphaOHase, CYP27B1) splice variants in HaCaT keratinocytes and other skin cells: modulation by culture conditions and UV-B treatment in vitro.

Seifert, M., Tilgen, W., & Reichrath, J. (2009) · PubMed · Cited by 30

1α,25-Dihydroxyvitamin D3 and Its TX527 Analog Inhibit the Growth of Endothelial Cells Transformed by Kaposi Sarcoma-Associated Herpes Virus G Protein-Coupled Receptor in Vitro and in Vivo

Pardo, V. G., Martı́n, D., Gutkind, J. S., Verstuyf, A., Bouillon, R., de Boland, A. R., & Boland, R. (2009) · Endocrinology · doi:10.1210/en.2009-0650 · Cited by 29

Immunohistochemical Detection of 1,25-dihydroxyvitamin D3 Receptors (VDR) in Human Skin

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An inherited variant in the gene coding for vitamin D ‐binding protein and survival from cutaneous melanoma: a B io G eno MEL study

Davies, J. R., Field, S., Randerson‐Moor, J. A., Harland, M., Kumar, R., Anic, G. M., Nagore, E., Hansson, J., Höiom, V., Jönsson, G. B., et al. (2013) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12193 · Cited by 28

Design, Synthesis, and Biological Action of 20R-Hydroxyvitamin D3

Lü, Y., Chen, J., Janjetović, Z., Michaels, P. D., Tang, E. K. Y., Wang, J., Tuckey, R. C., Slominski, A. T., Li, W., & Miller, D. D. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm201478e · Cited by 28

A Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial of Lovastatin for Various Endpoints of Melanoma Pathobiology

Linden, K. G., Leachman, S. A., Zager, J. S., Jakowatz, J. G., Viner, J. L., McLaren, C. E., Barr, R. J., Carpenter, P. M., Chen, W., Elmets, C. A., et al. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0189 · Cited by 28

Serum 25-hydroxyvitamin D3 levels and vitamin D receptor variants in melanoma patients from the Mediterranean area of Barcelona

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Expression analysis of CYP27B1 in tumor biopsies and cell cultures.

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22‐Oxa‐1,25‐dihydroxyvitamin D3 efficiently inhibits tumor growth in inoculated mice and primary histoculutre of cholangiocarcinoma

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Antiproliferative Activity of Double Point Modified Analogs of 1,25-Dihydroxyvitamin D2 Against Human Malignant Melanoma Cell Lines

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rs12512631 on the Group Specific Complement (Vitamin D-Binding Protein GC) Implicated in Melanoma Susceptibility

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1α,25‐dihydroxyvitamin D3 induced growth inhibition of PC‐3 prostate cancer cells requires an active transforming growth factor beta signaling pathway

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Amazing IL-9: revealing a new function for an “old” cytokine

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1α,25-Dihydroxyvitamin D3Specifically Induces Its Own Metabolism in a Human Cancer Cell Line

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BOMIRSKI MELANOMAS - A VERSATILE AND POWERFUL MODEL FOR PIGMENT CELL AND MELANOMA RESEARCH (REVIEW)

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Calcitriol Inhibits Hedgehog Signaling and Induces Vitamin D Receptor Signaling and Differentiation in thePatchedMouse Model of Embryonal Rhabdomyosarcoma

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A new steroidal 5,7-diene derivative, 3β-hydroxyandrosta-5,7-diene-17β-carboxylic acid, shows potent anti-proliferative activity

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RORα Binds to E2F1 To Inhibit Cell Proliferation and Regulate Mammary Gland Branching Morphogenesis

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The Transient Role for Calcium and Vitamin D during the Developmental Hair Follicle Cycle

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Effectiveness of 1α-Hydroxyvitamin D2 in InhibitingTumor Growth in a Murine Transgenic Pigmented Ocular Tumor Model

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Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer

Lin, Z., Marepally, S. R., Ma, D., Kim, T., Oak, A. S. W., Myers, L. K., Tuckey, R. C., Slominski, A. T., Miller, D. D., & Li, W. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00182 · Cited by 21

Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1

Tieu, E. W., Li, W., Chen, J., Kim, T., Ma, D., Slominski, A. T., & Tuckey, R. C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.02.010 · Cited by 20

What do we learn from the genome-wide perspective on vitamin D3?

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Autophagy and radiosensitization in cancer

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Sunlight, Vitamin D and Malignant Melanoma

Reichrath, J., & Reichrath, S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0437-2_22 · Cited by 19

Enhancing 1α-Hydroxylase Activity with the 25-Hydroxyvitamin D-1α-Hydroxylase Gene in Cultured Human Keratinocytes and Mouse Skin

Chen, T. C., Zhu, X. H., Holick, M. F., Kong, X., Holick, M. F., Flanagan, J. N., & Whitlatch, L. W. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01360.x · Cited by 18

Regression of advanced melanoma upon withdrawal of immunosuppression: case series and literature review

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Sun exposure before and after a diagnosis of cutaneous malignant melanoma: estimated by developments in serum vitamin D, skin pigmentation and interviews

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Influence of vitamin D3 metabolites on cell proliferation and cytotoxicity of adriamycin in human normal and neoplastic cells

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Induction of p53 and melanoma cell death is reciprocal with down‐regulation of E2F, cyclin D1 and pRB

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