Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors

Multilineage potential of adult human mesenchymal stem cells

Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052 · see citing works

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766 · see citing works

Fibroblasts in cancer

Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538 · see citing works

Detection of large-scale variation in the human genome

Iafrate, A. J., Feuk, L., Rivera, M. N., Listewnik, M. L., Donahoe, P. K., Qi, Y., Scherer, S. W., & Lee, C. (2004) · Nature Genetics · doi:10.1038/ng1416 · Cited by 2,892 · see citing works

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

Bhowmick, N. A., Chytil, A., Plieth, D., Gorska, A. E., Dumont, N., Shappell, S., Washington, M. K., Neilson, E. G., & Moses, H. L. (2004) · Science · doi:10.1126/science.1090922 · Cited by 1,401 · see citing works

Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors

Pollack, J. R., Sørlie, T., Perou, C. M., Rees, C. A., Jeffrey, S. S., Lønning, P. E., Tibshirani, R. J., Botstein, D., Børresen‐Dale, A., & Brown, P. O. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162471999 · Cited by 1,167 · see citing works

The molecular classification of multiple myeloma

Zhan, F., Huang, Y., Colla, S., Stewart, P., Hanamura, I., Gupta, S. K., Epstein, J., Yaccoby, S., Sawyer, J. R., Burington, B. E., et al. (2006) · Blood · doi:10.1182/blood-2005-11-013458 · Cited by 1,137 · see citing works

Matrix-based comparative genomic hybridization: Biochips to screen for genomic imbalances

Solinas‐Toldo, S., Lampel, S., Stilgenbauer, S., Nickolenko, J., Benner, A., Döhner, H., Cremer, T. J., & Lichter, P. (1997) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199712)20:4 · Cited by 993 · see citing works

TUMOR STROMA AND REGULATION OF CANCER DEVELOPMENT

Tlsty, T. D., & Coussens, L. M. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100224 · Cited by 981 · see citing works

Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

Hideshima, T., Mitsiades, C., Tonon, G., Richardson, P. G., & Anderson, K. C. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2189 · Cited by 932 · see citing works

Mesenchymal Stem Cells

Minguell, J. J., Erices, A. A., & Conget, P. A. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122600603 · Cited by 876 · see citing works

Human Bone Marrow–Derived Mesenchymal Stem Cells Do Not Undergo Transformation after Long-term In vitro Culture and Do Not Exhibit Telomere Maintenance Mechanisms

Bernardo, M. E., Zaffaroni, N., Novara, F., Cometa, A. M., Avanzini, M. A., Moretta, A., Montagna, D., Maccario, R., Villa, R., Daidone, M. G., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4690 · Cited by 694 · see citing works

Adaptation to culture of human embryonic stem cells and oncogenesis in vivo

Baker, D., Harrison, N. J., Maltby, E. L., Smith, K., Moore, H. D. M., Shaw, P. J., Heath, P. R., Holden, H. M., & Andrews, P. W. (2007) · Nature Biotechnology · doi:10.1038/nbt1285 · Cited by 635 · see citing works

Advances in biology of multiple myeloma: clinical applications

Hideshima, T., Bergsagel, P. L., Kuehl, W. M., & Anderson, K. C. (2004) · Blood · doi:10.1182/blood-2004-01-0037 · Cited by 582 · see citing works

Novel Markers for the Prospective Isolation of Human MSC

Bühring, H., Battula, V. L., Treml, S., Schewe, B., Kanz, L., & Vogel, W. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1392.000 · Cited by 456 · see citing works

High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients

Carrasco, D. R., Tonon, G., Huang, Y., Zhang, Y., Sinha, R., Feng, B., Stewart, P., Zhan, F., Khatry, D., Protopopova, M., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.03.019 · Cited by 425 · see citing works

Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis.

Moinfar, F., Man, Y., Arnould, L., Bratthauer, G. L., Ratschek, M., & Tavassoli, F. A. (2000) · PubMed · Cited by 402 · see citing works

Bone marrow mesenchymal stem cells are abnormal in multiple myeloma

Corre, J., Mahtouk, K., Attal, M., Gadelorge, M., Huynh, A., Fleury-Cappellesso, S., Danho, C., Laharrague, P., Klein, B., Rème, T., et al. (2007) · Leukemia · doi:10.1038/sj.leu.2404621 · Cited by 328 · see citing works

Selective Evolution of Stromal Mesenchyme with p53 Loss in Response to Epithelial Tumorigenesis

Hill, R., Song, Y., Cardiff, R. D., & Van Dyke, T. (2005) · Cell · doi:10.1016/j.cell.2005.09.030 · Cited by 324 · see citing works

Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma

Snijders, A. M., Schmidt, B. L., Fridlyand, J., Dekker, N. P., Pinkel, D., Jordan, R. C., & Albertson, D. G. (2005) · Oncogene · doi:10.1038/sj.onc.1208601 · Cited by 279 · see citing works

Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell‐therapy approaches: Further insights in the search for a fetal calf serum substitute

Bernardo, M. E., Avanzini, M. A., Perotti, C. G., Cometa, A. M., Moretta, A., Lenta, E., Fante, C. D., Novara, F., Silvestri, A. D., Amendola, G., et al. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20911 · Cited by 277 · see citing works

Bortezomib reduces serum dickkopf‐1 and receptor activator of nuclear factor‐κB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma

Terpos, E., Heath, D. J., Rahemtulla, A., Zervas, K., Chantry, A., Anagnostopoulos, A., Pouli, A. G., Katodritou, E., Verrou, E., Vervessou, E., et al. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06356.x · Cited by 222 · see citing works

High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization

Nakao, K. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh134 · Cited by 210 · see citing works

Phenotypic and functional characterization of bone marrow mesenchymal stem cells derived from patients with multiple myeloma

Arnulf, B., Lecourt, S., Soulier, J., Ternaux, B., Lacassagne, M.-N., Crinquette, A., Dessoly, J., Sciaini, A.-K., Benbunan, M., Chomienne, C., et al. (2007) · Leukemia · doi:10.1038/sj.leu.2404466 · Cited by 190 · see citing works

Quantification of MYCN, DDX1, and NAG Gene Copy Number in Neuroblastoma Using a Real-Time Quantitative PCR Assay

Preter, K. D., Speleman, F., Combaret, V., Lunec, J., Laureys, G., Eussen, B. H. J., Francotte, N., Julian Board, Pearson, A. D. J., Paepe, A. D., et al. (2002) · Modern Pathology · doi:10.1038/modpathol.3880508 · Cited by 181 · see citing works

GEPAS: a web-based resource for microarray gene expression data analysis

Herrero, J. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg591 · Cited by 180 · see citing works

Combined Total Genome Loss of Heterozygosity Scan of Breast Cancer Stroma and Epithelium Reveals Multiplicity of Stromal Targets

Fukino, K., Shen, L., Matsumoto, S., Morris, Q., Mutter, G. L., & Eng, C. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2866 · Cited by 140 · see citing works

Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q− syndrome

López‐Villar, O., Garcı́a, J. L., Sanchez-Guijo, F. M., Robledo, C., Villarón, E. M., Hernández‐Campo, P. M., López-Holgado, N., Díez‐Campelo, M., Barbado, M. V., Pérez‐Simón, J. A., et al. (2009) · Leukemia · doi:10.1038/leu.2008.361 · Cited by 138 · see citing works

Genomic profiling of gastric cancer predicts lymph node status and survival

Weiss, M. M., Kuipers, E. J., Postma, C., Snijders, A. M., Siccama, I., Pinkel, D., Westerga, J., Meuwissen, S. G. M., Albertson, D. G., & Meijer, G. A. (2003) · Oncogene · doi:10.1038/sj.onc.1206350 · Cited by 126 · see citing works

The Role of the Bone Marrow Microenvironment in the Pathophysiology of Myeloma and Its Significance in the Development of More Effective Therapies

Mitsiades, C. S., McMillin, D. W., Klippel, S., Hideshima, T., Chauhan, D., Richardson, P. G. G., Munshi, N. C., & Anderson, K. C. (2007) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2007.08.007 · Cited by 125 · see citing works

Novel therapeutic strategies targeting growth factor signalling cascades in multiple myeloma

Yasui, H., Hideshima, T., Richardson, P. G. G., & Anderson, K. C. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05860.x · Cited by 98 · see citing works

Microenvironmental Genomic Alterations and Clinicopathological Behavior in Head and Neck Squamous Cell Carcinoma

Weber, F., Xu, Y., Zhang, L., Patócs, A., Shen, L., Platzer, P., & Eng, C. (2007) · JAMA · doi:10.1001/jama.297.2.187 · Cited by 96 · see citing works

Total-Genome Analysis of BRCA1/2-Related Invasive Carcinomas of the Breast Identifies Tumor Stroma as Potential Landscaper for Neoplastic Initiation

Weber, F., Shen, L., Fukino, K., Patócs, A., Mutter, G. L., Caldés, T., & Eng, C. (2006) · The American Journal of Human Genetics · doi:10.1086/504090 · Cited by 94 · see citing works

The role of the stromal microenvironment in prostate cancer

Condon, M. S. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2004.08.002 · Cited by 92 · see citing works

Advances in Biology and Therapy of Multiple Myeloma

Barillé‐Nion, S., Barlogie, B., Bataille, R., Bergsagel, P. L., Epstein, J., Fenton, R. G., Jacobson, J. L., Kuehl, W. M., Shaughnessy, J. D., & Tricot, G. J. K. (2003) · Hematology · doi:10.1182/asheducation-2003.1.248 · Cited by 91 · see citing works

The malignant clone and the bone-marrow environment

Podar, K., Richardson, P. G. G., Hideshima, T., Chauhan, D., & Anderson, K. C. (2007) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2007.08.002 · Cited by 88 · see citing works

Mesenchymal stem cell abnormalities in patients with multiple myeloma

Garderet, L., Mazurier, C., Chapel, A., Ernou, I., Boutin, L., Holy, X., Gorin, N. C., Lopez, M., Doucet, C., & Lataillade, J. (2007) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190701593644 · Cited by 88 · see citing works

Array comparative genomic hybridization reveals genomic copy number changes associated with outcome in diffuse large B-cell lymphomas

Chen, W., Houldsworth, J., Olshen, A. B., Nanjangud, G. J., Chaganti, S. R., Venkatraman, E. S., Halaas, J. L., Teruya‐Feldstein, J., Zelenetz, A. D., & Chaganti, R. S. K. (2005) · Blood · doi:10.1182/blood-2005-07-2950 · Cited by 86 · see citing works

Cytogenetic analysis of human bone marrow‐derived mesenchymal stem cells passaged in vitro

Zhang, Z.-X., Guan, L.-X., Zhang, K., Wang, S., Cao, P., Wang, Y., Wang, Z., & Dai, L. (2006) · Cell Biology International · doi:10.1016/j.cellbi.2006.11.025 · Cited by 81 · see citing works

Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosis

Müller, I., Vaegler, M., Holzwarth, C., Tzaribachev, N., Pfister, S. M., Schüett, B. S., Reize, P., Greil, J., Handgretinger, R., & Rudert, M. (2008) · Leukemia · doi:10.1038/leu.2008.217 · Cited by 69 · see citing works

Pathophysiology of myeloma bone disease

Esteve, F., & Roodman, G. D. (2007) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2007.08.003 · Cited by 66 · see citing works

Abnormal cytokine production by bone marrow stromal cells of multiple myeloma patients in response to RPMI8226 myeloma cells

Zdzisińska, B., Bojarska-Junak, A. A., Dmoszyńska, A., & Kandefer‐Szerszeń, M. (2008) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-008-0022-5 · Cited by 63 · see citing works

5-Azacitidine has limited therapeutic activity in myelofibrosis

Mesa, R. A., Verstovšek, S., Rivera, C. E., Pardanani, A. D., Hussein, K., Lasho, T. L., Wu, W., & Tefferi, A. (2008) · Leukemia · doi:10.1038/leu.2008.136 · Cited by 62 · see citing works

Breakpoint position on 17q identifies the most aggressive neuroblastoma tumors

Łastowska, M., Cotterill, S. J., Bown, N. P., Cullinane, C., Variend, S., Lunec, J., Strachan, T., Pearson, A. D. J., & Jackson, M. S. (2002) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10089 · Cited by 60 · see citing works

Differentiation of canine bone marrow cells with hemopoietic characteristics from an adherent stromal cell precursor.

Huss, R., Hong, D.-S., McSweeney, P. A., Hoy, C. A., & Deeg, H. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.748 · Cited by 53 · see citing works

Identification of alterations in DNA copy number in host stromal cells during tumor progression

Pelham, R. J., Rodgers, L., Hall, I. M., Lucito, R., Nguyen, K. C. Q., Navin, N. E., Hicks, J. B., Mu, D., Powers, S., Wigler, M. H., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609635104 · Cited by 52 · see citing works

Stromal responses to carcinomas of the pancreas: Juxtatumoral gene expression conforms to the infiltrating pattern and not the biologic subtype

Ricci, F., Kern, S. E., Hruban, R. H., & Iacobuzio–Donahue, C. A. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.3.1501 · Cited by 36 · see citing works

Frequent gene dosage alterations in stromal cells of epithelial ovarian carcinomas

Tuhkanen, H. E., Anttila, M., Kosma, V., Heinonen, S. T., Juhola, M. T., Helisalmi, S., Kataja, V. V., & Mannermaa, A. (2006) · International Journal of Cancer · doi:10.1002/ijc.21785 · Cited by 36 · see citing works

Detection of inv(16) and t(16;16) by fluorescence in situ hybridization in acute myeloid leukemia M4Eo.

Hernández‐Rivas, J. M., González, M., Granada, I., Gutierrez, N. C., Chillón, C., Ramos, F., Ribera, J., González, M., Feliú, E., & Miguel, J. F. S. (2000) · PubMed · Cited by 35 · see citing works

The co‐expression of CD117 (c‐kit) and osteocalcin in activated bone marrow stem cells in different diseases

Huss, R., & Moosmann, S. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2002.03587.x · Cited by 32 · see citing works

An Integrated Physical and Gene Map of Human Distal Chromosome 17q24–Proximal 17q25 Encompassing Multiple Disease Loci

Kalikin, L. M., George, R. A. V., Keller, M. P., Bort, S., Bowler, N. S., Law, D., Chance, P. F., & Petty, E. M. (1999) · Genomics · doi:10.1006/geno.1998.5740 · Cited by 28 · see citing works

Bilateral multiple renal oncocytomas and cysts associated with a constitutional translocation (8;9)(q24.1;q34.3) and a rare constitutional VHL missense substitution

Teh, B. T., Blennow, E., Giraud, S., Sahlén, S., Hii, S.-I., Brookwell, R., Brauch, H. B., Nordenskjöld, M., Larsson, C., & Nicol, D. L. (1998) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199803)21:3 · Cited by 25 · see citing works

Origin of stroma cells in long-term bone marrow cultures from patients with acute myeloid leukemia

Zhang, W., Knieling, G., Vohwinkel, G., Martínez, T., Kuse, R., Hossfeld, D. K., & Dührsen, U. (1999) · Annals of Hematology · doi:10.1007/s002770050520 · Cited by 25 · see citing works

Defining Ploidy-Specific Thresholds in Array Comparative Genomic Hybridization to Improve the Sensitivity of Detection of Single Copy Alterations in Cell Lines

Ng, G., Huang, J., Roberts, I., & Coleman, N. (2006) · Journal of Molecular Diagnostics · doi:10.2353/jmoldx.2006.060033 · Cited by 20 · see citing works

Untitled work

Berenson (2001) · doi:10.1002/1097-0142(20010401)91:7

BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression

Roccaro, A. M., Sacco, A., Maiso, P., Azab, A. K., Tai, Y., Reagan, M. R., Azab, F., Flores, L. M., Campigotto, F., Weller, E. A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66517 · Cited by 794 · see citing works

Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production

McLean, K., Gong, Y., Choi, Y., Deng, N., Yang, K., Bai, S., Cabrera, L., Keller, E., McCauley, L., Cho, K. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45273 · Cited by 380 · see citing works

Pathogenesis beyond the cancer clone(s) in multiple myeloma

Bianchi, G., & Munshi, N. C. (2015) · Blood · doi:10.1182/blood-2014-11-568881 · Cited by 285 · see citing works

Upregulation of lncRNA MEG3 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells From Multiple Myeloma Patients By Targeting BMP4 Transcription

Zhuang, W., Ge, X., Yang, S., Huang, M., Zhuang, W., Chen, P., Zhang, X., Fu, J., Qu, J., & Li, B.-Z. (2015) · Stem Cells · doi:10.1002/stem.1989 · Cited by 274 · see citing works

The Role of Tumor Microenvironment in Multiple Myeloma Development and Progression

García-Ortiz, A., Rodríguez-García, Y., Encinas, J., Maroto-Martín, E., Castellano, E., Teixidó, J., & Martínez-López, J. (2021) · Cancers · doi:10.3390/cancers13020217 · Cited by 238 · see citing works

Mesenchymal stem cell secretome and regenerative therapy after cancer

Zimmerlin, L., Park, T. S., Zambidis, E. T., Donnenberg, V. S., & Donnenberg, A. D. (2013) · Biochimie · doi:10.1016/j.biochi.2013.05.010 · Cited by 168 · see citing works

Preclinical development of molecular-targeted agents for cancer

Ocaña, A., Pandiella, A., Siu, L. L., & Tannock, I. F. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.194 · Cited by 158 · see citing works

The bone-marrow niche in MDS and MGUS: implications for AML and MM

Ghobrial, I. M., Detappe, A., Anderson, K. C., & Steensma, D. P. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.197 · Cited by 151 · see citing works

CXCR4 Regulates Extra-Medullary Myeloma through Epithelial-Mesenchymal-Transition-like Transcriptional Activation

Roccaro, A. M., Mishima, Y., Sacco, A., Moschetta, M., Tai, Y., Shi, J., Zhang, Y., Reagan, M. R., Huynh, D., Kawano, Y., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.059 · Cited by 145 · see citing works

Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment

Chen, Y., Jacamo, R. O., Shi, Y.-X., Wang, R., Battula, V. L., Konoplev, S. N., Strunk, D., Hofmann, N., Reinisch, A., Konopleva, M. Y., et al. (2012) · Blood · doi:10.1182/blood-2011-11-389957 · Cited by 135 · see citing works

Multiple Myeloma Mesenchymal Stem Cells: Characterization, Origin, and Tumor-Promoting Effects

Reagan, M. R., & Ghobrial, I. M. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2212 · Cited by 133 · see citing works

Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-κB activity in myeloma cells

Markovina, S. S., Callander, N. S., O’Connor, S. L., Xu, G., Shi, Y., Leith, C. P., Kim, K., Trivedi, P., Kim, J., Hematti, P., et al. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-176 · Cited by 113 · see citing works

Mesenchymal stem cells in multiple myeloma: a therapeutical tool or target?

Xu, S., Veirman, K. D., Becker, A. D., Vanderkerken, K., & Riet, I. V. (2018) · Leukemia · doi:10.1038/s41375-018-0061-9 · Cited by 111 · see citing works

Evidences of Early Senescence in Multiple Myeloma Bone Marrow Mesenchymal Stromal Cells

André, T., Meuleman, N., Stamatopoulos, B., De Bruyn, C., Pieters, K., Bron, D., & Lagneaux, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059756 · Cited by 107 · see citing works

Phenotypic and genomic analysis of multiple myeloma minimal residual disease tumor cells: a new model to understand chemoresistance

Paiva, B., Corchete, L. A., Vídriales, M., Puig, N., Maiso, P., Rodríguez, I., Alignani, D., Burgos, L., Sánchez, M.-L., Bárcena, P., et al. (2016) · Blood · doi:10.1182/blood-2015-08-665679 · Cited by 104 · see citing works

Bone marrow-derived mesenchymal stromal cells are attracted by multiple myeloma cell-produced chemokine CCL25 and favor myeloma cell growth in vitro and in vivo

Xu, S., Menu, E., Becker, A. D., Van Camp, B., Vanderkerken, K., & Van Riet, I. (2012) · Stem Cells · doi:10.1002/stem.787 · Cited by 103 · see citing works

Granulocyte-like myeloid derived suppressor cells (G-MDSC) are increased in multiple myeloma and are driven by dysfunctional mesenchymal stem cells (MSC)

Giallongo, C., Tibullo, D., Parrinello, N. L., Cava, P. L., Rosa, M. D., Bramanti, V., Raimondo, C. D., Conticello, C., Chiarenza, A., Palumbo, G. A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7969 · Cited by 100 · see citing works

The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth

Pennisi, A., Ling, W., Li, X., Khan, S., Shaughnessy, J. D., Barlogie, B., & Yaccoby, S. (2009) · Blood · doi:10.1182/blood-2009-01-201954 · Cited by 96 · see citing works

Advances in the understanding of myeloma bone disease and tumour growth

Yaccoby, S. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08141.x · Cited by 95 · see citing works

The Role of Marrow Microenvironment in the Growth and Development of Malignant Plasma Cells in Multiple Myeloma

Giannakoulas, N. C., Ntanasis‐Stathopoulos, I., & Terpos, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094462 · Cited by 88 · see citing works

Epigenetic interplay between immune, stromal and cancer cells in the tumor microenvironment

García-Gómez, A., Rodríguez‐Ubreva, J., & Ballestar, E. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.02.013 · Cited by 86 · see citing works

Preclinical Activity of the Oral Proteasome Inhibitor MLN9708 in Myeloma Bone Disease

García-Gómez, A., Quwaider, D., Canavese, M., Ocio, E. M., Tian, Z., Blanco, J. F., Berger, A., Ortíz-de-Solórzano, C., Hernández‐Iglesias, T., Martens, A. C., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1657 · Cited by 84 · see citing works

Human Placenta-Derived Adherent Cells Prevent Bone loss, Stimulate Bone formation, and Suppress Growth of Multiple Myeloma in Bone

Li, X., Ling, W., Pennisi, A., Wang, Y., Khan, S., Heidaran, M. A., Pal, A., Zhang, X., He, S., Zeitlin, A., et al. (2010) · Stem Cells · doi:10.1002/stem.572 · Cited by 83 · see citing works

Upregulation of miR-135b Is Involved in the Impaired Osteogenic Differentiation of Mesenchymal Stem Cells Derived from Multiple Myeloma Patients

Xu, S., Santini, G., Veirman, K. D., Broek, I. V., Leleu, X. P., Becker, A. D., Camp, B. V., Vanderkerken, K., & Riet, I. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079752 · Cited by 82 · see citing works

Dasatinib as a Bone-Modifying Agent: Anabolic and Anti-Resorptive Effects

García-Gómez, A., Ocio, E. M., Crusoé, E. D. Q., Santamaría, C., Hernández‐Campo, P. M., Blanco, J. F., Sanchez-Guijo, F. M., Hernández‐Iglesias, T., Briñón, J. G., Fisac-Herrero, R. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034914 · Cited by 76 · see citing works

Immunomodulatory effect of mesenchymal stem cells

Herrero, C., & Pérez‐Simón, J. A. (2010) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2010007500033 · Cited by 74 · see citing works

A novel 3D mesenchymal stem cell model of the multiple myeloma bone marrow niche: biologic and clinical applications

Jakubı́ková, J., Cholujová, D., Hideshima, T., Gronesova, P., Šoltýsová, A., Harada, T., Joo, J., Kong, S., Szalat, R. E., Richardson, P. G. G., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12643 · Cited by 72 · see citing works

Personalized therapies in the cancer "omics" era

Ocaña, A., & Pandiella, A. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-202 · Cited by 67 · see citing works

Knockdown of long non-coding RNA H19 inhibits multiple myeloma cell growth via NF-κB pathway

Sun, Y., Pan, J., Zhang, N., Wei, W., Yu, S., & Ai, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-18056-9 · Cited by 66 · see citing works

Drug resistance in multiple myeloma: Soldiers and weapons in the bone marrow niche

Solimando, A. G., Malerba, E., Leone, P., Prete, M., Terragna, C., Cavo, M., & Racanelli, V. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.973836 · Cited by 65 · see citing works

Effect of the HDAC inhibitor vorinostat on the osteogenic differentiation of mesenchymal stem cells in vitro and bone formation in vivo

Xu, S., De Veirman, K., Evans, H., Santini, G. C., Vande Broek, I., Leleu, X., De Becker, A., Van Camp, B., Croucher, P., Vanderkerken, K., et al. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.182 · Cited by 64 · see citing works

Cell therapy with autologous mesenchymal stem cells—how the disease process impacts clinical considerations

Wang, J., Liao, L., Wang, S., & Tan, M. J. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2013.01.218 · Cited by 63 · see citing works

Distinct transcriptional profiles characterize bone microenvironment mesenchymal cells rather than osteoblasts in relationship with multiple myeloma bone disease

Todoerti, K., Lisignoli, G., Storti, P., Agnelli, L., Novara, F., Manferdini, C., Codeluppi, K., Colla, S., Crugnola, M., Abeltino, M., et al. (2009) · Experimental Hematology · doi:10.1016/j.exphem.2009.11.009 · Cited by 63 · see citing works

Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment

Poggi, A. D., & Giuliani, M. (2016) · Vaccines · doi:10.3390/vaccines4040041 · Cited by 62 · see citing works

Mesenchymal Stem Cells Derived from Bone Marrow of Diabetic Patients Portrait Unique Markers Influenced by the Diabetic Microenvironment

Phadnis, S. M., Ghaskadbi, S., Hardikar, A. A., & Bhonde, R. R. (2009) · The Review of Diabetic Studies · doi:10.1900/rds.2009.6.260 · Cited by 60 · see citing works

Citrullination of histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myeloma

McNee, G. S., Eales, K. L., Wei, W., Williams, D., Barkhuizen, A., Bartlett, D. B., Essex, S., Anandram, S., Filer, A. D., Moss, P. A. H., et al. (2016) · Leukemia · doi:10.1038/leu.2016.187 · Cited by 57 · see citing works

Multiple Myeloma and Bone: The Fatal InteractionPreprint

Marino, S., & Roodman, G. D. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031286 · Cited by 56 · see citing works

Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway

Xu, S., Evans, H., Buckle, C., Veirman, K. D., Hu, J., Xu, D., Menu, E., Becker, A. D., Broek, I. V., Leleu, X. P., et al. (2012) · Leukemia · doi:10.1038/leu.2012.126 · Cited by 55 · see citing works

Bone marrow inflammation in haematological malignancies

de Jong, M. M. E., Chen, L., Raaijmakers, M. H. G. P., & Cupedo, T. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01003-x · Cited by 54 · see citing works

Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease

García-Gómez, A., Rivas, J. D. L., Ocio, E. M., Dı́az-Rodrı́guez, E., Montero, J. C., Martín, M., Blanco, J. F., Sanchez-Guijo, F. M., Pandiella, A., Miguel, J. F. S., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2058 · Cited by 53 · see citing works

Characterization of Human Mesenchymal Stem Cells from Ewing Sarcoma Patients. Pathogenetic Implications

Amaral, A. T., Manara, M. C., Berghuis, D., Ordóñez, J. L., Biscuola, M., López‐García, M. Á., Osuna, D., Lucarelli, E., Alviano, F., Lankester, A. C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085814 · Cited by 53 · see citing works

The osteoblastic niche in the context of multiple myeloma

Toscani, D., Bolzoni, M., Accardi, F., Aversa, F., & Giuliani, N. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12578 · Cited by 52 · see citing works

Osteoblastogenesis and tumor growth in myeloma

Yaccoby, S. (2009) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428190903503438 · Cited by 52 · see citing works

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

Garcia-Gomez, A., Li, T., de la Calle-Fabregat, C., Rodríguez-Ubreva, J., Ciudad, L., Català-Moll, F., Godoy-Tena, G., Martín-Sánchez, M., San-Segundo, L., Muntión, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20715-x · Cited by 57 · see citing works

Bone Marrow Mesenchymal Stromal Cells in Multiple Myeloma: Their Role as Active Contributors to Myeloma Progression

Maiso, P., Mogollón, P., Ocio, E. M., & Garayoa, M. (2021) · Cancers · doi:10.3390/cancers13112542 · Cited by 48 · see citing works

ER stress arm XBP1s plays a pivotal role in proteasome inhibition-induced bone formation

Zhang, D., Veirman, K. D., Fan, R., Qiang, J., Zhang, Y., Li, L., Evans, H., Wang, Y., Lei, L., Wang, B., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02037-3 · Cited by 48 · see citing works

A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis

Li, R., Colombo, M., Wang, G., Rodriguez-Romera, A., Benlabiod, C., Jooss, N. J., O’Sullivan, J., Brierley, C. K., Clark, S., Pérez‐Sáez, J. M., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adj7552 · Cited by 48 · see citing works

Bone marrow-derived mesenchymal stem cells promote cell proliferation of multiple myeloma through inhibiting T cell immune responses via PD-1/PD-L1 pathway

Chen, D., Tang, P., Liu, L., Wang, F., Xing, H., Sun, L., & Jiang, Z. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1442624 · Cited by 48 · see citing works

Extracellular Matrix Remodeling by Bone Marrow Fibroblast-like Cells Correlates with Disease Progression in Multiple Myeloma

Slany, A., Haudek‐Prinz, V. J., Meshcheryakova, A., Bileck, A., Lamm, W. W., Zielinski, C. C., Gerner, C., & Drach, J. W. (2013) · Journal of Proteome Research · doi:10.1021/pr400881p · Cited by 47 · see citing works

Potential clinical applications of adult human mesenchymal stem cell (Prochymal®) therapy

Patel, A. N., & Genovese (2011) · Stem Cells and Cloning Advances and Applications · doi:10.2147/sccaa.s11991 · Cited by 45 · see citing works

Leukemia-associated genetic aberrations in mesenchymal stem cells of children with acute lymphoblastic leukemia

Shalapour, S., Eckert, C., Seeger, K., Pfau, M., Prada, J., Henze, G., Blankenstein, T. J. F., & Kammertoens, T. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0583-8 · Cited by 45 · see citing works

Multiple myeloma cells alter the senescence phenotype of bone marrow mesenchymal stromal cells under participation of the DLK1-DIO3 genomic region

Berenstein, R., Blau, O., Nogai, A., Waechter, M., Slonova, E., Schmidt-Hieber, M., Kunitz, A., Pezzutto, A., Doerken, B., & Blau, I. W. (2015) · BMC Cancer · doi:10.1186/s12885-015-1078-3 · Cited by 44 · see citing works

Acute Myeloid Leukemia Cells Educate Mesenchymal Stromal Cells toward an Adipogenic Differentiation Propensity with Leukemia Promotion Capabilities

Zhang, L., Zhao, Q., Cang, H., Wang, Z., Hu, X., Pan, R., Yang, Y., & Chen, Y. (2022) · Advanced Science · doi:10.1002/advs.202105811 · Cited by 44 · see citing works

IL21R expressing CD14 + CD16 + monocytes expand in multiple myeloma patients leading to increased osteoclasts

Bolzoni, M., Ronchetti, D., Storti, P., Donofrío, G., Marchica, V., Costa, F., Agnelli, L., Toscani, D., Vescovini, R., Todoerti, K., et al. (2017) · Haematologica · doi:10.3324/haematol.2016.153841 · Cited by 43 · see citing works

Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics

García-Gómez, A. (2014) · World Journal of Stem Cells · doi:10.4252/wjsc.v6.i3.322 · Cited by 41 · see citing works

Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche

Colombo, M., Galletti, S., Bulfamante, G., Falleni, M., Tosi, D., Todoerti, K., Lazzari, E., Crews, L. A., Jamieson, C. H. M., Ravaioli, S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10820 · Cited by 41 · see citing works

Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche

Tsukamoto, S., Løvendorf, M. B., Park, J., Salem, K. Z., Reagan, M. R., Manier, S., Zavidij, O., Rahmat, M., Huynh, D., Takagi, S., et al. (2018) · Leukemia · doi:10.1038/s41375-018-0161-6 · Cited by 40 · see citing works

Osteoblast suppression in multiple myeloma bone disease

Adamik, J., Galson, D. L., & Roodman, G. D. (2018) · Journal of bone oncology · doi:10.1016/j.jbo.2018.09.001 · Cited by 40 · see citing works

Therapeutic effects of intrabone and systemic mesenchymal stem cell cytotherapy on myeloma bone disease and tumor growth

Li, X., Ling, W., Khan, S., & Yaccoby, S. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1620 · Cited by 37 · see citing works

Extramedullary Multiple Myeloma: Challenges and Opportunities

Ho, M., Paruzzo, L., Minehart, J. C., Nabar, N. R., Noll, J. H., Luo, T., Garfall, A. L., & Zanwar, S. (2025) · Current Oncology · doi:10.3390/curroncol32030182 · Cited by 38 · see citing works

The Pattern of Mesenchymal Stem Cell Expression Is an Independent Marker of Outcome in Multiple Myeloma

Schinke, C., Qu, P., Mehdi, S. J., Hoering, A., Epstein, J., Johnson, S., van Rhee, F., Zangari, M., Thanendrarajan, S., Barlogie, B., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2627 · Cited by 35 · see citing works

The backbone of progress – preclinical studies and innovations with zoledronic acid

Green, J. R., & Guenther, A. (2011) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(11)70003-8 · Cited by 35 · see citing works

Novel Strategies for Immunotherapy in Multiple Myeloma: Previous Experience and Future Directions

Danylesko, I., Beider, K., Shimoni, A., & Nagler, A. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/753407 · Cited by 34 · see citing works

The Hemopoietic Stem Cell Niche Versus the Microenvironment of the Multiple Myeloma-Tumor Initiating Cell

Zipori, D. (2010) · Cancer Microenvironment · doi:10.1007/s12307-009-0034-7 · Cited by 33 · see citing works

Natural Killer Cells in the Malignant Niche of Multiple Myeloma

Venglár, O., Bago, J., Motais, B., Hájek, R., & Jelı́nek, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.816499 · Cited by 33 · see citing works

Sphingosine‐1‐phosphate activates chemokine‐promoted myeloma cell adhesion and migration involving α4β1 integrin function

García‐Bernal, D., Redondo-Muñóz, J., Dios‐Esponera, A., Chèvre, R., Bailón, E., Garayoa, M., Arellano‐Sánchez, N., Gutierrez, N. C., Hidalgo, A., Garcı́a-Pardo, A., et al. (2012) · The Journal of Pathology · doi:10.1002/path.4066 · Cited by 32 · see citing works

Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

Allegra, A., Innao, V., Allegra, A. G., Pugliese, M., Salvo, E. D., Ventura-Spagnolo, E., Musolino, C., & Gangemi, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112822 · Cited by 30 · see citing works

Bone Marrow Stromal Cell-Derived IL-8 Upregulates PVR Expression on Multiple Myeloma Cells via NF-kB Transcription Factor

Mekhloufi, A., Kosta, A., Stabile, H., Molfetta, R., Zingoni, A., Soriani, A., Cippitelli, M., Paolini, R., Gismondi, A., Ricciardi, M. R., et al. (2020) · Cancers · doi:10.3390/cancers12020440 · Cited by 32 · see citing works

Fibroblast activation protein protects bortezomib-induced apoptosis in multiple myeloma cells through β-catenin signaling pathway

Zi, F., He, J.-S., Li, Y., Wu, C., Wu, W.-J., Yang, Y., Wang, L., He, D.-H., Yang, L., Zhao, Y., et al. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.29924 · Cited by 31 · see citing works

Ex vivo identification and characterization of a population of CD13high CD105+ CD45− mesenchymal stem cells in human bone marrow

Muñiz, C., Teodósio, C., Mayado, A., Amaral, A. T., Matarraz, S., Bárcena, P., Sánchez, M. L., Álvarez‐Twöse, I., Díez‐Campelo, M., García‐Montero, A. C., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0152-8 · Cited by 31 · see citing works

Transcriptome Analysis of Mesenchymal Stem Cells from Multiple Myeloma Patients Reveals Downregulation of Genes Involved in Cell Cycle Progression, Immune Response, and Bone Metabolism

Fernando, R. C., Mazzotti, D. R., de Azevedo, H. F. Z., Sandes, A. F., Rizzatti, E. G., de Oliveira, M. B., Alves, V. L. F., Eugênio, A. I. P., de Carvalho, F., Dalboni, M. A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-38314-8 · Cited by 28 · see citing works

A Peculiar Molecular Profile of Umbilical Cord-Mesenchymal Stromal Cells Drives Their Inhibitory Effects on Multiple Myeloma Cell Growth and Tumor Progression

Ciavarella, S., Caselli, A., Tamma, A. V., Savonarola, A., Loverro, G., Paganelli, R., Tucci, M., & Silvestris, F. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0254 · Cited by 28 · see citing works

Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword

Kamrani, S., Naseramini, R., Khani, P., Razavi, Z. S., Afkhami, H., Atashzar, M. R., Nasri, F., Alavimanesh, S., Saeidi, F., & Ronaghi, H. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03741-x · Cited by 27 · see citing works

A worm gel-based 3D model to elucidate the paracrine interaction between multiple myeloma and mesenchymal stem cells

Spelat, R., Ferro, F., Contessotto, P., Warren, N. J., Marsico, G., Armes, S. P., & Pandit, A. S. (2020) · Materials Today Bio · doi:10.1016/j.mtbio.2019.100040 · Cited by 27 · see citing works

Multiple myeloma and bone marrow mesenchymal stem cells’ crosstalk: Effect on translation initiation

Attar‐Schneider, O., Zismanov, V., Dabbah, M., Tartakover‐Matalon, S., Drucker, L., & Lishner, M. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22378 · Cited by 24 · see citing works

Characterization of freshly isolated bone marrow mesenchymal stromal cells from healthy donors and patients with multiple myeloma: transcriptional modulation of the microenvironment

Alameda, D., Sáez, B., Lara‐Astiaso, D., Sarvide, S., Lasa, M., Alignani, D., Rodríguez, I., Gárate, S., Vilas‐Zornoza, A., Paiva, B., et al. (2020) · Haematologica · doi:10.3324/haematol.2019.235135 · Cited by 24 · see citing works

Germline Risk Contribution to Genomic Instability in Multiple Myeloma

Janz, S., Zhan, F., Sun, F., Cheng, Y., Pisano, M. D., Yang, Y., Goldschmidt, H., & Hari, P. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00424 · Cited by 23 · see citing works

Mesenchymal stem cells derived from multiple myeloma patients protect against chemotherapy through autophagy-dependent activation of NF-κB signaling

Yang, H., Zheng, Y., Zhang, Y., Cao, Z., & Jiang, Y. (2017) · Leukemia Research · doi:10.1016/j.leukres.2017.07.002 · Cited by 23 · see citing works

Mesenchymal stem cells secretomes' affect multiple myeloma translation initiation

Marcus, H., Attar‐Schneider, O., Dabbah, M., Zismanov, V., Tartakover‐Matalon, S., Lishner, M., & Drucker, L. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.03.003 · Cited by 21 · see citing works

Lenalidomide restores the osteogenic differentiation of bone marrow mesenchymal stem cells from multiple myeloma patients via deactivating Notch signaling pathway

Guo, J., Fei, C., Zhao, Y., Zhao, S., Zheng, Q., Su, J., Wu, D., Li, X., & Chang, C. (2017) · Oncotarget · doi:10.18632/oncotarget.19265 · Cited by 21 · see citing works

Hepatocyte growth factor pathway upregulation in the bone marrow microenvironment in multiple myeloma is associated with lytic bone disease

Kristensen, I. B., Christensen, J. H., Lyng, M., Møller, M. B., Pedersen, L., Rasmussen, L. M., Ditzel, H. J., & Abildgaard, N. (2013) · British Journal of Haematology · doi:10.1111/bjh.12270 · Cited by 20 · see citing works

Epigenetic Crosstalk between Malignant Plasma Cells and the Tumour Microenvironment in Multiple Myeloma

Allegra, A., Casciaro, M., Barone, P., Musolino, C., & Gangemi, S. (2022) · Cancers · doi:10.3390/cancers14112597 · Cited by 19 · see citing works

Common and different alterations of bone marrow mesenchymal stromal cells in myelodysplastic syndrome and multiple myeloma

Choi, H., Kim, Y., Kang, D., Kwon, A., Kim, J., Kim, J. M., Park, S., Kim, Y., Min, C., & Kim, M. (2020) · Cell Proliferation · doi:10.1111/cpr.12819 · Cited by 18 · see citing works

RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS

Seibold, M., Stühmer, T., Kremer, N., Mottok, A., Scholz, C. J., Schlösser, A., Leich, E., Holzgrabe, U., Brünnert, D., Barrio, S., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.223024 · Cited by 18 · see citing works

Depletion of regulator-of-G-protein signaling-10 in mice exaggerates high-fat diet-induced insulin resistance and inflammation, and this effect is mitigated by dietary green tea extract

Fang, X., Chung, J., Olsen, E., Snider, I., Earls, R. H., Jeon, J. H., Park, H. J., & Lee, J. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.06.004 · Cited by 18 · see citing works

Inhibiting PI3K–AKT–mTOR Signaling in Multiple Myeloma-Associated Mesenchymal Stem Cells Impedes the Proliferation of Multiple Myeloma Cells

Heinemann, L., Möllers, K. M., Ahmed, H. M. M., Wei, L., Sun, K., Nimmagadda, S. C., Frank, D., Baumann, A., Poos, A. M., Dugas, M., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.874325 · Cited by 15 · see citing works

Targeting the Bone Marrow Microenvironment

Moschetta, M., Kawano, Y., & Podar, K. (2016) · Cancer treatment and research · doi:10.1007/978-3-319-40320-5_6 · Cited by 15 · see citing works

Genome-wide association study of bone quality and feed efficiency-related traits in Pekin ducks

Li, G.-S., Liu, W., Zhang, F., Zhu, F., Yang, F., Hao, J.-P., & Hou, Z. (2020) · Genomics · doi:10.1016/j.ygeno.2020.09.023 · Cited by 15 · see citing works

Mesenchymal niches of bone marrow in cancer

Abarrategi, A., Mariñas‐Pardo, L., Mirones, I., Rincón, E., & Garcı́a-Castro, J. (2011) · Clinical & Translational Oncology · doi:10.1007/s12094-011-0706-x · Cited by 14 · see citing works

A Hyaluronan and Proteoglycan Link Protein 1 Matrikine: Role of Matrix Metalloproteinase 2 in Multiple Myeloma NF-κB Activation and Drug Resistance

Mark, C., Warrick, J. W., Callander, N. S., Hematti, P., & Miyamoto, S. (2022) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-21-0941 · Cited by 15 · see citing works

The ability of multipotent mesenchymal stromal cells from the bone marrow of patients with leukemia to maintain normal hematopoietic progenitor cells

Sorokina, T. V., Shipounova, I. N., Bigildeev, A., Петинати, Н. А., Дризе, Н. И., Turkina, A., Chelysheva, E. Y., Shukhov, O. A., Kuzmina, L. A., Parovichnikova, E. N., et al. (2015) · European Journal Of Haematology · doi:10.1111/ejh.12713 · Cited by 13 · see citing works

Contributions of the Bone Microenvironment to Monoclonal Gammopathy of Undetermined Significance Pathogenesis

Gámez, B., & Edwards, C. M. (2018) · Current Osteoporosis Reports · doi:10.1007/s11914-018-0479-z · Cited by 13 · see citing works

Imprinting of Mesenchymal Stromal Cell Transcriptome Persists even after Treatment in Patients with Multiple Myeloma

Lemaitre, L., Do Souto Ferreira, L., Joubert, M.-V., Avet-Loiseau, H., Martinet, L., Corre, J., & Couderc, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113854 · Cited by 13 · see citing works

Cytogenetic and molecular cytogenetic profile of bone marrow-derived mesenchymal stromal cells in chronic and acute lymphoproliferative disorders

Campioni, D., Bardi, M. A., Cavazzini, F., Tammiso, E., Pezzolo, E., Pregnolato, E., Volta, E., Cuneo, A., & Lanza, F. (2012) · Annals of Hematology · doi:10.1007/s00277-012-1500-8 · Cited by 13 · see citing works

Impact of cell fusion in myeloma marrow microenvironment on tumor progression

Wang, Z., Yuan, Y., Zhang, L., Min, Z., Zhou, D., Sun, Y., Wang, P., Ju, S., Li, J., & Fu, J. (2018) · Oncotarget · doi:10.18632/oncotarget.25742 · Cited by 12 · see citing works

Telomere length is positively associated with the expression of IL-6 and MIP-1α in bone marrow mesenchymal stem cells of multiple myeloma

Li, S., Jiang, Y. Z., Li, A., Liu, X., Xing, X., Guo, Y., Xu, Y., Hao, Y., & Zheng, C. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6885 · Cited by 12 · see citing works

SDF ‐1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of R ho A ‐ ROCK ‐ M yosin II

Choi, D. S., Stark, D. J., Raphael, R. M., Wen, J., Su, J., Zhou, X., Chang, C.-C., & Zu, Y. (2014) · International Journal of Cancer · doi:10.1002/ijc.29145 · Cited by 11 · see citing works

The Osteoblastogenesis Potential of Adipose Mesenchymal Stem Cells in Myeloma Patients Who Had Received Intensive Therapy

Lin, H., Hwang, S., Wu, S., Hsu, L., Liao, Y., Sheen, Y., Chuang, W., & Huang, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094395 · Cited by 10 · see citing works

Novel Developments in the Treatment of Multiple Myeloma-Associated Bone Disease

Johansen, M., Levring, M. B., Stokbro, K., Diaz‐delCastillo, M., Khan, A. A., Wickstrøm, L. A., Gundesen, M. T., Kristensen, I. B., Nyvold, C. G., Andersen, M. Ø., et al. (2023) · Cancers · doi:10.3390/cancers15235585 · Cited by 10 · see citing works

Characterization of the biological and transcriptomic landscapes of bone marrow-derived mesenchymal stem cells in patients with multiple myeloma

Yu, L., Zheng, C., Zhang, W., Liu, X., Zhou, Z., Wang, Z., Hua, H., Song, Z., Zhang, X., Liu, S., et al. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03308-2 · Cited by 8 · see citing works

Characterization of Mesenchymal Stem Cells Abnormalities in Multiple Myeloma.

Bourin, P., Corre, J., Mahtouk, K., Gadelorge, M., Laharrague, P. F., Klein, B., Reme, T. X., & Attal, M. (2006) · Blood · doi:10.1182/blood.v108.11.511.511 · Cited by 2 · see citing works

Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q− syndrome

López‐Villar, O., Garcı́a, J. L., Sanchez-Guijo, F. M., Robledo, C., Villarón, E. M., Hernández‐Campo, P. M., López-Holgado, N., Díez‐Campelo, M., Barbado, M. V., Pérez‐Simón, J. A., et al. (2009) · Leukemia · doi:10.1038/leu.2008.361 · Cited by 138 · see citing works

Mesenchymal Stem Cells from Patients with Myelodysplastic Syndromes Are Functionally and Genomically Abnormal.

López‐Villar, O., Sanchez-Guijo, F. M., Garcı́a, J. L., Porras, J. R. G., Villarón, E. M., López-Holgado, N., Pérez‐Simón, J. A., Miguel, J. F. S., & del Cañizo, M. C. (2007) · Blood · doi:10.1182/blood.v110.11.1916.1916

Bone Marrow Mesenchymal Stem Cells in Myelodysplastic Syndromes: Cytogenetic Characterization

Song, L., Guo, J., He, Q., Yang, L., Gu, S., Zhang, X., Wu, L.-Y., Li, X., & Chang, C. (2012) · Acta Haematologica · doi:10.1159/000339427 · Cited by 8 · see citing works

Clonal Abnormalities in MSC Derived from AML Bone Marrows

Andreeff, M., McQueen, T. J., Williams, C., Gu, J., Hopwood, V. L., Appleberry, T., Rich, C., Dallaire, S., Kornblau, S. M., & Wang, R. (2008) · Blood · doi:10.1182/blood.v112.11.2428.2428 · Cited by 2 · see citing works