Bone marrow mesenchymal stem cells are abnormal in multiple myeloma
Open accessAbstract
Recent literature suggested that cells of the microenvironment of tumors could be abnormal as well. To address this hypothesis in multiple myeloma (MM), we studied bone marrow mesenchymal stem cells (BMMSCs), the only long-lived cells of the bone marrow microenvironment, by gene expression profiling and phenotypic and functional studies in three groups of individuals: patients with MM, patients with monoclonal gamopathy of undefined significance (MGUS) and healthy age-matched subjects. Gene expression profile independently classified the BMMSCs of these individuals in a normal and in an MM group. MGUS BMMSCs were interspersed between these two groups. Among the 145 distinct genes differentially expressed in MM and normal BMMSCs, 46% may account for a tumor-microenvironment cross-talk. Known soluble factors implicated in MM pathophysiologic features (i.e. IL (interleukin)-6, DKK1) were revealed and new ones were found which are involved in angiogenesis, osteogenic differentiation or tumor growth. In particular, GDF15 was found to induce dose-dependent growth of MOLP-6, a stromal cell-dependent myeloma cell line. Functionally, MM BMMSCs induced an overgrowth of MOLP-6, and their capacity to differentiate into an osteoblastic lineage was impaired. Thus, MM BMMSCs are abnormal and could create a very efficient niche to support the survival and proliferation of the myeloma cells.
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Elevated IL-6 secretion by MSC has been detected after interaction with malignant cells in several epithelial, hematopoietic and mesenchymal cancers.
“Secretion of elevated levels of IL-6 by MSC has been detected upon interaction with malignant cells in several epithelial, hematopoietic and mesenchymal cancers (Table 2) [43, 69, 76, 77, 82, 115–119].”
From Mesenchymal stem cell secretome and regenerative therapy after cancer (2013) · cites this paper as [77]
The Results and Discussion (page numbers unavailable) report that bone marrow MSCs from multiple myeloma patients secreted more IL-6 than those from healthy donors. The Discussion also describes a myeloma-cell factor that can stimulate MSC IL-6 production. This supports the hematopoietic-cancer example, but the paper does not establish the claim across epithelial and mesenchymal cancers or show that the measured increase occurred specifically after malignant-cell interaction. (LLM, conf=0.86)
Experimental — accuracy not yet measuredMultiple myeloma mesenchymal stromal cells have different gene profiles from their counterparts in normal mesenchymal stromal cells.
“Notably, MM-MSCs have different gene profiles from their counterparts in normal MSCs [289, 290].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [289]
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- Authors
- Corre, J., Mahtouk, K., Attal, M., Gadelorge, M., Huynh, A., Fleury-Cappellesso, S., Danho, C., Laharrague, P., Klein, B., Rème, T., & Bourin, P.
- Affiliations
- Établissement Français du Sang (FR)
- Inserm (FR)
- Hôpital Purpan (FR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Bourin, P
- Venue
- Leukemia
- Published
- 2007-03-08
- Volume
- 21
- Issue
- 5
- Pages
- 1079-1088
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- PMC
- PMC2346535
- OpenAlex
- W2048064990
- Cited by
- 328
- References
- 62
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 13 · 2023: 11 · 2022: 12 · 2021: 20 · 2020: 18 · 2019: 10 · 2018: 18 · 2017: 21 · 2016: 21 · 2015: 18 · 2014: 23 · 2013: 25 · 2012: 25
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Leukemia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- multiple myeloma, bone marrow mesenchymal stem cells, tumor microenvironment, monoclonal gammopathy of undetermined significance, gene expression profiling, interleukin-6, DKK1, GDF15, angiogenesis, osteogenic differentiation
- MeSH terms
- Adult, Aged, Bone Marrow Cells, Cell Differentiation, Female, Hematopoiesis, Humans, Male, Middle Aged, Multiple Myeloma, Osteoblasts, Cytokines, Gene Expression Profiling, Cell Proliferation, Growth Differentiation Factor 15, Mesenchymal Stem Cells
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